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Collagen Restoration from Combined Radiofrequency Microneedling and Polydioxanone Filler in Oxidative Stress-Mediated Skin Aging Sinaga, Ruth Agustina; Paskaria, Cindra; Widowati, Wahyu
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4024

Abstract

BACKGROUND: Oxidative stress plays a central role in skin aging by promoting reactive oxygen species–mediated collagen degradation, fibroblast senescence, and dermal thinning. Although radiofrequency microneedling (RFM) and polydioxanone (PDO) filler individually stimulate collagen remodeling, evidence regarding their combined efficacy in oxidative stress induced skin aging models remains limited. This study evaluated the effects of combined RFM and PDO filler therapy in a D-galactose–induced oxidative stress model of skin aging.METHODS: Thirty female Sprague-Dawley rats were randomly assigned into five groups (n=5): normal control (NC), aging control (AC), RFM monotherapy, PDO monotherapy, and combination therapy. Oxidative aging was induced by daily intraperitoneal injections of 50 mg/kg for 8 weeks, followed by a single post-induction treatment session. Skin samples were collected at 12 weeks post-treatment for histological assessment of dermal thickness (hematoxylin–eosin), collagen density (Masson’s trichrome), and fibroblast count.RESULTS: D-galactose significantly reduced dermal thickness, collagen density, and fibroblast count in AC compared with NC (p<0.001). All treatment groups showed significant improvement versus AC (p<0.05). Notably, only the combination therapy restored collagen density to a level comparable with normal skin (35.22 [28.74–40.35]% vs. 37.83 [33.11–40.69]%, p=0.124). The combination group also showed the highest increases in dermal thickness and fibroblast numbers among treatment groups.CONCLUSION: In this preclinical model, combined RFM and PDO filler therapy demonstrated enhanced restoration of dermal structure and collagen under oxidative stress–mediated skin aging, supporting its potential role in skin rejuvenation strategies.KEYWORDS: collagen density, dermal regeneration, D-galactose, oxidative stress, skin aging
Co-Authors , Rizal - Lindayani AA Sudharmawan, AA Adha, Khoerotul Nur Fadhilah Afifah Bambang Sutjiatmo, Afifah Bambang Afifah, Ervi Agung Novianto, Agung Agus Susanto Ahmad Faried Alexandro, Garry Annaba, Aziz Arif, Julio Arinta, Yukko Armansyah, Adek Arrahmani, Betharie Cendera Aryenti, Aryenti Ayuni, Vini Azis, Rizal Bangun, Adityana Arta Batubara, Lilian Ch. Retnaningsih, Ch. Chandra Risdian Chen, Meriana Chiuman, Linda Cindra Paskaria Damayanti, Ndaru Andri Dani Dani Dewi Nurul, Dewi Dewi, Intan Keumala Dewi, Nindia Salsabila Mia Didik Priyandoko Djaja Rusmana Edriayani, Novi Edwin Setiabudi Edy Fachrial Eka Yudha Rahman Elisabeth, Mariska Eltania, The Fransiska Elvira, Cut Endah Purnamasari Esti Mumpuni, Esti Euis Reni Yuslianti, Euis Fahrauk, M. Fanny Rahardja Fauziyah, Nida Firyal Ferdiansyah, Rival Ferdinand, Sahna Ferry Sandra Fibrina, Dewi Fioni, Fioni Geeta, Ginting, Chrismis Novalinda Girsang, Ermi Gosandra, Sherrina O. Gunadi, Michael Sebastian Gunanegara, Rimonta Febby Hadiprasetyo, Dhanar Septyawan Halim, Nathanael HANA RATNAWATI Handayani, Rr. Anisa Siwianti Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Hartini Tiono Haryanti, Mathelda Weni Hernawati Hernawati Irfan Syarif, Irfan Irwan, Mulia Jeffrey ., Jeffrey Jo Suherman Johan Lucianus Joko Raharjo, Sentot Juansah, Rahadian Deden Julio Arif Jusri, Ridza Khainir Akbar, Khainir Khie Khiong Ksatrianto, Faris Kusdianti Kusdianti Liana Liana Lindayani, . Lister, I Nyoman Ehrich Lusiana Darsono MADE PHARMAWATI Malau, Reghita Claudia Manurung, Mian Maranata Br Marisca Evalina Gondokesumo, Marisca Evalina Marpaung, Hans Hotma Mars, Nicholas Mawarni, Evi Mulyasari, Tira Endang Muthmainnah, Anis Syabani Nafik, Said Nainggolan, Ita Margaretha Nasution, Ali Napiah Natadilandes, Reyhan Ngurah Intan Wiratmini Nia Kania Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Noviani, Indah Yuri Novilla, Arina Nunung Ainur Rahmah Nurjamil, Aris Muhammad Nursanti, Okta Obeng, Selonan Philips Onggowidjaja Pradipta, Regina Prayudha, Ramadhita Paramananda Purwoko, Agus Putri, Reika Yulia Qamarani, audina Qlintang, Sandy Qodariah, Rismawati Laila Qodriah, Rahmatul R. Sapto Hendri Boedi Soesatyo Rahma Micho Widyanto RAHMAT, DENI Rita Tjokropranoto Rizal Aziz, Rizal Rizal Rizal Sabrina, Adilah Hafizha Nur Sachrowardi, Qomariyah Romadhiyani Salfa Nindya, Faradhina Salsabila, Nindia Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sholihah, Ika Adhani Sijani Prahastuti Sinaga, Ade Putra Fratama Sinaga, Ruth Agustina Siregar, Irma Dolsyeria Solihat, Ananda Khairunisa Sormin, Delores Elisabeth Sosiawan, Insan Sri Utami Suci Nar Vikasari, Suci Nar Sugiaman, Vinna Kurniwati Suhantoa, Deviana Lavender Sukandar, Elin Y. Susi Endrini Susy Tjahyani Sutjiatmo, Afifah B Syamsi, Lusi Nursilawati Syamsudin Syamsudin Takasenserang, Oktaviana Teddy Marcus Zakaria Teresa Liliana Wargasetia Tjandrawati Mozef Tri Suciati Triharsiwi, Dwi Nur Udju D. Rusdi Utomo, Herry S Utoyo, Frederick Surya vera vera, vera Vinna K. Sugiaman Vinna Kurniawati Sugiaman, Vinna Kurniawati Vrianty, Dela Wahyu Surakusumah WAHYU WINARNO Wangguai, Vannia Wibowo, Satrio Haryo Benowo Widodo, Wahyu Setia Widya Kusuma, Hanna Sari Widya Kusuma Yuninda, Viranda Andria Yuslianti, Euis Reni Yusuf, Lydia Zahira, Nurul Zahra Zahiroh, Fadhilah Haifa