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Formulasi sediaan pasta gigi herbal ekstrak etanol bunga telang (Clitoria ternatea L.) dan uji aktivitas antibakteri terhadap bakteri Streptococcus mutans Rati , Yuliandini; Dalimunthe , Gabena Indrayani; Lubis, Minda Sari; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.479

Abstract

Dental and oral disease is a disease experienced by almost half of the world's population (3.58 billion people). Gum (periodontal) disease is the 11th most common disease in the world. One of the dental and oral diseases that has a fairly high prevalence in Indonesia is dental caries. The aim of this research was to evaluate the physical quality of toothpaste preparations with various concentrations (10%, 30% and 50%) and to determine the antibacterial activity of ethanol extract toothpaste preparations from butterfly pea flowers (Clitoria ternatea L.) against the growth of Streptococcus mutans bacteria.The stages of this research included processing plant materials, making ethanol extract of butterfly pea with ethanol 96% solvent, characterization examination, screening of phytochemicals, making herbal toothpaste preparations of butterfly pea extract, preparation evaluation, and testing the antibacterial activity of butterfly pea toothpaste against Streptococcus mutans using the well-diffusion method. Based on the research results, it can be seen that the antibacterial activity of the formula with the greatest zones of bacterial inhibition is F1 and F2, namely 21.85 mm and 21.15 mm with very strong inhibition criteria. The conclusion of this study is that herbal toothpaste with butterfly pea extract can prevent and treat dental caries caused by Streptococcus mutans bacteria.
Pembuatan lip balm nanoekstrak umbi bit (Beta vulgaris L.) dan bunga rosella (Hibiscus sabdariffa L.) sebagai pelembab alami Jannah, Miftahul; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.480

Abstract

One of the most sensitive parts of the outer skin on the face is the lips, as they are prone to extreme weather conditions such as heat and cold, which can cause dryness and chapping. To address this condition, it is essential to use a lip balm. One of the plants used as an active ingredient in lip balm formulations is beetroot and rosella flower. Nanoparticle-based cosmetics have advantages over micro-scale cosmetics. The objective of this research was to determine whether nano extracts of beetroot and rosella flower can be formulated into a lip balm preparation, whether beetroot and rosella flower extracts meet the characteristic requirements as nano extracts, and whether lip balm formulations from beetroot and rosella flower can be used as moisturizers. This research method is true experimental with a post-test control group design, where the results were observed after the treatment. The study uses samples of beetroot and rosella flowers. The stages of this research include sample preparation, characterization of simplicia, phytochemical screening, extraction and nano-extraction, lip balm formulation, physical quality evaluation, and moisture testing. The research results show that beetroot and rosella flower contain alkaloids, flavonoids, saponins, tannins, and anthocyanins. The beetroot and rosella flower extracts meet the characteristics of nanoextracts, with particle sizes of 261.64 nm for beetroot and 143.86 nm for rosella flowers. Beetroot and rosella flower formulated into a lip balm preparation can moisturize the lips, as evidenced by increased moisture and oil content on the lip skin before and after the preparation.
Uji aktivitas antibakteri fraksi n-heksana dan etil asetat daun bandotan (Ageratum conyzoides L.) terhadap bakteri Staphylococcus epidermidis Rafliza , Rista; Nasution , Haris Munandar; Dalimunthe , Gabena Indrayani; Mambang , D.Elysa Putri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.500

Abstract

Bandotan (Ageratum conyzoides L) is a wild plant that is easy to find in Indonesia, known to have medicinal properties and has antibacterial properties. The purpose of this study was to determine the antibacterial activity of the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum Conyzoides L) against Staphylococcus epidermidis bacteria.This research was conducted using an experimental method including sample collection, macroscopic examination, microscopic examination, simplicia manufacture, characteristic examination, phytochemical screening, preparation of ethanol extract, then fractionation, then testing of antibacterial activity against Staphylococcus epidermidis bacteria using the agar diffusion method. Data obtained from the diameter of inhibition were statistically analyzed using the Anova test, then followed by the Kruskal-Wallis test and the Ducan test. The results of macroscopic examination, with dark color, egg-shaped, two pointed, obtuse leaf base, serrated leaf margins, hairy veins on the upper and lower surfaces, slightly hairy young leaves, white hair color and pinnate veins. The results of microscopic examination, xylem, covering hair, mesophyll and anomocytic type of stomata. The simplicia characteristic results obtained water content of 7.3%, water-soluble essence content of 32.72%, 42.5% ethanol-soluble extract content, total ash content of 3 .3% and acid insoluble ash content of 1.8%. Phytochemical screening of simplicia powders and extracts showed the presence of alkaloids, glycosides, flavonoids, tannins, saponins and steroids. The results of the antibacterial activity test of the n-hexan fraction on Staphylococcus Epidermidis bacteria at concentrations of 10%, 30%, 50% and 70% were included in the resistant category. Meanwhile, the ethyl acetate fraction at a concentration of 10%, 30% and 50% is in the resistant category, at a concentration of 70% it is in the intermediate category. So it can be concluded that the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum conyziodes L) have activity against Staphylococcus epidermidis bacteria.. 
Uji aktivitas antibakteri fraksi n-heksana dan etil asetat daun bandotan (Ageratum conyzoides L.) terhadap bakteri Staphylococcus epidermidis Rafliza , Rista; Nasution , Haris Munandar; Dalimunthe , Gabena Indrayani; Mambang , D.Elysa Putri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.500

