Article Per Year (5 Year)
p-Index From 2021 - 2026
10.388
P-Index
This Author published in this journals
All Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Window of Health : Jurnal Kesehatan Alami Journal (Alauddin Islamic Medical) Journal Journal of Midwifery and Nursing Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Syntax Idea UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Borneo Journal of Medical Laboratory Technology Green Medical Journal Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Wal'afiat Hospital Journal Jurnal EduHealth Muhammadiyah Medical Journal Jurnal Kolaboratif Sains Journal of Aafiyah Health Research (JAHR) Formosa Journal of Science and Technology (FJST) Jurnal Kesehatan Kusuma Husada Jurnal Sains dan Kesehatan Journal of Community Health Provision Innovative: Journal Of Social Science Research Ranah Research : Journal of Multidisciplinary Research and Development WAL'AFIAT HOSPITAL JOURNAL Jurnal Medika Nusantara Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Kesehatan Fakumi Medical Journal Holistik Jurnal Kesehatan Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Journal of Asian-african Focus in Health KREATIF: Jurnal Pengabdian Masyarakat Nusantara
Prema Hapsari Hidayati
Department Of Internal Medicine, Faculty Of Medicine, Universitas Muslim Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary Other

Published : 79 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 79 Documents
Search

 4   5   6   7   8 
UJI EFEKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK MENIRAN (Phyllanthus niruri L) PADA TIKUS YANG DIINDUKSI DENGAN DEXAMETHASONE Nur Rahma; Ida Royani; Nasrudin Andi Mappaware; Prema Hapsari; Nur Fadhillah Khalid
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 8 No 01 (2026): April
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v8i01.411

Abstract

ABSTRAK Hiperglikemia merupakan masalah kesehatan global yang memerlukan penanganan efektif. Mengingat tingginya risiko efek samping dan biaya pengobatan konvensional, pencarian alternatif alami menjadi relevan. Tanaman Meniran (Phyllanthus niruri L) telah dikenal karena kandungan flavonoidnya yang berpotensi sebagai antihiperglikemik. Penelitian ini bertujuan untuk menguji dan membandingkan efektivitas ekstrak meniran dengan obat standar Metformin dalam menurunkan kadar glukosa darah. Studi ini menggunakan desain experimental pre and post control pada 20 ekor Tikus Putih (Rattus novergicus) yang diinduksi hiperglikemia menggunakan Dexamethasone dosis 0,09 mg/kgBB/hari. Hewan uji dibagi menjadi empat kelompok perlakuan, meliputi kontrol positif Metformin dan tiga variasi dosis ekstrak Meniran (300 mg, 400mg, dan 500mg/kgBB/hari) yang diekstraksi melalui maserasi etanol 96%. Hasil penelitian menunjukkan bahwa Metformin dan ekstrak Meniran efektif menurunkan kadar glukosa darah subjek uji secara signifikan mulai hari ketiga. Yang menarik, ekstrak Meniran terbukti lebih efektif dalam menurunkan kadar glukosa darah dibandingkan Metformin pada hari ketiga, menyimpulkan bahwa ekstrak Meniran (Phyllanthus niruri L) memiliki potensi kuat dan menjanjikan sebagai agen antihiperglikemik alami yang dapat menjadi alternatif pengobatan. ABSTRACT Hyperglycemia is a global health problem requiring effective management. Given the high risk of side effects and cost of conventional treatment, the search for natural alternatives is relevant. The Meniran plant (Phyllanthus niruri L) is known for its flavonoid content, which has potential as an antihyperglycemic agent. This study aimed to test and compare the effectiveness of Meniran extract with the standard drug Metformin in reducing blood glucose levels. The study employed an experimental pre and post control design on 20 White Rats (Rattus novergicus) whose hyperglycemia was induced using Dexamethasone at a dose of 0.09 mg/kgBW/day. The test animals were divided into four treatment groups, including Metformin positive control and three dose variations of Meniran extract (300mg, 400mg, and 500mg/kgbw) extracted through 96% ethanol maceration. The results showed that both Metformin and Meniran extract were effective in significantly reducing the blood glucose levels of the test subjects starting from the third day. Notably, the Meniran extract proved to be more effective in reducing blood glucose levels than Metformin on the third day, concluding that Meniran extract (Phyllanthus niruri L) has strong and promising potential as a natural antihyperglycemic agent that can be an alternative treatment.
Hubungan High Density Lipoprotein dengan Fatty Liver pada Mahasiswa Fakultas Kedokteran Universitas Muslim Indonesia yang Mengalami Obesitas: The Relationship Between High-Density Lipoprotein and Fatty Liver in Students of the Faculty of Medicine, Muslim University of Indonesia Who Experience Obesity Muhammad Surya Samudra; Prema Hapsari Hidayati; Dian Fahmi Utami; Febie Irsandy; Dwi Pratiwi
Jurnal Kolaboratif Sains (Special Issue) Jurnal Kolaboratif Sains (JKS) - July 2026
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v9i7.11576

