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All Journal Journal of Food and Pharmaceutical Science Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL ILMU SOSIAL Indonesian Journal of Applied Linguistics (IJAL) Pharmaciana: Jurnal Kefarmasian Lingua Jurnal Bahasa dan Sastra Indonesian Journal of Cancer Chemoprevention Jurnal EECCIS Habitat Indonesian Journal of Geospatial Jurnal Hubungan Internasional Jurnal Penelitian Humaniora Majalah Obat Tradisional Preventif: Jurnal Kesehatan Masyarakat IJoLE: International Journal of Language Education Majalah Farmaseutik Indonesian Journal of Chemistry Scientific Journal of Reflection : Economic, Accounting, Management and Business JISIP: Jurnal Ilmu Sosial dan Pendidikan JFIOnline Jurnal Mandala Pharmacon Indonesia Jurnal Fundadikdas (Fundamental Pendidikan Dasar) Suar Betang Syntax Idea Jurnal Pengabdian Masyarakat Borneo Jurnal Ilmiah Edunomika (JIE) Jurnal Ekonomi Dan Bisnis DINAMIKA GLOBAL : JURNAL ILMU HUBUNGAN INTERNASIONAL International Journal of Electrical, Energy and Power System Engineering (IJEEPSE) Jurnal INOVTEKSeri Elektro Elektrika Borneo Pendagogia: Jurnal Pendidikan Dasar Jurnal Genre (Bahasa, Sastra, dan Pembelajarannya) Jurnal Pengabdian Masyarakat Madani Kontigensi: Jurnal Ilmiah Manajemen International Journal of Agricultural Social Economics and Rural Development (Ijaserd) Jurnal Tadbir Peradaban Jurnal Pajak dan Bisnis (Journal of Tax and Business) Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding ProBisnis : Jurnal Manajemen Papua Journal Of Diplomacy And International Relations International Journal on Education Insight Media Farmasi Indonesia Jurnal Ilmiah Kampus Mengajar Jurnal Keilmuan dan Keislaman Jurnal Sosial dan Sains Journal of Artificial Intelligence and Digital Business JESCEE- Journal of Emerging Supply Chain, Clean Energy, and Process Engineering JISIP UNJA (Jurnal Ilmu Sosial Ilmu Politik Universitas Jambi) International Journal of Sharia Business Management Wacana: Journal of the Humanities of Indonesia Wistara: Jurnal Pendidikan Bahasa dan Sastra DIMASEKA Tematik Linguanusa : Social Humanities, Education and Linguistic Amerta Berkala Arkeologi INERSIA JGuruku: Jurnal Penelitian Guru Indonesian Journal of Forestry Research Jurnal Online Skripsi Manajemen Rekayasa Konstruksi (JOS-MRK) Jurnal Ilmiah Manajemen Profetik Preventif : Jurnal Kesehatan Masyarakat
Sugeng Riyanto
Program Studi Agroekoteknologi, Fakultas Pertanian, Universitas Udayana
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Transportation Other

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MEKANISME PENEKANAN EKSPRESI N-RAS EKSTRAK KULIT JERUK KEPROK (Citrus reticulata) SEBAGAI AGEN KEMOPREVENTIF N., Perdana Adhi; D., Andita Pra; P.K.W., Diah Ayu; Riyanto, Sugeng; Meiyanto, Edy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 3 (2009)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One targeting point of cancer treatment, especially liver cancer is the suppression of N-Ras expression, inhibition of c-Src activity and CYP1A2 in the liver cells. The aim of the research in to explore the anticarcinogenesis effect of the ethanolic extract of C. reticulata peel through suppression of N-ras expression and the binding afinity and interaction of polimetoksiflavon compound found in the peel of Citrus Reticulata, namely tangeretin and nobiletin to the target protein using molecular docking. Geometry structure optimization tangeretin and nobiletin were done with the software Molecular Operating Environment (MOE) for Windows. The optimum structure conformation of tangeretin and nobiletin were approached using semiempirik AMBER99 method. The process of docking of the test compound to the bindingsite c-Src (PDB ID: 1FMK) and CYP1A2 (PDB ID: 1AE4) were done using the software Molecular Operating        Environment (MOE) for Windows in the conditions without water. From the docking process found that the lowest scoring value is tangeretin in conditions without water.  