Abstract

Bandotan (Ageratum conyzoides L) is a wild plant that is easy to find in Indonesia, known to have medicinal properties and has antibacterial properties. The purpose of this study was to determine the antibacterial activity of the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum Conyzoides L) against Staphylococcus epidermidis bacteria.This research was conducted using an experimental method including sample collection, macroscopic examination, microscopic examination, simplicia manufacture, characteristic examination, phytochemical screening, preparation of ethanol extract, then fractionation, then testing of antibacterial activity against Staphylococcus epidermidis bacteria using the agar diffusion method. Data obtained from the diameter of inhibition were statistically analyzed using the Anova test, then followed by the Kruskal-Wallis test and the Ducan test. The results of macroscopic examination, with dark color, egg-shaped, two pointed, obtuse leaf base, serrated leaf margins, hairy veins on the upper and lower surfaces, slightly hairy young leaves, white hair color and pinnate veins. The results of microscopic examination, xylem, covering hair, mesophyll and anomocytic type of stomata. The simplicia characteristic results obtained water content of 7.3%, water-soluble essence content of 32.72%, 42.5% ethanol-soluble extract content, total ash content of 3 .3% and acid insoluble ash content of 1.8%. Phytochemical screening of simplicia powders and extracts showed the presence of alkaloids, glycosides, flavonoids, tannins, saponins and steroids. The results of the antibacterial activity test of the n-hexan fraction on Staphylococcus Epidermidis bacteria at concentrations of 10%, 30%, 50% and 70% were included in the resistant category. Meanwhile, the ethyl acetate fraction at a concentration of 10%, 30% and 50% is in the resistant category, at a concentration of 70% it is in the intermediate category. So it can be concluded that the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum conyziodes L) have activity against Staphylococcus epidermidis bacteria.. 
Formulasi sediaan pasta daging lidah buaya (Aloe vera (L.)Burm.f.) dan uji aktivitas antibakteri terhadap bakteri Streptococcus mutans Meutia, Cut; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.524

Abstract

Introduction: Aloe vera (Aloe vera (L.) Burm.f.) is a plant that contains 95% water. The rest is in the form of other active ingredients (essential oils, amino acids, minerals, vitamins, enzymes, and glycoproteins). The type of aloe vera used to make herbal aloe vera is the Barbadensis type, which contains substances for human needs, such as Vitamins A, B1, B2, B6, B12, Vitamin E, and Vitamin C. This plant can also cure diabetes, heart disease, and other diseases.  Aloe vera can be formulated into toothpaste preparations because it can improve hygiene and reduce plaque in the mouth. Objective: This study aimed to make a new formulation of (aloe vera (L.) Burm.f.) as a toothpaste preparation and evaluate its antibacterial activity against Streptococcus mutans bacteria. Methods: This study uses an experimental method. In this study, aloe vera was formulated as toothpaste. The physical evaluation carried out included tests for water content, total ash content, water-soluble extract content, ethanol-soluble extract content, acid-insoluble extract content, organoleptic test, oh test, homogeneity test, spreadability test, adhesion test, test viscosity, and foam formation test. Results: Based on the research results, it can be seen that aloe vera flesh has antibacterial activity against Streptococcus mutans bacteria. Conclusion: This research concludes to make a new formulation of (aloe vera (L.) Burm.f.) as a toothpaste preparation and evaluate its antibacterial activity against Streptococcus mutans bacteria.
Penentuan kadar flavonoid total ekstrak etanol kayu kuning (Arcangelisia flava (L.) Merr. ) dan uji antibakteri Staphylococcus aureus . Nuraida, Nuraida; Ridwanto, Ridwanto; Daulay , Anny Sartika; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.598

