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Fatimawali .
Universitas Sam Ratulangi
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ANALISIS KANDUNGAN RHODAMIN B PADA LIPSTIK ILEGAL YANG BEREDAR DI PASAR LANGOWAN TIMUR Kamu, Priska Eliasa; Fatimawali; Suoth, Elly Juliana
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.31680

Abstract

Penggunaan bahan-bahan tertentu yang dapat membahayakan kesehatan konsumen menjadi permasalahan yang timbul dalam peredaran produk kosmetik. Salah satu bahan berbahaya yang digunakan pada lipstick adalah Rhodamin B yang dapat menyebabkan kanker jika digunakan dalam jangka waktu yang panjang. Tujuan penelitian ini untuk mengidentifikasi dan mengetahui kadar Rhodamin B pada lipstik ilegal yang beredar di pasar Langowan Timur. Pengujian secara kualitatif yaitu dengan metode Kromatografi Lapis Tipis dan secara kuantitatif menggunakan metode Spektrofotometri UV-Vis. Hasil dari penelitian ini secara kualitatif yaitu dengan menggunakan metode Kromatografi Lapis Tipis (KLT) terdapat 2 sampel lipstik yang teridentifikasi mengandung Rhodamin B dengan nilai Rf 0,77. Analisis kuantitatif menggunakan metode Spektrofotometri UV-Vis, kadar Rhodamin B sampel B sebesar 11,4 µg/mL  ± 0,010 dan pada sampel C sebesar 11,1 µg/mL  ± 0,003. Kesimpulan dalam penelitian ini adalah terdapat 2 merek lipstik yang beredar di pasar Langowan Timur mengandung Rhodamin B, sehingga perlu adanya pengawasan dari pihak terkait terhadap peredaran kosmetik yang illegal.
The Influence of Physical Activity, Nutritional Status, Age, and Gender on the Health-Related Quality of Life Among Adolescents in Bolaang Mongondow Regenc Kumala Dewi, Citra; Fatimawali, Fatimawali; Posangi, Jimmy
Al Makki Health Informatics Journal Vol. 2 No. 3 (2024): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v2i3.31

Abstract

This study analyzed the influence of Physical Activity, Nutritional Status, Age, and Gender on Adolescent Health and Quality of Life in Bolaang Mongondow Regency. This was an analytic study with a cross-sectional approach conducted in junior and senior high schools in Bolaang Mongondow Regency in October 2023 with a total sample of 406. The results of the study found that physical activity and nutritional status had a p>0.05 value in all domains, while the age variable had a p<0.05 value in the psychological and social domains, the gender variable had a p<0.05 value in the psychological domain, then to analyze the most influential variables, the researcher conducted a logistic regression test and obtained the results of the gender and age variables having the most decisive influence on the quality of life of adolescent health in the psychological domain by 8.6%. This study concludes that Physical Activity and Nutritional Status are unrelated and do not affect the quality of life of adolescents in the Bolaang Mongondow district. At the same time, the variables of age and gender influence only the psychological and social domains of quality of life health; gender and age variables have the most decisive influence. This study implies that Physical Activity and Nutritional Status are not the main factors that influence the quality of life of adolescents in Bolaang Mongondow Regency. However, Age and Gender have a more significant influence, especially on psychological aspects.
Evaluasi Implementasi Program Usaha Kesehatan Gigi Sekolah (Ukgs) di Wilayah Kerja Puskesmas Talawaan Priska F. Umboh; Wulan P. J. Kaunang; Fatimawali Fatimawali; Jimmy Posangi; Jane Tahulending; Very Londa
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.48222

Abstract

Masalah kesehatan gigi dan mulut masih menjadi tantangan serius dalam sistem pelayanan kesehatan di Indonesia, khususnya pada anak usia sekolah dasar. UKGS merupakan salah satu program puskesmas yang bertujuan untuk meningkatkan derajat kesehatan gigi siswa. Penelitian ini bertujuan untuk mengevaluasi pelaksanaan program Usaha Kesehatan Gigi Sekolah (UKGS) di wilayah kerja Puskesmas Talawaan menggunakan pendekatan model evaluasi CIPP (Context, Input, Process, Product). Penelitian ini bersifat kualitatif deskriptif dengan teknik pengumpulan data melalui wawancara mendalam, observasi, dan telaah dokumen. Hasil penelitian menunjukkan bahwa pelaksanaan UKGS belum berjalan optimal. Sistem regulasi yang tidak jelas, keterbatasan sumber daya manusia di sekolah, kurangnya sarana prasarana penduking kegiatan, serta anggaran terbatas menjadi hambatan utama dalam pelaksanaan program. Selain itu, kegiatan UKGS seperti sikat gigi massal, pelatihan guru pembina UKGS dan dokter gigi kecil, belum dilakukan secara rutin dan sistematis. Kesimpulan dari penelitian ini menegaskan bahwa program ini masih butuh perhatian khusus dari berbagai pihak mengingat kasus kejadian karies sampai saat ini masih terus meningkat. Penelitian ini merekomendasikan perlunya regulasi teknis yang jelas, pelatihan petugas UKGS, peningkatan anggaran, serta kelengkapan sarana prasarana untuk mengoptimalkan pelaksanaan UKGS.
Characterization of Thelenota ananas and Its Potential as a Natural Source of Antioxidants Budiarso, Fona; Sorisi, Angle; Fatimawali, Fatimawali
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.63976