Abstract

Fatty liver atau Non-Alcoholic Fatty Liver Disease (NAFLD) merupakan salah satu manifestasi gangguan metabolik yang sering ditemukan pada individu obesitas. Kadar High Density Lipoprotein (HDL) yang rendah diketahui berhubungan dengan gangguan metabolisme lipid dan berpotensi meningkatkan risiko terjadinya perlemakan hati. Mengetahui hubungan kadar High Density Lipoprotein (HDL) dengan kejadian fatty liver pada mahasiswa Fakultas Kedokteran Universitas Muslim Indonesia yang mengalami obesitas. Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional. Sampel penelitian berjumlah 33 mahasiswa obesitas yang dipilih menggunakan teknik purposive sampling. Kadar HDL diperiksa melalui pemeriksaan laboratorium darah, sedangkan status fatty liver ditentukan melalui pemeriksaan ultrasonografi (USG) hati. Analisis hubungan dilakukan menggunakan uji Chi-Square dengan tingkat signifikansi p<0,05. Sebagian besar responden berjenis kelamin laki-laki (60,6%), berada pada kategori obesitas II (54,5%), dan memiliki kadar HDL rendah (48,5%). Kejadian fatty liver ditemukan pada 11 responden (33,3%). Analisis bivariat menunjukkan adanya hubungan yang signifikan antara kadar HDL dengan kejadian fatty liver (p=0,022). Responden dengan kadar HDL rendah memiliki proporsi fatty liver lebih tinggi (56,3%) dibandingkan responden dengan HDL normal (15,4%), sedangkan tidak ditemukan kasus fatty liver pada responden dengan HDL tinggi. Terdapat hubungan yang signifikan antara kadar HDL dengan kejadian fatty liver pada mahasiswa Fakultas Kedokteran Universitas Muslim Indonesia yang mengalami obesitas. Kadar HDL yang rendah berhubungan dengan peningkatan risiko terjadinya fatty liver. ABSTRACT Fatty liver, or Non-Alcoholic Fatty Liver Disease (NAFLD), is a metabolic disorder commonly observed among individuals with obesity. Reduced High-Density Lipoprotein (HDL) levels are linked to disturbances in lipid metabolism and may contribute to a higher risk of developing fatty liver. This study aimed to analyze the relationship between HDL levels and the occurrence of fatty liver among obese students at the Faculty of Medicine, Muslim University of Indonesia. An observational analytic study with a cross-sectional design was conducted. A total of 33 obese students were selected using purposive sampling. HDL levels were measured through blood laboratory examinations, while fatty liver status was assessed using abdominal ultrasound (USG). The association between variables was analyzed using the Chi-Square test with a significance level of p < 0.05. The majority of participants were male (60.6%), classified as obesity class II (54.5%), and had low HDL levels (48.5%). Fatty liver was identified in 11 respondents (33.3%). Bivariate analysis indicated a significant relationship between HDL levels and fatty liver disease (p = 0.022). Individuals with low HDL levels showed a higher proportion of fatty liver (56.3%) compared to those with normal HDL levels (15.4%), while no cases were observed among participants with high HDL levels. The findings demonstrate a significant association between HDL levels and fatty liver in obese medical students at the Faculty of Medicine, Muslim University of Indonesia, indicating that lower HDL levels are related to an increased risk of fatty liver disease
Gambaran Hasil CT Scan pada Pasien Diabetes Melitus dengan Stroke di RSKD Dadi Makassar Tahun 2024–2025 Muhammad Arif Taufik; Prema Hapsari Hidayati; Dian Fahmi Utami; Mochammad Erwin Rachman; Muh. Jabal Nur
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1191