Abstract

Indonesia has a diversity of plant species used as traditional medicine, one of which is yellow wood (Arcangelisia flava (L.) Merr.), this yellow wood is antibacterial, anti-inflammatory, antiseptic and antipyretic. It is known that yellow wood contains saponins, flavonoids, alkaloids, tannins, and steroids that can treat malaria, fever, rheumatism and itching. This study aims to determine the value of total flavonoid content contained in yellow wood extract in various ethanol concentrations (50%, 70% and 96%) and to determine the antibacterial inhibition zone in yellow wood extract. The stages of this study include processing plant materials, making ethanol extracts of yellow wood with ethanol concentrations of 50%, 70% and 96% using the maceration method then the extract obtained is concentrated with a rotary evaporator, examining characteristics, phytochemical screening, determining the total flavonoid content of yellow wood extract concentrations (50%, 70% and 96%) by UV-Vis spectrophotometric method and antibacterial test of Staphylococcus aureus  by diffusion method. The results showed that ethanol extract of yellow wood contains alkaloid, flavonoid, tannin, saponin, and steroid/terpenoid compounds. The results of the determination of total flavonoid content in yellow wood extract at 50% concentration amounted to 0.815200888 ± 0.02445546 mg QE/g, 70% concentration amounted to 1.0660462967 ± 0.03265799 mg QE/g and at 96% concentration amounted to 1.6781149 ± 0.0085 mg QE/g. Antibacterial test on 96% yellow wood extract obtained an inhibition zone of 18.05 mm with a strong category.
Penentuan konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak dan nanopartikel ekstrak daun pepaya (Carica Papaya L.) terhadap Bakteri Cutibacterium acnes Khofifah , Nur; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.720

Abstract

One of the skin diseases that often occurs is acne (Acne vulgaris). Acne is caused by the activity of the Cutibacterium acnes bacteria. Current acne treatment still depends on the use of antibiotics, but long-term use of antibiotics can cause bacterial resistance. Therefore, it is necessary to develop alternative treatments for acne that are effective and safe, one of which is by using medicinal plants. One plant that has potential is papaya leaves (Carica papaya L.). This research aims to determine the minimum inhibitory concentration (MIC) and minimum killing concentration (KBM) of ethanol extract and papaya leaf extract nanoparticles as well as testing antibacterial activity against Cutibacterium acnes bacteria. The research was carried out experimentally. The independent variables are the concentration of papaya leaf extract (6.25% concentration, 12.5% ​​concentration, 25% concentration and 50% concentration), and the concentration of papaya leaf extract nanoparticles (0.625% concentration, 1.25% concentration, 2.5% concentration % and Concentration 5%). The dependent variable is the antibacterial activity of papaya leaf ethanol extract and nanoparticles extract against Cutibacterium acnes. Characterization of the size of the extracted nanoparticles using a Particle Size Analyzer (PSA). The characteristic results for the extract size were 2,203.45 nm while the size of the extract nanoparticles was 330.27 nm. The minimum inhibitory concentration (MIC) value of 1.25% papaya leaf ethanol extract nanoparticles is better than 12.5% ​​papaya leaf ethanol extract, and the minimum lethal concentration (KBM) value of 5% papaya leaf ethanol extract nanoparticles is better than papaya leaf ethanol extract 50% against Cutibacterium acnes bacteria. 5% papaya leaf ethanol extract nanoparticles have the same antibacterial ability as 50% papaya leaf ethanol extract and are sensitive to Cutibacterium acnes bacteria, so it can be said that 5% papaya leaf ethanol extract nanoparticles can reduce the dose concentration of antibacterial compounds up to one-tenth of the time compared to ethanol extract papaya leaves 50% (1:10)
Penetapan kadar flavonoid ekstrak metanol kulit kayu raru (Cotylelobium lanceolatum Craib) pada variasi konsentrasi pelarut menggunakan metode spektrofotometri UV-Vis Nasution, Kartika Zsaskia; Daulay, Anny Sartika; Ridwanto, Ridwanto; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.724