Docking Results of tangeretin compared with the experimental ligan in the target CYP1A2, shows the interaction of tangeretin stronger than the interaction of ligan an α-naphtoflavon. Meanwhile, the target protein, c-Src, interaction endogenous ligan (ATP) is much stronger than the interaction with the test compound and ligan comparison Imatinib. Therefore, it is estimated that the mechanism of liver cancer hepar inhibition in molecular docking is through CYP1A2 inhibition. ABSTRAK Salah satu titik tangkap pengobatan kanker khususnya kanker hepar adalah penekanan ekspresi N-Ras, penghambatan protein c-Src dan aktivitas CYP1A2 di hepar.  Penelitian ini bertujuan untuk mengetahui afinitas dan interaksi senyawa berkerangka polimetoksiflavon pada kulit jeruk keprok (Citrus reticulata) yaitu tangeretin dan nobiletin terhadap protein target tersebut menggunakan molecular docking. Optimasi geometri struktur tangeretin dan nobiletin dilakukan dengan piranti lunak Molecular Operating Environment for Windows.  Konformasi optimum tangeretin dan nobiletin dihasilkan menggunakan metode semiempirik AMBER99. Kemudian dilakukan proses docking senyawa uji dengan bindingsite c-Src (PDB ID : 1FMK) dan CYP1A2 (PDB ID : 1AE4) menggunakan piranti lunak Molecular Operating Environment for Windows dalam kondisi tanpa air. Dari hasil yang diperoleh dapat diperkirakan bahwa mekanisme penghambatan kanker hepar secara docking molekuler adalah melalui penghambatan CYP1A2
MEKANISME PENEKANAN EKSPRESI N-RAS EKSTRAK KULIT JERUK KEPROK (Citrus reticulata) SEBAGAI AGEN KEMOPREVENTIF N., Perdana Adhi; D., Andita Pra; P.K.W., Diah Ayu; Riyanto, Sugeng; Meiyanto, Edy
Jurnal Farmasi Indonesia Vol 4, No 3 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i3.17

Abstract

One targeting point of cancer treatment, especially liver cancer is the suppression of N-Ras expression, inhibition of c-Src activity and CYP1A2 in the liver cells. The aim of the research in to explore the anticarcinogenesis effect of the ethanolic extract of C. reticulata peel through suppression of N-ras expression and the binding afinity and interaction of polimetoksiflavon compound found in the peel of Citrus Reticulata, namely tangeretin and nobiletin to the target protein using molecular docking. Geometry structure optimization tangeretin and nobiletin were done with the software Molecular Operating Environment (MOE) for Windows. The optimum structure conformation of tangeretin and nobiletin were approached using semiempirik AMBER99 method. The process of docking of the test compound to the bindingsite c-Src (PDB ID: 1FMK) and CYP1A2 (PDB ID: 1AE4) were done using the software Molecular Operating        Environment (MOE) for Windows in the conditions without water. From the docking process found that the lowest scoring value is tangeretin in conditions without water.  Docking Results of tangeretin compared with the experimental ligan in the target CYP1A2, shows the interaction of tangeretin stronger than the interaction of ligan an α-naphtoflavon. Meanwhile, the target protein, c-Src, interaction endogenous ligan (ATP) is much stronger than the interaction with the test compound and ligan comparison Imatinib. Therefore, it is estimated that the mechanism of liver cancer hepar inhibition in molecular docking is through CYP1A2 inhibition. ABSTRAK Salah satu titik tangkap pengobatan kanker khususnya kanker hepar adalah penekanan ekspresi N-Ras, penghambatan protein c-Src dan aktivitas CYP1A2 di hepar.  Penelitian ini bertujuan untuk mengetahui afinitas dan interaksi senyawa berkerangka polimetoksiflavon pada kulit jeruk keprok (Citrus reticulata) yaitu tangeretin dan nobiletin terhadap protein target tersebut menggunakan molecular docking. Optimasi geometri struktur tangeretin dan nobiletin dilakukan dengan piranti lunak Molecular Operating Environment for Windows.  Konformasi optimum tangeretin dan nobiletin dihasilkan menggunakan metode semiempirik AMBER99. Kemudian dilakukan proses docking senyawa uji dengan bindingsite c-Src (PDB ID : 1FMK) dan CYP1A2 (PDB ID : 1AE4) menggunakan piranti lunak Molecular Operating Environment for Windows dalam kondisi tanpa air. Dari hasil yang diperoleh dapat diperkirakan bahwa mekanisme penghambatan kanker hepar secara docking molekuler adalah melalui penghambatan CYP1A2
