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All Journal International Journal of Public Health Science (IJPHS) International Journal of Evaluation and Research in Education (IJERE) HAYATI Journal of Biosciences JURNAL HUKUM Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Lahan Suboptimal Proceedings of Annual International Conference Syiah Kuala University - Social Sciences Chapter Jurnal Kedokteran Brawijaya Jurnal Pendidikan Sains Biogenesis: Jurnal Ilmiah Biologi Current Biochemistry Research Journal of Life Science Jurnal Wasian Jurnal Pendidikan Biologi Indonesia Buletin Keslingmas Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Science and Technology Indonesia JOIV : International Journal on Informatics Visualization Jurnal Manajemen Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUKASI Biosfer: Jurnal Pendidikan Biologi Jurnal Administrasi dan Manajemen Pendidikan at-tamkin: Jurnal Pengabdian kepada Masyarakat Amerta Nutrition Biota Bioedusiana: Jurnal Pendidikan Biologi GERVASI: Jurnal Pengabdian kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Jurnal Pengabdian Kepada Masyarakat (Mediteg) Prosiding Seminar Nasional Teknik Mesin Dedikasi: Jurnal Pengabdian Masyarakat Business Journal : Jurnal Bisnis Dan Sosial JAMP : Jurnal Administrasi dan Manajemen Pendidikan Diseminasi : Jurnal Pengabdian kepada Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Journal Informatic, Education and Management (JIEM) Jurnal Pengabdian kepada Masyarakat Nusantara Yumary: Jurnal Pengabdian kepada Masyarakat Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Masyarakat Indonesia ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Berkala Penelitian Hayati Journal of Research in Instructional Jurnal Ilmiah Kesehatan (JIKA) International Journal of Science and Society (IJSOC) Journal of Disruptive Learning Innovation (JODLI) Indonesian Community Journal Jurnal Pijar MIPA Sci-Tech Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram MINERAL Semanggi: Jurnal Pengabdian kepada Masyarakat Jurnal Keuangan dan Bisnis Research Horizon Journal International Journal of Teaching and Learning (INJOTEL) VISA: Journal of Vision and Ideas Prosiding Seminar Nasional Unimus Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Exhibition and Seminar on Science and Creative Technology – Al Azhar Proceeding Media for Empowerment, Mobilization, and Innovation in Research & Community
Hendra Susanto
Universitas Negeri Malang
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Journal : Science and Technology Indonesia

 1 
Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells Dewi Sekar Miasih; Yuslinda Annisa; Sri Rahayu Lestari; Hendra Susanto; Sunaryono
Science and Technology Indonesia Vol. 7 No. 4 (2022): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1699.595 KB) | DOI: 10.26554/sti.2022.7.4.417-426

Abstract

Single bulb garlic (SBG) has the potential as an immunomodulator; however, it has low solubility and bioavailability. A lipid-based delivery system, that is, the self-nanoemulsifying drug delivery system (SNEDDS), offers a novel opportunity in drug delivery. SBG can be a suitable candidate for SNEDDS development. This research aims to describe the physical stability, toxicity test of the SNEDDS, and SNEDDS SBG potential as antiinflammation in 3T3-L1 cells. The SNEDDS is made with various ratios of concentrations of carrier oil, surfactants, and cosurfactants, namely, 0.50: 3.45: 0.96, and added with SBG extract (SBGE) of 20 mg/mL. The results of the response test of SNEDDS SBGE formulation indicate an average and standard deviation of emulsification time of 16.38±3.01 (second), pH 7.21±0.08, and transmittance of 98.40±0.23(%). The average nanoemulsion size is 14.333±0.416 nm, polydispersion index of 0.213±0.056, and zeta potential of -14.67±0.72 mV. The results of the physical stability test indicate no segregation, deposition, cracking, or creaming in all nanoemulsion samples and SNEDDS SBG. The MTT test in a dose of 62.5, 125, 250, 500, 100, 2000, and 4000 µg/mL suggests that the highest viability of the 3T3-L1 cells is at a dose of 2000 µg/mL, which is 97.83%±1.55%. Therefore, SNEDDS SBGE can be a potential candidate for oral preparation by increasing bioavailability and reducing toxicity in the 3T3-L1 cells. An antiinflammatory test on the TNF-???? and IL-1???? expressions influences the 3T3-L1 cells. the SNEDDS of SBGE has the potential to reduce the expression of TNF-???? and IL-1???? and increase IL-10 expression in the methylglyoxal-induced 3T3-L1 cells.
Tapping into the Power of Sol-Gel Method for Enhanced Antimicrobial Activity of Titania Nanoparticles Saputra, Kormil; Masruroh, Masruroh; Susanto, Hendra; Apsari, Retna
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.546-555

