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All Journal HAYATI Journal of Biosciences PROSIDING SEMINAR NASIONAL Majalah Kedokteran Bandung Health Science Journal of Indonesia Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Medical Journal of Indonesia Nexus Biomedika Nexus Kedokteran Translasional Jurnal Farmasi Klinik Indonesia Biomedika Jurnal Media Gizi Indonesia (MGI) Majalah Obat Tradisional Jurnal Gizi dan Kesehatan Smart Medical Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health Amerta Nutrition Jurnal Respirologi Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Jurnal Dunia Gizi Pena Medika : Jurnal Kesehatan Narra J Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences Jurnal Kesehatan Kusuma Husada Journal of Health and Nutrition Research Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Journal Research Midwifery Politeknik Tegal Media Penelitian dan Pengembangan Kesehatan Jurnal Pembaruan Kesehatan Indonesia Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Jurnal Kesehatan Masyarakat

Dono Indarto

Universitas Sebelas Maret

Author-ID : 286620

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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HUBUNGAN KURANG ENERGI KRONIK DAN ANEMIA PADA IBU HAMIL DENGAN STATUS GIZI BAYI USIA 6-12 BULAN DI KABUPATEN BOYOLALI (CORRELATION CHRONIC ENERGY DEFICIENCY AND ANEMIA DURING PREGNANCY WITH NUTRITIONAL STATUS OF INFANT 6 – 12 MONTHS IN BOYOLALI REGENCY) Yunilla Prabandari; Diffah Hanim; Risya Cilmiaty AR; Dono Indarto
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 39 No. 1 (2016)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v39i1.5964.1-8

ABSTRACTMalnutrition still becomes a problem in developing countries such as Indonesia. In Boyolali regency the prevalence of stunting and wasting of infants was 27,5 percent and 6,6 percent respectively. The aim of this study was to analyze the correlation between chronic energy deficiency and Anemia on pregnant mothers with the nutritional status of infants aged 6-12 months. Prospective cohort design was implemented in authorized administration of 6 Community Health Centers of Boyolali Regency. A number of 40 pregnant mothers who had record of chronic energy deficiency and Anemia during third trimester and have infants aged 6-12 months participated in the study. Statistic analyzed were performed using the Peason’s Correlation method. The study failed to show the relationship between chronic energy deficiency during pregnancy and z-score of weight for age (WAZ), height for age (HAZ) and weight for height (WHZ) of infants p>0.05 while anemic pregnant mother found a correlation with Z-score of weight for height (WHZ) of infants (p<0.05), but had not correlation with z-score of weight for age (WAZ), height for age (HAZ) (p>0.05) of infant 6-12 months. Thus, early improvement nutrition program for adolescence should be done to prevent malnutrition in pregnant mothers such as chronic energy deficiency and anemia.ABSTRAK Gangguan gizi masih merupakan masalah di negara berkembang termasuk Indonesia. Di Kabupaten Boyolali prevalensi balita pendek (stunting) sebesar 27,5 persen dan kurus (wasting) 6,6 persen. Penelitian ini bertujuan menganalisis hubungan riwayat kurang energi kronik (KEK) dan anemia pada ibu hamil dengan status gizi bayi usia 6-12 bulan. Desain Penelitian adalah kohort prospektif di enam wilayah Puskesmas, di Kabupaten Boyolali. Partisipan terdiri dari 40 ibu yang memiliki riwayat KEK dan anemia pada kehamilan trimester III, memiliki bayi berusia 6-12 bulan. Analisis statistik menggunakan uji korelasi pearson. Pada penelitian ini tidak ditemukan hubungan riwayat KEK pada ibu hamil dengan status gizi bayi usia 6-12 bulan (Indeks BB/U, PB/U dan BB/PB) (p>0,05). Riwayat anemia pada ibu hamil berhubungan dengan status gizi bayi indeks BB/PB (p<0,05), akan tetapi tidak berhubungan dengan status gizi indeks BB/U dan PB/U (p>0,05). Perbaikan pencegahan kurang gizi dan anemia pada masa remaja atau calon pengantin diperlukan untuk mencegah terjadinya gizi kurang pada ibu hamil dan generasi selanjutnya.

