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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan Vegetalika VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL KIMIA SAINS DAN APLIKASI AL KAUNIYAH Buletin Penelitian Tanaman Rempah dan Obat Biotropika Jurnal Aplikasi Bisnis dan Manajemen (JABM) E-Journal Jurnal Sumberdaya Hayati Majalah Obat Tradisional BERITA BIOLOGI JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) INDONESIAN JOURNAL OF ESSENTIAL OIL Al-Kimia Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Aplikasi Teknologi Pangan Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Indonesian Journal of Chemistry Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Biosaintifika: Journal of Biology & Biology Education Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) Jurnal Aplikasi Teknologi Pangan Journal of Tropical Crop Science Acta Biochimica Indonesiana Seminar Nasional Lahan Suboptimal Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia JURNAL MEDIA KESEHATAN Kumawula: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Electrical Engineering and Computer Science Buletin Penelitian Tanaman Rempah dan Obat Sains dan Matematika Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society Andalasian International Journal of Agricultural and Natural Sciences Proceeding of Mulawarman Pharmaceuticals Conferences Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Jurnal Sylva Lestari Indonesian Journal of Cancer Makara Journal of Science Jurnal Kedokteran Hewan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Molekul: Jurnal Ilmiah Kimia Jurnal Tumbuhan Obat Indonesia Policy Brief Pertanian, Kelautan, dan Biosains Tropika Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Indonesian Journal of Forestry Research Indonesian Journal of Jamu
Irmanida Batubara
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, IPB University, IPB Dramaga Campus, Bogor 16680, Indonesia. Tropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Molecular Dynamics Simulation of Bioactive Compounds Against Six Protein Target of Sars-Cov-2 As Covid-19 Antivirus Candidates Fikry Awaluddin; Irmanida Batubara; Setyanto Tri Wahyudi
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 2, November 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i2.21634

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus that causes Coronavirus 2019 (COVID-19). To date, there has been no proven effective drug for the treatment or prevention of COVID-19. A study on developing inhibitors for this virus was performed using molecular dynamics simulation. 3CL-Pro, PL-Pro, Helicase, N, E, and M protein were used as protein targets. This study aimed to determine the stability of the selected protein-ligand complex through molecular dynamics simulation by Amber20 to propose bioactive compounds from natural products that have potential as a drug for COVID-19. Based on our previous study, the best value of free binding energy and protein-ligand interactions of the candidate compounds are obtained for each target protein through molecular docking. Corilagin (-14.42 kcal/mol), Scutellarein 7-rutinoside (-13.2 kcal/mol), Genistein 7-O-glucuronide (-10.52 kcal/mol), Biflavonoid-flavone base + 3O (-11.88 and -9.61 kcal/mol), and Enoxolone (-6.96 kcal/mol) has the best free energy value at each protein target. In molecular dynamics simulation, the 3CL-Pro-Corilagin complex was the most stable compared to other complexes, so that it was the most recommended compound. Further research is needed to test the selected ligand activity, which has the lowest free energy value of the six target proteins.
Potential Use of Indonesian Medicinal Plants for Cosmetic and Oral Health: A Review Irmanida Batubara; Muhammad Eka Prastya
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i1.16252

Abstract

Medicinal plants have gained much importance in cosmetic development due to their abundant bioactive compounds and relatively fewer side effects. Indonesia comprises a diverse range of medicinal plants, along with multiple ethnicities and cultures. For decades, Indonesian traditional medicinal plants, known as jamu, had been utilized for skin care, skin whitening, and oral health. In the present review, several Indonesian medicinal plants have been discussed in relation to their potency for cosmetic and oral health. Recent scientific evidences showed that medicinal plants reviewed in this paper have the appropriate bioactivities with the major requirements for cosmetic and oral health including antioxidant, antiglycation, skin whitening via tyrosinase inhibitor and melanogenesis inhibition, antiacne activities (against Propionibacterium acnes and Staphylococcus epidermidis) and biofilm degradation against Streptococcus mutans, Staphylococcus aureus and Candida albicans. One of plant, namely Zingiber officinale reported having all of those requirements indicating the most potential for cosmetic and oral health agents. In summary, further research on Indonesian medicinal plants should be conducted to provide holistic knowledge for the development of cosmetic and oral health products.
Screening Marker Components Of Tyrosinase Inhibitor From Xylocarpus Granatum Stem Latifah K Darusman; Irmanida Batubara; Catharina Lopolisa
Jurnal Kimia Valensi JURNAL Valensi Volume 2, No. 3, November 2011
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.653 KB) | DOI: 10.15408/jkv.v2i3.111