Abstract

Increasing bacterial resistance to antibiotics has become a serious threat to global public health. In this context, this study aims to evaluate the antimicrobial activity of titanium dioxide nanoparticles (TiO2 NPS) synthesized using the sol-gel method. TiO2 NPS samples were prepared and characterized for morphology via field-emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) analysis. Kirby-Bauer disc diffusion method was used to test the antimicrobial activity of TiO2 NPS against Gram positive bacteria Staphylococcus aureus, Gram negative bacteria Escherichia coli, and pathogenic fungus Aspergillus penicillioides. The results showed that TiO2 NPS effectively inhibited the growth of microorganisms, with significant inhibition zones especially against fungi. The antimicrobial mechanism of TiO2 NPS involves the formation of hydroxyl radicals and superoxide ions that damage the cell membrane of microorganisms. The implications of this study are the development of potential antimicrobial nanomaterials for biomedical and environmental applications, as well as the importance of considering the physical and chemical properties of TiO2 NPS in designing effective infection treatment strategies.
Co-Authors Achmada, Putra Fernanda Dwi Adeodatus Yuda Handaya Adim Firmansah Adinda Marcelliantika Aditya Rifqi Fauzi Afis Baghiz Syafruddin Agung Witjoro Agus Barmawi Agus Subagyo Agusta Rakhmat Taufani Agustina, Rena Silvia Ahmad Hapiz Ahmad Khanali Ahmad Taufiq Ahmad Taufiq Ainun Nikmah Ajeng Daniarsih Alby Aruna Alby Aruna Aldri Frinaldi Ali Mustofa Almas Dwi Khairana Amaliyah Firdaus, Sa’diyatul Rizqie Anastya Eka Kharisma Andi Basuki Anggarani, Dinar Arsy Anggarani, Dinar Arsy Arsy Annisa, Yuslinda Arbin Janu Setiyowati, Arbin Ardana, I Kade Karisma Gita Ari Gunawan Ari Gunawan Ari Gunawan ARIF HIDAYAT Arif Hidayat Aripriharta - Arisatya Bharotoyakti Aruna, Alby Aulanni'am, Aulanni'am Aulanni’am, Aulanni’am Azriel Farrel Kresna Aditya Bagus Priambodo Bahrullah Akbar Betty Lukiati cahya, uci dwi Chang, Chun-Yen Choirunisa', Nindiana Chrisna Budi Satriyo Chusna, Nadiya Miftachul Claresia Tsany Kusmayadi Deny Setiawan Deny Setiawan Dewi Murni Dewi Sekar Miasih Dhaniswara K. Harjono Diah Setiawati Didik Dwi Prastyo Didik Setyo Heriyanto Dinar Arsy Anggarani Dwi Listyorini Eka Putri Surya El Baroroh, Alif Rosyidah Facthur Rohman Fatchur Rohman Fatchur Rohman Faturrahman Fauzi, M Imam Fitrah Amalia Salim Friska, Renny Futri Yuliana Fuzani, Sri Dinasyah Ratna Hadi Suwono Hadi, Sholihul Hari Rudijanto. IW Heru Wahyu Herwanto Hidayati Maghfiroh Hulman Panjaitan, Hulman