Abstract

Diabetes Mellitus (DM) is a metabolic disease with an increasing prevalence and a risk of causing macrovascular complications such as stroke. This study aimed to describe the characteristics of Diabetes Mellitus patients with stroke complications based on CT-scan results at RSKD Dadi Makassar in 2024–2025. This was a descriptive observational study with a retrospective design using medical record data. Samples were taken using a total sampling technique, comprising 60 patients, and analyzed univariately using the Statistical Product and Service Solutions (SPSS) version 26. The results showed that the majority of respondents were in the late elderly group (>56 years) at 66.7%, female (51.7%), and from the Makassar ethnic group (63.3%). Most respondents experienced hyperglycemia in random blood glucose (66.7%) and had uncontrolled fasting blood glucose (68.3%) and HbA1c (76.7%) levels. CT-scan results were dominated by non-specific cerebral infarction (68.3%), with ischemic stroke as the most common type (93.3%), a length of stay of 5–10 days (53.3%), and right-sided hemiparesis as the most common clinical manifestation (45.0%). It was concluded that DM patients with stroke complications were generally elderly, female, had poor glycemic control, and were dominated by ischemic stroke with non-specific cerebral infarction. Abstrak. Diabetes Melitus (DM) merupakan penyakit metabolik dengan prevalensi yang terus meningkat dan berisiko menimbulkan komplikasi makrovaskular berupa stroke. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien Diabetes Melitus yang mengalami komplikasi stroke berdasarkan hasil CT-scan di RSKD Dadi Makassar tahun 2024–2025. Penelitian ini merupakan penelitian observasional deskriptif dengan desain retrospektif menggunakan data rekam medis. Sampel diambil dengan teknik total sampling sebanyak 60 pasien dan dianalisis secara univariat menggunakan Statistical Product and Service Solutions (SPSS) versi 26. Hasil penelitian menunjukkan mayoritas responden berusia lansia akhir (>56 tahun) sebanyak 66,7%, berjenis kelamin perempuan (51,7%), dan berasal dari Suku Makassar (63,3%). Sebagian besar responden mengalami hiperglikemia pada GDS (66,7%) serta memiliki kadar GDP (68,3%) dan HbA1c (76,7%) yang tidak terkontrol. Hasil CT-scan didominasi oleh infark serebri tidak spesifik (68,3%) dengan jenis stroke terbanyak berupa stroke iskemik (93,3%), lama rawat inap terbanyak 5–10 hari (53,3%), dan manifestasi klinis tersering berupa hemiparese dextra (45,0%). Disimpulkan bahwa pasien DM dengan komplikasi stroke umumnya berusia lanjut, berjenis kelamin perempuan, memiliki kontrol glikemik yang buruk, dan didominasi oleh stroke iskemik dengan gambaran infark serebri tidak spesifik.
Proteinuria Pasien Diabetes Melitus dan Obesitas Poli Penyakit Dalam RS Ibnu Sina Makassar Indah Lestari; Dzul Rizka; Prema Hapsari; Pratiwi L Basri; Nur Hidayah
Green Medical Journal Vol 1 No 1 (2019): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (596.595 KB) | DOI: 10.33096/gmj.v1i1.18

