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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) International Journal of Public Health Science (IJPHS) Jurnal Ilmiah Farmasi Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Indonesian Journal of Biotechnology Global Medical and Health Communication Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Pharmacon INDONESIAN JOURNAL OF PHARMACY Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Public Health of Indonesia Jurnal Farmasi Sains dan Komunitas THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Medica Hospitalia Jurnal Farmagazine Jurnal Health Sains Journal of Holistics and Health Sciences (JHHS) Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Klinik dan Sains Borobudur Pharmacy Review Jurnal Permata Indonesia Sciences of Pharmacy Journal of Global Pharma Technology Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Farmasi Galenika Indonesian Journal of Pharmacology and Therapy
Dyah Aryani Perwitasari
Fakultas Farmasi, Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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KUALITAS HIDUP PASIEN KANKER DI RSPAU DR. SUHARDI HARDJOLUKITO, YOGYAKARTA, INDONESIA: QUALITY OF LIFE OF CANCER PATIENTS IN DR. SUHARDI HARDJOLUKITO HOSPITAL, YOGYAKARTA, INDONESIA Lamhot B Simanjuntak; Mukti A Berlian; Siswandi Siswandi; Berry H Putra; Gugun Suhendra; Muhammad AR Saputra; Dania Haafizah; Lalu M Irham; Imaniar Faridah; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.472

Abstract

Penyakit kanker masih menjadi masalah kesehatan masyarakat di seluruh dunia dan masih merupakan penyebab kematian. Terapi pada pasien kanker dapat menimbulkan efek samping, yang akan mempengaruhi kualitas hidup pasien. Tujuan penelitian ini adalah mendapatkan gambaran kualitas hidup pasien kanker di RSPAU dr. Suhardi Hardjolukito, Yogyakarta, Indonesia. Penelitian ini menggunakan desain cross sectional yang dilakukan selama bulan Mei-Agustus 2022 di RSPAU dr. Suhardi Hardjolukito. Kriteria inklusi adalah pasien dewasa dengan diagnosa kanker yang menjalani rawat jalan di RSPAU dr. Suhardi Hardjolukito selama bulan Mei-Agustus 2022. Pengukuran kualitas hidup menggunakan kuesioner EORTC-QLQ-C30. Sejumlah 101 pasien kanker bersedia menjadi subyek dalam penelitian ini. Fungsi kesehatan umum pasien mempunyai nilai yang rendah, sedangkan fungsi fisik, peran, emosi, kognisi dan sosial mempunyai nilai diatas 80%. Gejala terparah yang dialami pasien kanker adalah kelemahan (fatigue) dan diikuti oleh nyeri dan insomnia. Pasien kanker yang menjalani kemoterapi di RSPAU dr. Suhardi Hardjolukito, mengalami efek negatif dari penyakit kanker dan terapinya sehingga mengalami penurunan fungsi kualitas hidup. Pihak RSPAU dr. Suhardi Hardjolukito diharapkan dapat memberikan pelayanan tambahan yang sesuai dengan kondisi pasien kanker untuk meningkatkan kualitas hidupnya.
LUARAN TERAPI DAN KUALITAS HIDUP PASIEN DMT2 YANG MENGGUNAKAN INSULIN DI APOTEK X KOTA YOGYAKARTA: THERAPEUTIC OUTCOMES AND QUALITY OF LIFE OF T2DM PATIENTS USING INSULIN AT PHARMACY X YOGYAKARTA CITY Wahyu Rahmatulloh; Menit Ardhiani; Imaniar Noor Faridah; Haafizah Dania; Lalu Muhammad Irham; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.742

