p-Index From 2021 - 2026
13.453
P-Index
This Author published in this journals
All Journal Biology, Medicine, & Natural Product Chemistry Journal of Islamic Pharmacy Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Inovasi Farmasi Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat HERBAPHARMA : Journal of Herb Farmacological Borneo Journal Of Pharmascientech Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Mandala Pengabdian Masyarakat Well Being Jurnal EduHealth PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah STIKES Yarsi Mataram Jurnal Lentera International Journal of Science and Environment Journal of Engineering Science and Technology Management Business and Economic Publication Jurnal Ilmiah Multidisiplin Indonesia Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Media Akademik (JMA) Assoeltan: Indonesian Journal of Community Research and Engagement Contemporary Journal of Applied Sciences (CJAS) International Journal of Global Sustainable Research Indonesian Journal of Community Empowerment Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Penelitian Sains dan Kesehatan Avicenna IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia SEARCH: Science Education Research Gotong Royong Jurnal Pengabdian Kepada Masyarakat Al-Amin Interaksi : Jurnal Pengabdian Kepada Masyarakat Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara Jurnal Ilmu Kesehatan J-CEKI Joong-Ki Amaluna: Jurnal Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian HelFin Journal Multicore International Journal of Multidisciplinary (MIJM) International Journal of Science and Society (IJSS) Jurnal Kajian dan Inovasi Ilmu (JKII) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service Journal Abdimas Paspama Service Jurnal Bioteknologi & Biosains Indonesia
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Journal of Engineering Science and Technology Management

Prediction of Activity Spectra for Substances (PASS) Technology From Sambung Nyawa (Gynura procumbens (Lour) Merr) Saristiana, Yuneka; Prasetyawan, Fendy; Savitri, Lisa
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.206

Abstract

This study investigates the activity of various compounds as inhibitors, enhancers, agonists, antagonists, and substrates in biochemical pathways. The results indicate that the highest activity is observed in chlordecone reductase inhibition (Pa: 0.984, Pi: 0.001), followed by HIF1A expression inhibition (Pa: 0.969, Pi: 0.002) and membrane integrity agonist activity (Pa: 0.968, Pi: 0.002). Notably, several compounds exhibit significant inhibitory effects on enzymes such as peroxidase (Pa: 0.966), kinase (Pa: 0.958), and NADPH oxidase (Pa: 0.939). Additionally, CYP1A substrates and inducers demonstrate relevant metabolic interactions, indicating potential roles in drug metabolism. These findings provide insights into the pharmacological significance of these compounds, which may contribute to the development of novel therapeutic agents.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
Co-Authors Abd Rofiq Achmad Wahdi Adiyansyah Lukman Hakim Akhmal Muslikh, Faisal Akhmal, Faisal Alshol, Mohammad Firdaus Althaf Rajahala B Sinun Alves, Silvina Sandra X. Amanda, Cornelia Ana Amalia Anak Agung Indah Krisnadewi Anis Akhwan Dhafin Anis Akhwan Dhafin Anis Akwan Dhafin Anita Dwi Setyarini Apriliyani, Fitria Ardianto, Nanda Arifani Siswidiasari arikha ayu susilowati Arista Wahyu Ningsih Arsiaty Sumule Ary Kristijono Asrizal Azis Astutik, Widhi Ayu Angger Putri M. Soleh Azis, Asrizal Baarik Lana Fadli Bandhi Prasetya Nugroho Besan, Ema Jayanti Besan, Emma Jayanti Candra Arifin, Candra Chadra Arifin Chandra Arifin Charliandri Saputra Wahab Dafin, Anis Akhwan Dahbul, Nura Ali Dameria, Gempita Hutami Datin An Nisa Sukmawati Deo Rudita Febrian Waly Dewi Retno Puspitosari Dian Permatasari, Yunita Dyah Aryantini, Dyah Edda, Ilda Rambu Eka Hayati Rhomah Eka Nur Fatmawati Elfred Rinaldo Kasimo, Elfred Rinaldo Elsa Mahardika Dhafin Elsa Mahardika Putri Elsa Mahardika Putri Elsa Mahardika Putri Ema Tri Wulan Emma Jayanti Besan Erawati, Dyah Anisa Indri Evi Kurniawati, Evi Evi Nurul Hidayati Faisal Akhmal Muslihk Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fita Sari Fita Sari, Fita Fitrani Khansa Fitriani, Evi Tunjung Freitas, Maria Do Carmo Da Costa Gunawan Pamudji Widodo Hakim, Adiyansyah Lukman Hamzah, Hasyrul Hasriyani Hasriyani Hasriyani, Hasriyani Herman Hilmi, Mochammad Hanif Ibrahim Fadlannul Haq Ibrahim Irsyadul Ibad Ibrahim Iskandar Alfaris Ika Purwidyaningrum Ilhawa Zahra Imran, Arlan K Indrayanti, Dian Iramadona, Putri Ayu Isma Oktadiana Ivan Junius Mesak Juan Vega Mahardhika Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Karingga, Devangga Darma Kholis, Muhammad Akbar Nur Khumaeni, Eko Hidayaturrohman Koernia, Lilik Wahidah Kristjono, Ary Laili, Nur Fahma Leny Witaning Kusumati Lily Aina Lusiana Aprillia M. Wahyu Ariawan Ma'arif, Burhan Maharani Dwi Pratiwi Marhenta, Yogi Bhakti maswan daulay Ma’arif, Burhan Mebung, Konradus Klala Megasari, Elly Meri, Meri milda, ratna Mildawati, Ratna Mildwati, Ratna Muhammad Alviyan Shutiawan Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Muslihk, Faisal Akhmal Muslikh, Faisal Nanda Ardianto Nanda Ardianto Neni Probosiwi Nimas Ayu Rahardini Nina Nur Jannah Nisa Azzahra Dentika Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Octavian Ashido Nababan Okky Intan Mawarni Okky Intan Mawarni okta, isma Oktadiana, Isma Permata, Agung Prasetyo Nugroho, Bandhi Prayoga Fery Yuniarto Prayogi, Syaiful Purnomo Puspitosari, Dewi Retno Putri, Elsa Mahardika Raharjo, Susilo Margining Ratna Mildawati Ratno Setyobudi Restyana, Anggi Rhomah, Eka Hayati Rika Wahyu Pujiastini Rochmad Krissanjaya Rofiq, Abd Rohmah, Eka Hayati Rosa Juwita Hesturini Sado, Yosep Mansen Salim Efendy Salmasfattah, Novyananda Salmasfattah, Novynanda savitri, Lisa Setyawan, Ferdinta Daniasta Shinta Mayasari Shinta Mayasari Shutiawan, Muhammad Alviyan Siti Nur Maulita Sugeng Rianto Sugeng Santoso Susilo Margining Raharjo Syntia Tanu Juwita Tri Wulan, Ema Tsamrotul Ilmi Wahab, Charliandari Saputra Widhi Astutik Widiyastuti, Asih Winartiana Winartiana, Winartiana Wisnu Haryo Widyoko Wulan, Ema Tri Yanti, Novirma Yogi Bhakti Marhenta Yosep Mosse Yuneka Sarisitiana Yuneka Saristiana Yuniarto, Prayoga Feri Yunita Dian Permatasari Zahra, Ilhawa Zenmas, Syendriva Zeptyan