Abstract

Background: The prevalence of diabetes mellitus in the world has increased which is certainly accompanied by a rapid increase in the incidence of its chronic complications like kidney disorders. Insulin resistance, the patophysiology of diabetes mellitus, also associated with obesity, which both are the main risk factors for cardiovascular events. Obesity also known as a risk factor for kidney disease that proved by the presence of proteinuria in obesity patients. Objective: To determine the correlation of obesity with occurrence of proteinuria in patients with type 2 DM in internal medicine polyclinic Ibnu Sina Hospital Makassar. Method: A cross sectional study on 32 type 2 DM patients at Ibnu Sina Hospital as measured by body weight, height and waist circumference. Urinalysis examination is also performed at that time. Results: In this study, there were 4 patients (12,5%) patients with proteinuria (+), 1 patient (3.1%) with proteinuria (++), 2 patients (6.3%) with proteinuria (+++) and 1 patient (3.1%) with proteinuria (++++). According to BMI, we found that 17 patients (53.1%) were overweight, 5 patients (15.6%) were class 1 obesity, no class 2 obesity patient, and 1 patients (3.1%) were class 3 obesity. In Waist circumference examination we found that in normal waist circumference group there is 1 patient that did not has proteinuria while in the abnormal waist circumference group, 8 patients out of 31 patients have proteinuria. After doing statistical analysis to assess the correlation of obesity with proteinuria obtained p value> 0.05. Similarly, the correlation analysis waist circumference with proteinuria obtained p value> 0.05. Conclusion: There is no correlation between obesity and proteinuria as well as waist circumference and proteinuria correlation in type 2 DM patients.
Implementasi Program Bakti Sosial Mahasiswa Kedokteran sebagai Upaya Pemberdayaan Masyarakat: (Studi Kegiatan Fakultas Kedokteran UMI Bersama BEM KBMFK Universitas Muslim Indonesia Tahun 2025) Nasrudin Andi Mappaware; Irna Diyana Kartika Kamaluddin; Wawan Susilo; Faizul A; Andi Alamanda Irwan; M. Hamsah; Berry Erida Hasbi; Indah Lestari Daeng Kanang; Prema Hapsari Hidayati; Anna Sari Dewi; Dwi Anggita; Sidrah Darma; Nevi Sulvita Karsa; Zulfikri Khalil Novriansyah; Mohammad Reza Zainal Abidin; Muhammad Fauzul Azhim; Astra Budiati Nusrat; Muhammad Irsan Muflih Mundzir; Mufthiar Muhtar; Rizky Nurhumairah Sarifuddin; Wulan Purnamasyani S; Waode Inayatu Zahra Khairunnufus
KREATIF: Jurnal Pengabdian Masyarakat Nusantara Vol. 6 No. 2 (2026): Jurnal Pengabdian Masyarakat Nusantara
Publisher : AMIK Veteran Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/kreatif.v6i2.11053

Abstract

The Grand Social Service (Bakti Sosial Akbar) organized by KBMFK-UMI is an initiative that reflects the academic community's empathy and care for society, especially those in need. The activity aims to express a sense of social responsibility by providing various services to the community. These services include health checks, education, blood donation drives, mass circumcision, Basic Life Support (BLS) training, and the distribution of the Susu Anak Negeri (SUSAN) program. Through these efforts, the event seeks to alleviate some of the burdens faced by local communities while promoting health awareness and knowledge. In addition to offering essential services, this event is designed to strengthen relationships among students, faculty members, and the local residents by fostering a spirit of togetherness and collaboration. The implementation of this community service activity is made possible by the full support of the academic community at the Faculty of Medicine, Universitas Muslim Indonesia, ensuring that all activities are carried out effectively and precisely. It is expected that the positive outcomes of this event will not only benefit the community but also contribute to building a stronger sense of social solidarity and cooperation among all involved.
Pengaruh Waktu Pemberian Antibiotik Spektrum Luas terhadap Mortalitas Pasien Sepsis: Systematic Review Reza Farelim Wardana; Prema Hapsari Hidayati; Risna Rajab; Faisal Sommeng; Muhammad Yusuf Sidang Amin
Jurnal Medika Nusantara Vol. 4 No. 3 (2026): Jurnal Medika Nusantara
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v4i3.2844