Abstract

The sea cucumber Thelenota ananas, commonly found in tropical waters, possesses significant biological potential. This study aims to assess the antioxidant potential of Thelenota ananas extract obtained from the Manado sea. The simplicia was analyzed for organoleptic properties, moisture content (9.8%), and ash content (23%). Bioactive compounds were identified through color and foam reactions, while antioxidant activity was measured using the DPPH method. The extract was found to contain saponins, terpenoids, and alkaloids. The antioxidant activity of the extract, with an IC50 value of 99.8 ppm, demonstrates strong antioxidant properties, though less potent than the control, vitamin C (IC50 of 45.5 ppm). These findings suggest that while Thelenota ananas extract exhibits substantial antioxidant activity, it is still less effective than vitamin C. This research highlights the potential of Thelenota ananas as a natural antioxidant source for the development of health products.
Pharmacist-led education on beyond-use date (BUD) improves community knowledge at a community pharmacy Solang, Jonathan Adrian Natanael; Kandou, Grace Debbie; Fatimawali, Fatimawali
Holistik Jurnal Kesehatan Vol. 20 No. 2 (2026): Volume 20 Nomor 2
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v20i2.2858

Abstract

Background: Beyond-Use Date (BUD) refers to the time limit for using a medication after the packaging is opened or the medication is prepared, as opposed to the expiration date. Public understanding of BUD remains limited, potentially leading to medication use exceeding safe limits, reducing therapeutic effectiveness, and increasing risks to patient safety. Pharmacists play a strategic role in educating the public through health promotion activities in community pharmacies. Purpose: To determine the effect of education provided by BUD pharmacists on the public's level of knowledge. Method: This study used a pre-experimental design with a single-group pretest-posttest. A total of 44 participants who met the inclusion criteria were selected using random sampling at Rophin Jovins Varma (RJV) Pharmacy. The study procedure included a pretest to measure initial knowledge, followed by education provided by pharmacists about BUD, and a posttest to assess changes in knowledge after the intervention. Data were collected using a 15-question questionnaire. Data were analyzed descriptively to describe the distribution of knowledge levels and inferentially using the Wilcoxon Signed Rank Test to assess differences before and after the intervention. Results: Before the intervention, most respondents had low to moderate levels of knowledge. After the intervention, there was a significant improvement, with the majority of participants achieving a high level of knowledge. Statistical analysis showed a significant difference between pre- and post-intervention knowledge levels. Conclusion: Education provided by pharmacists regarding BUD significantly improved community knowledge. Educational interventions through health promotion activities within the pharmacist community were effective in increasing community understanding of the safe and rational use of medicines. Suggestion: Pharmacists are encouraged to provide ongoing education regarding BUD to promote safe and rational use of medicines.   Keywords: Beyond-Use Date (BUD); Community Knowledge; Community Pharmacy; Pharmacist-Led Education.   Pendahuluan: Beyond-use date (BUD) merupakan batas waktu penggunaan obat setelah kemasan dibuka atau obat diracik, berbeda dengan tanggal kedaluwarsa. Pemahaman masyarakat mengenai BUD masih terbatas, sehingga berpotensi menyebabkan penggunaan obat melewati batas aman, menurunkan efektivitas terapi, serta meningkatkan risiko terhadap keselamatan pasien. Apoteker memiliki peran strategis dalam memberikan edukasi kepada masyarakat melalui kegiatan promosi kesehatan di komunitas apoteker. Tujuan: Untuk mengetahui pengaruh edukasi yang diberikan oleh apoteker BUD terhadap tingkat pengetahuan masyarakat. Metode: Penelitian ini menggunakan desain pre-eksperimental dengan rancangan one group pretest–posttest. Sebanyak 44 partisipan yang memenuhi kriteria inklusi dipilih menggunakan teknik accidental sampling di Apotek Rophin Jovins Varma (RJV). Prosedur penelitian meliputi pre-test untuk mengukur tingkat pengetahuan awal, dilanjutkan dengan pemberian edukasi oleh apoteker mengenai BUD, serta post-test untuk menilai perubahan tingkat pengetahuan setelah intervensi. Data dikumpulkan menggunakan kuesioner yang terdiri dari 15 pertanyaan. Analisis data dilakukan secara deskriptif untuk menggambarkan distribusi tingkat pengetahuan dan secara inferensial menggunakan uji Wilcoxon Signed Ranks Test untuk menilai perbedaan sebelum dan sesudah intervensi. Hasil: Sebelum intervensi, sebagian besar responden memiliki tingkat pengetahuan rendah hingga sedang. Setelah intervensi, terjadi peningkatan yang signifikan, dengan mayoritas partisipan mencapai tingkat pengetahuan tinggi. Analisis statistik menunjukkan adanya perbedaan yang bermakna antara tingkat pengetahuan sebelum dan sesudah intervensi. Simpulan: Edukasi yang diberikan oleh apoteker mengenai BUD secara signifikan meningkatkan pengetahuan masyarakat. Intervensi edukasi melalui kegiatan promosi kesehatan di komunitas apoteker efektif dalam meningkatkan pemahaman masyarakat mengenai penggunaan obat yang aman dan rasional. Saran: Apoteker diharapkan memberikan edukasi berkelanjutan mengenai BUD untuk meningkatkan penggunaan obat yang aman dan rasional.   Kata Kunci: Beyond-Use Date (BUD); Community Knowledge; Community Pharmacy; Pharmacist-Led Education.
Mechanistic Exploration of Moringa oleifera Leaf Bioactives in Prostate Cancer Using Network Pharmacology Tengke, Feniea Wulan Agaype; Tallei, Trina Ekawati; Turalaki, Grace Lendawati Amelia; Tendean, Lydia Estelina Naomi; Kaseke, Martha Marie; Niode, Nurdjannah Jane; Fatimawali, Fatimawali
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.105