RISIKO INISIASI MENYUSU DINI DAN PRAKTEK ASI EKSKLUSIF TERHADAP KEJADIAN STUNTING PADA ANAK 6-24 BULAN (EARLY BREASTFEEDING INITIATION AND EXCLUSIVE BREASTFEEDING AS RISK FACTORS OF STUNTING CHILDREN 6-24 MONTHS-OLD) M Rizal Permadi; Diffah Hanim; Kusnandar Kusnandar; Dono Indarto
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 39 No. 1 (2016)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v39i1.5965.9-14

ABSTRACTSome of causes of stunting are the deferment of early breastfeeding initiation and the administration of the non-exclusive breastfeeding. The objective of this study was to elaborate relationship of early breastfeeding initiation and exclusive breastfeeding administration history to the stunting. This sudy used the observational analytical research method with the cross-sectional design. Its subjects were 33 stunting and 77 non-stunting children aged 6-24 months in Boyolali Regency. Data was analyzed by using the chi-square test and multiple logistic regression analysis. The stunting children who got the early breastfeeding initiation were 14, and those who did not get the early breastfeeding initiation were 19. The stunting children who got the exclusive breastfeeding were 4 and those who did not get the exclusive breastfeeding were 29. Early breastfeeding initiation and exclusive breastfeeding had a significant correlation with the stunting as indicated by the p-value <0.05. The children who did not get the early breastfeeding initiation have the possibility of 3.69 times higher to suffer from stunting than those who got the early breastfeeding initiation. In addition, the children who did not get the exclusive breastfeeding have the possibility of 9.5 times higher to suffer from stunting than those who got the exclusive breastfeeding. Therefore, nutrition education to the gestational mothers on the importance of exclusive breastfeeding administration is required.ABSTRAK Penyebab masalah stunting antara lain akibat dari penundaan inisiasi menyusu dini (IMD), dan pemberian air susu ibu (ASI) tidak eksklusif. Penelitian ini bertujuan untuk menganalisis hubungan IMD dan ASI eksklusif dengan kejadian stunting. Penelitian observasional ini dilaksanakan di Boyolali dengan menggunakan pendekatan cross-sectional. Partisipan terdiri dari 33 anak stunting dan 77 anak tidak stunting berusia 6-24 bulan. Analisis data menggunakan uji chi-square dan regresi logistik berganda. Partisipan anak stunting yang mendapatkan IMD sebanyak 14 orang dan tidak mendapatkan IMD sebanyak 19 orang. Anak stunting yang mendapatkan ASI eksklusif sebanyak 4 orang dan yang tidak sebanyak 29 orang. Inisiasi menyusu dini dan ASI eksklusif memiliki hubungan yang bermakna dengan kejadian stunting (p<0,05). Anak yang tidak mendapatkan IMD memiliki kemungkinan 2,63 (1,02-6,82) kali lebih tinggi mengalami kejadian stunting, selain itu anak yang tidak mendapatkan ASI eksklusif memiliki risiko mengalami kejadian stunting 7,86 (2,43-25,4) kali lebih tinggi dibandingkan anak yang mendapatkan ASI eksklusif. Oleh karena itu, diperlukan edukasi gizi kepada ibu hamil mengenai pentingnya pemberian ASI eksklusif.

HUBUNGAN ASUPAN MAKANAN, SUPLEMENTASI Fe DAN ASAM FOLAT DENGAN KADAR HEMOGLOBIN PADA IBU HAMIL RIWAYAT KURANG ENERGI KRONIS DAN ANEMIA SAAT MENYUSUI (THE RELATIONSHIP OF FOOD INTAKE, Fe AND FOLIC ACID SUPPLEMENTATION ON HEMOGLOBIN LEVEL IN PREGNANT WOMEN) Indah Kusumawati; Dono Indarto; Diffah Hanim; Suminah Suminah
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 39 No. 2 (2016)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v39i2.5155.

