<![CDATA[The increasing global life expectancy has led to a rapidly growing elderly population, resulting in a higher prevalence of Alzheimer’s disease and a pressing need for effective diagnostic solutions. Despite advances in medical imaging, the early and accurate detection of Alzheimer’s disease remains a major challenge due to subtle differences in brain structures across disease stages. However, the interpretation of MRI images still depends heavily on the abilities of individual medical personnel, which risks introducing subjectivity and potential errors in the diagnostic process. In this context, particularly deep learning, emerges as an effective strategy to overcome these limitations by automating the analysis of medical images and reducing human bias. To address this issue, a custom Convolutional Neural Network (CNN) model was developed from scratch for Alzheimer’s disease classification using brain MRI images. To enhance data diversity and mitigate overfitting, a combination of Albumentations and CutMix data augmentation techniques was applied, yielding an initial classification accuracy of 90%. Model performance was further optimized using a Genetic Algorithm (GA), which efficiently explored the hyperparameter space and identified optimal configurations, boosting classification accuracy to 96%. The optimized model demonstrated robust generalization across all disease categories, confirming the effectiveness of the proposed approach. This research contributes to the development of a more reliable and adaptive deep learning framework for early-stage Alzheimer’s disease detection, offering potential support for clinical diagnostic systems]]>