Abstract

Diabetes Mellitus (DM) merupakan suatu krisis global terutama pada fase urbanisasi yang cepat, perubahan gaya hidup, dan pola makan yang tidak sehat. Prevalensi Diabetes Mellitus Type 2 (DMT2) di Indonesia pada tahun 2018 sebanyak 8.5% yang artinya sebanyak 20.4 juta masyarakat Indonesia menderita DMT2. Berbagai pengobatan yang efektif telah sering didapatkan pasien DMT2 tetapi kadar gula darah masih belum terkontrol sehingga akan mempengaruhi kualitas hidupnya. Tujuan penelitian ini yaitu mengetahui hubungan luaran terapi dengan kualitas hidup pada pasien DMT2 yang menggunakan insulin. Penelitian dilaksanakan  dengan desain cross-sectional, menggunakan instrumen kuesioner Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) dan data rekam medis pada pasien DMT2 yang menggunakan insulin di Apotek X Kota Yogyakarta. Hasil penelitian menunjukkan bahwa dari 50 responden yang memenuhi kriteria inklusi, sebanyak 48% berjenis kelamin laki-laki dan 52% berjenis kelamin perempuan dan didominasi umur >60 tahun sebanyak 60%. Gambaran luaran terapi gula darah puasa (GDP) menunjukkan hasil terkontrol sebanyak 22% dan tidak terkontrol 78%. Kualitas hidup baik pada domain fungsi fisik sebanyak 72%, energi 22%, tekanan kesehatan 92%, kesehatan mental 56%, kepuasan pribadi 44%, kepuasan pengobatan 54%, efek pengobatan 20% dan frekuensi gejala penyakit 60%. Hasil uji chi-square menunjukkan tidak ada hubungan yang bermakna antara luaran terapi dengan kualitas hidup (p>0.05). Kata Kunci : luaran terapi gula darah puasa (GDP), kualitas hidup, diabetes mellitus type 2
KEPATUHAN DAN LUARAN TERAPI PADA PASIEN DIABETES MELITUS TIPE 2 PENGGUNA INSULIN DI APOTEK X YOGYAKARTA: COMPLIANCE AND TREATMENT OUTCOMES IN TYPE 2 DIABETES MELLITUS PATIENTS USING INSULIN AT PHARMACY X YOGYAKARTA Muhammad Fathurrahman; Menit Ardhiani; Imaniar Noor Faridah; Haafizah Dania; Lalu Muhammad Irham; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.743

Abstract

Diabetes melitus (DM) adalah suatu gangguan metabolisme yang ditandai dengan gula darah yang naik secara berlebihan akibat gangguan sekresi insulin, kerja insulin, atau keduanya. Gangguan metabolisme karbohidrat, lemak dan protein pada penderita diabetes disebabkan oleh kurangnya aktivitas insulin pada sel target. Tujuan penelitian ini untuk mengetahui hubungan antara kepatuhan penggunaan insulin dengan luaran terapi klinis di Apotek X. Penelitian ini menggunakan desain studi Cross Sectional dan pengambilan data dilakukan secara prospektif menggunaka kuisioner Medication Adherence Report Scale (MARS) dan data hasil laboratorium. Analisa dapat dilaksanakan menggunakan uji Chi-square. Hasil penelitian menunjukkan kepatuhan tinggi  sebesar 6 responden (30%) dan kepatuhan rendah sebesar 14 responden (70%). Uji chi-square menunjukkan hubungan antara penggunaan insulin dengan HbA1c dengan p-value = 0,01, hubungan antara penggunaan insulin dengan Gula Darah Puasa dengan p-value = 0,024, dan tidak ada hubungan antara penggunaan insulin dengan Gula Darah Sewaktu dengan p-value = 0,807. Hal tersebut menunjukkan bahwa kepatuhan penggunaan insulin mempengaruhi terkontrolnya luaran terapi klinis pasien. Kata Kunci : Diabetes Melitus, Insulin, HbA1c, GDP, GDS, Apotek
DIABETES DISTRESS PADA PASIEN DIABETES MELLITUS TIPE 2 YANG MENGGUNAKAN INSULIN DI APOTEK X : DIABETES DISTRESS ON TYPE 2 DIABETES MELLITUS PATIENTS USING INSULIN IN PHARMACY X Denys Chichi Kusumastuti; Menit Ardhiani; Imaniar Noor Faridah; Haafizah Dania; Lalu Muhammad Irham; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.745

