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All Journal ACTA VETERINARIA INDONESIANA Jurnal Veteriner Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Majalah Obat Tradisional Jurnal Ilmiah Mahasiswa Veteriner Jurnal Pendidikan Kimia (JPKim) Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Asian Journal of Social and Humanities Jurnal Medika Veterinaria Jurnal Agripet
Ummu Balqis
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Narra J

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Phytocompounds of Nigella sativa seeds extract and their neuroprotective potential via EGR1 receptor inhibition: A molecular docking study Kulsum, Kulsum; Syahrul, Syahrul; Hasbalah, Kartini; Balqis, Ummu
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.173

Abstract

Bioactivity of Nigella sativa seed extract has the potential as a neuro-protector, offering its promising utility in the clinical setting for brain injury management. This study aimed to identify the phytocompounds contained in the extract of N. sativa seeds and further screen their respective neuronal anti-inflammatory activities in silico. The extract of N. sativa seeds was prepared through successive maceration using non-polar to polar solvents (n-hexane and ethanol, respectively). The phytocompounds in the ethanolic extract were initially identified through qualitative analysis and further analyzed with gas chromatography-mass spectrometry (GC-MS). The spectral data were compared with the compound library for identification. The identified phytocompounds were then simulated computationally for their binding affinities toward the active pocket of early growth response-1 (EGR1) receptor (PDB: 14r2a). We found that the ethanolic extract of N. sativa seeds were predominantly constituted of hexadecanoic acid, ethyl ester (17.15%); linoleic acid ethyl ester (15.0%); octadecanoic acid (13.26%); and ethyl oleate (10.38%). The binding affinity of the phytocompounds ranged from -7.49 kcal/mol (methyl palmitoleate) to -14.31 kcal/mol (9-hexadecanoic acid, methyl ester), with 12 compounds having binding affinity < -10 kcal/mol. In conclusion, ethanolic extract of N. sativa seeds are rich with fatty acids that have active as anti-inflammatory and may exert neuronal protection by inhibiting EGR1 receptor. Studies using animal models to confirm the activity are warranted.
Oxygen saturation profile in traumatic brain injury animal model after propofol administration Kulsum, Kulsum; Syahrul, Syahrul; Hasbalah, Kartini; Balqis, Ummu; Suryadi, Taufik
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.189

