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PERBANDINGAN RESPON IMUNOLOGI EMPAT KOMBINASI ANTIRETROVIRAL BERDASARKAN KENAIKAN JUMLAH CD4 Mariam, Siti; Radji, Maksum; Budi, Erwanto
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 3 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This research was conducted to determine the differencies in immunological response of the four first-line antiretroviral combination, that is lamivudin-Zidovudin-Nevirapin, lamivudin-Zidovudin-Evapirenz, lamivudin-Stavudin-Nevirapin and lamivudin Stavudin-Evapirenz, which were based on increase in CD4 of patients and the factors influencing it in patients HIV / AIDS in Dr. H. Mahdi Marzoeki Bogor. The study was conducted retrospectively using data from Medical Record (MR) patients from March 2006 until March 2010 on patients who had CD4 examination every 3-4 months for using antiretroviral. Provided for descriptive analysis and statistical analysis were 335 patients and 73 patients resfectively . The results showed that the increase in the average patient's CD4 count were different for their four combinations of antiretroviral drugs, but on the basis of statistical tests using ANOVA showed that differences in CD4 cell increase were not significant. Factors patient's age, number of opportunistic infections, CD4 early and drugs used to treat opportunistic infections did not affect the increase in CD4 of patients.   ABSTRAK Penelitian ini dilakukan untuk mengetahui perbedaan respon imunologi dari empat kombinasi antiretroviral lini pertama yaitu Lamivudin-Zidovudin-Nevirapin, Lamivudin-Zidovudin-Evapirenz, Lamivudin-Stavudin-Nevirapin dan Lamivudin-Stavudin-Evapirenz berdasarkan peningkatan  CD4 pasien dan faktor-faktor yang mempengaruhinya pada pasien HIV/ AIDS di Rumah Sakit Dr. H. Marzoeki Mahdi Bogor.  Penelitian dilakukan secara retrospektif menggunakan data dari Catatan Medik (MR) pasien dari bulan Maret 2006 sampai Maret 2010 pada pasien yang mempunyai hasil pemeriksaan CD4 setiap 3-4 bulan selama menggunakan antiretroviral. Diperoleh 335 pasien untuk analisis deskriptif dan 73 pasien untuk analisis statistik. Hasil penelitian menunjukkan bahwa kenaikan CD4 rata-rata pasien berbeda dari keempat kombinasi ARV, tetapi berdasarkan uji statistik menggunakan ANOVA menunjukkan bahwa perbedaan kenaikan CD4 tidak bermakna. Faktor-faktor umur pasien, jumlah infeksi oportunistik, CD4 awal dan obat yang digunakan untuk mengobati infeksi oportunistik tidak mempengaruhi kenaikan CD4 pasien.
PERBANDINGAN RESPON IMUNOLOGI EMPAT KOMBINASI ANTIRETROVIRAL BERDASARKAN KENAIKAN JUMLAH CD4 Mariam, Siti; Radji, Maksum; Budi, Erwanto
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.51

Abstract

This research was conducted to determine the differencies in immunological response of the four first-line antiretroviral combination, that is lamivudin-Zidovudin-Nevirapin, lamivudin-Zidovudin-Evapirenz, lamivudin-Stavudin-Nevirapin and lamivudin Stavudin-Evapirenz, which were based on increase in CD4 of patients and the factors influencing it in patients HIV / AIDS in Dr. H. Mahdi Marzoeki Bogor. The study was conducted retrospectively using data from Medical Record (MR) patients from March 2006 until March 2010 on patients who had CD4 examination every 3-4 months for using antiretroviral. Provided for descriptive analysis and statistical analysis were 335 patients and 73 patients resfectively . The results showed that the increase in the average patient's CD4 count were different for their four combinations of antiretroviral drugs, but on the basis of statistical tests using ANOVA showed that differences in CD4 cell increase were not significant. Factors patient's age, number of opportunistic infections, CD4 early and drugs used to treat opportunistic infections did not affect the increase in CD4 of patients.   ABSTRAK Penelitian ini dilakukan untuk mengetahui perbedaan respon imunologi dari empat kombinasi antiretroviral lini pertama yaitu Lamivudin-Zidovudin-Nevirapin, Lamivudin-Zidovudin-Evapirenz, Lamivudin-Stavudin-Nevirapin dan Lamivudin-Stavudin-Evapirenz berdasarkan peningkatan  CD4 pasien dan faktor-faktor yang mempengaruhinya pada pasien HIV/ AIDS di Rumah Sakit Dr. H. Marzoeki Mahdi Bogor.  Penelitian dilakukan secara retrospektif menggunakan data dari Catatan Medik (MR) pasien dari bulan Maret 2006 sampai Maret 2010 pada pasien yang mempunyai hasil pemeriksaan CD4 setiap 3-4 bulan selama menggunakan antiretroviral. Diperoleh 335 pasien untuk analisis deskriptif dan 73 pasien untuk analisis statistik. Hasil penelitian menunjukkan bahwa kenaikan CD4 rata-rata pasien berbeda dari keempat kombinasi ARV, tetapi berdasarkan uji statistik menggunakan ANOVA menunjukkan bahwa perbedaan kenaikan CD4 tidak bermakna. Faktor-faktor umur pasien, jumlah infeksi oportunistik, CD4 awal dan obat yang digunakan untuk mengobati infeksi oportunistik tidak mempengaruhi kenaikan CD4 pasien.