Abstract

Diabetes Mellitus Tipe 2 (DMT2) yaitu penyakit kronis yang dapat menyebabkan komplikasi serius. Hal inilah yang membuat penderita DMT2 mengalami distress. Diabetes distress merupakan kondisi yang menggambarkan stress psikologi yang dialami penderita sebagai manifestasi dari rasa takut mengenai hal negatif akibat penyakit diabetes mellitus. Penelitian ini bertujuan untuk mengetahui gambaran distress pada pasien DMT2 yang menggunakan insulin di Apotek X. Penelitian dilakukan menggunakan rancangan cross sectional selama bulan Juni-September 2022 di Apotek X, Yogyakarta. Kriteria responden penelitian adalah semua pasien DMT2 yang datang ke Apotek X dan sesuai dengan kriteria inklusi.  Kriteria inklusinya yaitu: pasien >18 tahun yang terdiagnosa DMT2, telah menggunakan insulin (baik tunggal maupun kombinasi dengan insulin atau oral antihiperglikemia) minimal 3 bulan sebelum rekrutmen penelitian dan bersedia mengikuti penelitian ini. Instrumen penelitian menggunakan kuesioner Diabetes Distress Scale (DDS). Dari 75 responden mengalami diabetes distress tingkat rendah (94,67%) dan tingkat sedang (5,33%). Domain distress yang berpengaruh pada pasien DMT2 yaitu beban emosional (1,30), pengobatan (1,29), interpersonal (1,18), dan dokter/tenaga kesehatan (1,14). Disimpulkan bahwa pasien DMT2 yang menggunakan insulin di Apotek X mengalami diabetes distress tingkat ringan dengan domain yang paling berpengaruh adalah distress beban emosional. Kata kunci: Diabetes Mellitus Tipe 2, Diabetes Distress Scale, Diabetes distress
DEVELOPMENT OF KNOWLEDGE, PERCEPTIONS, AND PUBLIC ATTITUDES QUESTIONNAIRE FACING THE ERA OF COMPULSORY HALAL MEDICINE CERTIFICATION Ahmad Azrul Zuniarto; Nurkhasanah Mahfudh; Dyah Aryani Perwitasari; Siti Pandanwangi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1002

Abstract

A questionnaire is an instrument used to collect data from several people or respondents through a set of questions to be answered. The validity and reliability of the questionnaire describe how well the preparation of the questionnaire was related to the measurement scale. Reliability indicates that the questionnaire is consistent when repeatedly used. This study aimed to obtain a valid and reliable questionnaire on community knowledge, perceptions, and attitudes toward halal drugs.  The reliability of the knowledge questionnaire, perceptions, and attitudes was defined using  Cronbach's alpha. This cross-sectional study was conducted online from January to February 2023, with 600 respondents in six provinces on Java Island. The knowledge questionnaire validation test used Point Biserial, perception, and attitude of using the Pearson Product Moment. The majority of respondents were aged <25 years (73%), the dominant last level of education was the secondary level (66.5%), and most of the jobs were students (38.7%). The r value of the knowledge domain obtained is (0.209-0.662) which was greater than the r table (0.080) and met the validity criteria, the perception domain (0.471-0.764), and the attitude domain (0.250-0.757) which is greater than the r table and satisfies the validity criteria. The Cronbach’s alpha value of the knowledge domain obtained was 0.730, that of the perception domain was 0.756, and that of the attitude domain was 0.723, which was > 0.6 and meets the reliability criteria...
MISSENSE MUTATIONS IN THE IRAK1 GENE ARE ASSOCIATED WITH AN INCREASED RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS Adnan Adnan; Dyah Aryani Perwitasari; Rita Maliza; Nanik Sulistyani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1073

Abstract

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in humans. Missense SNPs can change protein structure and function. This study aimed to determine missense SNPs of the IRAK1 gene that can affect the amino acid sequence and lead to changes in protein structure and function, as well as their relationship as a risk factor for SLE. In this in silico method, several bioinformatics tools have been used to identify missense SNPs, including their properties and impacts, as well as their interaction networks with proteins. The tools used were PolyPhenv2, SIFT, PhD-SNP, PROVEAN, SNAP, Panthers, I-Mutant 3.0, and GeneMania. Four missense SNPs, rs11465830, rs1059702, rs1059703, and 10127175, were obtained from the NCBI SNP database. The SIFT test results showed that all the SNPs were tolerant. In the test results obtained using PolyPhen, the four SNPs were benign. The results of the probe test indicated that the four SNPs were neutral. When tested with SNAP, one SNP was neutral, and three others had an impact. In the PhD-SNP test, all SNPs were neutral. In the panther test, all SNPs were benign. The I-mutant assay showed that the four SNPs could decrease protein stability. Tests with GeneMania have reported that most interactions between genes were between IRAK1 and MYD88, and physical interactions were the most dominant form of interaction. Conclusion. rs10127175, rs11465830, rs1059702, and rs1059703 are missense SNPs in IRAK1, which can disrupt protein stability and be a risk factor for SLE. Keywords: IRAK1, SNP, Missense, Systemic Lupus Erythematosus
ADAPTATION AND VALIDATION OF THE INDONESIAN VERSION OF THE HEALTH BELIEF MODEL INSTRUMENT FOR PARENTS Eka Wuri Handayani; Fredrick Dermawan Purba; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1101