Pregnant women with past history of CED have a higher risk 2,76 times to suffer anemia than normal pregnant women. Fe and folic acid supplementation is one program to overcome iron deficiency anemia in the pregnant women in Boyolali but the incidence rate of anemia remains high (42,9%). This study was to analyze the relationship of food intake, Fe and folic acid supplementation on hemoglobin level in pregnant women with history of CED and anemia of breastfeeding women. This research study used analytic observation with cross sectional approach. The subject of 42 breastfeeding women with past history of CED and anemia in the third trimester of pregnancy in five public health centers in Boyolali. Data of supplementation and nutrient intake was obtained by interview. Nutritional status was determined using upper arm circumference and BMI. Hemoglobin level was measured by using cyanmethemoglobin method. Statiscally analyzed using correlation and multiple regression tests. The breastfeeding women had low food intake (<70% RDA) including macro and micro nutrients. Food intake and nutritional status in breastfeeding women negatively affected hemoglobin level in breastfeeding women (B=-0,005; p=0,040 and B=-0,134; p=0,016 respectively). Fe and folic acid supplementation in pregnant women with CED and anemia significantly influenced hemoglobin level during breastfeeding (B=0,720; p=0,016). Completed supplementation of iron-folic acid in pregnant women with CED and anemia could increase 0,720 g/dL hemoglobin levels during breastfeeding.Ibu hamil dengan kurang energi kronis (KEK) berpeluang menderita anemia 2,76 kali dari pada ibu hamil normal. Suplementasi Fe dan asam folat merupakan salah satu cara mengatasi anemia defisiensi besi tetapi angka kejadian ibu hamil di Kabupaten Boyolali dengan anemia masih tinggi (42,9%). Penelitian ini bertujuan menganalisis hubungan asupan makanan, suplementasi Fe dan asam folat dengan kadar hemoglobin pada ibu hamil riwayat KEK dan anemia saat menyusui. Jenis penelitian observasional analitik dengan pendekatan cross sectional. Subjek penelitian 42 ibu menyusui dengan riwayat KEK dan anemia pada trimester III dari lima Puskesmas di Boyolali. Data suplementasi Fe dan asam folat serta asupan zat gizi diperoleh dengan wawancara. Status gizi ditentukan dengan LILA dan IMT. Kadar hemoglobin ditentukan dengan metode cyanmethemoglobin. Analisis statistik menggunakan uji korelasi dan multivariat regresi ganda. Hasil menunjukkan bahwa asupan energi, lemak, karbohidrat, zat besi dan asam folat pada ibu menyusui termasuk kategori defisit (<70% AKG). Asupan makanan dan status gizi ibu menyusui berhubungan negatif terhadap kadar hemoglobin saat menyusui (B=-0,005, p=0,040 dan B=-0,134, p=0,016). Suplementasi Fe dan asam folat pada ibu hamil riwayat KEK dan anemia berhubungan secara signifikan terhadap kadar hemoglobin saat menyusui (B=0,720, p=0,016). Dapat disimpulkan bahwa suplementasi Fe dan asam folat pada ibu hamil KEK dan anemia berpeluang menaikkan 0,720 g/dL kadar hemoglobin ibu saat menyusui.

Antibacterial and Antibiofilm of Cinnamomum burmanii Bark Oil (CbBO) against Klebsiella pneumoniae ATCC 700603: In Vitro Study Inayati, Inayati; Hartono, Hartono; Indarto, Dono; Suryawati, Betty
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97396

