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Anti-inflammatory Effect of n-Hexane Fraction of Kentut leaves (Paederia scandens L.) on Male White Rats (Rattus novergicus) Yazid, Muhammad Ilfan; Rijai, Laode; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/mpbb3e50

Abstract

The anti-inflammatory effect of fart plant leaf extract (Paederia scandens L.) on white rats (Rattus norvegicus) has been carried out. This research shows that the effective dose of the n-hexane fraction of P. scandens leaf extract provides the best anti-inflammatory effect on white rats' feet soles. The study used an artificial edema formation method and periodically measured the volume of white mice's legs using a plethysmometer. The doses used for the extract are 100mg/200g BW, 150mg/200g BW, and 200mg/200g BW. The research data was observed visually. The effective dose of P. scandens leaf extract, which has the best anti-inflammatory effect, is 150mg/200g BW.
In Vitro Free Radical Scavenging Activity of Lagerstroemia speciosa PERS leaves on 1,1-diphenyl-2-picrylhydrazyl Rezqiyana, Gita Anna; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/2y5gxp24

Abstract

This study aims to determine the yields and free radical scavenging activity based on IC50 value of the extract and the fraction of Lagerstroemia speciosa Pers leaves. The leaves of L. speciosa were macerated using 96% methanol and then practioned using different kinds of solvent based on its polarity including n-hexane, ethyl acetate, and n-butanol. The result showed that the yield of methanol extract obtained from L. speciosa levaes was 5.45% of dried samples obtained, the fraction of n-hexane 19.12%, the fraction of ethyl acetate 4,7%, and the fraction of n-butanol 1.93%. Testing of antioxidant activity is performed with the 1,1-Diphenyl-2- Picryl Hydrazyl (DPPH) by spectrophotometry UV-Visible. Absorbanse measurement was conducted with spectrophotometry at the wave lenght of 516 nm. Data was analyzed with linear regresion to obtain value of IC50. The result of research showed that the extract and fractions of L. speciosa leaves have activity as an antioxidant with the IC50 value of methanolic extract L. speciosa leaves was 12.5 ppm, n-hexane fraction was 18.75 ppm, ethyl acetate fraction was 21.87 ppm, n-butanol was 8.37 ppm.
Activity antibacterial from honey kelulut (Trigona sp.) against bacteria Staphylococcus epidermidis Sita, Annisa Aulia; Rijai, Laode; Rija'i, Hifdzur Rashif
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/0a3qnh10

Abstract

Honey kelulut is derived from the kelulut bee (Trigona sp.), which is native to Kalimantan and belongs to the Trigona genus of stingless bees. The honey produced by the Trigona genus has a well-documented antibacterial property. Study objective accomplished. This text discusses the potent antibacterial action of kelulut honey. The antibacterial testing method employed is the well diffusion method, utilizing the bacterium Staphylococcus epidermidis as the test organism. An antibacterial test was conducted by measuring the diameter of the zone of inhibition against bacteria. The results were obtained from concentrations of 40%, 60%, 80%, and 100%. Then the resistance diameter was measured for each concentration. The most optimal outcomes were achieved in the antibacterial test using honey kelulut. The honey kelulut with an 80% concentration exhibited a medium resistance level of 10.2 mm, while the 100% concentration demonstrated a strong resistance level of 13.7 mm.
Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo Salam, Supriatno; Hikmawan, Baso Didik; Samsul, Erwin; Herman, Herman; Ahmad, Islamudin; Rijai, Laode; Nafiah, Mohd Azlan
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35515

Abstract

Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.
Edukasi Beyond Use Date (BUD) kepada Masyarakat di Puskesmas Lempake Samarinda Samsul, Erwin; Sari, Indah Dewi; Pasaribu, Handayani; Mus, Nurul Muhlisa; Hikmawan, Baso Didik; Arifuddin, M.; Rusman, Arman; Riki, Riki; Bone, Mahfuzun; Herman, Herman; Junaidin, Junaidin; Febrina, Lizma; Ibrahim, Arsyik; Rijai, Hifdzur Rashif; Ahmad, Islamudin; Almeida, Maria; Rijai, Laode; Arifian, Hanggara
Sevanam: Jurnal Pengabdian Masyarakat Vol 5 No 1 (2026): Maret
Publisher : Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/sevanam.v5i3.5684