Abstract

Traumatic brain injury (TBI) is a traumatic that often leads to death due to untreatable cerebral hypoxia, indicated by oxygen saturation of <90%. Cerebral hypoxia is rarely monitored and thereby often overlooked as a cause of mortality and monitoring oxygen saturation is an accurate method to detect the condition. Propofol, an anesthetic agent, is commonly used in the management of TBI; however, its effect on brain tissue and cerebral hypoxia in TBI cases is not well understood. The aim of this study was to evaluate the profile of oxygen saturation in TBI animal model after propofol administration. A laboratory experimental study was conducted, involving 18 male Rattus novergicus rats (aged 4–8 weeks with weight between 150–200 grams) divided into three different treatment groups (non-TBI, TBI without propofol, and TBI with propofol). Oxygen saturation was measured regularly from day 1 to day 8 using pulse oximetry. The oxygen saturation percentages were compared between the TBI rats with and without propofol administration using independent Student t-rest. The results revealed significant reductions of oxygen saturation levels of animals within propofol-treated TBI group compared to that of the untreated-TBI group (p<0.05), with the average oxygen saturation ranging from 80.8%±6.96% vs 86.8%±5.48%. This finding suggests a reducing effect of propofol administration on oxygen saturation levels in rats with TBI and this potentially causes cerebral hypoxia.
Co-Authors . Azhar . Darmawi . Darmawi . Darmawi . Darniati . Fakhrurrazi . Ismail . Muthmainnah . Muttaqien . Nurliana . Rasmaidar Abdul Harris Abdul Harris Abdul Harris Abdul Harris Abdullah Hamzah Abdullah Hamzah Adi Firmansyah Afifah Nur Oriyasmi Aminuddin Aminuddin Amiruddin Amiruddin Amiruddin Amiruddin Ananda Putri Lestari Angreini, Meliyantika Annisa, Aiza Aprilia Wardana Aprilia Wardana Arman Sayuti Arman Sayuti Astri Wulandari Awaluddin Awaluddin Ayu Agita Ginting Azhar Azhar Azhar Azhar Azhar Azhar Azhari Azhari Azmi Zul Baehaqi Bagus Dwijayanti bakti suganjar Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto budianto panjaitan Connie Januari Cut Dahlia Iskandar Cut Mentari Fatihah Amran Cut Nila Thasmi Cut S. Utami Cut Syeila Utami Darmawi . Darmawi D Darmawi D Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Denny Irmawati Hasan Dessy Florenstina BR. G Dian Masyitha Dian Masyitha dian masyithah Didik T Subekti divina dinda hayati Doly Ihsan Siregar Dwina Aliza Dwinna Aliza Dwinna Aliza Dwinna Aliza Eko Karunia Friyan Eliawardani Eliawardani Elsa Mariane Ramadani Erdiansyah Rahmi Erdiansyah Rahmi Erina Erina Erina Erina Erina Erina Erwin Erwin Erwin Erwin Erwin Erwin Erwin Erwin Etriwati E Eva Fitriyaningsih EVA FITRIYANINGSIH Fachriyan H Pasaribu Fachriyan H Pasaribu Fachriyan H. Pasaribu Fachriyan H. Pasaribu Fachriyan Hasymi Pasaribu Fachriyan Hasymi Pasaribu Fadli A Gani Faisal Mustafa Farida Athaillah Farida Athaillah Farida Athaillah Farida Athaillah Febiola Rama Sari Febiola Rama Sari febri ramadana Fera Febrina Ferdian, Riyan Fitriani Fitriani Fitriani Fitriani Fitriani Fitriani Gholib Gholib Ginta Riady Hamdan Hamdan Hamdani Budiman Hamdani Budiman Hamny Sofyan Hasan, Denny Irmawati Hasan, Desi Salwani Hasbalah, Kartini Helmi, T. Zahrial Henni Vanda Hidayati Hidayati Ismail Ismail Ismail Ismail Juli Melia Kulsum Kulsum, Kulsum laksmita patma ningrum M Aman Yaman M Daud AK M Jalaluddin M Nur Salim M Nur Salim M. Hanafiah M. Hasan M. Nur Salim M. Yogi Riyantama Isjoni Mahdi Abrar Maimun Syukri, Maimun Marwiyah M Maryam Maryam Maryam Maryam Masda Admi Mirna Safrani Fauzi Muhammad Fathur Ridho Muhammad Hambal Muhammad Hambal Muhammad Hambal Muhammad Hanafiah Muhammad Jalaluddin Muhammad Jalaluddin Mulyadi Adam Mulyadi Mulyadi Muslim Akmal Muslina Muslina, Muslina Mustafa Sabri Muttaqien Bakri Muttaqien Muttaqien Muttaqien Muttaqien N. Nazaruddin NA, Zuhrawaty Nabila Latifa Hafizsha Nabilah Putroe Agung Nanda Afrizan Nauval Gibran Lubis Nazaruddin Nazaruddin Nazaruddin Nazaruddin Nora Usrina Nur rachmatika Nur Salim Nurjannah Annah Nurliana Nurliana Nurul Fitria Nuzul Asmilia Nuzul Asmilia Rachmad Suhanda Rahmat Nazif Rasmaidar R Rastina Rastina Raudia Tuzzahra Razali Daud Razali Daud Razali Daud resti aulia putri Retno D Soejoedono Retno D Soejoedono Retno D. Soejoedono Retno D. Soejoedono Retno Damayanti Soejoedono Rhoza Indra Rinidar Rinidar Rinidar Rinidar Risa Tiuria rizki nurliyanti siregar Rosmaidar Rosmaidar Rosmaidar Rosmaidar Rosmaidar Rosmaidar Roza Dea Silvina Rusli Rusli Rusli Rusli Samadi Samadi sariati latif Siti Aisyah Siti Aisyah Siti Aisyah Siti Aisyiah sri yuliati Sugito - Sugito Sugito Sugito Sugito Sukma, Zahwa Tamara Syafruddin Syafruddin Syafruddin Syafruddin Syahrul Syahrul T Armansyah TR T. Armansyah T. Armansyah T. Armansyah TR T. Fadrial Karmil T. Fadrial Karmil T. Reza Ferasyi T. Zahrial Helmi Tapielaniari - Taufik Suryadi, Taufik Teuku R. Ferasyi Triva Murtina Lubis Utami, Cut Suraiya Wahyuni Vinky Claudya Fransiska viola erian Wahyuni, Sri Widya Wati Winaruddin Winaruddin winaruddin winaruddin Yudha Fahrimal Yudha Fahrimal Zainuddin Zainuddin Zainuddin Zainuddin Zamzami, Rumi Sahara zena fisdiora Zico, Hanifa Zuhrawati NA Zuhrawati Zuhrawati Zuraidawati Zuraidawati