Lucia Tri Suwanti, Lucia Tri
Department Of Veterinary Parasitology, Faculty Of Veterinary Medicine, Airlangga University, Surabaya, East Java, Indonesia. Institute Of Tropical Diseases, Airlangga University, Surabaya, East Java, Indonesia.

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Journal : Universa Medicina

Toxic compounds of Curcuma aeruginosa causes necrosis of mice hepatocytes Eka Pramyrtha Hestianah; Idha Kusumawati; Lucia Tri Suwanti; Sri Subekti
Universa Medicina Vol. 33 No. 2 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.118-125

Abstract

BACKGROUNDPeople have been using Curcuma aeruginosa rhizome as a traditional herbal medicine as appetite stimulant, without realizing its side effects. Herbal plants contain tens to hundreds of compounds, some of which are toxic. The aim of this research was to determine which toxic compound of Curcuma aeruginosa rhizome has an impact on apoptosis and PARP-1 expression of hepatocytes in male mice.METHODSEighty eight male Balb C mice were divided into 10 groups treated respectively with Curcuma aeruginosa rhizome cloroform extract, methanol extract, essential oil, infusion, and press juice, at dosages of 0.004g/kgBW and 0.06g/kgBW, and 1 control group. The treatment was given orally once a day for 10 days and on the 11th day, the research animals were sacrificed, and their liver taken for histopathologic slide preparation with Apopteq Detection Kit, and immunofluorescence. Compounds in Curcuma aeruginosa rhizome were analyzed with gas chromatography/mass spectrometry. The data obtained were analyzed by one-way ANOVA, and Partial Least Squares to determine which compounds had an impact on murine hepatocytes.RESULTSThe result of one way ANOVA showed that the chloroform groups at dosages of 0.004g/kgBW and 0.06g/kgBW showed the highest apoptosis of mice’s hepatocytes (p<0.05). There were significant differences in PARP-1 expression between control and treatment groups. The highest PARP-1 expression was in the essential oil group at a dosage of 0.06g/kg BW (p<0.05).CONCLUSIONCurcuma aeruginosa rhizome given to mice orally causes necrosis of mice’s hepatocytes.
Co-Authors A'la, Rofiqul Abdul Samik Adi Sofyan Ansori, Muhammad Adikara, Tatang Santanu Agustina, Firanda Akbar Wijaya Putra Purnama Aksono HP., Eduardus Bimo Al Arif, M Anam Alasrorik, Muhammad Hizbulloh Alfina Azkiana Amara Lintang Pagati Amirotul Azhimah Ana Amaliah Anam Al Arif andi jayawardhana Andi Jayawardhana Anton Sulistiono Arief Budiman Arief Budiman Arif Pratiwi Arimbi Arimbi Aswin, Ahmad Azizah Bilqis Nurkarimah Bambang Sektiari Lukiswanto Bani Bacan Hacantya Yudanagara Benjamin Christoffel Tehupuring, Benjamin Christoffel Boedi Setiawan Bryan Ahmad Affan Lubis Budiarto Budiarto Choirunnisa, Indaka Rachmah Chusniati, Sri Cyuzuzo Callixte Dadik Rahardjo, Dadik Desiandura, Kurnia Dewi Purwatiningsih Dewi, Aprilia Kurnia Didik Handijatno Didik Handijatno Dinda Eka Putri Diyantoro Diyantoro, Diyantoro Djoko Legowo Doohan Mahendra Dwi Ananda, Novita DWI PUTRI RAHMAWATI Dyah Ayu Kurniawati Dyah Ayu