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All Journal Acta Pharmaceutica Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Best Journal (Biology Education, Sains and Technology) PREPOTIF : Jurnal Kesehatan Masyarakat ad-Dawaa : Journal of Pharmaceutical Sciences Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Riset Kefarmasian Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Madaniya Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Chemical Science and Technology Jurnal Kesehatan Tambusai Jurnal Pengabdian Masyarakat (ABDIRA) Indonesian Journal of Pharmaceutical Education JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth FORTE JOURNAL Jurnal Farmanesia Journal of Health and Medical Science International Journal of Health and Pharmaceutical (IJHP) Jurnal Ilmu Psikologi dan Kesehatan Jurnal Farmasi Klinik dan Sains FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Jurnal Ilmu Kesehatan dan Gizi Journal of Pharmaceutical and Sciences. Indonesian Journal of Education And Computer Science FASKES : Jurnal Farmasi, Kesehatan, dan Sains Medic Nutricia : Jurnal Ilmu Kesehatan Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Seroja Husada: Jurnal Kesehatan Masyarakat Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan J-CEKI
Haris Munandar Nasution
Faculty Of Pharmacy, Universitas Muslim Nusantara Al Washliyah, Medan, North Sumatera, Indonesia
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Bioautographic Analysis And Antibacterial Activity Test Of Mengkudu Leaf (Morinda Citrifolia L.) Ethanol Extract On The Bacteria Propionibacterium Acnes Satri Situmorang, Rati; Munandar Nasution, Haris; Sari Lubis, Minda; Putri Rahayu, Yayuk
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.821 KB) | DOI: 10.51601/ijhp.v3i1.129

Abstract

Noni contains alkaloids, flavonoids, tripertinoid, protein, lime, iron, carotene, glycosides antarkiron. The content of anthraquinin, scaloptin, flavonoid and adaptogen compounds are active compounds that have antifungal and antimicrobial effects. The antibiotics commonly used are antibiotics such as tetracycline, clindamycin and others. These chemical-based antibacterials have many negative side effects, therefore other alternatives are needed as antibacterials, one of which is by using noni. This study aims to analyze bioautography and determine the antibacterial activity of noni leaf ethanol extract against Propionibacterium acnes bacteria.This research was conducted experimentally using noni leaf ethanol extract with concentrations of 30%, 40%, 50% as independent variables and bioautographic analysis and antibacterial activity as dependent variables. The bioautography analysis was performed using TLC and the antibacterial activity test was performed using paper discs.The results of antibacterial testing of noni leaf ethanol extract with a concentration of 30% had an inhibition zone of 8.36 mm with a medium category, a concentration of 40% had an inhibition zone of 10.3 mm with a strong category and a concentration of 50% had an inhibition zone of 11.1 mm in a strong category. positive control tetracycline 30µg had an inhibition zone of 20.8 mm which was categorized as very strong. The results of the bioautography test using contact bioautography using the mobile phase of chloroform: n-hexane (7:3). The inhibition zone was obtained at an Rf value of 0.17, and the characteristics of the chromatogram spots were carried out by spraying 10% FeCl3 suspected that the spots were flavonoid compounds.
Bioautographic Analysis And Antibacterial Activity Test Of Curry Leaf (Murraya Koenigii (L) Spreng) Ethanol Extract On The Bacteria Propionibacterium Acnes Muhammad Wahyu Ikhsan, Muhammad Wahyu Ikhsan; Munandar Nasution, Haris; Putri Rahayu, Yayuk; Pandapotan Nasution, M.
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.65 KB) | DOI: 10.51601/ijhp.v3i1.130