Abstract

The aim of our research was to screen the marker components of tyrosinase inhibitor from Xylocarpus granatum stem collected from Pulau Sebuku, South Kalimantan, Indonesia.  The screening method started from selection of part of X. granatum, stem or stem bark.  Stem and stem bark of X. granatum were dried and grounded before submitted to methanol.  The stem extracts is more potent as tyrosinase inhibitor (IC50 for monophenolase is 45.12 μg/ml and diphenolase is 31.59μg/ml) compared to the bark extracts. The IC50 values of kojic acid as positive control are 17.43μg/ml for monophenolase and 20.69 μg/ml for diphenolase. The stem extract then separated with silica gel column chromatography and preparative thin layer chromatography.  The results showed that component with Rf 0,25 and 0.63 (TLC analysis with stationary phase silica gel GF254 and mobile phase ethyl acetic: methanol (8:2)) are the marker components as tyrosinase inhibitor for X. granatum.
Medicinal Plants in East Sumba that Potential as Natural Dyes for Ikat Weaving Martini Ndamunamu; Irmanida Batubara; Leti Sundawati
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 2, November 2019
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.792 KB) | DOI: 10.15408/jkv.v5i2.9249

Abstract

The revival of the natural dyes comes from an awareness of maintaining health and preserving the environment. Medicinal plants can be used as a source of the natural dyes. This study aimed to determine the medicinal plants in East Sumba Regency potentially exploited as a natural dye for ikat weaving. Plant data was obtained from Tana Tuku village and Mbatakapidu village in East Sumba Regency. A total 13 species of plants were extracted to dye cotton fabric and mordant by FeSO4 (ferrous sulphate), Al2(SO4)3 (alum) dan CaCO3 (lime). The intensity of color L*, a*, b* were analyzed by Kruskal Wallis test and Duncan post hoc test. The fastness of washing test analyzed by a gray color change scale and staining scale standard. The results showed that the ferrous sulphate mordant produced dark color and the alum mordant produced bright color. The intensity of red color was shown by Swietenia macropylla King and Leucaena leucocephala when it was mordanting by lime. The intensity of yellow color was shown by Woodfordia fruticosa (L.) Kurz with alum and Syzigium polyanthum with lime. The color change was not significant at 40 oC of washing shown by Tamarindus indica and Leucaena leucocephala mordanting by ferrous sulphate, Leucaena leucocephala, Bombax ceiba and Timonius timon mordanting by alum, Tamarindus indica, Leucaena leucocephala, Timonius timon mordanting with lime. All natural dyes did not stain the upholsteries.
Tea Constituent in Protecting Glyphosate Effect on Human Breast Cancers Cells (MCF-7) Growth Batubara, Irmanida; Suprihatini, Rohayati; Mariya, Silmi; Achmadi, Suminar Setiati; Sokoastri, Valentina; Mulyatni, Agustin Sri; Hakim, Arif Rakhman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 2, November 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i2.33229