Husna Nur Wanah I Kade Karisma Gita Ardana I Made Wirawan Ibrohim Ida Ayu Setyawati Sri Krisna Dewi Ida Rohmah Susiani Ika Sasti Ferina, Ika Sasti Ikramina Yusti Amina Imam Sofii Indah Nur Laili Izza, Jasmine Nurul Janiar Pitulima Jasmine Nurul Izza Jasmine Nurul Izza Joshua Andrew Kamal Agung Yudayana Kamal, Abu Hena Mostofa Kevin Radinal Kormil Saputra Krisnawati, Dyah Ika Kristianty, Grace Triana Kusmayadi, Claresia Tsany Kusnunnahari Kusnunnahari, Kusnunnahari Kustiariyah Tarman Lianto Lianto Linggasari, M.I. Dewi Lulik Inggarwati Lusttilanang, Pius Lya Rizka Herawati M Iqbal Najib Fahmi M. Ikhsan M. Rasjad Indra Markus Diantoro Marshanda Putri, Anggia Marwan Marwan Masruroh MASRUROH Mega Safithri Miasih, Dewi Sekar Miftahul Hasanah Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Moch Sholeh Mochammad Imron Awalludin Moh. Zainul Falah Mohamad Amin Mohammed, Najib Muhammad Adib Amin Muhammad Rifqi Hariri Muhammad Saefi Muharni, Andi Murni Sapta Sari Muslihati Najmi, Ikhwan Najmi, M. Ikhwan Nik Ahmad Nizam Nik Malek Nik Malek, Nik Ahmad Nizam Nurcahya Setiawan Nurlita Indah Wahyuni, Nurlita Indah Nurul Hidayat Nurul Izza, Jasmine Oriny Tri Ananda Paidi Paidi Pramono, Agus Joko Prayogi, Moch. Bagus Putri Diyah Anggraini Putri, Kuntum Kinanthi Rachmawati , Hidajah Radhiyah, Rizqa Rajib Muhammad Basthony Rasjad Indra Ratnapuri, Adisti Rawe, Nining Sahara H A Restianto, Yanuar Retna Apsari Ricadonna Raissa Rizqa Radhiyah Robi, Fikri Syahir Rony Irawanto Rui Alfadel Saputra S, Muh Akbar Sabrina, Andiani Salsa Satia Nur Maharani Satria Adiguna Seha, Siti Nur Setyarini, Ni Luh Putu Shinta Setyohadi, Taat Sholeh , Moch sholeh, moch Sholihah, Nida Anisatus Sholihul Hadi Silvi Tri Oktavia Sinta Kusuma Dewi Siti Maisaroh Siti Zubaidah Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Soenar Soekopitojo Soerjadjanegara, Moermahadi Sri Endah Indriwati Sri Rahayu Lestari Sri Rahmawati ST. Ulfawanti Intan Subadra Subadra, ST. Ulfawanti Intan Sudjari Sudjari Sudjari Sudjari Suharti Sujito . Sukiman . Sulfa, Devi Mariya Sunaryono Sunaryono Sunaryono, Sunaryono Supratman Tabba Susriyati Mahanal Suwarno Suwarno Suwistika, Rima Sya'rawi, Muhammad Akram Tjahyono, Seto Tono, E.P.S.B Taman Tri Endharti, Agustina Trijoyo Purnomo, Jerry Dwi Umi Fitriyati Utami Sri Hastuti Verdamil, Ainun Cornelia Wahyu Pratama, Ade Wandreina, Lucky Meisya Wibi Riawan Wiedia Carullina Purwanti Wijiasih, Wijiasih Wira Eka Putra Wisnubroto Wisnubroto Wisnubroto, Wisnubroto Wiwin Apriani Wuragil, Dyah Kinasih Yuda Handaya, Adeodatus Yudi Susanto Yuliana, Futri Yunita Rakhmawati Yuslinda Annisa Zahra Firdaus