Many cases of multidrug-resistant (MDR) bacterial infections are caused by Klebsiella pneumoniae (K.pn), an infectious disease bacterium. Hospital inpatients can be exposed to this occurrence; MDR has transformed 26.96% of infections at Klaten Hospital into highly infectious biofilms, while 54.49% of infections have produced biofilms. Approximately 80% of bacterial illnesses resistant to antibiotics are caused by biofilm-forming bacteria. To reduce biofilm formation, antibacterial compounds, one of which comes from natural products, are necessary. Renowned for its essential oil, Cinnamomum burmanii Bark Oil (CbBO) has been utilized extensively in herbal medicine to combat pathogenic bacteria such as Pseudomonas aeruginosa, Candida albicans, Enterobacter spp., and Staphylococcus aureus. This study aims to evaluate CbBO’s antibacterial capabilities using the microdilution method and its antibiofilm properties against K. pneumoniae ATCC 700603 using the MTT test. A CbBO minimum bactericidal concentration (MBC) of 0.25 mg/mL and a minimum inhibitory concentration (MIC) of 0.125 mg/mL were employed for antibacterial activity. The antibiofilm potential was determined by measuring the minimum biofilm eradication concentration (MBEC) at 0.5 mg/mL and the minimum biofilm inhibition concentration (MBIC) at 0.25 mg/mL. In conclusion, CbBO demonstrated antimicrobial and antibiofilm qualities. However, a greater concentration of CbBO was required for antibiofilm formation than for antibacterial purposes.

Identification of nutrients and phytochemicals of raja banana (Musa acuminata) peels extracted with ethanol and acetone solvents and its potential as an anti-obesity agent Susilawati, Eva; Indarto, Dono; Susilawati, Tri Nugraha
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2483

Banana peel is a waste that has the potential as an anti-obesity agent due to its nutritional and phytochemical content. This study aims to analyze and compare the content of macronutrients, micronutrients, and phytochemical compounds in raja banana peel extracts. The maceration method was performed during the preparation of extracts by using ethanol and acetone solvents. The nutritional and phytochemical contents of the extracts were compared to determine which solvent produced the optimum anti-obesity properties. The ethanol extract consists of water (17,68%), minerals (22,76%), protein (3,50%), carbohydrates (47,98%), and vitamin C (0,82%). The phytochemical content includes flavonoids (73,38 mgQE/g), tannins (0,32%), and chrysin (1,16 mg/L). In conclusion, the ethanol extract of Raja banana peel contains higher nutrients and phytochemicals than the acetone extract, showing greater potential as an anti-obesity agent. Further research is needed to test its bioactivity in vivo or in vitro.

RELATIONSHIP OF DIETARY INTAKE AND PHYSICAL ACTIVITY WITH BODY COMPOSITION IN ADULTS: A CASE-CONTROL STUDY Thesman, Inggrit Bela; Indarto, Dono; Suselo, Yuliana Heri
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3230

Obesitas yang ditandai dengan kelebihan lemak tubuh dan gangguan komposisi tubuh menyebabkan gangguan kesehatan dan risiko tinggi terhadap kasus penyakit tidak menular. Penelitian ini bertujuan untuk mengevaluasi hubungan antara asupan karbohidrat, lemak, protein, serta aktivitas fisik dengan persentase lemak visceral dan massa otot pada individu dewasa yang mengalami obesitas. Studi analitik observasional ini menggunakan desain kasus kontrol, dengan merekrut 25 partisipan dengan status berat badan normal dan 25 partisipan obesitas. Pengumpulan data dilakukan menggunakan Semi Quantitative Food Frequency Questionnaire (SQFFQ) dan aktivitas fisik dinilai menggunakan International Physical Activity Questionnaire-Short Form (IPAQ-SF). Asupan makan dan aktivitas fisik tidak berhubungan dengan persentase lemak sementara, regresi linear ganda menunjukkan bahwa asupan karbohidrat (B = 0,007, β = 0,171, p = 0,028), aktivitas fisik (B = -0,001, β = -0,200, p = 0,028), jenis kelamin (B = 6,041, β = 0,522, p < 0,001), dan BMI (B = -1,021, β = -0,961, p < 0,001) merupakan prediktor signifikan untuk persentase massa otot. Temuan penelitian ini menunjukkan bahwa terdapat hubungan yang signifikan antara asupan karbohidrat dan aktivitas fisik dengan persentase massa otot setelah disesuaikan dengan faktor perancu. Konsumsi karbohidrat disertai aktivitas fisik dapat meningkatkan massa otot.