Abstract

Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although the early administration of broad-spectrum antibiotics is recommended, its impact on mortality remains inconsistent. This systematic review was conducted by searching PubMed, the Cochrane Library, and Scopus in accordance with the PRISMA guidelines.
Hubungan Lama Hemodialisa dan Tingkat Stres dengan Tingkat Kecemasan pada Pasien Gagal Ginjal Kronis di Rumah Sakit Bhayangkara Makassar Manggung Manggung; Rezky Putri Indarwati Abdullah; Ilma Khaerina Amaliyah Bakhtiar; Prema Hapsari Hidayati; Nevi Sulvita Karsa
MAHESA : Malahayati Health Student Journal Vol 6, No 10 (2026): Volume 6 Nomor 10 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i10.25123

Abstract

ABSTRACT Chronic kidney disease patients undergoing hemodialysis frequently experience psychological distress that may interfere with treatment adherence and quality of life. To analyze the relationship between hemodialysis duration, stress level, and anxiety level among chronic kidney disease patients undergoing hemodialysis at Bhayangkara Hospital Makassar. This analytic observational study used a cross-sectional design in 2025 among 56 chronic kidney disease patients receiving hemodialysis. Stress was measured using the Perceived Stress Scale-10 (PSS-10) and anxiety using the Generalized Anxiety Disorder-7 (GAD-7). Associations were tested using Spearman correlation. Most participants reported moderate-to-severe stress (moderate 42.9%; severe 35.7%) and mild-to-moderate anxiety (mild 44.6%; moderate 46.4%). Longer hemodialysis duration was associated with lower stress (p0.001; r=-0.712) and lower anxiety (p0.001; r=-0.642). Stress level was positively associated with anxiety level (p0.001; r=0.523). Conclusion: Hemodialysis duration is inversely related to stress and anxiety, while higher stress is associated with higher anxiety. Routine screening and integrated psychosocial support are recommended, particularly for patients in the early phase of hemodialysis. Keywords: Hemodialysis, Chronic Kidney Disease, Stress, Anxiety, GAD-7.  ABSTRAK Pasien penyakit ginjal kronis yang menjalani hemodialisa sering mengalami beban psikologis yang dapat memengaruhi kepatuhan terapi dan kualitas hidup. Menganalisis hubungan lama menjalani hemodialisa, tingkat stres, dan tingkat kecemasan pada pasien penyakit ginjal kronis yang menjalani hemodialisa di Rumah Sakit Bhayangkara Makassar. Penelitian observasional analitik dengan desain potong lintang pada tahun 2025 terhadap 56 pasien penyakit ginjal kronis yang menjalani hemodialisa. Tingkat stres diukur menggunakan Perceived Stress Scale-10 (PSS-10) dan tingkat kecemasan menggunakan Generalized Anxiety Disorder-7 (GAD-7). Analisis hubungan menggunakan uji korelasi Spearman. Sebagian besar responden mengalami stres sedang–berat (sedang 42,9%; berat 35,7%) dan kecemasan ringan–sedang (ringan 44,6%; sedang 46,4%). Lama hemodialisa berhubungan negatif dengan tingkat stres (p0,001; r=-0,712) dan tingkat kecemasan (p0,001; r=-0,642). Tingkat stres berhubungan positif dengan tingkat kecemasan (p0,001; r=0,523). Semakin lama menjalani hemodialisa, tingkat stres dan kecemasan cenderung menurun, sedangkan peningkatan stres diikuti peningkatan kecemasan. Skrining psikologis dan dukungan psikososial terintegrasi perlu dipertimbangkan, terutama pada fase awal hemodialisa. Kata Kunci: Hemodialisa, Penyakit Ginjal Kronis, Stres, Kecemasan, GAD-7.
The Role of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Preventing Cardiovascular Complications in Type 2 Diabetes Mellitus Saffanah Rizkah Muttaqinah Anwar; Prema Hapsari Hidayati; Pratiwi Nasir Hamzah
Journal of Asian-african Focus in Health Vol. 4 No. 3 (2026): Journal of Asian-african Focus in Health
Publisher : ScieClouds Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71435/741778