Co-Authors . Sardjiman Abdul Muis Prasetia, Abdul Muis Abdul Razak Abdul Rohman Achendri M. Kurniawan Ade Irawan Adhitya Rahmat Taufiq Adriansyah, Muhammad Agung Endro Nugroho Agus Budi Wahyudi Agus Sugiarto Agustin Dita Lestari, Agustin Dita Ainayah, Ainun Aji, Gagas Pamulyo Aji, Kilau Mustika Bayu Ali Muhammad Alqarni, Wais Anggita Rosiana Putri Appulembang, Fedroyanto Arieff Salleh Rosman Arindra, Anisa Putri Armin Naibaho Athaya, Utari Zain Atiqa Sabardila Aulia Rahman Ayuningtias, Putri Aziz, Thoriq Bidin , Sheena Binar Asrining Dhiani Budiman, Achmad Budiono Budiono Cahyani, Anna Cecilia, Alda Dwi Chatarina Umbul Wahyuni Cipto, Bambang D., Andita Pra D., Andita Pra Dachlan, Yoes P Dadang Suganda Dandung Novianto Daniel Happy Putra Darwin Nahwan David David Deni Suwardhi Dian Ardifah Iswari Djoko Santoso Dwi Haryanti Dwi Ratnaningsih, Dwi Edy Meiyanto Efendi, Medi Effendy, Rustam Endah Dwi Setyowati Endah Puspitasari Endang Lukitaningsih Endarsti, Dewi Eny Pemilu Kusparlina Etty Sulistyowati Faisal Anwar Fajar A. Lumakso, Fajar A. Farahwahida Mohd. Yusoff Fatria, Ega Fauzan . Fauzobihi, Fauzobihi Fa’uzhobihi, Fa’uzhobihi Ferdiansah, Doni Akbar Ferdiansyah, Rizky Fernandez, Ceferino Carrera Firdaus, Aulya Firdaus, Mohammad Adif Syahbana Fitriah Fitriah Fresiliasari, Oktavie Furi, Desy Ika Ratna Ghusaebi Hadi Suyono Handayani, Siti Dyah Hanifah, Risti Ulfi Hapsari, Ratih Indri Hardana, Andrean Eka Harry Soekotjo Dahlan Harun Joko Prayitno Haryadi, Rofiq Noorman Hastira, Muhammad Fajhriyadi Herudin Herudin, Herudin HM, Usman Huda, Abil Imaniar Ilmi Pariasa Ina Fitria Ismarlin Indang Dewata Irawati, Diwi Acita Irfan Miftahul Fauzi Ismail , Mohd Hafizal Ismuni, Mutdi Jang, Young Pyo Jhauharotul Muchlisyiyah, Jhauharotul Kazutaka maeyama Keppi Sukesi Khairullah, Septi Kliwon Hidayat Koesoemo Ratih Kurniati, Zakiah Kusumawati, Citra Andriani Laela Khasanah, Isrofiah Laode Muhammad Fathun, Laode Lilik Wahyuni Listyowati, Andang Andriani Luh Putu Ratna Sundari Luhur, Yudhistiro Pambudi Mado, Ismit Maemonah, Maemonah Mahardika, Brenand Putra Moch. Sholeh, Moch. Mohamad Aspollah Sukari, Mohamad Aspollah Mudofir Muhammad Akbar Muhammad, Aqsa Fahrezi Murtiningsih, Tenny Mutaufiq, Ali N., Perdana Adhi N., Perdana Adhi Nadiva, Vina Maharani Nafissah, Nur Azkiah Naimul Faizah, Naimul Nasution, Ali Napiah Ningsih, Sri Saripah nita puspita sari Noorman Haryadi, Rofiq Nur Anisa Nur Rohman Nurachmadi, Senki Nuraini, Syaila Nuranisa, Aprilda P.K.W., Diah Ayu P.K.W., Diah Ayu Palma, Miguel Pamungkas, Bima Putra Pangestu, Imam Aji Paryanto Patria Julianto Permatasari, Lina Pontan, Darmawan Prasetyaningrum, Dian Islami Priya Haresmita, Perdana Purnomo, Fadjar Putra, Alzam Darma Putra, Brian Nugroho Putri Wardani, Kartika Putri, Sherly Oktaviana Putria, Vina Deni Qomariah Qomariah Rachmawati, Dyah Ayu Raharjo, Bobby Asukmajaya Rahmah, Annuriah Rahmawati, Rahmawati Riki Nasrullah Rina Astuti Rinawati, Tri Ririn Threesiana, Ririn Rizkiana, Citra Rohman, Abdul Abdul Ruslim Said, Fitriani Saihul Anwar Sandi, Muhamad Santosa Pradana Putra Setya Negara Sartika, Linda Septania, Aulia Surya Setyaningsih, Widiastuti Shadrina, Annisa Shahrel Ahmad SA Shavira, Nismara Arsya Sinambela, Stivani Ismawira Siswantoro, Ajik Siti Nurhasanah Siti Zubaidah Situmorang, Fransiscus P Souisa, Johanis Sriwijayanti Sulistyawati Subagus Wahyuono Subhi Munir Sudibyo Martono Suhariyanto Suhariyanto Sukmawati Basuki Suparman, Tatang Supiyono, Supiyono Surbakti, Jesica Natasha Surwandono Surwandono Suryadi, Akhmad Suryawardana, Edy Susanto Susanto Syahfrizal Tahcfulloh Takdir Ali Mukti, Takdir Ali Tamrin, Alzat Gunawan Taqiyya, Rahmah Tommi Yuniawan Tulus Warsito, Tulus Tulus Widiarso Tuzzahra, Sakila Uemura, Haruki Urviy, Urviy Sausan Listikhawa Usman , HM Utarindasari, Destiana Utomo, Medea Rahmadhani Wagiati Wahya Wahya Wibawa, Almas Asyam Widyakto, Adhi Widyastuti, SM Wulandari, Sri Wahyu Yakub Nasucha Yudana, Frisdian Vhanatha Yusup Rohmadi Yusup, Putri Meida