Abstract

Curry leaf (Murraya koenigii (L) Spreng) is one of the plants known to have antibacterial compounds. Curry leaves are also known as temurui leaves and are useful as a natural food flavoring. Curry leaves contain flavonoid compounds, alkaloids, calcium, zinc, riboflavin, folic acid. This study aimed to analyze the bioautography and antibacterial activity of ethanol extract of curry leaves against Propionibacterium acnes bacteria. The research method was carried out experimentally. Curry leaf simplicia extract was made with 96% ethanol as solvent. Curry leaf ethanol extract was made in various concentrations, namely 30%, 40% and 50%. The positive control used was Tetracycline HCl and the negative control was DMSO. The tests carried out on curry leaf simplicia included phytochemical screening, macroscopic examination, microscopic examination, water content examination, examination of water soluble extract content, examination of ethanol soluble extract content, examination of ash content and examination of acid insoluble ash content, bioautographic analysis he results of phytochemical screening showed that curry leaves contain secondary metabolites, namely flavonoids, alkaloids, tannins, saponins, steroids/triterpenoids, and glycosides. The results of the antibacterial activity showed that curry leaves could be used as antibacterial because they had strong inhibition at concentrations of 30%, 40% and 50%, namely 10.3 mm, 11.7 mm and 13.6 mm against P. acnes bacteria. The results of bioatuography showed that the Rf value in the clear zone was 0.17 with a ratio of chloroform:n-Hexane (8:2) on the chromatogram spots by spraying 10% FeCl3 positive for flavonoid compounds which were marked in black.
Formulation Of Anti-Acne Extract Aloe Vera (Aloe vera (L.) Burm.f.) In Hibiting The Activity Of Propionibacterium acnes Bilal, Mohd.; Sari Lubis, Minda; Yuniarti, Rafita; Munandar Nasution, Haris
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i1.140

Abstract

Aloe vera (Aloe vera (L.) Burm.f.) is widely used as an alternative medicine to treat various types of diseases and is now widely used as an antibacterial, one of which is against the acne bacteria Propionibacterium acnes. The purpose of this study was to determine the gel preparation of aloe vera extract (Aloe vera (L.) Burm.f.) which has activity against  Propionibacterium acnes and to see if the gel preparation produced has good and stable quality. Aloe vera ethanol extract was made by maceration method, then the extract was made in a gel preparation and then tested for antibacterial activity against  Propionibacterium acnes by the agar diffusion method using several concentration variations: 2.5%, 5%, and 10%. Furthermore, the inhibitory power of 2.5% has a medium category, the inhibition of 5% has a medium category, and the inhibition of 10% has a strong category. then tested for organoleptic, homogeneity test, pH dispersion and physical stability of the preparation. The results of the study showed that the gel preparation of aloe vera extract had antibacterial activity against Propionibacterium acnes, namely a concentration of 2.5% inhibition zone of 8.8 mm including the medium category, 5% concentration of the inhibitory zone of 9.8 mm including the medium category, the concentration of 10 % with an inhibition zone of 12.9 mm including the strong category. The conclusion of this study is that the gel preparation of 10% aloe vera ethanol extract concentration has the best inhibition. Then the stability test was then carried out, which included, the organoleptic did not change significantly, the homogeneity test showed good results, while the dispersion test showed good results, and the pH test showed good results according to skin pH.
UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN VARIAN TEH KOMBUCHA BERDASARKAN LAMA MASA FERMENTASI Mayani, Nurhikma; Pulungan, Ainil Fithri; Nasution, Haris Munandar; Yuniarti, Rafita
Jurnal Farmanesia Vol 12 No 2 (2025): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v12i2.6671