Abstract

Type 2 diabetes mellitus is one of the leading causes of morbidity and mortality associated with cardiovascular complications. Advances in antihyperglycemic therapy have demonstrated that sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists) not only improve glycemic control but also play an important role in preventing cardiovascular complications. However, evidence regarding their mechanisms of action, clinical benefits, and roles in cardiovascular prevention remains scattered across the literature. Objective of the research to review the current scientific evidence regarding the role of SGLT2 inhibitors and GLP-1 receptor agonists in preventing cardiovascular complications in patients with type 2 diabetes mellitus based on published studies. This study employed a narrative literature review using a systematic literature search approach. A literature search was conducted in the PubMed database for articles published between 2021 and 2026, following the PRISMA 2020 guidelines. A total of 15 eligible articles were included, comprising randomized controlled trials, cohort studies, observational studies, systematic reviews, meta-analyses, and post-hoc analyses. Results of the research showed that the synthesis of the included studies demonstrated that SGLT2 inhibitors consistently reduced the risk of hospitalization for heart failure, major adverse cardiovascular events (MACE), cardiovascular mortality, and the progression of chronic kidney disease. In contrast, GLP-1 receptor agonists were more effective in reducing atherosclerotic cardiovascular events through improvements in vascular function and metabolic risk factors. Several studies also suggested that combination therapy with both drug classes may provide greater cardiorenal benefits than monotherapy. SGLT2 inhibitors and GLP-1 receptor agonists have complementary roles in preventing cardiovascular complications in patients with type 2 diabetes mellitus. Therapeutic selection should be individualized according to patients' clinical characteristics and cardiovascular risk profiles to optimize cardiorenal outcomes.
High Sugar Intake and Insulin Resistance in Obesity Putri Sakinah Alsia Rumakat; Prema Hapsari Hidayati; Darariani Iskandar
Journal of Asian-african Focus in Health Vol. 4 No. 3 (2026): Journal of Asian-african Focus in Health
Publisher : ScieClouds Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71435/741774