Kurniawati Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah Eka Pramyrtha Hestinah Eko Agus Suyono Eko Agus Suyono Eldatia Utari Putri Elok Apriliawati Endang Retno Surjaningrum Endang Suprihati Erma Safitri Esti Yunitasari Estoepangestie, Agnes Theresia Soelih Fadlilah, Shinta Levea Ni'matul Fania Selfiannisa Fatmawati, Mira Fatmawati Fauziah Fitri Hernanto Febrina Dian Permatasari Fedik Abdul Rantam Felita Widyaningsih Fitri, Paraswita Eindah Fransiska Cicilia Beka Fuzianingsih, Eka Noviya Galaxy Guardian Gandul Atik Yuliani Gunanti Mahasri Hana Eliyani Hani Plumeriastuti Hanna Harnida, Hanna Harijani, Nenny Helen Susilowati, Helen Hemasayu Nirmala Putri Heni Puspitasari Heny Arwati Hernanda, Ary Setya Herry Agoes Hermadi Hidajanti, Nove Ida Yuniarti Idha Kusumawati Imam Mustofa Indah Norma Triana, Indah Norma Indasari, Elly Nur Ine Karni Ira Sari Yudaniayanti Kadek Rachmawati Khairullah, Aswin Rafif Koesdarto Koesdarto Koesnoto Supriandono Kuncorojakti, Suryo Kurniawan, Muhammad 'Ahdi Kurniawati, Dyah Ayu Kusnoto Kusnoto Kusnoto Kusnoto Kusnoto, Kusnoto Lantip Muhammad Dewabrata Lilik Maslachah Lutfi Agus Salim M Iqbal Maulana Ginting Mafruchati, Maslichah Mahendra Pujiyanto Margaretha, Josephira Intan Marselaonety La’lang Masdiana C Padaga Melani Anggraini Meles, Dewa Ketut Meta Aprilia Mirni Lamid Mochamad Donny Koerniawan Mochammad Donny Koerniawan Mohammad Sukmanadi Moses, Ikechukwu Benjamin Muchammad Yunus Mufa, Ramy Inas Mahirah Mufasirin Muhammad Ahdi Kurniawan Muhammad Ridwan Muhammad Rofi&#039; Prasetya Muhammad Rofi' Prasetya Mustofa Helmi Effendi Ngakan Made Rai Widjaja Ni Komang Aprilina Widisuputri Nidom, Chairul Anwar Niluh Selly Frantika Nunuk D.R. Lastuti Nunuk Dyah Retno Lastuti Nunuk Dyah Retno Lastuti Nur Ainy Fardana N. Nurdianto, Arif Rahman Nursalim, Muhammad Tauhid Nusdianto Triakoso Permatasari, Dian Ayu Poedji Hastutiek Prasetya, Muhammad Rofi' Pratama, Bima Putra Pratama, Ponasari Galuh Pratiwi, Arif Primarizky, Hardany Puput, Sesa Purnamasari, Kartika Rachma Woro Anggarani Rahadju Ernawati Rahmahani, Jola Ramandinianto, Sancaka Chasyer Ratna Damayanti Retno Yuli Rimayanti Rimayanti Rina Vitriasari Riwu, Katty Hendriana Priscilia Rochmah Kurnijasanti Romy Muhammad Dary Mufa Santoso, Kuncoro Puguh Saputra, Rakan Mahiid Sarmanu, Sarmanu Septian Hakim Susantoputro Sesa Puput Febriyanti Setiawan Koesdarto Setiawan Kusdarto Soeharsono Soeharsono Sri Mulyati Sri Mumpuni Sri Subekti Suherni Susilowati Sunarso, Agus Supriyadi Suzanita Utama Tatik Hernawati Taufik Tri Laksono Tita Damayanti Lestari Tony Hartono Tri Wahyu Suprayogi Tyasningsih, Wiwiek Tyasningsih, Wiwiek Ulfah Juniarti Siregar Utami, Kinanti Putri Vanna Lidya Kharisma Vindo Rossy Pertiwi Wahidan Qodiip Maulana Wahyudi, Nurul Tri Warda Nafalizza Efendi Warsito, Sunaryo Hadi Widi Nugroho Widisuputri, Ni Komang Aprilina Widiyatno, Thomas Valentinus Widya Paramita Lokapirnasari Wijaya, Andi Yasmin Wisnu Nurcahyo Wiwik Misaco Yuniarti Wurlina, W Yonatan Dimascahyo Budianto Yulianna Puspitasari Yunus, Muchammad Yunus, Muchammad Zhaza Afililla