Abstract

ABSTRACT There are still some people who do not understand the difference between the expiration date (Expired Date/ED) and the drug usage limit (Beyond Use Date/BUD). BUD is the time limit for drug use after compounding or after the primary packaging is opened. This activity aims to increase public knowledge, understanding, and awareness regarding the importance of paying attention to the safe limit for drug use or Beyond Use Date (BUD), so that people can use drugs wisely, safely, and responsibly. The activity implementation method includes counseling, material presentation, distribution of leaflets or brochures, and filling out pre-tests and post-tests. The number of participants who took part in this activity was 26 people. The results of the health promotion activity at the Lempake Community Health Center, Samarinda City showed that the average knowledge of participants about Beyond Use Date before providing education was 31.92%, and increased to 88.08% after being given information. Thus, it can be concluded that this activity was successful in increasing public knowledge regarding Beyond Use Date in the Lempake Community Health Center area, Samarinda City.. Key words: Beyond Use date (BUD), Expired date (ED), Lempake Health Center Samarinda City
NMR-Based Metabolic Profiling and Anticancer Activity of Nephelium ramboutan-ake and Nephelium lappaceum Flesh Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rijai, Laode; Ahmad, Islamudin; Rusman, Arman; Hikmawan, Baso Didik; Rija'i, Hifdzur Rashif; Almeida, Maria
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104162

Abstract

In this research, 1H-NMR-based metabolomics assessed the metabolite profiles of two Nephelium species flesh, specifically Nephelium ramboutan-ake and Nephelium lappaceum. Our research findings indicate that the metabolite profile of N. ramboutan-ake is qualitatively identical, although numerically distinct from that of N. lappaceum. The PLSDA data indicate that N. ramboutan-ake possesses elevated concentrations of acetic acid, malic acid, GABA, and succinic acid compared to N. lappaceum. In N. lappaceum, alanine and glucose serve as the distinguishing metabolites. Additionally, the anticancer efficacy of two Nephelium samples was assessed. As a result, the anticancer properties of N. ramboutan-ake were superior to those of N. lappaceum. PLS analysis indicated that GABA exhibited the most positive connection with the anticancer activity of Nephelium samples. These results indicate that the higher GABA concentrations of N. ramboutan-ake have a beneficial effect on its anticancer activity.
Studi Etnofarmasi Tumbuhan Berkhasiat Obat pada Ibu Nifas di Desa Batu Timbau Kutai Timur Devanty Fadilla; Nur Masyithah Zamruddin; Laode Rijai
Journal of Pharmacy and Clinical Practice Vol. 1 No. 2 (2026): Journal of Pharmacy and Clinical Practice
Publisher : PT Bukuloka Literasi Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65307/jpcp.v1i2.149

Abstract

Ethnopharmacy is a branch of science that studies the use of traditional medicine based on local knowledge passed down through generations. Indonesia has high biodiversity and cultural diversity, providing great potential for the utilization of medicinal plants, particularly in postpartum care. This study aims to identify and document the use of medicinal plants among postpartum mothers of the Kutai ethnic group in Batu Timbau Village, Batu Ampar District, Kutai Timur Regency, Kalimantan Timur. This research employed a qualitative descriptive method, with data collected through observation, semi-structured interviews, and documentation using purposive sampling involving 35 postpartum mother informants. Data were analyzed qualitatively and quantitatively using Use Value (UV) analysis to determine the relative importance of each species based on its frequency of use.The results showed that the community utilizes medicinal plants from 29 families, predominantly the Zingiberaceae family, for postpartum care. The plants are used as single preparations or in combinations to accelerate postpartum recovery, reduce pain, increase stamina, support uterine involution, and enhance breast milk production. The plant with the highest UV value is katuk leaf (0.714), indicating its high relative level of use among the studied community. Keywords: ethnopharmacology, medicinal plants, postpartum women, traditional medicine, Use Value.
Studi Etnofarmasi Tumbuhan Berkhasiat Obat pada Ibu Nifas di Desa Batu Timbau Kutai Timur Devanty Fadilla; Nur Masyithah Zamruddin; Laode Rijai
Journal of Pharmacy and Clinical Practice Vol. 1 No. 2 (2026): Journal of Pharmacy and Clinical Practice
Publisher : PT Bukuloka Literasi Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65307/jpcp.v1i2.149