Abstract

Latar Belakang: Teh kombucha berasal dari fermentasi tradisional teh manis yang menggunakan simbiosis bakteri asam asetat dan spesies ragi yang memilki aktivitas antibakteri dan antioksidan. Teh kombucha mengandung metabolit sekunder flavonoid, saponin, tanin, steroid yang dapat bersifat sebagai antibakteri. Bakteri Escherichia coli umum hidup di dalam saluran pencernaan manusia atau hewan, dan Staphylococcus aureus umunya terdapat pada kulit. Tujuan: untuk mengetahui teh kombucha memiliki aktivitas antibakteri dan antioksidan serta pengaruh lama fermetasi terhadap akttivitas antibakteri dan antioksidan. Metode: menggunakan true Experimental. Pada penelitian ini fermetasi teh menggunakan kombucha pengujian antibakteri dan antioksidan berdasarkan lama fermentasi dan karakterisasi teh kombucha. Hasil: bahwa varian teh kombucha dapat digunakan sebagai antibakteri dan antioksidan. Pada uji aktivitas antioksidan pada teh hitam memiliki nilai IC50 paling tinggi pada hari ke-12 yaitu (45,5750) sedangkan pada teh oolong memiliki nilai IC50 paling tinggi pada hari ke-18 yaitu (30,5632). Uji aktivitas antibakteri diameter daya hambat terhadap bakteri Esherichia coli pada daun teh oolong paling besar pada hari ke-21 yaitu (15,7) sedangkan pada teh staphylococcus aureus terhadap daun teh hitam paling besar terdapat pada hari ke-21 yaitu (14,03).
ANTIOXIDANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF GREEN GEDI LEAVES (Abelmoschus manihot L.) USING CUPRAC (CUPRIC ION REDUCING ANTIOXIDANT CAPACITY) METHOD Kaban, Vera Estefania; Nasri, Nasri; Suci, Nurul; Lubis, Muhammad Fauzan; Rani, Zulmai; Nasution, Haris Munandar
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i02.20644

Abstract

Free radicals induce oxidative stress, which plays a pivotal role in the pathogenesis of various degenerative diseases. Abelmoschus manihot L., locally known as green gedi, is recognized for its rich secondary metabolite content with potential antioxidant properties. This study aimed to evaluate the antioxidant activity of the hydroalcoholic extract of green gedi leaves using the Cupric Ion Reducing Antioxidant Capacity (CUPRAC) method. Extraction was conducted via maceration using a 90% hydroalcoholic solvent, followed by comprehensive phytochemical screening and simplicia characterization. The antioxidant capacity was quantified by determining the IC50 value through linear regression analysis of inhibition percentage versus concentration. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids. The hydroalcoholic extract exhibited "very strong" antioxidant activity, yielding an IC50 value of 41.65 ± 0.30 µg/mL. Although this potency was slightly lower than the pure quercetin standard, it demonstrates a significant capacity for free radical neutralization. These findings underscore the potential of Abelmoschus manihot L. as a robust natural antioxidant source, supporting its further development into phytopharmaceuticals or functional health supplements for the prevention of oxidative stress-related conditions.
PENETAPAN KADAR FLAVONOID TOTAL DAN TANIN SERTA UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SIAK-SIAK (Dianella ensifolia (L.) Redoutè) Rifqi, M. Ainur; Yuniarti, Rafita; Lubis, Minda Sari; Nasution, Haris Munandar
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 5 No. 2 (2026): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v5i2.6294

Abstract

Daun siak-siak (Dianella ensifolia (L.) Redoutè) merupakan tanaman obat tradisional yang secara empiris digunakan dalam pengobatan penyakit infeksi, namun kajian ilmiah terkait kandungan metabolit sekunder dan aktivitas biologisnya masih terbatas. Penelitian ini bertujuan untuk mengetahui kadar flavonoid total, tanin, serta aktivitas antibakteri ekstrak etanol daun siak-siak terhadap Staphylococcus epidermidis. Penelitian dilakukan secara eksperimental dengan penetapan kadar flavonoid total menggunakan metode spektrofotometri UV-Vis melalui pereaksi AlCl₃ dan natrium asetat, sedangkan kadar tanin ditentukan dengan metode Folin–Ciocalteu menggunakan asam galat sebagai standar. Aktivitas antibakteri diuji menggunakan metode difusi cakram pada konsentrasi ekstrak 10%, 15%, dan 20%, dengan antibiotik sebagai kontrol positif dan aquadest sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ekstrak etanol daun siak-siak mengandung flavonoid total sebesar 52,98 ± 0,26 mg/g dan tanin sebesar 196,47 ± 118,78 mg/g. Aktivitas antibakteri meningkat seiring peningkatan konsentrasi ekstrak, dengan zona hambat pada konsentrasi 20% masing-masing sebesar 22,8 mm, 24,167 mm, dan 27,067 mm yang tergolong aktivitas antibakteri sangat kuat. Berdasarkan hasil tersebut, dapat disimpulkan bahwa daun siak-siak memiliki potensi sebagai sumber antibakteri alami yang kaya senyawa polifenol dan berpeluang dikembangkan sebagai bahan fitofarmaka.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MARBOSI-BOSI (Tarenna polycarpa (miq.) koord. & Valeton) TERHADAP BAKTERI Staphylococcus aureus Nasution, Wardah; Nasution, Haris Munandar; Dalimunthe, Gabena Indrayani; Zulmai Rani
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 5 No. 2 (2026): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v5i2.6351