Therapeutic Potential of Synbiotic Roselle Extract Yogurt in Modulating Inflammatory Markers and Oral Microbiota in a Rat Model of 5-Fluorouracil-Induced Oral Mucositis Sena, Anantha; Mudigdo, Ambar; Arief, Irma-Isnafia; Indarto, Dono
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.58-70

Mucositis is a common complication in cancer patients undergoing 5-fluorouracil (5-FU) chemotherapy. Roselle (Hibiscus sabdariffa) extract in synbiotic yogurt could be a beneficial alternative because it might change the inflammatory response and oral microbiota. The study aimed to investigate the effects of synbiotic roselle extract yogurt on inflammatory responses and oral microbiota in oral mucositis caused by 5-FU. An experimental study with twenty-four Sprague-Dawley rats divided into four groups (n=6): healthy control (NC), disease control (PC), synbiotic roselle extract yogurt therapy (P1), and standard therapy (P2) groups. This study evaluated the number of bacterial colonies, expression of COX-2 and caspase-1, and levels of IL-1β and VEGF (days 4 and 7). The P1 group had a significantly increased beneficial lactic acid bacteria (6.91±0.87) and a decrease in pathogenic bacteria, including Staphylococcus aureus (3.89±0.05), Escherichia coli (0), and Enterobacter aerogenes (1.78±0.29), compared to the PC group. Additionally, there was a statistically significant increase in VEGF levels in the tissue (0.07±0.03 ng/mL), a decrease in serum IL-1β levels (48.02±10.29 pg/mL), and an expression of caspase-1 and COX-2 compared to the PC group (p<0.05). Synbiotic roselle extract yogurt shows promise as a therapeutic strategy for managing mucositis by restoring microbial balance and mitigating inflammation.

In Silico and In Vitro Approach of Preeclampsia Prophylaxis from Water of Kalianda Kopyor Fitriana, Fitriana; Soetrisno, Soetrisno; Sulistyowati, Sri; Indarto, Dono
Jurnal Kesehatan Masyarakat Vol. 21 No. 1 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v21i1.3468

Preeclampsia (PE) stands as a prominent cause of maternal mortality in developing nations, yet a standardized therapy for PE has not been established. Some pregnant women in Lampung have consumed the water of young kopyor coconut fruit from the Kalianda variety (WKK), although its therapeutic effects remain unexplored. This study aimed to investigate WKK phytochemicals through in vitro and silico analyses. Liquid Chromatography-Mass Spectrometry (LCMS) was employed for phytochemical analysis, while an in silico study involved Autodock, Autodock Tools, Autodock Vina, Biovia Discovery Studio 2020, and Open Babel GUI, alongside pharmacokinetics prediction using the pkCSM strategy. The study assessed the inhibitory potential of WKK on Gentiatibetine and curcumenolacto C, targeting the PE ACE2 receptor (1R24) through molecular docking with the 3D structure. Post-docking analysis, including binding affinities, hydrophobic interactions, and pharmacokinetic predictions, was conducted. WKK exhibited relatively low binding affinities for Gentiatibetine (-4.86 kcal/mol), curcumenolactone C (-2.96 kcal/mol), and aspirin (-5.12 kcal/mol). Multiple hydrophobic interactions were observed, such as Van der Waals, Salt Bridge, Conventional Hydrogen Bond, Alkyl, 162, and Lys 129. The receptor IR displayed a high bond-free energy, like aspirin docked with the same gene receptor. Pharmacokinetics predictions indicated that WKK possesses a favorable profile. In conclusion, WKK phytochemicals demonstrated a notable docking score comparable to aspirin, suggesting its potential for preventive therapy use.

