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The effect of epigallocatechin 3-gallate (EGCG) on Sertoli and Leydig cells counts and spermatozoa quality of rats (Rattus norvegicus) exposed to monosodium glutamate Indira, Sitti Az-Zahra; A Ashiila Tsabita; susilowati, Suherni; Sri Pantja Madyawati; Yudaniayanti, Ira Sari; kusnoto, kusnoto; Legowo, Djoko; Hidajati, Nove; Kadek Rachmawati
Ovozoa: Journal of Animal Reproduction Vol. 15 No. 1 (2026): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v15i1.2026.56-64

Abstract

This study aimed to determine the preventive effect of epigallocatechin 3-gallate (EGCG) on the number of Sertoli and Leydig cells in white rats (Rattus norvegicus) exposed to monosodium glutamate (MSG). This study used 25 male rats which were divided into five groups. The C– group was given only 1% Na-CMC, while the C+ group received 1% Na-CMC and 120 mg/kg BW of MSG. The T1, T2, and T3 groups were administered EGCG at doses of 4, 8, and 16 mg/kg BW, respectively, along with 120 mg/kg BW of MSG. All treatments were administered orally for 28 days. After the treatment period, the rats were sacrificed on day 29. Their testes were collected and processed into histological specimens using hematoxylin eosin (H&E) staining. The results showed that MSG exposure significantly decreased (p <0.05) the number of Sertoli and Leydig cells in the C+ group compared to the C– group. In contrast, the T1, T2, and T3 groups showed increased cell counts following EGCG administration. Epigalocathecin-3-gallate at a dose of 8 mg/kg BW showed the best potential in maintaining spermatozoa motility, viability, and plasma membrane integrity in rats exposed to MSG. EGCG, as an antioxidant, can reduce lipid peroxidation in the spermatozoa plasma membrane, thereby improving spermatozoa viability, motility, and plasma membrane integrity. In conclusion, the administration of EGCG mitigates the harmful effects of MSG on Sertoli and Leydig cell counts in white rats, with an optimal dose of 8 mg/kg BW.
Co-Authors A Ashiila Tsabita Abdul Samik, Abdul Abdullah Hasib Ach. Resa Fachrizi Aditya Irawan Aftabuddin Rz, Muhammad Agung Budianto Achmad, Agung Budianto Agustono, Bodhi Ahmad Hanif Azzam Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Anas Bad’rosana Prawindi Arimbi Aryaloka, Suhita Azwani, Nabila Badri Munir Sukoco Benjamin Christoffel Tehupuring, Benjamin Christoffel BUDI UTOMO Budi Utomo Candra Panji Asmoro, Candra Panji Cesaria, Mayrena Ayu Chrismanto, Dony Chrisnahutama, Adrian Chusniati, Sri Cindy Ercha Aulia Putri Dadik Rahardjo Dikman, Dicky Mohammad Dimas Kunto Satrio Dito Herrys Dika Putra Djoko Legowo Emy Koestanti Sabdoningrum Endang Suprihati Epy Muhammad Luqman Erick Fajar Subhekti ERMA SAFITRI Erma Safitri Estoepangestie, A.T.Soelih Fachry Abda El Rahman Fajar Ramadhan Subiyantoro Fajarwati, Rini Fedik Abdul Rantam Fendy Suhariadi Feri Hendriyanto Frida Aulya Arningdiah Gandul Atik Yuliani Hana Eliyani Hani Plumeriastuti Hardaningtyas, Enggar Hariyono Hariyono Hendriyanto, Feri Heni Puspitasari Hermin Ratnani Herry Agoes Hermadi Hidanah, Sri Ika WAHYUNI IMAM MUSTOFA Indah Norma Triana, Indah Norma Indira, Sitti Az-Zahra Ira Sari Yudaniayanti Irawan, Adinda Riezki Iskandari, Novia Nur Ismudiono Ismudiono Ismudiono Ismudiono, Ismudiono Iwan Sahrial Hamid Iwan Sahrial Hamid Jihan Pangestuningrum Kadek Rachmawati Kevin Mardotillah Kurniawan, Muhammad ‘Ahdi Kusnoto Kusnoto Kusnoto, Kusnoto Lailiyah, Fahlevi Legowo, Djoko Leo Yosdimyati Romli Linda Sutanto Lucia Tri Suwanti, Lucia Tri Maryana Siska Silviani Masruro, Novia Alfi Masyitoh, Herlina Meles, Dewa Ketut Mirni Lamid Moh. Sukmanadi Mufasirin Muhammad Al-Syafiq bin Abdul Halim Muhammad Aulia Rahman Muhammad Ikmal Robih Mustofa Helmi Effendi M’ Izi Kumala Lazuardi Sultoni Nawangwulan, Tantri Nenny Harijani Ni Luh Ayu Megasari Ni Made Sukartini Nidom, Chairul Anwar Nove Hidajati Nurdianto S., Ricko Nuurin Ajrin Karim octavia, Arinda Paramita L, Widya Paramita, Chici Ayu Pradana, Giffari Danindra Praja, Ratih Novita Prasetyo, Ivo Febrina Prastiya, Ragil Angga Pudji Srianto Purwono, Rudi Qodri, Winda Nurul Lailatil Rahmatullah, Aldin Akbar Ratna Damayanti Reisinta, Dinda Renaldi, Nogi Retno Sri Wahjuni Retta, Ayun Tria Marga Rimayanti Rimayanti . Rimayanti R Rimayanti R, Rimayanti Rimayanti Rimayanti Risanti Handayani Rochmah Kurnijasanti Rochmi, Siti Eliana Rudi Purwono Saputra, Hijrah Saputro, Amung Logam Sarmanu, Sarmanu Sayi Datur Rohmah Seagames Waluyo, Seagames Shifa Fauziyah Soeharsono Soeharsono Sri Hidanah Sri Mulyati Sri Mulyati Suherni Susilowati Sukma, Puspa Permata Sukmanadi, Mohammad Sunarso, Agus Suparto Wijoyo Supriyadi Supriyadi Suzanita Utama Tan, Chin Xuan TARZAN PURNOMO Tasya Apritalia Putri Tatik Hernawati Teguh Hari Sucipto, Teguh Hari Tita Damayanti Lestari Tjuk Imam Restiadi Tri Wahyu Suprayogi Trilas Sardjito Tyasmingsih, Wiwiek Ummaisyah, Winadya Reika Wahjuni, Retno Sri Warsito, Sunaryo Hadi Wenny Nur Azizah Wibawati, Prima Ayu Widiantoro, Krisna Widiyatno, Thomas Valentinus Widjiati . Widjiati Widjiati, Widjiati Widodo, Oky Setyo Widya Paramita Lokapirnasari Wurlina, W Yeni Dhamayanti Yolifia Rahma Milenia Zahrorona, Amira Halimah