Abstract

Ethnopharmacy is a branch of science that studies the use of traditional medicine based on local knowledge passed down through generations. Indonesia has high biodiversity and cultural diversity, providing great potential for the utilization of medicinal plants, particularly in postpartum care. This study aims to identify and document the use of medicinal plants among postpartum mothers of the Kutai ethnic group in Batu Timbau Village, Batu Ampar District, Kutai Timur Regency, Kalimantan Timur. This research employed a qualitative descriptive method, with data collected through observation, semi-structured interviews, and documentation using purposive sampling involving 35 postpartum mother informants. Data were analyzed qualitatively and quantitatively using Use Value (UV) analysis to determine the relative importance of each species based on its frequency of use.The results showed that the community utilizes medicinal plants from 29 families, predominantly the Zingiberaceae family, for postpartum care. The plants are used as single preparations or in combinations to accelerate postpartum recovery, reduce pain, increase stamina, support uterine involution, and enhance breast milk production. The plant with the highest UV value is katuk leaf (0.714), indicating its high relative level of use among the studied community. Keywords: ethnopharmacology, medicinal plants, postpartum women, traditional medicine, Use Value.
Aktivitas Peredaman Radikal Bebas DPPH Ekstrak dan Fraksi Daun Knema pallens W.J.deWilde Hifdzur Rashif Rija'i; La Ode Rijai; Arman Rusman
Usadha Journal of Pharmacy Vol. 5 No. 2 (2026): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v5i2.1043

