p-Index From 2020 - 2025
9.586
P-Index
This Author published in this journals
All Journal Jurnal Civics: Media Kajian Kewarganegaraan Efisiensi : Kajian Ilmu Administrasi BAPALA LingTera The Journal of Pure and Applied Chemistry Research KEMBARA Journal of Business and Behavioural Entrepreneurship Jurnal Penelitian Pendidikan IPA (JPPIPA) ETNOLINGUAL Jurnal Basicedu Andragogi: Jurnal Diklat Teknis Pendidikan dan Keagamaan Arkhais - Jurnal Ilmu Bahasa dan Sastra Indonesia Academy of Education Journal Santhet: (Jurnal Sejarah, Pendidikan Dan Humaniora) Ghancaran: Jurnal Pendidikan Bahasa dan Sastra Indonesia ENTITA: Jurnal Pendidikan Ilmu Pengetahuan Sosial dan Ilmu-Ilmu Sosial Jurnal Abdimas Pariwisata Borneo Educational Journal (Borju) Jurnal Kewarganegaraan Jurnal Disastri: Pendidikan Bahasa dan Sastra Indonesia Journal of Social Interactions and Humanities (JSIH) Jurnal Basicedu Public Health and Safety International Journal (PHASIJ) International Journal of Learning Reformation in Elementary Education Journal of Pedagogy and Education Science MODERAT: Jurnal Ilmiah Ilmu Pemerintahan Sewagati Kopula: Jurnal Bahasa, Sastra, dan Pendidikan Jurnal Osadhawedyah bidang Medis dan Kesehatan Jurnal Keperawatan International Journal Linguistics of Sumatra and Malay (IJLSM) Jurnal Pembelajaran Bahasa dan Sastra Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Ilmiah Kesehatan Mandira Cendikia IJHABS Belajar Bahasa : Jurnal Ilmiah Program Studi Pendidikan Bahasa dan Sastra Indonesia Journal of Social and Community Development Al-Hayat: Journal of Islamic Education Menulis: Jurnal Penelitian Nusantara Jurnal Keperawatan (e-Journal) Innovative Journal of Community Engagement (IJCE) Jurnal Bisnis dan Pembangunan
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : The Journal of Pure and Applied Chemistry Research

Design, Synthesis, and In Silico Study of Two N-Substituted Pyrazinamide Analogs as Potential Antituberculosis Agents Zulqurnain, Muhammad; Wati, First Ambar; Nurjanah, Ana; Kavin, Layli Adha Nadira; Afifah, Rizqi Nur; Suyatno; Santoso, Mardi
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7939

