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Journal : Medula

Pengaruh Pemberian Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp) Terhadap Gambaran Sel Hepatosit Tikus Putih Jantan Galur Sprague-Dawley Ruslani, Nada Oktista; Susianti, Susianti; Graharti, Risti; Rudianto, Waluyo
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1693

Abstract

Syzygium myrtifolium Walp., commonly known as red shoot leaves, is an ornamental plant rich in bioactive compounds such as flavonoids, tannins, and terpenoids, which exhibit antioxidant, anticancer, and antibacterial properties. However, administration at high doses may lead to hepatotoxic effects. The liver plays a central role in drug metabolism and is the first organ exposed to toxic agents, making it highly susceptible to hepatocyte necrosis. This study aimed to evaluate the effect of ethanol extract of Syzygium myrtifolium leaves on liver histopathology in male white rats (Rattus norvegicus). This experimental study employed a post-test only control group design with three groups: control, 2000 mg/kgBW, and 5000 mg/kgBW. The extract was administered orally, and hepatocyte necrosis was assessed using a histopathological scoring system. Statistical analysis included Shapiro-Wilk, Levene’s Test, One Way ANOVA, and post hoc LSD. Histopathological examination revealed normal hepatocytes in the control group, focal necrosis in the 2000 mg/kgBW group, and extensive necrosis in the 5000 mg/kgBW group. Statistical analysis confirmed normally distributed and homogeneous data, while ANOVA indicated significant differences among groups (p=0.001). Post hoc LSD test further demonstrated significant differences between the control and treatment groups as well as between both treatment doses. In conclusion, oral administration of ethanol extract of Syzygium myrtifolium leaves induces hepatocyte necrosis in male white rats, with the severity of liver damage increasing in a dose-dependent manner.
Hubungan Hipertensi dengan Penyakit Jantung Koroner (PJK): Tinjauan Pustaka Worocahyo, Avis Meyvika; Kurniati, Intanri; Damayanti, Putri; Susianti, Susianti
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1694