Abstract

Knema pallens W.J.deWilde, yang secara lokal dikenal dengan nama Penggugut, merupakan tumbuhan endemik Kalimantan yang termasuk ke dalam famili Myristicaceae. Spesies ini umumnya ditemukan di ekosistem hutan dataran rendah, wilayah berpasir, serta kawasan hutan bakau. Meskipun memiliki potensi hayati yang khas, kajian ilmiah mengenai aktivitas bioaktif dari spesies ini masih sangat terbatas. Penelitian ini bertujuan untuk menentukan persentase rendemen, profil fitokimia, serta aktivitas peredaman radikal bebas secara kuantitatif dari ekstrak dan fraksi daun Knema pallens. Metode yang digunakan meliputi ekstraksi secara maserasi menggunakan pelarut metanol, dilanjutkan dengan fraksinasi cair-cair menggunakan pelarut n-heksana, etil asetat, dan n-butanol. Uji aktivitas antiradikal dilakukan dengan metode peredaman radikal DPPH (2,2-difenil-2-pikrilhidrazil) yang dinyatakan dalam nilai Inhibitory Concentration 50% (IC₅₀). Hasil penelitian menunjukkan bahwa rendemen tertinggi diperoleh dari fraksi n-heksana sebesar 28,9%, diikuti oleh fraksi n-butanol (9,8%), ekstrak metanol (8,04%), dan fraksi etil asetat (7,83%). Skrining fitokimia mengindikasikan adanya senyawa alkaloid, flavonoid, fenolik, serta steroid/triterpenoid dalam ekstrak dan fraksi yang diuji. Hasil uji aktivitas antiradikal menunjukkan nilai IC₅₀ sebesar 50,426 ppm (ekstrak metanol), 80,863 ppm (fraksi n-heksana), dan 40,981 ppm (fraksi etil asetat). Fraksi etil asetat menunjukkan aktivitas peredaman radikal paling kuat dengan nilai IC₅₀ terkecil. Dengan demikian, dapat disimpulkan bahwa ekstrak dan fraksi daun Knema pallens memiliki potensi antiradikal yang tergolong kuat hingga sangat kuat. Temuan ini mengindikasikan bahwa daun Knema pallens berpotensi untuk dikembangkan sebagai sumber agen antioksidan alami yang prospektif dalam bidang farmasi dan kesehatan.
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes M. Arifuddin; Rezti Amanda; Arfiani Arifin; Arfina Sukmawati Arifin; Iswahyudi Iswahyudi; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Arsyik Ibrahim; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Co-Authors Aan Qanitina Hanif Abdul Rahman, Janggo Adam M. Ramadhan Ade Purnama Septiani Aditya Fridayanti Aditya Fridayanti Aditya Fridayanti Adzimahtinur Pradawahyuningtyas Agus Setiawaty Alfenia Rahmayanti Almeida, Maria Amanda, Rezti Andi Berbi Ollan Yunus Andi Nurazmi Andini Eka Bahari Putri Anggreini, Putri Anintia Nitami Faradillah Anisha Putri Anjanie Medyawati Utami Annisa Anugrah Putri Annisa Mercury Ardella Safilla Arfiani Arifin Arfina Sukmawati Arifin Arief Fadillah Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arniah Arniah Arsyik Ibrahim Arsyik Ibrahim Arum, Alvionita Puspa Aryanti Aryanti Ayu Ulfa Sari Badawi, Satriani Baso Didik Hikmawan Bohari Yusuf Bone, Mahfuzun Brilian Dwisaputra Bandu Bulan, Adisty Sindi Chairunnisa Arbain Claudea Ersamy Janafrish Deasy Novia Sari Defriana Defriana Delti Delaya Busa Desire Janetha Asdedi Destri Erawaty Desy Aulia Rahmah Desy Triary Sandi Devanty Fadilla Dewi Maimunah Dewi Mayasari Dewi Nurmashita Dewi Rahmawati Dimas Aqil Fikrinda Dina Sofia Djoko Setyadi Dyera Wahyu Heraningtyas Eka Rizky Meilinda Emil Bahtiar Erwin Samsul Erwin Samsul Ester Melenya Looys Nababan Euis Julaeha Eva Hairdiana Umar Fadhil, Andi Raihan Fadhli Nurrahman W Fahriani Iatiqamah Jafar Fahriani Istiqamah Jafar Fahrul Rozi Fahrul Rozi Fajar Prasetya Fajar Prasetya Farah Erika Farah, Harra Ismi Fatma Sari Fauziah Halimatussa’diah