Abstract

Tuberculosis (TB) is an infectious yet often overlooked disease that remains a significant global challenge. Pyrazinamide (PZA), a key drug in the first-line TB treatment regimen, is used to reduce the duration of therapy, making it a compound of great interest for further exploration. Two pyrazine-2-carboxamide analogs have been successfully synthesized and reported, followed by an in-silico evaluation of their potency as antituberculosis agents. Yamaguchi reagent was employed as a coupling agent between pyrazine-2-carboxylic acid and corresponding amine, yielding N-(cyclohexylmethyl) pyrazine-2-carboxamide (D) and N-(4-cyclooctyl) pyrazine-2-carboxamide (E) in 60% and 55%, respectively. The molecular docking analysis of compounds (D) and (E) demonstrated lower binding energies (-7.65 and -7.37 kcal/mol, respectively), in comparison with the standard TB drugs, pyrazinamide and isoniazid. Additionally, ADME and pharmacokinetics evaluations revealed that compounds (D) and (E) meet the essential criteria for oral drug candidacy. These findings suggest that the pyrazinamide analogs (D) and (E) hold significant potential as promising antimycobacterial agents for tuberculosis therapy.
Co-Authors Abdullah, Abduljabbar Abni, Septia Rizqi Nur Achadi Budi Santosa Adibah Belva Adelia Afifah, Rizqi Nur Agung Praptono Agung Septiadi Agustini, Ni Made Sri AGUSTYA PRATIWI, MASYITHA Ainun Mardhiah Anas Ahmadi Anas Ahmadi Andi Ahmad Munajat Arif Adi Saputro Artadiyanti, Ni Made Novi Aryani, Reni Asrori, Muhamad Zainul Asteria, Prima Vidya AYU ANJARSARI, PUTRI Ayu Lestari AYU RISWATI, MARDIYAH Bachtera Indarto, Bachtera Bambang Yulianto Billah, A.A.M Bramantoro, Ardianto Budi Astuti Caecilia Putri Gennosa Cahyaningsih, Ayu Marlina Danti I, Dania Rithma Danur Bagaskoro Satria Ulung Darni DEVI QORIAYUNI, RIZKY Diah Utami Lutfiani Dian Sita Hapsari Didik Imam Margatot Djoko Widodo Dody Hartanto Dwi Riyanti Dwiyanti Utami Elisa Umami Ety Fitriyani Feriandi, Yoga Ardian fitriana, ika Frans Marzuki Gatut Yudoyono George Mason Ghina Nurjannah Gilbert William Onsent Gontjang Prajitno Hary Hermawan Heidy Andriani Heni Pujiastuti Hidayati, Dian IRWANSYAH Islamiati, Zuha Nur ITOK DWI KURNIAWAN Kavin, Layli Adha Nadira Kendis Hutamia Kevin Pierre Armando Leatemia Khoiri, Abdul Aziz KHOLIFAH Kriswanto, Didi Kusnanto Lalu Apriliansah Lindriany, Julita Lusiana Manik, Toba Sastrawan Mardi Santoso Marusaha Simarmata Masyithah Maghfirah Rizam Maulidiyah, Ajeng Putri Cahyani Moh. Yusril Hermansya Mohammad, Nhelbourne K. MUFID, YAN Muhammad Assegaf Baalwi Muhammad Rizky Irawan Muhammad Zahidi Mulyono Muthmainnah, Melania Suweni Muntini NABILAH, AMALIA Nafilah Azhar Anindita Nahak, Theresia Wilmince Naim, Haniifan Muhammad Nandaita Miftahul Lael Nasori Nofianus Elu Nugroho, Dhimas Setyo Nurjanah, Ana Oki Purnomo Ollcyalliztacyra Baktinadi Pamukhti, Bagas Biyanzah Drajad Pradikta, Zendy Purwaningsih, Sriyani Purwati Anggraini, Purwati Putri, Maritza Dita Fiorenza APrilia Putri, Phasa Amalia Arzetty Rafiq, Abdul Ragil Marghubi Raharjo, Resdianto Permata Rahayu, Septia Rahmatika, Nuniek Rahul Kristian Sitompul Ranthy Pancasasti, Ranthy Regita Citrazalzabilla Ria Fitriah Rikke Kurniawati Romadhon, Sahrul RONI Rudi Umar Susanto Rudiana Agustini Salmah Salsabila, Ti’laili Satria Tegar Ade Purnama Sebastian Nayaka Arella Taufano Setya Yuwana Sintha Amelia Sanada Siti Partini Suardiman Siti Rahma Soleman Soepardi, Djojok Sofyan Manullang Sri Susanti Sudikan, Setya Yuwana Suhartono Sukirman Supratno, Haris Supratono Karel Pareres Susanto, Rudi Umar Susi Maulida, Susi Susilo Indrawati Suwandana, Engkin Syamsul Sodiq Tengsoe Tjahjono, Tengsoe Tika Julaika Tursilowati, Diyah Ayu Indah Urip Zaenal Fanani Vincentia Audia Kirana Putri Vini Novilia Virgiawan Rambu Rabana Wantini Wati, First Ambar Widowati, Azza Nuriah Wijaya Gati , Norman Yohana, Nabilla Yosua Rony Yuliana, Rohmah Yunianika, Ika Tri Yuniseffendri Zixy Mahar Nurtias Zulqurnain, Muhammad