Abstract

Children are a crucial population requiring COVID-19 vaccination. With the global rollout of COVID-19 vaccines, the increasing number of unvaccinated children and adolescents has raised concerns. To was translated, adapted, and validate the Health Belief Model instrument for parents of children aged 6–11 years regarding COVID-19 vaccination in the Indonesian language. Cross-cultural translation and adaptation were conducted according to international standards. The instrument testing process, according to Beaton et al., (2020), involves five stages: forward translation, synthesis of the translation results, back translation, review of the back translation, and readability testing. Respondents were purposively selected from the parents of children aged 6–11 years. Face and content validity were achieved for the Indonesian version of Health Belief Model for parents of children aged 6–11 years. The validity of each statement item was assessed using Pearson Correlation with a significance level of 0.05 and 193 respondents, resulting in an r table value of 0.1406. The constructs within the Health Belief Model were deemed valid based on the Pearson Correlation values, as the coefficient values were greater than the r-table value (r > 0.1406; p < 0.05). The constructs in the Health Belief Model were also reliable, with a Cronbach’s alpha value of 0.657. The culturally adapted Indonesian version of the Health Belief Model instrument for parents of children aged 6–11 years regarding COVID-19 vaccination is considered valid and reliable for use in research among the parent population of children aged 6–11 years in the context of COVID-19 vaccination.
PENGETAHUAN, KUALITAS HIDUP DAN BIAYA SAKIT PASIEN DENGUE DI RS PKU MUHAMMADIYAH GAMPING Supadmi, Woro; Elvinda, Esty; Aryani Perwitasari, Dyah; Noor Faridah, Imaniar
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 2 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i2.1428

Abstract

The incidence of dengue virus infection in the D.I. Yogyakarta reached 3,618 cases in 2020. Based on its clinical manifestations, dengue virus infection is divided into Dengue Fever (DF), Dengue Haemorrhagic Fever (DHF), and Dengue Shock Syndrome (DSS). This study aims to identify the level of knowledge, quality of life, and costs of dengue patients at PKU Muhammadiyah Gamping Hospital from March 2021 to October 2021. This study used a cross-sectional design. The measurement of the patient's knowledge level used a questionnaire knowledge of dengue, while the quality of life was assessed using EQ-5D-5L for adult patients and EQ-5D-Y for pediatric patients. The cost of illness data from the hospital finance database. This study involved 31 respondents with the characteristics aged 16-40 years (54.84%), male (87.1%), using BPJS insurance (80.65%), and an average length of stay of 4 days (51.61%). The patient's level of knowledge about dengue, knowledge of dengue prevention, and dengue prevention behavior reached 74.20% (sufficient), 74.20% (sufficient), and 77.42% (sufficient) respectively. The quality of life of dengue patients reached 100% and 85.2% in DF patients, while the DHF patients felt a few anxious/depressed (sad). The average cost of illness in DF patients was Rp. 2,796,386 and Rp. 3,378,537 in DHF patients.
STUDI KUALITATIF PERSEPSI APOTEKER DAN KADER KESEHATAN DALAM PEMANTAUAN OBAT ANTI TUBERKULOSIS DI PUSKESMAS MLATI II SLEMAN Nurfadilasari, Ulfa Mustofa; Perwitasari, Dyah Aryani; Ghozali, MT; Supadmi, Woro
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1714