Abstract

Glyphosate, which has been documented as a contaminant in tea, promotes the proliferation of human breast cancer cells (MCF-7). Tea, on the other hand, includes various antioxidants, including epigallocatechin gallate (EGCG), which may protect against cancer cell proliferation. The purpose of this research is to determine the preventive effect of concentrated brewed green tea on MCF-7 development caused by glyphosate. The glyphosate concentration that promotes MCF-7 development was determined using a serial concentration of glyphosate. Glyphosate concentrations of up to 64 mg/L were shown to have no effect on MCF-7 cell proliferation. Concentrated brewed tea and EGCG 200 mg/L have the potential to suppress MCF-7 cell proliferation in the presence of glyphosate up to 512 mg/L. The combination of glyphosate and concentrated brewed tea or EGCG protects against glyphosate toxicity via altering the expression of tumor suppressor protein (p53).
Component Discrimination and Anti-skin-aging Potency of Emprit and Red Ginger Essential Oil: Chemometric, Molecular Docking and Molecular Dynamics Study Badrunanto, Badrunanto; Asoka, Shadila Fira; Wahyuni, Wulan Tri; Farid, Muhammad; Wahyudi, Setyanto Tri; Batubara, Irmanida
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 2, November 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i2.32765

Abstract

Emprit and red ginger essential oils (EOs) are natural sources of antioxidants that have the potential to be used in cosmetics, one of which is as an anti-skin-aging. The aim of this study was to determine the component differences and anti-skin-aging potential of the two EOs. The components were determined by GC-MS, while discrimination was done by chemometric. The potential of the components as the anti-skin-aging were evaluated by molecular docking and molecular dynamics (MD) simulations. A total 66 components were identified in both EOs, where eucalyptol (17.92%) and camphene (15.12%) were the main component in emprit and red ginger, respectively. Chemometric analysis revealed two discriminant clusters highlighting their dissimilarity with germacrene D and α-zingiberene are the key markers for differentiation. The docking and MD simulations were demonstrated the four main components of emprit EO, namely α-curcumene, α-zingiberene, β-bisabolene and β-sesquiphellandrene, have the best docking scores and interact with the enzymes with a relatively stable interaction. AdmetSAR evaluation of the four components has shown good bioavailability and declared safe. This study succeeded in revealing two ginger EOs differences based on their components and demonstrated the emprit ginger EO was more promising as a natural anti-skin-aging agent for further research.