Clinical Manifestations and Behavior Changes in Rats Treated with Jamaican Cherries Extract (Muntingia calabura) Afdhaliya, Noor Khalwati; Indarto, Dono; Wasita, Brian
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Iron deficiency anemia (IDA) in female adolescents is one of the health problems, which occupied 8th position as a cause of global disability and is the main cause of anemia in reproductive women. Iron tablet supplementation is the government program to reduce IDA prevalence in Indonesia but often results in gastrointestinal side effects. Jamaican cherries fruits contain vitamin C, iron and flavonoids, which play essential roles in iron metabolism. This study aimed to investigate the effects of Jamaican cherries fruits ethanol extract on clinical manifestations and behavior changes in female Wistar rats. This randomized controlled trial with pre-posttest control group design used 24 female Wistar rats, aged 10 -12 weeks and were randomly divided into 6 groups: N, positive control (PC: AIN-93M low iron food + elemental iron) and treatments (T1-4: AIN-93M low iron food + 0.26, 0.35, 0,5 or 0.75g/ 100g Body Weight (BW) Jamaican cherries fruits extract respectively for 28 days). Clinical manifestations, reflexes and behavior changes were observed at day 0, 14 and 28 interventions. BW data were analyzed using one way ANOVA and repeated measures ANOVA tests. All rats had normal reflexes and did not show clinical manifestations and behavior changes. The average of rat BW in T1-4 groups did not significantly differ before (p=0.896), during (p=0.884) and after treatment (p=0.775) but the average of rat BW in the T1 group increased significantly (p=0.012). In conclusion, administering Jamaican cherries fruits ethanol extracts up to 0.75g/100g BW has no toxic effects in female Wistar rats. Abstrak: Anemia defisiensi besi (ADB) pada remaja putri merupakan salah satu masalah kesehatan yang menempati posisi ke-8 sebagai penyebab disabilitas tingkat global dan penyebab utama anemia pada ibu hamil. Suplementasi tablet besi merupakan program pemerintah untuk mengurangi prevalensi ADB di Indonesia tetapi sering menimbulkan efek samping di saluran percernaan. Buah kersen mengandung vitamin C, zat besi dan flavonoids yang berperan penting dalam metabolisme besi. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah kersen terhadap manifestasi klinis dan perubahan perilaku tikus Wistar betina. Penelitian randomized controlled trial ini dengan pre-posttest control group design dengan menggunakan 24 ekor tikus Wistar betina umur 10 -12 minggu dan dibagi secara acak menjadi 6 kelompok: normal, kontrol posistif (KP) dan perlakuan (P1-4). Tikus di KP diberi pakan AIN-93M dengan besi rendah + besi elemental sedangkan P1-4 diberi pakan yang sama ditambah 0.26, 0.35g, 0,5g atau 0.75g/100g berat badan (BB) secara berturut-turut ekstrak buah kersen selama 28 hari. Manifestasi klinis, reflek dan perubahan perilaku tikus diamati pada hari ke-0, 14 dan 28. Data BB dianalisis menggunakan uji one way ANOVA dan uji repeated measures ANOVA. Semua tikus memiliki reflek yang normal dan tidak menunjukkan manifestasi klinis dan perubahan perilaku. Rerata BB tikus pada P1-4 tidak berbeda signifikan sebelum (p=0,896), selama (p=0,884), maupun setelah perlakuan (p=0,775) tetapi rerata BB tikus P1 meningkat secara signifikan (p=0,012). Kesimpulan, pemberian ekstrak buah kersen hingga 0,75g/100g BB tidak menyebabkan toksisistas tikus Wistar betina.

Dual Extracts of Star Fruit Leaves and Toddalia accuelata Leaves as Antiobesity in Rats Sundari, Isti; Indarto, Dono; Dirgahayu, Paramasari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