Abstract

Background: Long-term treatment of tuberculosis can cause side effects that cause concern for patients. The side effects experienced by patients have an impact on treatment compliance and drug withdrawal. Efforts to control drug withdrawal require the role of pharmacists and cadres in monitoring treatment. Objective: to explore the perception of understanding and actions of pharmacists and cadres in monitoring anti-tuberculosis drugs. Method: This study is qualitative study with a case study approach. Participants selection using purposive sampling namely pharmacists, cadres and TB program holders who are involved in monitoring TB treatment. The number of participants was six people. Results: interview transcripts were analyzed thematically using software QSR NVivo 12. We categorized into three themes : drug side effects, medication adherence, and treatment success. Conclusion: pharmacists' understanding and actions in monitoring TB treatment are good. While the cadres' understanding and actions regarding the side effects of drugs are not good enough, the importance of compliance with taking medication and the success of treatment is good
Penggunaan Sefepim Untuk Demam Neutropenia Pada AML di RSUP Dr. Kariadi Semarang Septiantoro, Bayu Prio; Perwitasari, Dyah Aryani; Pradipta, Indra
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.583 KB) | DOI: 10.36408/mhjcm.v7i1.423

Abstract

Latar belakang: Demam neutropenia merupakan salah satu efek samping kemoterapi yang paling serius, karena adanya infeksi dapat berkembang dengan cepat dan dapat mengancam jiwa. Antibiotik yang diindikasikan untuk profilaksis pada pasien demam neutropenia diantaranya adalah sefepim. Penelitian ini bertujuan untuk mengetahui durasi kebutuhan sefepim terhadap perbedaan rejimen kemoterapi AML, serta luaran terapinya di RSUP Dr. Kariadi, Semarang. Metode: Penelitian ini menggunakan rancangan deskriptif dengan pengambilan data secara restrospektif dari bulan Juni 2018 hingga April 2019 di satu ruangan rawat inap RSUP Dr. Kariadi, Semarang. Kriteria inklusi adalah pasien usia 18-64 tahun dengan diagnosa AML yang mengalami demam neutropenia dengan riwayat pernah menjalani kemoterapi, mendapatkan terapi antibiotik sefepim. Kriteria eklusi dalam penelitian ini yaitu pasien yang alergi terhadap sefepim, yang tidak melanjutkan pengobatannya, dengan program cangkok sumsum tulang dan dengan adanya diagnosa sepsis/septik syok sebelum diberikannya sefepim. Hasil: Total sebanyak 15 pasien memenuhi kriteria inklusi. Durasi pemberian sefepim yang paling banyak adalah kelompok dengan pemberian 8-14 hari (46,7%), selanjutnya ?7 hari (33,3%), sedangkan pemberian selama >14 hari tidak ditemukan. Pasien yang meninggal pada penelitian ini sebanyak 3 pasien (20%), dengan 2 pasien diantaranya teridentifikasi mengalami sepsis karena sefepim yang resisten akibat patogen ESBL E. coli, sedangkan satu lainnya tidak diketahui patogen penyebabnya. Kesimpulan: Pasien dengan rejimen intensif rata-rata memerlukan durasi terapi yang lebih lama. Munculnya patogen ESBL khususnya E. coli mempunyai luaran yang jelek dan angka kematian yang lebih tinggi, sehingga kita sarankan untuk menggunakan karbapenem daripada sefepim untuk kondisi ini. Kata kunci: Demam neutropenia, leukemia myeloid akut, sefepim Backgound: Febrile neutropenia is one of the most serious side effects of chemotherapy, because the infection can develop rapidly which can be life-threatening. Cefepime is drug of choice that indicated for prophylaxis in patients with febrile neutropenia. The aim of this study was