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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

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Immunomodulatory activity of kersen leaf extract (Muntingia calabura) on diabetic rats: analysis of immune response Hasan, Fonnie Esther; Yunus, Reni; Magdalena, Magdalena
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 6 No 2 (2024): Promising and valuable research towards diagnosis, prognosis and treatment of dis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v6i2.5746

Abstract

The immune response to high blood glucose levels leads to an inflammatory response and also produces inflammation mediators. Immunomodulatory functions of Kersen (Muntingia calabura) need further enhancement to ensure that its benefits are more widely recognized by the public. This study aims to determine the immunomodulatory activity of Kersen leaf in inducing and modulating the immune response in diabetic rats. This study was an experimental laboratory with a pre-and post-test with a control group design. The subjects were 30 white rats (Rattus Novergicus Wistar Strain), were treated with extract M. calabura dose 1 (100 mg/kg bw/day), dose 2 (200 mg/kg bw/day), dose 3 (300 mg/kg bw/day). For clinical evaluation, three control groups were formed, including a Normal Control Group, a Diabetes Mellitus (DM) Positive Group, and a DM Positive Group treated with Anti-Diabetic Drugs. The highest amount of IFN-γ concentrations were found in the DM positive control group + antidiabetic drugs (710.3 ± 27.2 ng/mL).  The highest number of Nitrit Oxide (NO) concentration was found in the DM positive control group (103.7 ± 10.2 µmol/L). The highest average amount of pancreatic β cell regeneration was found in the normal control group.  The DM positive control group and the treatment group had a significant difference (p < 0.05) It means that there is a significant difference in the data of all treatment groups, or these three groups have anti-diabetic activity by repairing or preventing damage to the pancreas organ in DM rats. This study revealed that M. calabura possesses immunomodulatory activity, capable of inducing and modulating immune responses in diabetic rats.
Co-Authors Abd. Asis Abdat, Nilna Aulia Abdi Dharma Adinata, Ahmad Farid Adriansyah Adriansyah Aep Saefullah Ahmad Busyairi, Ahmad Ahmad Harjono Aji, Lalu Febrian Siswandi Al-Husna, Khofifah Indah Amalia, Mekar Meilisa Andina Dwijayanti Andini, Sri Anwar Efendi Ari Susanti Aria Gusti Arief, Ilham Arifin Hidayat, Arifin Asmaripa Ainy Asnah Asnah Asnaty, Elvina Astrid Novita, Astrid Astuti, Yulia Az Zahra, Intan Azis, Abd Basyuni, Maftuh Batu Bara, Khoiriah Bhae, Benediktus Yoseph Budi Hariono Budi Harto Cahaya Harahap, Norlan Christie, Fleury Citra Arta, Deddy Novie Daulay, Adelina Khairani Daulay, Khoirunnisa DAULAY, MUHAMMAD ROIHAN Deliati, Deliati desi kristanti, desi Dewi, Nurul Aulia Dwi Zulfita Elisabeth, Febriyani Endayana, Bestari Erawadi Erawadi, Erawadi Fajri, Muhammad Iqbal Fathurrahman Fathurrahman Fathurrahman Fathurrahman Fatiha Putri Aura Diva Firstianty Wahyuhening Fibriany Fristiohady, Adryan Fuadi, Wirdatul Gamar Al Haddar, Gamar Al Gobel, Sri Yunanci Van Hamdah, Isnaini Noor Hammad, Hammad Harahap, Khoirunnisa Haryandi, Yopi Hasan, Fonnie Esther Hasibuan, Hasbi Anshori Hendrawan, Henky Hendy Tannady Henny Tannady Tan Hidayati, Parni Hikayat, Sohibul Hilda, Leyla Hindratni, Findy Humairoh, Mamai Husen Windayana, Husen Hutabarat, Arnold Sultantio I Putu Ayub Darmawan Jak, Yanuar Joko Ariawan Juliawati, Poniah Julistyono Widodo Julita, Yustina Junita, Nita Kahpi, Mhd Latip Kartono , Khamaludin, Khamaludin Kristianus Kristianus Kurniawati Kurniawati Kusnadi, Iwan Henri Laurentius Prasetyo Lelya Hilda Lestari, Triana Yuni Lily Restusari Lisa Amelia Lisarani, Varetha M Rafiq Manalu, Ega Putri Duana Marderina, Marderina Masitah, Tina Herianty Mas’odah, Siti Mauliana Mauliana, Mauliana Maulidi Maulidi Mayong Andreas Acin Melly, Melly Mohd. Rafiq Muhammad Darwis Dasopang Muhammad Iqbal Munir Munir, Munir Na'afi, Septiana Nalle, Patri Alinda Nasution, Asmainun Nasution, Muhammad Ilyas Nazulfah, Indah Nur Aisyah, St. Nurdiani, Tanti Widia Nurfitriyani, Nurfitriyani Nurul Kholifah, Nurul Nuryana, Arief Oktaviani, Haifah Dwi Ola, Andi Tenri Pane, Gina Soya Parameswara, Marsanda Claudia Pattiware, Andi Permatasari, Mutia Pranata, Rio Pratama, Tania Lingga Primadi Candra Susanto Rafik, Muhammad raharjo, itot bian Rahayu, Diah Afrianti Ramdhani, Hadiyati Adilla Reni Yunus, Reni Ricka Handayani Rifdah, Assyifa Rini Susana Riski, Nesia Rosyihan Anwar, Iklima Rutmauli Hutagaol Safitri, Anggia Cahyani Salehan, Salehan Samah, Eri Saraswati, Diah Ayu Sari, Ade Risna Sari, Baiq Davina Lolita Setyawan, Antonius Ary Shintia, Deah Sibarani, Lelawati Sipahutar, Marnita Siregar, Nurfitriani M Siti Annisa Wahdiniawati, Siti Annisa Siti Komariah Situmeang, Mahyudin Sofyan, Harnavela Somantri, Diki Sri Kusuma Wardani, Ketut Sri Mulyani SRI RAHAYU Sriyanto, Darmawan Subroto, Desty Endrawati Sugiarti Sugiarti Suharman Suharman, Suharman Suhartini, Eka Suhendra, Ade Sukmawan , Raden Sumper Mulia Harahap, Sumper Mulia Sutjiatmo, Bayu Prabowo Syaeba, Muhammad Syaebah, muhammad Syahrial Ayub, Syahrial Syainah, Ermina Syarifuddin, Surya Tulim, Anto Wheny Khristianto Widiya, Yayu Widjayanti, Carolina Ety WOLLY CANDRAMILA Yanti, Hafizah Rahma Yanto, Endra Yayat Suharyat Yohanes Totok Suyoto Yusuf, Alfian Zubaidah R, Zubaidah Zulkairnain, Rezkie