Abstract

Daun marbosi-bosi (Tarenna polycarpa (Miq.) Koord. & Valeton) memiliki banyak kegunaan, termasuk sebagai bahan minuman herbal, dan obat tradisional. Buah ini mengandung antioksidan dan nutrisi yang berpotensi sebagai agen antibakteri, terutama terhadap Staphylococcus aureus . Penelitian Penelitian ini dilakukan untuk menilai kemampuan antibakteri dari ekstrak etanol daun Marbosi-bosi (Tarenna polycarpa (Miq.) Koord. & Valeton) terhadap pertumbuhan bakteri Staphylococcus aureus. Tanaman Marbosi-bosi mengandung beragam metabolit sekunder, antara lain flavonoid, tanin, saponin, dan triterpenoid, yang dikenal memiliki aktivitas sebagai agen antibakteri alami. Keberadaan senyawa-senyawa tersebut diharapkan dapat menjadi dasar dalam pengembangan ekstrak sebagai pilihan terapi jerawat berbasis bahan herbal. Tahapan penelitian diawali dengan pembuatan ekstrak dari simplisia daun Marbosi-bosi melalui teknik maserasi menggunakan pelarut etanol 96%. Selanjutnya, pengujian daya hambat antibakteri dilakukan menggunakan metode difusi cakram terhadap bakteri penyebab jerawat dan infeksi kulit, yaitu Staphylococcus aureus. Hasil pengamatan menunjukkan bahwa ekstrak dengan konsentrasi 45% menghasilkan diameter zona hambat paling besar, yaitu sebesar 16,23 mm terhadap Staphylococcus aureus, yang tergolong ke dalam kategori aktivitas antibakteri kuat. Temuan ini menunjukkan bahwa ekstrak etanol daun Marbosi-bosi memiliki potensi untuk dikembangkan lebih lanjut sebagai komponen aktif alami dalam formulasi sediaan farmasi.
Co-Authors Adelia Ramadani Adjelie, Tiara Adyani Maulinda Ahmad Rasyid Ridho Alaina, Nadila Alfi Wahyudi Nasution Amaliana, Amaliana Ananda , Nadia Andjelie, Tiara Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Apmarja, Sarah Utami Aris Munandar Aryunda, Divia Asmarani, Asmarani Aulia Fitri, Aulia Aulia Sari Auza , Maharani Ayu , Tri Indah Pagar Azhar, Gustika Barutu, Liza Anisa Shevia Basaniah Basaniah Bilal, Mohd. BJ Sutrisna Cici Andriani Cindy Priscilia Cindy Widya Rosa Br Simarmata Cut Dian Mala Luthfia Cut Erika Maulydya D Elysa Putri Mambang D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang Daeng Elysa Putri Mambang Daulay , Anny Sartika Delvi Amira Hutagaol Dikki Miswanda Dina Agustia Parlin Dina Suciati Saragih Dinda Sari Utami Dini Rahmadani Dwi Jati, Fatma Ellyza, Chella Emmy Wiriandini Ercha Minanda Fahmi Fahmi Farida Yani Fathur Rahman Fatimah, Cut fatur Rahman, fatur Febiyani, Rica Fithri Pulungan, Ainil Fitri Mulyani, Fitri Fitri, Nurul Fitri, Raissa Friyani, Lilah Gabena Indrayani Dalimunthe Gultom, Syarifah Elena Hafizha, Putri Hasanah, Qori Hasibuan , Nabila Hasim Hasibuan, Supia Indah Hastri Kholifah Humaira, Yara Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Hutagaol, Delvi