Abstract

Prostate cancer remains one of the most prevalent malignancies in men worldwide, while current therapeutic strategies are often associated with adverse effects and the emergence of drug resistance, highlighting the need for safer and more effective alternatives. This study aimed to elucidate the multitarget molecular mechanisms of bioactive compounds derived from Moringa oleifera leaves against prostate cancer using an integrated in silico network pharmacology approach. A total of 137 bioactive compounds were collected from LC–MS/MS profiling data and phytochemical databases, of which 20 compounds with high predicted biological activity were prioritized based on Way2Drug PASS analysis. Potential protein targets were predicted and intersected with prostate cancer–associated genes to identify shared targets. Protein–protein interaction network analysis revealed 536 overlapping targets, with ten hub proteins, ESR1, AKT1, SRC, EGFR, TP53, HSP90AA1, PIK3CA, HSP90AB1, PIK3R1, and MAPK1, identified as central nodes. Pathway enrichment analysis demonstrated that these targets were predominantly involved in cancer-related signaling pathways, including pathways associated with EGFR tyrosine kinase inhibitor resistance. Pharmacokinetic and toxicity assessments indicated that several compounds, such as isorhamnetin, kaempferol, tocopherol, and afzelin, exhibited favorable drug-likeness properties and low predicted toxicity. Overall, these findings suggest that bioactive compounds from Moringa oleifera leaves exert anticancer effects through a multitarget and multi pathway mode of action rather than single-protein modulation. This study provides systematic insight into the molecular mechanisms underlying the anti–prostate cancer potential of Moringa oleifera leaves and supports their relevance as candidates for further experimental validation and drug development.
Co-Authors Aaltje E. Manampiring Aaltje E. Manampiring Aaltje E. Manampiring Aaltje Ellen Manampiring Aaltje Manampiring Aaltje Manampiring Aaltje Manampiring Aaltje Manampiring Abas, Abdul Hawil Abdul Jalil Abubakar, Poetry M.S. Abubakar, Poetry Melinda Adeanne Wullur Adikila, Gregorius Giani Adithya Yudistira Adrian Umboh Ahmad Haekal Alamri, Firdaus Alexander S. L. Bolang Andini Andrew Pangemanan, Andrew Angelique C. M. Tanan Anggelia Nelisa Kapantow Angle Sorisi Anita Linda Yohana Pratasik Anita Mamuaya Anita Rahel Meilina Paendong Anjely Jessica Makatempuge Annisa Hamka Antasionasti, Irma Apolonia Amelintje Gusmão Awoah Asriyana S Kaseng Astrid Noviera Iksan Axl L. Windah Ayu Fauzia Malinda B H. R. Kairupan Baharuddin, Fatmawaty Bahter, Julia V.F. Barasarathi , Jayanthi Basalamah, Rizqah BEIVY JONATHAN KOLONDAM Bernadus, Zefanya Bernadus, Zefanya G Billy J Kepel Billy J Kepel Billy J. Kepel Billy J. Kepel Billy Johnson