The imbalance between food intake and energy expenditure can lead to obesity. Obesity is a major risk factor for chronic diseases such as cardiovascular disease and can cause premature death worldwide. This study is aimed to investigate the effect of Star Fruit Leaves Extract (SLE) and T. accumulate Leaves Extract (TLE) combination on Body Weight (BW), Body Mass Index (BMI), and Fat Content (FC) of obese rats. Male Wistar rats aged 5 weeks, with BW of 100-150 g were induced with a High Fat Diet (HFD) and 10% fructose solution for 30 days. A total of 18 rats were randomly divided into 3 groups, namely Negative Control (NC), Therapy (T), and Normal (N). After 35 days of treatment compared to the NC group, the mean BW of the T group was significantly lower (p=0.014) and the mean decrease was significantly higher (p less than 0.001). Similarly, the mean BMI and FC of the T group were significantly lower and the decrease in the mean of both groups was significantly higher than that of the NC group (p less than 0.001). Therefore, the combination of SLE and TLE can be used as a treatment for obesity because it reduces BW, BMI, and FC better than only a low-calorie diet.Abstrak: Ketidakseimbangan antara asupan makanan dan pengeluaran energi dapat menyebabkan obesitas. Obesitas merupakan faktor risiko utama terjadinya penyakit kronis seperti penyakit kardiovaskular dan dapat menyebabkan kematian dini di seluruh dunia. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi Ekstrak Daun Belimbing (EDB)dan Ekstrak Daun T. accuelata (EDT) terhadap Berat Badan (BB), Indeks Massa Tubuh (IMT), dan kandungan lemak tikus obesitas. Tikus wistar jantan umur 5 minggu, BB 100-150 g diinduksi dengan pakan tinggi lemak dan larutan fruktosa 10% selama 30 hari. Sebanyak 18 ekor tikus dibagi secara acak menjadi 3 kelompok yaitu Kontrol Negatif (KN), Terapi (T), dan Normal (N). Setelah 35 hari perlakuan dibandingkan dengan kelompok KN, rata-rata BB kelompok T secara signifikan lebih rendah (p=0,014) dan rata-rata penurunannya lebih besar secara signifikan (p kurang dari 0,001). Demikian pula, rata-rata IMT dan kandungan lemak kelompok T secara signifikan lebih rendah dan penurunan rata-rata kedua kelompok tersebut secara signifikan lebih besar dibandingkan dengan kelompok KN (p kurang dari 0,001). Oleh karena itu, kombinasi EDB dan EDT dapat digunakan sebagai pengobatan obesitas karena dapat menurunkan BB, IMT, dan kandungan lemak lebih baik daripada diet rendah kalori saja.