Febrina Mahmudah Femy Linggi Allo Fika Aryati Firzan Nainu Fisi Karimah Khoirunnisa Fitri Rhamadhani Fitriani Fitriani Florensius Rinaldi F Fush Shilat Jibalathuull Hadi Kuncoro Hadi Kuncoro Hajrah Hajrah Hajrah Hajrah Hanggara Arifian Hardian Hardian Hardiana Sepryanti Palinoan Hariati Hariati Helmi Helmi Herliani Herliani Herliani Herliani Herman Herman Hernawati, Desy Hidayat Hidayat Hidfdzur Rashif Rija'i Hifdzur Rashif Rija’i Husein Hernadi Bahti Ibrahim, Arsyik Iffah Karina Ghassani Ina Indriyani Indah Puspa Dewi Indri Verrananda M Inul Ahmanda Reiza Islamudin Ahmad Islamudin Ahmad Iswahyudi Iswahyudi Iswahyudi Iswahyudi Jaka Fadraersada Janggo Abdul Rahman Jeny Maryani Liu Jeremia Giawa, Agusto Jessica Jumiati Catur Ningtyas Junaidin Junaidin Junaidin, Junaidin Jusmiati Jusmiati Kadir, Nurdianah Abdul Kama Tasawa, Gymnastiyar Kartika Damasanti Mamonto Khoiriyah Anbar Mufidah Kiki Argananta Kiki Nur Azizah Hidayatul Fitria Kindi Farabi Kusnul Nurhidayah Lestari, Wahyu Yunita Lia Novita Alydrus Lia Puspitasari Lilis Pania Anugrah Lisna Meylina Lisna Meylina Lita Nur Hanifa Lizma Febrina M Arifuddin M. Arifuddin M. Arifuddin M. Arifuddin, M. M. Rahmad Ramadhan Mahfuzun Bone Marlyan Bone MARYAM, SYARIFAH Maya Apriliani Maziyyah Husna Mega Silvia Meilisa Athiyah Meilita Efliana Mersi Mersi Mira Susanti Mirhansyah Ardana Mohd Azlan Nafiah, Mohd Azlan Muhammad Alhimni Rusdi Muhammad Faisal Muhammad Rasyid Indrawan Mukti Priastomo Mus, Nurul Muhlisa Nadia Rahma Kusuma Dewi Nia Oktaviani Ninin Kartika Ulfa Nisa Naspiah Novalia Debora Novalinda Novalinda Novita Eka Kartab Putri Novita Eka Kartab Putri Novita Sari Nugra Ilmahdi Nunuk Hidayanti Nur Masyithah Zamruddin Nur Masyithah, Z Nur Mita Nur Shidiq Nurul Annisa Nurul Fitriani Nurul Fitriani Nurul Hasanah Oktaviany Triana Olivia Siregar, Vita Oppi Yolan Destiyana Pasaribu, Handayani Pasuria Panjaitan Petrina Febrianti Pindo Hardika P.A.N Puji Rahayu Purwita Sari, Regina Putri Anggraeni Putri Purnamasari Rafika Hasdina Rahmadani, Agung Rahmat Budiman Rama Febryanto Ramadhan, M. Rahmad Rania Afifa Yasmin Rashif Rijai, Hifdzur Raudhatul Munawassalmiah Rezky Khairun Nisaa, Nur Rezqiyana, Gita Anna Rezti Amanda Richardus Rayendra Euriko Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki Riki RIKI RIKI, RIKI Rina Adilla Akmalia Ririn Novriyanti Risa Yusnita Riska Harfiani Junaid Risna Agustina Rohani Rohani Rolan Rusli Ruli Kuswati Rullah Hermanda Rusdi, Muhammad Alhimni Rusman, Arman Rymond Jusuf Rumampuk Sabaniah Indjar Gama Salam, Supriatno Santy Dara Krisnawati Saputri, Mitha Sari, Indah Dewi Sealti Puji Salea Selvi Jumiatul Astati Serly Monika Putri Sibarani Evy Morita Sinthary, Venna Sita, Annisa Aulia Siti Aisyah Siti Hardiyanti Siti Hardiyanti Siti Hasanah Siti Ulfah Hidayah Sri Andriani Allo Bulawan Sri Indah Mulyawan Dewi Sri Windarti Sukemi Sukemi Sulistiarini, Riski Suparningtyas, Juniza Firdha Supriatno Supriyatna Sutardjo Susan Susan Syamsiar, Syamsiar Syarifah Hudaya Tari Maulidina I.P Tasya, Indriana Tetra Hidayat Tias Puspita Sari Tina Dwi Rahayu Unang Supratman Usman Usman Vendryca Reckow Venna Shintary Venna Sinthary VICTORIA YULITA FITRIANI Vika Aura Rislianti Vilca Veronica Hasiani Vina Maulidya Vinny Indriani Vinny Sukma Wijayana Putri W.C. Taylor Wahyu Widayat Welinda Dyah Ayu Whenny Whenny Wijaya, Viriyanata Wirhanuddin, Wirhanuddin Wisnu Cahyo Prabowo Wulan Maulida Yazid, Muhammad Ilfan Yiska Priscilla Septilita Yoshihito Shiono Yuniarti Pudji Rahayu Yuspian Nur Yuyun Arlita