Kepe Billy Kepel Billy Kepel Billy Kepel Bodhi , Widdhi Budiarso, Fone D.H. Butue, Leobernard Catur Riany Celik, Ismail Changiz Mohiyeddini Cheisy Anastasya Gratia Lengkong Chintya G. Derek Citra Kumala Dewi Damaris, Damaris Datu, Olvie S. Datu, Olvie Syenni Debbie Retnoningrum Debora Tandi DEBY AFRIANI MPILA Defny Silvia Wewengkang Deliyana Lanti Desye Nurmalita Tanan Devianitta Sarapi Dian Pratiwi Dian Pratiwi Dina Rombot Dolongtelide, Jeclin Inebel Donald Andreas Chandra Dos D. L. E. Br Siagian Edward Nangoy, Edward Eka Mulya Muthalib Ekawati Tallei, Trina Elly Suoth Endang Triastuti Engka, Joice Nancy ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Eva M. Mantjoro Farhan A. Bidullah Fatima Fatima Fatmawaty Badaruddin Feti Fatimah Feybe Ireine Kumayas Fona Budiarso Frans S. M. Mintardjo Frederika Filly Toad Frenly Wehantouw Frisky S. Badi, Frisky S. Friyan Criscanus Manopo Gabriela Clementine Ranti Gani Jumaat Gani, Maria A Gani, Maria A. Gayatri Citraningtyas Gazali Gazali Gemi Nastiti Gerungan, Yizreel Y. GONI, BRIGITA CHRISTANIA AURORA Gosal, Leonardo Delvin Grace Debbie Kandou Grenshannya Anasthasya Pua Greta J. P. Wahongan Gustaaf A. E. Ratag Hamdiyah Hamzah Hamidah Sri Supriati Hanna Elga Sulu Hariyanto, Yuanita Amalia Hasan, Puput Herawati Hasan, Puput Herawati Said Hasanuddin, Israyati R. Hebber, Tri Heedy M Tjitrosantoso Henki Rotinsulu, Henki Herny E.I. Simbala Hosea Jaya Edy I Dewa Ayu Accyuta Kirana I Dewa Ayu Prabawati I Putu Andika Arianta Inda V. M. Rawung, Inda V. M. Intan Baiduri Irawan Yusuf Irawan Yusuf Irma Antasionasti Irma Antasionasti Irma Antasionasti Irma Febrianti Wahongan Irma Tristanti Iswanto Toling Jainer P Siampa Jainer Pasca Siampa Jane Tahulending Jayanto, Imam Jeane Mongi Jimmy Posangi Jimmy Posangi Jimmy Posangi Jimmy Posangi John Socrates Kekenusa John Socrates Kekenusa Josepin P Konda Julianri Lebang Julianri Sari Lebang Julianri Sari Lebang Jurike Kaunang Kairupan, Tara S. Kalalo, Marko Jeremia Kalalo, Tekla Kamaruddin Kamaruddin Kambey, Debora F. Kamu, Priska Eliasa Kapondo, Gwendolyn L. Karamoy, Eunike M. Kawengian, Shirley ES. Keintjem, Brigieta Kepel, Billy Kepel, Billy Johnson Kepel, Regina E.M. Kezia Pangemanan Kissi Parengkuan Konda, Josepin P Kuliahana, Ana Kumowal, Selphina Lady zha-zha Luntungan Lampus, Christania Landy A. Ch Lolaen LAPIAN, ALDA JULISTY GABRIELA Lasut, Misella R. C. Lasut, Misella Regina Laurencia Diva Bernadette Artantyo Lengkong, Cheisy Anastasya Gratia Lidya Togelang Lidya Valda Mamoto Lisa Kepel M Fadhel Nurmidin M. Pertiwi, Junita Ma'ruf, Nurul Qalbiyyah Makatambah, Venila Malino, Angeline Priscillia Mambo, Christi Diana Manampiring, Aaltje Ellen Mansur, Nurfauziah Mantjoro, Eva M. Maria Immaculata Tangkau Marina Mamarimbing Marko Jeremia Kalalo Marko Jeremia Kalalo Martha Marie Kaseke Maulydia, Nur B. Max