Co-Authors . TRIVADILA Ade Heri Mulyati, Ade Heri Adi Santoso Adi Santoso Afriyanti , Ani Agung Prasetyo Agustin Sri Mulyatni Ahmad Izuddin Aini Fazriani Ainun Nasution Akhirudin Maddu Ali Mahmoud Muddathir Ali Mahmoud Muddathir Alifian Ariansyah Alzamori, Winda Amalia Prihaningsih Ananda, Fira Angga Crystal Loasana Yami Anggraeni, Nurah Anissa Permatasari Anisya Elsa Shafira Anne Carolina Annisa Permata Sari Anthony Nyangson Steven Apriza Yuswan Ariansyah, Alifian Arif Rakhman Hakim Arif Rakhman Hakim Arifin, Poppy F. Arinana Arinana Arista, Galih Saputra Arnold Patogi Siahaan Arnold Patogi Siahaan Asih Gayatri Asoka, Shadila Fira Asti Yosela Oktaviana Audah, Kholis Abdurachim Aulia Putri, Faradina Auliya Ilmiawati Ayu Rahmania Lestari Ayuningsih, Sylvia Azis, Sandra Badrunanto, Badrunanto Baiq Ayu Aprilia Mustariani Bambang Pontjo Priosoeryanto Batubara, Razethy Behling, Hermann Budi Arifin Budiarti, Eka Budiarti, Eka Cahya Septyanti Cahya, Hanifah Dwi Catharina Lopolisa Cece Sumantri Cecep Kusmana Christy Efiyanti Cindy Larasati, Cindy Cinta Badia Br Ginting, Rohani Dadang Muhammad Hasyim Daniel Happy Putra Dea Nurafifah Dea Nurafifah Decsa Medika Hertanto Dedi Fardiaz Devi Aristyanti Dewi, Trisni Dhieka Avrilia Lantana Diah Pamungkas Dikhi Firmansyah Dilaika Septorini Dina Ragillia Sari Diposani, Diva Putri Dista, Rama Djoko Santoso Djoko Santoso Dodi Nandika Dona Octavia Dudi Tohir Dwi Retnowati Dyah Iswantini DYAH PERWITASARI -FARAJALLAH Edi Mirmanto Egra, Saat Eka Budiarti Eka Budiarti Eka Winarni Sapitri Elza Wijaya Endang Kintamani Endang Prangdimurti Endar Marraskuranto Eni Sumarni Eni Sumarni Enny Rimita Sembiring Epi Taufik Erma Suryanti Erna Subroto Erniati Erniati Erniati Eti Rohaeti Eti Rohaeti Evi Kurniawaty Evie Nihayah Evul Winoto Evul Winoto Failasufa, Adzkia Faiza, Lucky Lia Farhana Halimah Rusyda Fazriani, Aini Febriani, Elsa Fendy Fikry Awaluddin Fikry Awaluddin Fikry Awaludin Fiqa Annisa Rakhmatika Fira Asoka, Shadila Folkes Laumal Folkes Laumal Fransiska Devy Junardy Gunawan, Fransisca Gustini Syahbirin Handika Dwi Prasetyo Herry Suhardiyanto Hunaefi, Dase Husnawati, . I Nyoman Pugeg Aryantha Imelda Imelda Indah D. Dewijanti Indrawan, Dikky Indri Yati Intan Noviarni Irene, Angelina Irma Herawati Suparto Irma Hermawati Suparto Irma Isnafia Arief Irma Suparto Izuddin, Ahmad Izza Firdausi Hadiyanto Jahnk, Svea Lina JARWADI BUDI HERNOWO Julkipli Julkipli Julkipli Julkipli, Julkipli Junardy, Fransiska Devy Khalida Shabiba Nursyamsi Kholis Abdurachim Audah Kholis Abdurachim Audah Kilala Tilaar Kosei Yamauchi Kurniawaty, Evi Kuroki, Yutaka Latifah Darusman latifah K Darusman Latifah K Darusman Latifah K Darusman Latifah K Darusman Latifah K Darusman Latifah Kosim Darusman LATIFAH KOSIM DARUSMAN Latifah Kosim Darusman Latifah Kosim Darusman LATIFAH KOSIM DARUSMAN Lela Mukmilah Yuningsih Leti Sundawati Lina Karlinasari Lucia Dhiantika Witasari Lucia Dhiantika Witasari, Lucia Dhiantika Lucky Lia Faiza Luky Adrianto Lutfia Mutmainnah Luthfiana, Widya Lydia Octifani M. Rafi Maily Mustofa Mardho Tillah Mardho Tillah Mardho Tillah, Mardho Martini Ndamunamu Mashuri Waite Mashuri Waite Maulana, Faizal Mawasti, Titi Mella Monica Mohamad Gazali Mohamad Rafi Mohamad Solahudin Morina Adfa Muddathir, Ali Mahmoud Muhamad Nursid Muhammad Ana Syabana Muhammad Asril Muhammad Eka Prastya Muhammad Eka Prastya Muhammad Eka Prastya Muhammad Farid Muhammad Farid Muhammad Nursid