Abstract

High sugar intake, particularly from added sugars and sugar-sweetened beverages, is known to contribute to the increasing prevalence of obesity and insulin resistance, which are risk factors for various metabolic diseases. The Objective of the review  to determine the relationship between high sugar intake and insulin resistance in obesity based on published research findings. This study used a literature review method by searching articles through the PubMed databases published between 2021 and 2026. Article selection was conducted based on the PRISMA 2020 guidelines, resulting in 12 articles that met the inclusion criteria. Literature synthesis demonstrates that high sugar consumption, particularly liquid fructose, drives insulin resistance through hepatic de novo lipogenesis (DNL), accumulation of toxic plasma ceramides, low-grade systemic inflammation (elevated CRP and IL-6), gut microbiota dysbiosis, and altered expression of lipogenic genes (e.g., MEG3 and FTO). Isocaloric fructose restriction studies showed significant improvements in insulin sensitivity and reduction of hepatic fat, independent of substantial weight loss. Furthermore, a bidirectional vicious cycle exists where higher baseline insulin resistance reinforces sensory preferences for sugar-sweetened foods. There is a strong and causal relationship between high sugar intake and insulin resistance in obesity, mediated by complex molecular and metabolic pathways. Restricting added sugar intake, especially from sugar-sweetened beverages, is highly recommended as a primary prevention and clinical management strategy for obesity.
Co-Authors A. Husni Esa Darussalam AB, Tarisya Febriyanti Baso Abbas Zavey Nurdin Abdillah, Andi Rachmat Abdullah, Rezky Putri Indarwati Achmad Haruns Muchsin Ade Rahmy Sujuthi Afifah Ridha Humairah Afriansyah, Rafli Agnes Feterina Parwati Gosal Agung Sukriadi Ahyar, Muammar Aisyah Nabilah Sulthan Aisyah Primaputri Ali Aspar Mappahya Alifya, Kafka Mutiara Almirah, Michaella Amrizal Muchtar Ana Meliyana Andi Adam Indra Andi Alamanda Irwan Andi Alamanda Irwan Andi Ambar Yusufputra Andi Dhedie Prasatia Sam Andi Kartini Eka Yanti Andi Kartini Eka Yanti Andi Kartini Eka Yanti Andi Kartini Eka Yanti Yanti Andi Muhammad Luthfi Parewangi Andi Siti Nur Pranana Ummah Feqqi Anggita, Dwi Anna Sari Dewi Ardiansar , Abdul Mubdi Arfan, Rafidah Arifuddin Karim, Abdul Mubdi Ardiansar Arina F Arifin Arina Fathiyyah Arifin Armanto Makmun Arni Isnaini Arfah Aryani, Aulia As'ad, Andri Ashar Magguliling Tayibu Ashari, Anjelia Farmana Asram, Andi Asrini Safitri Asrini Safitri Asrini Safitri Assofi, A. Syarifah Balqis Astra Budiati Nusrat Astri Wahyuni Atika Ananda Putri Ayu Lestari Bakhtiar, Ilma Khaerina Basyar Basyar Dahliah Dahliah AZ Dahliah Dahliah Dahliah, Dahliah Danial, Nurul Fauziah Darariani Iskandar Darariani Iskandar Darussalam, Andi Husni Esa Daulima, Shaula Vaganza Devita Nurul Ainiah, A. Dian Fahmi Utami Dian Fahmi Utami Dirgahayu L, Andi Millaty Dwi Anggita Dwi Anggita Dwi Anggita Dwi Pratiwi Dzul Rizka Edward Pandu Wiriansya Edward Pandu Wiriansya Eka Yanti, Andi Kartini Erida Hasbi, Berry Erlin Syahril Fadhillah, Fadhillah Fadil Mula Putra Faisal Sommeng Faizul A Fatkhurroman, Imam Febie Irsandy Febie Irsandy Febie Irsandy Febriyanti, Andi Gina Fendy Dwimartono Firiansyah, Alief Rezeky G. Gunawan Gina Isni Djanuaresty Iskandar Hadi, Santriani Hamsah, M. Hamsah, Muhammad Hamzah, Pratiwi Nasir Harahap, Muhammad Wirawan