R.J. Runtuwene Mega Fatimah Rosana Meilani Jayanti Melkianus, Brando Miranti Aike Wemay Mohtar, Khumairah Monalisa Karinda Morgen Ekaputra Pangaila Muh. Rifaldi Latarang Muharli Qadri Kanon Mutiara Cantika Mutiara Ramadani Mutmainah Mutmainah Nainggolan, Ivana C. Naray, Gueen L. G. Natasya Ester Rebeca Tamahiwu Natsir, Rosdiana Ni Wayan Dianti Nova Hellen Kapantow Novelina Irianti Damanik Nurdjannah J. Niode Nurfitriani Nurfitriani, Nurfitriani Nurhamidin, Anastasia P.R. Oksfriani Jufri Sumampouw Olivia C. Mulalinda Olivia G. Mokolensang, Olivia G. Olvie Datu Olvie Syenni Datu Olvie Syenni Datu Olvie Syennie Datu Omega Agral Owu, Nadya M. PANI, PUTRI MARGARETHA GLAUDY Pantow, Natalia M. Patrick Muljono Patrick Muljono, Patrick Paukiran, Degol Paulina Yamlean Paulina yamlean Paulina Yamlean Pehino, Albrita Pendong, Christa Hana Angle Pertiwi, Junita Maja Poluakan, Ricko Johanes Prasetio, Nathanael F. Prayoga, Deshanda Kurniawan Priska F. Umboh Puasa, Novanda S. Purwanto, Diana Shintawati Putri, Ida A. R. Putri, Prisna Aswarita Rahadian, Rifky Aditya Rahmad Dian Rambi, Christani I J Ratte, Titah Amelia Ratu, Belinda D. P. M. Ratulangi, Andrew Johanes Refa Riski Aulia Regina Masengi, Angelina Stevany Rengur, Zul Aini Rifqi Adithya Rika Wulandari Rimporok, Aprilia Rinaldi Idroes RINI Rio Windy Sondakh Ristanti Pratiwi Rizya Marchilia Mamahit Rotinsulu, Sarah Rotty, Linda WA. Rufi'i Rumagit, Tjandra A. RUMALUTUR, CHRISTHALIA IEWANDA Rumangu, Chrisa P. Rundengan, Gerald Sahi, Makbul Renaldi Salsabila, Febrisa Sarah Mariana Pattuju Saranita V. G. Polii sari sakinah Sherly Dawile Shintia, Arini Siampa, Jainer P Siampa, Jainer Pasca Siboantua Broolin Simanjuntak Siringo-Ringo, Aurian Fricilia Siti Suhartini Sitti Romlah Solang, Jonathan Adrian Natanael Sri Sudewi Sri Sudewi, Sri Sriwaningsih S Nahe Stevana F.A. Paat Sugeha, Inti Rizcy Sari Sumual, Acika Syifa Katili Talla, Tamrin Tallei, Trina Ekawati Tania, Adinda Dwi Tendean, Lydia Estelina Naomi Tengke, Feniea Wulan Agaype Terence Kanzil Titah Amelia Ratte Tjandra A. Rumagit Tjandra, Regina F. Trina E Tallei Trina E Tallei Trina E. Tallei, Trina E. Trina Ekawati Tallei TRINA EKAWATI TALLEI Trina Ekawati Tallei Trina Tallei Trina Tallei Trina Tallei Turalaki, Grace Lendawati Amelia V. Lomotu, Dinda Vanessa J. T. Seran, Vanessa J. T. VERY LONDA Vibrila Berliana Djanas Watania, Marcela Wawo, Arsianita Ester Welong Seftian Surya Weny I Wiyono Weny Wiyono Widdhi Bodhi Widdhi Bodhi Widdhi Bodhi widdhi Bodhi Widdhi Bodhi Widdhi Bodhi Widhi Bodhi Widya Hana Putri Gerung Wijaya, Puspita Windy Sumarauw Wulan P. J. Kaunang Wulan Palilingan, Wulan Wulan Tuerah Wungouw, Herlina Ineke Surjane Wungouw, Herlina IS. Yohanes Adithya Koirewoa Yulia Maria Jarut Yulianty Sanggelorang Yuyun Andriani Agus Zahra Zahra Zainal Abidin Zulfikri Zulfikri, Zulfikri