Abstract

The use of plant-based traditional medicine remains a common practice in developing countries, with more than 80% of the population relying on it for healthcare and treatment. In Indonesia, natural medicines continue to be a primary choice for public health, aligning with local traditions and cultural practices. One such medicinal plant is raru bark, which possesses various pharmacological activities, including antidiabetic, astringent, antilaxative, antibacterial, antiseptic, antidiarrheal, and blood-clotting properties. This study aims to characterize the methanol extract of raru bark and determine its flavonoid content using UV-Vis spectrophotometry. The research stages included plant material processing, methanol extraction, characterization tests, macroscopic and microscopic examinations, phytochemical screening, and flavonoid quantification. Phytochemical analysis revealed that the methanol extract of raru bark contains flavonoids, tannins, saponins, and triterpenoids. Characterization tests showed that all evaluated parameters met the required standards. Flavonoid quantification was performed by determining the maximum wavelength of quercetin using UV-Vis spectrophotometry at different solvent concentrations. The results indicated that the total flavonoid content at a 96% solvent concentration was 1.625 ± 0.153 mgQE/g, at 70% was 1.318 ± 0.003 mgQE/g, and at 50% was 1.146 ± 0.006 mgQE/g.
Penetapan kadar flavonoid total ekstrak etanol 70% dan ekstrak etil asetat daun sambung nyawa (Gynura procumbens (Lour)Merr.) secara spektrofotometri UV-Vis Rahmadani , Adevika; Ridwanto, Ridwanto; Daulay , Anny Sartika; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.751

Abstract

Sambung nyawa leaves (Gynura procumbens L.) are a simplicia with various medicinal properties. One of the chemical compounds in sambung nyawa leaves that plays a crucial role in treatment is flavonoids. Flavonoids in sambung nyawa leaves have benefits as antihypertensive, antioxidant, antihyperglycemic, and anti-inflammatory agents. Different drying methods for simplicia affect the total flavonoid content in the extract.The stages of this research included plant material processing, the preparation of ethanol and ethyl acetate extracts, characterization tests, phytochemical screening, and the determination of total flavonoid content in the ethanol extract and ethyl acetate extract of sambung nyawa leaves using visible spectrophotometry. The extracts of sambung nyawa leaves were made using the maceration method with 70% ethanol and ethyl acetate, and the obtained extracts were concentrated using a rotary evaporator. Total flavonoid content was then determined using visible spectrophotometry. Phytochemical screening of the ethanol and ethyl acetate extracts of sambung nyawa leaves revealed the presence of chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The total flavonoid content in the ethanol extract was found to be 6.5149 ± 0.0314 mcg/g of sample, while the ethyl acetate extract had a total flavonoid content of 77.6695 ± 0.1199 mcg/g of sample.
Formulasi orally disintegrating tablet dari serbuk kembang kol (Brassica oleracea var. botrytis L.) dengan variasi konsentrasi sari tapai sebagai disintegrant Lestari, Sri Indah; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.773