Co-Authors - Khaeruman Abdul Haeba Ramli Aditya Halim Perdana Kusuma Putra Putra Adrifa, Zacky Putra Agung Aji Perdana Agung Edi Rustanto Ahmad Suriansyah Ahmad Zainal Ajat Sudrajat Al Kausar, Al Kausar Almansuri, Anton Amalia Sapriati Amrullah Amrullah Ardhana, Nugroho Aji Arif, Zaenal Arifah, Muhammad Syahroni Arifin, Antoni Ludfi Arsyi Rizqia Amalia Aulia, Nur Nabila Azhar Nampira, Ardi Bagiastra, I Ketut bt Rushdi, Hashlina Budi, Erwanto Budi, Erwanto Catur Kepirianto Cholifihani, Muhamad Cholifihani, Muhammad Damayanti, Si Luh Putu Dedi Junaedi, Dedi Defran, Hanif Muhammad Dewi Purnamasari Dewi, Maya Puspita Diatmika, Anak Agung Ketut Dihin Septyanto Din Azwar Uswatun Djoko Sutrisno Ekawati, Rosa Eni Rosnija Eric Hermawan Ernawati Ernawati Eros Rosmiati Evi Novita Fadillah, Nida Sri Nur Fatiani, Kurunul Fika Aryani Hamidah, Asti Hendriadi, Hendriadi Herlina Herlina Hidayat, Yusup Rachmat I Ketut Suma I Wayan Suastra Ida Bagus Putu Arnyana Ida Nurhaida Imelda Fajriati Indrajaya, Titus Irsan Tricahyadinata IRWANSYAH Irwansyah Irwansyah Ismaya, Sakti Brata Judijanto, Loso Juliana Juliana Kadafi, M. Amin Kalim, Muchamad Nur Kanaya, Aida Suni Khoidar Amirus Khoirunisa, Nurul Laela Fitriani, Baiq Lutfiyah, Zalfa Waspa Macdhy, Reshanty Dea Nur Maharani, Alfiana Citra Majid Wajdi Maksum Radji Maratis, Jerry Megawaty Meidiyanty, Elvira Muhammad Nafi Annury, Muhammad Nafi Naldo, Jufri Naldo Nefianto, Tirton Nurishlah, Laesti Nurpadilah, Maila Oktavia, Kiki Nur Omar, Rina Haji Panji Kresna, Egi Petrus Jhon Alfred Depa Dede Pindiharti, Dewi Prakoso, Hauzan Afif Prasetyo, Wisnu Budi Pratama, Mario Putra Purbasari, U.K. Purnomo, Subekhi Hadi Rahayu Apriliaswati Ramdan Samadi, Mochammad Riyanti Riyanti Rohani, Laila Rois, Ajun Rojuaniah Rojuaniah Ropi Marlina Rozamuri, Arif Murti Saadillah, Ramdhani Saputra, Radiansyah Harry Sari, Fitri Eka Sari, Hani Mayang Sayyidatul Fadlilah Septiningrum, Kartika Ayu Setyaningrum, Angela Selvia Shunhaji, Akhmad Silvester Masias Siso Sina, Muhammad Ibnu Sinaga, Samuel J. Siti Nurhidayati Siti Tarwiyah Sujatmiko, Anang Suriyadi, Suriyadi Suroyo Suroyo Surryanto Djoko Waluyo Suryani, Devina Ratna Susanto Susanto Sutawidjaya, Ahmad Hidayat Sutawijaya, Ahmad Hidayat Syahla, Tamara Syech Idrus Thamanda, Dhea Rusli Toaha, Muhammad Vikaliana, Resista Wicaksana, Harits Hijrah Widiyanti, Indri Ayu WIJAYA WIJAYA, WIJAYA Yogi Prihandoko Yohana, Erni Yolanna, Yolla Yusuf, Marwah