Muhammad Nursid Mujahidah, Ummahatul Mulya Sari Mulyatni, Agustin Sri Munawaroh, Fauziyatul Mustofa, Maily Mutia Ramadani Nadia Prilliane Putri Nadiah, Nur Syafiqah Nadila Fany Ashafani Nampiah Sukarno Nancy Dewi Yuliana Nevianti Zamany Neviaty P Zamani NEVIATY PUTRI ZAMANI Nina Ratna Djuita Ning Ima Arie Wardayanie, Ning Ima Arie Ninuk Purnaningsih Nisa Lelita Fadilah Nisa, Ulfiatun Novita Ariani NUNIK SRI ARIYANTI Nur Syafiqah Nadiah Mohammad Rafi Nurheni Wijayanto Nurlela Nurlela Nursyamsi, Khalida Shabiba Nuzulia, Nur A Pamungkas, Diah Pamungkas, Diah Daru PAMUNGKAS, DIAH DARU Poppy F. Arifin Prayogo, Yanico Hadi Priyadi, Yogo Suro Purwantiningsih Sugita Putri Utami, Putri Putri, Nadia Prilliane Rachmayanti, Yanti Rahadyanoto Trimulia Rahmi Nur Wahidah Rahmi Utami Rahminiwati, Min Rakhmat, Asep Rakhmatika, Fiqa Annisa Raphael Aswin Susilowidodo Ratte, Marina Razethy Batubara Refilda Refilda Rerenstradika Tizar Terryana Reza Ro'isatul Umma Ria Heni Sigiro Riana, Elisa Nurma Rika Indri Astuti RIKA RAFFIUDIN Rikno Harmoko Rita Kartika Sari Rohani Cinta Badia Ginting ROHAYATI SUPRIHATINI Rohayati Suprihatini Romi Irka Putra Rosalina Wisastra Rosalina, Dian S.Pd. M Kes I Ketut Sudiana . Saat Egra Saat Egra Saat Egra SAEPUDIN RAHMATULLAH Saifanah Setiawan, Nabilah Salina Febriany Sandra Arifin Aziz Sari, Dina Ragillia Sari, Yessie W Sastia Prama Putri Sayusti, Tiara Setyanto Tri Wahyudi Shadila Fira Asoka Shadila Fira Asoka Shafira Ananda Djakaria Shafira, Anisya Elsa Siahaan, Arnold Patogi Sihegiko Kanaya Silmi Mariya SILMI MARIYA Sintho Wahyuning Ardie Siswoyo Siswoyo SITI SA’DIAH Sitompul, Rahmadi Slamet Widodo Slamet Widodo Soekisman Tjitrosoedirdjo Sri Listiyowati Sri Nurdiati Sri Purwanti Sri Purwanti Sri Purwanti Sri Sugiarti Sri Wahyuni Sri Wilarso Budi Steven, Anthony Nyangson Stevia Septiani Subroto, Erna SUHARINI, YUSTINA SRI Suharti, Sri SUMINAR S. ACHMADI SUMINAR SETIATI ACHMADI Suparto, Irma Suparto, Irma Supriyanto Supriyanto Supriyanto Susilowidodo, Raphael Aswin Takemori, Hiroshi Tamsin, Aqlia Hanna Nurfatiha Taopik Ridwan Taopik Ridwan Taopik Ridwan Tatang Tiryana Taufik Ridwan Taufik Ridwan, Taufik Tilaar, Kilala Tintin Sarianti Titi Mawasti Tjandrawati Mozef Tohir, Dudi Tohru Mitsunaga Tohru Mitsunaga Tohru Mitsunaga Tohru Mitsunaga Trisni Untari Dewi Tunnisa , Fitra Ummi Zahra, Ummi Upik Kesumawati Hadi Uswatun Hasanah Utami Dyah Syafitri Utut Widyastuti Valentina Sokoastri Valentina Sokoastri Veby Tri Yani Veby Tri Yani Vera Permatasari Wahyuni, *Wulan Tri Wahyuni, Wulan T Waras Nurcholis Wasrin Syafii Wati, Vivi Septya Wijaya, Elza Winanda, Witri WINDRA PRIAWANDIPUTRA, WINDRA Wisastra, Rosalina Wisnu Ananta Kusuma Witri Winanda Wulan Tri Wahyuni Yamauchi, Kosei Yana Rubiyana Yana Rubiyana, Yana Yanico Hadi Prayogo Yanti Rachmayanti Yefrida Yefrida Yessie Widya Sari Yogo Suro Priyadi Yudiwanti Yudiwanti Wahyu E. Kusumo Yuliana Galih Dyan Anggraheni YULIN LESTARI Yuni Kartika Yuni Kartika, Yuni Yusuf Ryadi Yuyun Nisaul Khairillah Zaenal Abidin Zamany, Nevianti Za’aziza Ridha Julia Zuraida Hanum Zuraida Hanum Zuraida Hanum