Hasan Hasan Hasliyawati Hasan Hasta Handayani Hendrian Chaniago Herlambang Andre Hermiaty I Irmayanti Ida Royani Ida Royani Ilma Khaerina Amaliyah Bakhtiar Imran Safei Imran Safei Imran Safei, Imran Imran, Muh. Indah Lestari Indah Lestari Daeng Kanang Indah Lestari Daeng Kanang Inna Mutmainnah Inna Mutmainnah Musa Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti, Irmayanti Irna Diyana Kartika Irna Diyana Kartika Kamaluddin Irwan, Andi Alamanda Iswan Wahab, M. Iwan Kurniawan Jabal Nur, Muhammad Jafar, Muh. Alfian Jumarti Ika Wulandari MZ Kamaluddin, Irna Diyana Kartika Kamandali, Buok Aria Kanang, Indah Lestari Daeng Karim, Abdul Mubdi Ardiansar Arifuddin Khairun, Nadhifah Wasila M. Hamsah M. Iswan Wahab M. Yogi Riyantama Isjoni M.Abrar Naufal Hidayatullah ZA Makmun, Armanto Mamile, Rahmawati Manggung Manggung Mappaware, Nasrudin Andi Marzelina Karim Miftahul Jannah Mochammad Erwin Rachman Mochammad Erwin Rachman Mochammad Erwin Rachman, Mochammad Erwin Mohammad Reza Zainal Abidin Mubarak, Andi Firman Mufia Muin Mufthiar Muhtar Muh Anugrah Ramadhan Muh. Fadil Asrar Muh. Jabal Nur Muhammad Arif Taufik Muhammad Fauzul Azhim Muhammad Irsan Muflih Mundzir Muhammad Jabal Nur, Muhammad Jabal Muhammad Surya Samudra Muhammad Taufiqurrahman, Muhammad Muhammad Yasin Arsal Muhammad Yatsrib Semme Muhammad Yusuf Sidang Amin Mulyadi, Farah Ekawati Musa, Inna Mutmainnah Mutiara Amalia Muzammilia Nadraini Namirah, Hanna Aulia Nasrudin Andi Mappaware Nasrudin Andi Mappaware Natsir, Pratiwi Nevi Sulvita Karsa Nevi sulvita karsa Nirwana Laddo Ni’ma Haifa Amin Novriansyah , Zulfikri Khalil Novriansyah, Zulfikri Khalil Nur Fadhillah Khalid Nur Hidayah Nur Rahma Nur, M. Jabal Nurfachanti Nurmadilla, Nesyana Nursyamsi Nursyamsi Nurul Faiqah Nurul Fiqriyatul Islamiyah P.Amir, Suliati Paulus Pratiwi L Basri Pratiwi Nasir Hamzah Pratiwi Natsir Purnama, Rahmiaty Purnamasari, Reeny Putri Sakinah Alsia Rumakat R Rahmawati Rachmat Faisal Syamsu Rachmat Faisal Syamsu Rachmat Faisal Syamsu Rachmat Faisal Syamsu Rachmat Latief Rahmah, Marlyanti Nur Rahmatul Atika Jamal Rahmawati Mamille Rahmawati, Rahmawati Ramadhan, Muh. Dwi Cahyo Rasfayanah Rasfayanah Ratih Natasha Maharani Ratih Natasha Maharani Ratu Sri Bestari Reza Farelim Wardana Rezky Pratiwi L Basri Rezky Putri Indarwati Abdullah Rezky Putri Indarwati Abdullah Ridha Humairah, Afifah Rifka Yusraeni Rismayanti Risna Rajab Risna Sri Wahyuni M Rizal Basry Rizky Nurhumairah Sarifuddin Rusman Saffanah Rizkah Muttaqinah Anwar Safitri, Asrini Santriani Hadi Sarah Sarwati, Athiyyah Sarinah Mandella Rumlawan Selviani Sherliana, Sherliana Shofiyah Latief Shulhana Mokhtar Sidrah Darma Sigit Dwi Pramono Sitti Rukiyah Syawal Sodiqah, Yani Sri Irmandha Sri Irmandha K Sri Irmandha Kusumardhani Sri Julyani Sri Vitayani Sri Wahyu Sri Wahyu Sri Wahyuni Gayatri St. Nur Ashilah Nafi’ah St. Nur Ashilah Nafi’ah Suci Ramadhani Sudirman Katu, Sudirman Suliati P Amir Sultan Buraena Sultan Buraena Surdam, Zulfiyah Syahril, Erlin Syamsu Rijal Syarif Hidayatullah Syarifuddin Wahid Syarifuddin, Erwin Tabri, Nur Ahmad Tahir, Nur Cahyani Taufik, Muhammad Akram Tola, Aqilah Faizah Waode Inayatu Zahra Khairunnufus Wawan Susilo Wiriansya, Edward Pandu Wisudawan Wisudawan Wisudawan Wisudawan, Wisudawan Wulan Purnamasyani S Yani Sodiqah Yani Sodiqah Yanti, Andi Kartini Eka Yudistira, Amanda Tasya Reghinaa Putri Yuniati, Lisa Yusuf Kidingallo Zulfikri Khalil Novriansyah Zulfitriani Murfat Zulfiyah Surdam Zulfiyah Surdam