Amira Huzeila Nisa Siregar Ihsan Fadhilah Ika Yeni Siahaan Ilmi Widya Sari Imelda Natasia Br S Meliala Indah Nasution Indah Triutami Harahap Indrayani, Gabena Junia Fitri Hayani Khofifah , Nur Kiki Rawitri Krisna Juniharta Napitupulu Leni Safriani Lestari, Sri Indah Linda, Rosa Lubis, Minda Sari lubis, muhammad fauzan Lubis, Nadya Frestika Luthfianida, Arifna M Pandapotan Nasution M Pandapotan Nasution M Pandapotan Nasution M. Alfaruqi M. Pandapotan Nasution M. Pandapotan Nasution M. Pandapotan Nasution Mambang , D.Elysa Putri Mambang, D. Elsya Putri Mambang, Elysa Putri Maya Syafira Mayani, Nurhikma Meutia, Cut Miftahul Jannah Minda Sar Lubis Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Ari Mukhtizar Muhammad Hizbullah Muhammad Pandapotan Nasution Muhammad Wahyu Ikhsan, Muhammad Wahyu Ikhsan Munaziatul Jannah Munthe, Herlina Nasri Nasri, Nasri Nasution , Muhammad Amin Nasution, Kartika Zsaskia Nasution, M. Pandapotan Nasution, Nur Sahadah Nasution, Wardah Natasya, Siti Adinda Nazirah, Nazirah Nazuhra, Oca Nelsa Fahira Ningtias, Anggitha Niswa, Khairun Nofa Lismandaria Novika Utami Nur Hanifah Nuraida Nuraida Nuratika, Eli Nurliansyah, Nurliansyah Nursyafira, Arini Nurul Hasanah Ovalina Sylvia Br. Ginting Pandapotan Nasution, M. Pertiwi, Rahma Prasetyo , Healthy Aldriany Purba , Intan Sabila Putri Puteri, Cut Intan Annisa Putri , Adilla Putri Intan Sari Putri Khairani Putri Mambang, D. Elysa Putri Rahayu, Yayuk Putri, Nadya Iwani Rafika, Intan Maya Rafita Yuniari Rafita Yuniart Rafliza , Rista Rahayu , Yayuk Putri Rahmadani , Adevika Rapita Yuniarti Rati , Yuliandini Rawitri, Kiki Ridho, Ahmad Rasyid Ridwanto Ridwanto Ridwanto Ridwanto Ridwanto Rifqi, M. Ainur Rina Azhari Ritonga , Septi Ani Riza Syafira Rizki, Ayu Fadillah RR. Ella Evrita Hestiandari Rukmana, Siti Sabila , Anisa Safira , Liyuza Safitri , Nurhaliza sahrianti, Hikmah Sari, Syilvi Rinda Sarmadansyah Sarmadansyah Sartika Daulay, Anny Sasnita, Merida Satri Situmorang, Rati Selfia Lestary Sepriani, Ananda Sinaga, Novita Yulianti Siregar , Anisah Siti Aisyah Jamil Situmorang, Lusi Grasia Situmorang, Rati Satri Sony , Suyefri Sri Harti Sri Natalia Saragih Sri Ria Ranti Sri Wahyuni Sri Wahyuni Sri Wahyuni Suci, Nurul Sulwiyatul K Sani Supiyani, Supiyani Syafira, Nona Syaiful Bahri Syalsabila Putri Syara, Nurdiani Syarifah Elena Gultom Tawir Rina Rezeki Tri Damaiyanti Trizaldi, Asep Try Santi Kisria Darsih Ummi Khairani Rambe Vera Estefania Kaban Wahdaniati , Tri Widya Sari Widya Sari Widya, Rizka Yanti, Rahma Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Apriani Br.Lubis Yuniarti , Rafita Yuniarti, Rafita Zannah , Muhamad Zikra Maqfirah Ziza Putri Aisyia Fauzi Zulmai Rani