Co-Authors ., Hudiyono A.A. Ketut Agung Cahyawan W Adam Haviyan Nasrullah Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Ahmad Hamim Sadewa Akbar, Muh. Syaiful Ali Djamhuri Ambar Mudigdo Amilia Yuni Damayanti Andina, Puri Dwi Argyo Demartoto, Argyo Ari Natalia Probandari Arief Suryono Arta Farmawati Asti Swari Paramanindita Astri Purwanti Avelia, Annisa Ayusari, Amelya Augusthina Azizah, Shofura Azzumar, Farchan Badri, Baarizah Febriana Balgis . Balgis . Balgis Balgis Balgis Balgis Bambang Purwanto Baruroh, Durotul Bhisma Murti Brian Wasita Brian Wasita Brian Wasita Brian Wasita Budianto, Pepi Budiyanti Wiboworini Budiyanti, Novita Damayanti, Ana Dandi Sanjaya Dea Linia Romadhoni Dewi, Dwi Hananta Diah Kurnia Mirawati Dian Eka Widyasari Didik Gunawan Tamtomo Didik Gunawan Tamtomo Didik T Subekti Didik Tamtomo, Didik Diffah Hanim Diffah Hanim Diffah Hanim Diffah Hanim Diffah Hanim Dina Okfina Ria Dinar Putri Rahmawati Diyantana, Wawan Endang Sutisna Sulaeman Ernawati Ernawati Eti Poncorini Pamungkasari Fadhila Balqis Nurfitria Fajar Alam Putra, Fajar Alam Fara Ayu Febyawati, Hani Farchan Azzumar Firdaus, Jihan Fitriana Fitriana Gilang Akbar Shobirin Gracia, Vera Viviana Deo Hambarsari, Yetty Hamidi, Baarid Luqman Hani Fara Ayu Febyawati Hartono Hartono Hastami, Yunia Hastuti, Nunik Maya Hermanu Joebagio Heru Sulastomo Herviana, Herviana Hudiyono . Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Nurwati Ida Nurwati Inayati Inayati Indah Kusumawati Irma Isnafia Arief Isfaizah Isti Sundari Iwansyah, Ade Chandra Jatmiko Susilo Jatu Aphridasari Jusup, Sinu Andhi Jusup, Sinu Andhi K Kusnandar Kezia Elian Devina Kurniagung, Philipus Prihantiko Kusnandar Kusnandar Kusnandar, K Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Laksana, Budi Liana, Gladya Lady Lilik Wijayanti Luberta Ebta Wiyani M Rizal Permadi M. Yogi Riyantama Isjoni Mahendra Wijaya Martha Arum Nugraheni Maryati, Warsi Mashuri, Yusuf Ari Mila Ulfia Muchsin Doewes Muhammad, Faizal Nanda Eka Sri Sejati Nasrullah, Adam Haviyan Ningrum, Sri Setiyo NINGRUM, TYAS SARI RATNA Niniek Purwaningtyas Noor Khalwati Afdhaliya Nor Istiqomah Nor Istiqomah Nor Istiqomah Nugroho, Anung N. Nunuk Suryani Nurfitria, Fadhila Balqis Nurinasari, Hafi Nurochim, Erna Nurwati, Ida Nurwijayanti Oktaviani, Ratna Pamungkasari, Eti P. Paramasari Dirgahayu Paramasari Dirgahayu Perdana, Muhammad Vidi Pesik, Riza N. Prabaningtyas, Hanindia Riani Prahesti, Ratna Prasetyaningsih, Roh Hastuti Pratama, Yoga Mulia PRATHITA NITYASEWAKA Pratiwi, Ayudhia Purnama, Siswanta Jaka Purwaningsih, Yustina Puspita, Rumeyda Chitra Putri, Anak Agung Alit Kirti Estuti Narendra Putri, Risma Aliviani Putri, Widya Kaharani R. Aj. Sri Wulandari Rahardjo, Setyo Sri Rahardjo, Setyo Sri RAJ Sri Wulandari Ratih D. Yudhani Ratna Kusumawati Ratna Kusumawati Ratna Oktaviani Retiyansa, Yesi Retiyansa, Yesi Reviono Reviono Ristinawati, Ira Risya Cilmiaty AR Risya Cilmiaty, Risya Rivan Danuaji Riza N. Pesik Riza Novierta Pesik Riza Novierta Pesik RUBEN DHARMAWAN Sajidan Sarah Safira Umarghanies Sari, Septi Ayu Arum Yuspita Satriani, Hayu Andita Sejati, Nanda Eka Sri Selfi Handayani Selfi Handayani Sena, Anantha Setyaningrum, Th. Catur Wulan Setyo Sri Rahardjo Shanti Listyawati Sinu Andhi Jusup Soetrisno Soetrisno Soetrisno Sri Sulistyowati Sri Wulandari Sugiarto - Sugiarto S Sugiarto Sugiarto Sugiarto Sugiarto Suminah Suminah Sunarto Tetes Lugito Sundari, Isti Suradi Suradi SUROTO SURYAWATI, BETTY Susanti, Rahmah Purwaningsih Febri Suselo, Yuliana Heri Suselo, Yuliana Heri Suselo, Yuliana Heri Susilawati, Eva Tamtomo, Didik Gunawan Tedjo, Raden Andi Ario Tejomukti, Teddy Thesman, Inggrit Bela Tiyas, Dwi Wahyuning Tonang Dwi Ardyanto Tri Agustina Tri Agustina, Tri Tri Harsono Tri Harsono Tri Nugraha Susilawati Ulfia, Mila Umarghanies, Sarah Safira Utami, Agustina Dwi Vitri Widyaningsih Vitria Sari Dewi Vitria Sari Dewi Wahyuni, Ardianti Wardhani, Lusi Oka Wariyanti, Astri Sri Widiasih, Ghina Widyanti, Fera Wijayanti, Poppy Winda Rizki Pebrina Batubara Wulandari, R. AJ. Sri Wulandari, RAJ Sri Yarso, Kristanto Y. Yatty Destani Sandy Yoga Mulia Pratama Yudhani, Ratih D. yulia lanti retno dewi Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Suselo Yuliana Heri Suselo Yunilla Prabandari Yusrizal, Mirza

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