Abstract

Coronary Artery Disease (CAD) is still one of the leading causes of mortality worldwide, including in Indonesia with a steadily rising prevalence. Hypertension is recognized as a major risk factor, as it accelerates atherosclerosis, induces endothelial dysfunction, and promotes cardiac structural changes that ultimately lead to coronary artery narrowing. This study employed a literature review approach by analyzing scientific articles discussing the association between hypertension and CAD in Indonesia. The findings show a significant relationship between hypertension and CAD, with p-values < 0.05 across multiple studies, and hypertensive individuals found to be more than twice as likely to develop CAD compared to normotensive individuals. Pathophysiologically, chronic hypertension contributes to hemodynamic disturbances, cardiac remodeling, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system (RAAS), thereby accelerating atherosclerosis and triggering myocardial infarction. These results highlight the importance of early detection and effective management of hypertension as essential strategies for preventing cardiovascular complications.
Co-Authors Ade Yonata Adilla Justisia Aditya Kusumaningtyas Hudisaputeri Aditya Permana Agusta Saraswati Agustyas Tjiptaningrum Ahmad Farizan Radhitya Ahmad Syah Putra Ainin Aniah, Pratiwi Ajeng Defriyanti Pusparini Akuba, Nanda Nurrohim Aldo Fatejarum Ambarwati, Yuli Andhini, Friska Andi Setiawan Andrian Rivanda Andriansah, M. Anggi Setiorini Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Anisa Nuraisa Jausal Anisa Nuraisa Jausal Arif Setiawansyah Arini Meronica Arninda Rahman Atmajaya, Yudhi Audya Pratiwi Putri Riyanda Ayu Ningsih Ayu Tiara FItri Azkiya Bahren Nortajulu Balqis Mezzaluna D'Azzuri Bara Ade Wijaya Suprayitno Bayu Anggileo Pramesona Betta Kurniawan betta kurniawan Betta Kurniawan, Betta Buana, Faris Agung Cana, Arla Erit Siktia Catur Ariwibowo Catur Ariwibowo Damayanti, Putri Daulay, Suryani Agustina Dedi Hermawan Devi Rahmadiani Diah Septia Liantari, Diah Septia Dian Isti Angraini Dian Isti Angraini Dyah Wulan Sumekar Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Endro Prasetyo Wahono Ersa, Rakhmigasti Citra Ety Apriliana Ety Apriliana Ety Apriliana Eva Lusina, Septia Evi Kurniawati, Evi Evi Kurniawaty Exsa Hadibrata Fahrezi Fathilla Farida Hakim Lamuhammad Fatriyadi Suwandi, Jhons Febrianti, Arlin Fendi Setiawan Fitri Sofiatin Fitria Saftarina Gemayangsura Gemayangsura Gemayangsura, Gemayangsura Giok Pemula Giska Tri Putri Hadibrata, Exsa Hana Muthi'a Putri Handayani Dwi Utami Hanna Mutiara, Hanna Happy, Terza Aflika Hardiansyah, Ridwan Hendra Tarigan, Sibero Hendri Busman Hendri Busman Hijami, Nurul 'Afifah Ibnu Fadilah Indri Windarti Intan Kusumaningtyas Intanri Kurniati Irawan Budi Waskito Irma Liani Ismunanto, Aziza Regina Kinasih Isvari, Gusti Ayu Made Prathita Iswandi Darwis Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi John Hendri Joni, Agnesia Priskila Justisia, Adilla Kamalia, Avissa Medina Khairun Nisa Khairun Nisa Kinanti Rahmadhita Kurniawaty, Evi Lanang Rachmadi M. Ridho Ulya M. Yusran Mallarangeng, Andi Nafisah Tendri Adjeng Marcellia, Selvi Maya Ganda Ratna Mayasari, Diana Mela Liberti Octoriani Simaremare Merry Indah Sari Muhamad Yogie, Fadli Muhammad Ariq Naufal Muhammad Yogie, Fadli Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Nabila Shafira Naufal, Muhammad Ariq Ni Luh Gede Ratna Juliasih Ni Putu Sari Widiyani Nisa Karima Nisa Karima Novianty, Detty Novita Carolia Novita Carolia Nurhasanah Nurhasanah Oktadoni Saputra, Oktadoni Oktafany Oktafany Ovalia, Nora Wilya Pemula, Giok Peni Ahmadi Pratiwi, Ainin Aniah Putri, Najwa Naraniya Putu Ristyaning Ayu R Supriyanto Rachel Junita Sitepu Ramadhana Komala Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Ratri Mauluti Larasati Reimma Emily Rachman Rengganis Wardani, Dyah Wulan Sumekar Reni Zuraida Rianto, Muhamad Arif Rie Dahniar Marissa Marpaung Rika Lisiswanti Rika Oktaria Rinawati Rinawati Risal Wintoko Riski Pangestu Risti Graharti Rizki Hanriko Rodiani Rodiani Rodiani, Rodiani Roro Rukmi Windi Perdani, Roro Rukmi Rosbhaiti Chodijah Rudianto, Waluyo Rudiyanto, Waluyo Ruslani, Nada Oktista Sangging, Putu Ristyaning Ayu Septia Eva Lusina Septiani, Linda Siti Raqiya Rasyid Smith Imanuel Saputra Sofyan Musyabiq Wijaya Soraya Rahmanisa Soraya, Yeni Sri Agustina Suharmanto Suharmanto Suharmanto Sulthan Alam Yasyfa Surriandari, Latifah Dwi Suryadi Islami Suryani Agustina Daulay Sutarto Sutarto Sutarto Sutopo Hadi Sutyarso Sutyarso Sutyarso Sutyarso Sutyarso Syafira Alifia Audiani SYAIFUL BAHRI Syaiful Bahri Syazili Mustofa Tara Aulianova Tasya Hani Fatwa Tri Umiana Soleha Tutik Ernawati Victoria Hawarima W, Dyah Wulan Sumekar R. W., Dyah Wulan Sumekar R. Waluyo Rudianto Waluyo Rudiyanto Wardani, Dyah Wulan Wawan Abdullah Setiawan Wido Gamani Worocahyo, Avis Meyvika Yadika, Adilla Dwi Nur Yolanda Fratiwi Yudhi Atmajaya Yudho Prabowo, Arif Yunianto, Andi Eka Yuningrum, Hesti Zahra, Aulia Jannatuz Zakiah Zakiah