to determine the duration of the cefepime needs of differences in AML chemotherapy regimens, and the outcomes in Dr. Kariadi General Hospital Center, Semarang. Method: The study used descriptive design with retrospective data collection from June 2018 to April 2019 in an inpatient room at Dr. Kariadi General Hospital Center, Semarang. The inclusion criteria are patients aged 18-64 years old with diagnosis of AML who has febrile neutropenia with a history of having undergone chemotherapy with cefepime prophylaxis. The exclusion criteria in this study were allergy to cefepime, patients who did not continue their treatment, bone marrow transplant programs and diagnosis of sepsis / septic shock before the administration of cefepime. Result: A total of 15 patients met the inclusion criteria. The most duration of cefepime was in the group with 8-14 days (46,7%), then ?7 days (33,3%), whereas> 14 days were not found. The patients who died in this study were 3 patients (20%), with 2 patients identified as having sepsis due to the pathogen ESBL E. coli cefepime resistant, while the other one did not know the causative pathogen. Conclusion: Patients with an intensive regimen require a longer duration therapy. The emergence of ESBL pathogens especially E. coli has poor outcomes and a higher mortality rate, so we recommend using carbapenem rather than cefepime for this condition. Keywords: Febrile neutropenia, acute myeloid leukemia, cefepime
Co-Authors Abdi Wira Septama Adi Wira Septama Adnan Adnan Adnan Adnan Adnan Adnan Adnan, Adnan Adriyanto Rochmad Basuki Agung Permata Ahmad Azrul Zuniarto Aisyi, Mururul Ajeng Diantini Ajeng Diantini Akrom, Akrom Ambarwati, Sindy Cisna Anak Agung Gede Sugianthara Ananda Muhammad Naafi Ananda Muhammad Naafi, Ananda Muhammad Andalusia, Rizka Andriana Sari Andriana Sari Andriana Sari Andriana Sari Angella, Widi Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Annisa Annisa Awalia Rahma MH Sibadu Ardan Kensanovanto Arief Muttaqien Arief Rahman Afief Arifin, Bustanul Ariska Wigatiningtyas Astagiri Yusuf, Prasandhya Athika Darumas Putri Aulia Rahman B Simanjuntak, Lamhot Baiq Adelina Atbam Munawwarah Baiq Nurbaety Bambang Purwoko Barkah Djaka Purwanto Barkah Djaka Purwanto Baroroh, Faridah Bayu Prio Septiantoro Bayu Prio Septiantoro Bayu Prio Septiantoro Bayu Tri Murti Berry H Putra Boisi, Cici Feronika Bramadi Arya Bustanuddin As Suaidy Bustanul Arifin Bustanul Arifin Candradewi, Susan Fitria Cheung, Rocky Cut Fatia Ulfa Cut Fatia Ulfa Damayanti, Elok Dania Haafizah Darwis Darwis darwis darwis, darwis Denys Chichi Kusumastuti Desi Kusumawati, Desi Desty Kusumaningsih Dewi Wulandari Dewi Wulandari Dewi, Masita Sari Dian Prasasti Dian Prasasti Dias Ananda Sulistya Didi Rohadi Didik Setiawan Didik Setiawan Dwi Utami Eka Wuri Handayani Elli Nur Hayati Endang Darmawan Endang Darmawan Endang Darmawan Endang Yuniarti Endang Yuniarti Endang Yuniarti Esty Elvinda Farah Bidara Farida, Imaniar Noor Faridah Baroroh Faridah, Imaniar Fatimah Sri Kurniawati Fatimah, Salma Auliya Fatkhiya, Musa Fitri Febriana, Sri Awalia Febriana, Sri Awalia Fitri Nur Mahmudah Fredrick Dermawan Purba Gina Noor Djalilah Gugun Suhendra Gugun Suhendra Gurning, Sri Handayani Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Hadiq, Shabran Handayani, Eka Wuri Haridini Intan Mahdi Haridini Intan Mahdi Haridini Intan Mahdi Hasniah Hasniah Hazena Misgi Damayanti, Hazena Misgi Hendrik Hendrik Hendy Ristiono, Hendy Herjanti Ratnawiningsih Herjanti Ratnawiningsih Herjuna Hardiyanto Herlina, Tetie Hidayah Karuniawati Ikrimah Nisa Utami