Abstract

Cauliflower (Brassica oleracea var. botrytis L.) has a nutritional content consisting of calcium, magnesium, potassium, phosphorus, and low saturated fat. It has vitamin C, which helps increase body immunity. Orally Disintegrating Tablet preparations can dissolve quickly when placed on the tongue, formulated for ease of use of drugs for patients who have difficulty swallowing. Therefore, disintegrants are very important in ODT preparations. Tapai extract has a sweet, slightly sour taste and disintegrates immediately when placed on the tongue. This research aimed to determine whether cauliflower powder with tapai extract disintegrants can be formulated into ODT preparations and which formulation is the best.  This research included characterization of simplicia, making pre-formulation by mixing all ingredients, evaluating pre-formulation, and tablet printing by direct compression method. Then, the tablet evaluation was carried out. The disintegrant was tapai extract with 5%, 7.5%, and 10% concentrations. Data were analyzed using the One Way ANOVA method. The results of the formulation evaluation, the flow time test obtained <10 seconds, which is easy to flow; the angle of repose test obtained 26˚, the category is very good; and the compressibility test obtained 18-20%, which is quite good. The results of the tablet evaluation in the organoleptic test obtained round tablets, sweet taste, brownish-white color, and distinctive odor. The weight uniformity test on all formulas did not have any deviating weights; the size uniformity test met the requirements, the hardness test obtained 1-3 kg, the friability test obtained 0.4-0.7%, the petri dish disintegration time test obtained 44.07-52.48 seconds, and the mouth disintegration time test obtained 53.07-57.78 seconds and the wetting time test obtained 53.21-54.87 seconds. The best formula is formula 3, with a 10% tapai extract concentration.
Co-Authors Adelia Ramadani Adjelie, Tiara Adyani Maulinda Ahmad Rasyid Ridho Alaina, Nadila Alfi Wahyudi Nasution Amaliana, Amaliana Ananda , Nadia Andjelie, Tiara Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Apmarja, Sarah Utami Aris Munandar Aryunda, Divia Asep Trizaldi Asmarani, Asmarani Aulia Fitri, Aulia Aulia Sari Auza , Maharani Ayu , Tri Indah Pagar Azhar, Gustika Barutu, Liza Anisa Shevia Basaniah Basaniah BJ Sutrisna Cici Andriani Cindy Priscilia Cindy Widya Rosa Br Simarmata Cut Dian Mala Luthfia Cut Erika Maulydya D Elysa Putri Mambang D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang Daeng Elysa Putri Mambang Daulay , Anny Sartika Delvi Amira Hutagaol Dikki Miswanda Dina Agustia Parlin Dina Suciati Saragih Dinda Sari Utami Dini Rahmadani Ellyza, Chella Emmy Wiriandini Ercha Minanda Farida Yani Fathur Rahman Fatimah, Cut Fatma Dwi Jati fatur Rahman, fatur Febiyani, Rica Fithri Pulungan, Ainil Fitri Mulyani, Fitri Fitri, Nurul Fitri, Raissa Friyani, Lilah Gabena Indrayani Dalimunthe Gultom, Syarifah Elena Hafizha, Putri Hasanah, Qori Hasibuan , Nabila Hasim Hasibuan, Supia Indah Hastri Kholifah Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Hutagaol, Delvi Amira Huzeila Nisa Siregar Ihsan Fadhilah Ika Yeni Siahaan Ilmi Widya Sari Imelda Natasia Br S Meliala Indah Nasution Indah Triutami Harahap Indrayani, Gabena Junia Fitri Hayani Khofifah , Nur Kiki Rawitri Krisna Juniharta Napitupulu Leni Safriani Lestari, Sri Indah Linda, Rosa Lubis, Minda Sari Lubis, Nadya Frestika Luthfianida, Arifna M Pandapotan Nasution M Pandapotan Nasution M Pandapotan Nasution M. Alfaruqi M. Pandapotan Nasution M. Pandapotan Nasution M. Pandapotan Nasution M. Pandapotan Nasution Mambang , D.Elysa Putri Mambang, D. Elsya Putri Mambang, Elysa Putri Maya Syafira Meutia, Cut Miftahul Jannah Minda Sar Lubis Mohd. Bilal Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Ari Mukhtizar Muhammad Hizbullah Muhammad Pandapotan Nasution Muhammad Wahyu Ikhsan Muhammad Wahyu Ikhsan Munaziatul Jannah Munthe, Herlina Nasution , Muhammad Amin Nasution, Kartika Zsaskia Nasution, M. Pandapotan Nasution, Nur Sahadah Natasya, Siti Adinda Nazirah, Nazirah Nazuhra, Oca Nelsa Fahira Ningtias, Anggitha Niswa, Khairun Nofa Lismandaria Novika Utami Nur Hanifah Nuraida Nuraida Nuratika, Eli Nurliansyah, Nurliansyah Nurul Hasanah Ovalina Sylvia Br. Ginting Pertiwi, Rahma Prasetyo , Healthy Aldriany Purba , Intan Sabila Putri Puteri, Cut Intan Annisa Putri , Adilla Putri Intan Sari Putri Khairani Putri Mambang, D. Elysa Putri Rahayu, Yayuk Putri, Nadya Iwani Rafika, Intan Maya Rafita Yuniari Rafita Yuniart Rafita Yuniarti Rafliza , Rista Rahayu , Yayuk Putri Rahmadani , Adevika Rapita Yuniarti Rati , Yuliandini Rati Satri Situmorang Rawitri, Kiki Ridho, Ahmad Rasyid Ridwanto Ridwanto Ridwanto Ridwanto Ridwanto Rina Azhari Ritonga , Septi Ani Riza Syafira RR. Ella Evrita Hestiandari Rukmana, Siti Sabila , Anisa Safira , Liyuza Safitri , Nurhaliza sahrianti, Hikmah Sari, Syilvi Rinda Sarmadansyah Sarmadansyah Sartika Daulay, Anny Sasnita, Merida Selfia Lestary Sepriani, Ananda Sinaga, Novita Yulianti Siregar , Anisah Siti Aisyah Jamil Situmorang, Lusi Grasia Situmorang, Rati Satri Sony , Suyefri Sri Harti Sri Natalia Saragih Sri Ria Ranti Sri Wahyuni Sri Wahyuni Sri Wahyuni Sulwiyatul K Sani Supiyani, Supiyani Syafira, Nona Syalsabila Putri Syara, Nurdiani Syarifah Elena Gultom Tawir Rina Rezeki Tri Damaiyanti Ummi Khairani Rambe Wahdaniati , Tri Widya Sari Widya Sari Widya, Rizka Yanti, Rahma Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Apriani Br.Lubis Yuniarti , Rafita Yuniarti, Rafita Zannah , Muhamad Zikra Maqfirah Ziza Putri Aisyia Fauzi Zulmai Rani