Imaniar Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Intan Fatah Kumara Irma Risdiana Irma Risdiana Irma Risdiana, Irma Iskak, Iskak Islami, Safira Nur Jamhari Jamhari Jarir At Thobari Juwita, Dina Ratna Kania Agustina Kaptein, A.A Khuluq, Husnul Kiki Lukman Kintoko, Kintoko Kodriati, Nurul Kuluq, Muhammad Husnul Kurniawan, Nurcholid Umam Kurniawati, Fatimah Sri Kurniyati, . Kurniyati, . Lalu M Irham Lalu Muhammad Irham Lamhot B Simanjuntak Lamhot B Simanjuntak Lamhot B Simanjuntak Lestari, Mardiana Puji Lianawati Lianawati Like Efriani Lisza Niarisessa Lutfi Sukma Pratiwi Luthfiah Luthfiah M Rifqi Rokhman M. Rifqi Rokhman M. Rifqi Rokhman M. Rifqi Rokhman Made Ary Sarasmita Mahdi, Haridini Intan Mahfudh , Nurkhasanah Maliza, Rita Marwin Marwin Marwin Marwin Masita Sari Dewi Meki Pranata Melinda Widianingrum Melinda Widianingrum Melodia Rezadhini Melodia Rezadhini Menit Ardhiani Menit Ardhiani Muamala, Anisa Muh. Deni Kurniawan Muhammad AR Saputra Muhammad Ardhani Muhammad Dwi Suprobo Muhammad Fathurrahman Muhammad Thesa Ghozali Mukti A Berlian Muliyani Muliyani Muliyani Muliyani Muliyani, Muliyani muliyani, muliyani muliyani Mulyani, Sri Mumfasiroh Saputri Mururul Aisyi Mururul Aisyi Mustika Muthaharah mustika muthaharah Mustofa Mustofa muthaharah, mustika Mutmainnah Siradjuddin Muttaqien, Arief Nabial Chiekal Gibran Nabilah Nabilah Nabilah Nabilah Nadia Utami Noor Naili Ra fi&#039;ah Nanik Sulistyani Nasriyah, Chotijatun Nazhipah Isnani Nguyen, Thang Ni Made Ary Sarasmita Nidia Yuni Lestari Nidia Yuni Lestari, Nidia Ninda Sari Wahyuningtyas Noerhidayati, Elly Novi Milasari Novitasari, Putri Rachma Nuni Ihsana Nur Aida Nur Azizah Nur Mahdi Nur Rahmi Hidayati, Nur Rahmi Nurcholid Umam Nurcholid Umam Kurniawan Nurcholid Umam Kurniawan Nurcholid Umam, Nurcholid Nurfadilasari, Ulfa Mustofa Nurkhasanah Mahfudh Nurul Kodriati Nyoman Kertia Oni Yulianta Wilisa P.D. Pratiwi Pandanwangi , Siti Pendicho Eko Yuliyanto Permatasari, Anggraeni Pradika, Jaka Pradipta, Indra Prasasti, Dian Pratama, Kharisma Pratiwi, P.D. Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Putri Pertiwi Qarriy 'Aina Urfiyya Qarriy Aina Urfiyya Ra fi'ah, Naili Ra fi'ah, Naili Rachma Greta Putri Ratu Matahari Ratu Matahari Retno Murwanti Reza Aditya Nugroho Rezadhini, Melodia Riana Prastiwi Handayani Rini, Vina Angga Rizka Andalusia Rizka Andalusia Rizka Andalusia Rizka Novia Atmadani Rizky, Muhammad Arif Robi’ah Adawiyah Rocky Cheung Rocky Cheung Rocky Cheung RR. Ella Evrita Hestiandari Rr. Erni Kusuma Putri Sabaan, Wahid Sabaan, Wahid Saidah Rauf Santoso, Setiyo Budi Satibi Satibi Sawitri Sawitri Sawitri Sawitri Septiantoro, Bayu Prio Setiyati Jatiningsih Simanjuntak, LB Sindy Cisna Ambarwati Siswandi Siswandi Siswandi Siswandi Siswandi Siswandi Siswandi, Siswandi Siti Pandanwangi Siti Urbayatun Solikhah Sri Awalia Febriana Sri Handayani Gurning Sri Mulyani Suhendra, Gugun Suin Rina Dewi Sulastri Sulastri Sulastri Sulastri Supadmi, Woro Woro Supadmi Susan Fitri Candradewi Susan Fitri Candradewi Susan Fitria Candradewi Susilo, Rinto Suwijiyo Pramono Syifa Imelda Teguh Uji Sungkowo Tomi . Triantoro Safaria Triantoro Safaria Tuty Lia Syahfitri Ully Adhie Mulyani Ully Adhie Mulyani Vicryanto Halid Vina Angga Rini Wahyu Rahmatulloh Wahyu Widyaningsih Wahyudi, Andrey Wilisa, Oni Yulianta Wilisa, Oni Yulianta Wirawan Adikusuma Woro Supadmi Woro Supadmi Woro Supadmi Woro Supadmi Woro Supadmi Wulandari, D Yeni Alfiana Ratnasari Yudha Rizky Nuari Yuli Rachmawati Yuli Rachmawati Yusuf, Prasandhya Astagiri Zulkarnain Zulkarnain Zulkarnain Zulkarnain Zuniarto, Ahmad Azrul