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16. Healing Process Of Burns (Vulnus combustion) Degrees IIB Using Mixed Leaf (Spondias dulcis F.) Fresh And Dry With Vaselin In Rats (Rattus Norvegicus) Ummu Balqis; Mirna Safrani Fauzi; Zuhrawati NA; Nazaruddin Nazaruddin; Razali Daud; Abdullah Hamzah; Darniati Darniati
Jurnal Medika Veterinaria Vol 13, No 1 (2019): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v13i1.4310

Abstract

           The aims of this research was looked to determine the healing process of burns  Grade II B using a mixture of fresh and dried leaf kedondong with vaseline white rats (Rattus norvegicus). Animals used were 18 rats. This study was designed using three treatment groups namely (KI) vaseline, (KII) mixture of crushed leaves and fresh kedondong (KIII) mixture of crushed dried leaves kedondong and each two replications. Burns made on the backs of mice and the treatments are done twice a day for 21 days.Observation research parameter is the description of macroscopic and microscopic observed at day 7, 14, and 21 in the skin tissue with hematoxylin and eosin staining. The observation of macroscopic studies showed that the formation of a reddish color, presence of edema, and loss of the fastest consecutive scab is KI, KIII, and KII, while the formation of a scab fastest respectively KIII, KI and KII. The observation of histopathology showed on day 7, KI, KII and KIII found inflammatory cell infiltration, hemorrhage and edema with the spread of many.on the 14th day of KI and KII infiltration of inflammatory cells and their udema much, whereas KIII inflammatory cell infiltration decreased, and hyperemia increase, on the 21st day KI, KII and KII inflammatory cell infiltration, hyperemia and hemorrhage spread with a little, but KI and KII oedemanya still being spread. Based on the results of this study concluded that KIII accelerate the healing process of burns on rats
Histopathology of Heart Rats (Rattus norvegicus) Due to the Use of Cooking Oil Siti Aisyah; Ummu Balqis; Eko Karunia Friyan
Jurnal Medika Veterinaria Vol 8, No 1 (2014): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v8i1.3346

Abstract

This research aims to study the histopathological picture of rats (Rattus norvegicus) heart as a result of the provision of waste cooking oil3x, 6x, and 9x frying. This study used 20 male white rats (Rattus norvegicus) weighing of ± 300 g. Rats were grouped into 4 treatment groups,adapted for one week, feed and drink ad libitum. The second week to eight week rats were given orally cooking oil every day with a dose of 1 ml. A group of rats was given cooking oil (negative control). Group B, C, and D were given cooking oil 3x, 6x, and 9x frying. Mi ce were euthanizedafter 60 days, then necropsied to collect the heart. Heart was then put into Neutral Buffered Formalin (NBF) for fixation, then follow withhistopathology preparation. Parameters measured were hyperemia, hemorrhage, degeneration, necrosis of the heart. Results were analyzeddescriptively with the scoring system. Test results are grouped into three categories, namely, mild (+), moderate (++), and weight (+++). Thehystopathological results of the heart found were an increasing number of hyperemia, hemorrhage, degeneration, necrosis as a result of thefrequency of frying.____________________________________________________________________________________________________________________Key words: heart, cooking oil, rats 
20. The Histological Structure of Tegal Duck (Anas javanicus) Spleen at Different Age Nabila Latifa Hafizsha; Hamdani Budiman; Hamny Hamny; Dian Masyitha; Cut Dahlia Iskandar; Ummu Balqis; Muhammad Jalaluddin
Jurnal Medika Veterinaria Vol 11, No 2 (2017): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v11i2.3522

Abstract

The aim of the  study was to determine the histological structure of tegal duck (Anas javanicus) spleen according to ages variation. One month, 2 month and 3 months of tegal duck were used as the sample of this study. The spleen of each duck was analyzed by Hematoxylin-Eosin (HE) method, then observed under light microscope. The result of this study performed there were the differences of histological structure of the ducks spleen. The capsule thickness had increased along with increasing age, which was 16.0 ± 1.0 µm; 25.3 ± 2.5 µm; and 29.0 ± 1.0 µm. The boundary between the two pulp in the tegal duck 3 months  old more obvious than 1 month or 2 months old. The diameter of white pulp had increased in the oldest duck. It can be concluded that the development of spleen histological structure was more perfect with the  increasing age of tegal duck.
EFEK PENINGKATAN SUHU TERHADAP JUMLAH LEUKOSIT IKAN NILA (Oreochromis niloticus) (The Effect of Temperature Increase on Leukocyte Count of Nile Tilapia (Oreochromis niloticus)) Nauval Gibran Lubis; Sugito Sugito; Zuhrawati Zuhrawati; Zuraidawati Zuraidawati; Nuzul Asmilia; Hamny Hamny; Ummu Balqis
Jurnal Medika Veterinaria Vol 10, No 1 (2016): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v10i1.4033

Abstract

The aim of this research was to find out the effect of water temperature increase on leucocyte count of nile tilapia. The blood sample from 9 tilapia with weigh of 40-50 g were used in this study. The research was conducted using completely randomized design (CRD) with 3 treatments and 3 replications. Treatment P1 as a control with aquarium temperature was maintained at 29±1 C. Water temperature in treatment P2 and P3 was maintained at 32±1 C and 35±1 C respectively. The aquarium size in each treatment group was 80x60x40 cm with height of water 30 cm. The treatment was done for 15 days and on day 16th, the blood were collected from caudal vein. Data were analyzed with analysis of variance (Anova) and followed with Duncan's multiple range test. The result showed that total leucocyte count (x 105/mm3) of nile tilapia in group P1, P2, and P3 were 3.08±0.88, 1.70±0.52, and 1.69±0.20 respectively. lts showed that an increase in temperature significantly affect (P0.05) the leucocyte count of nile tilapia. The conclusion of this research is the increase in water temperature in aquarium decrease the leucocyte count of nile tilapia.
Healing Process Of Burns Using Ambarella Leaf (Spondias dulcis F.) and Vaselin in Rats (Rattus norvegicus) Ummu Balqis; Dian Masyitha; Fera Febrina
Jurnal Medika Veterinaria Vol 8, No 1 (2014): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v8i1.3318

Abstract

The aims of this research was to find out the healing process of second degree burn in rats (Rattus norvegicus) using ambarella leaf (Spondias dulcis F.) and vaselin on histopathologically. The research consisted of 4 treatment groups and 3 rats each, P1(double distilled water), P2 (ambarella leaf + double distilled water), P3 (vaselin), and P4 (ambarella leaf + vaselin). Treatment was done twice a day for 21 days. The research parameters are inflammatory reactions and distribution of collagen tissue. Data were analyzed descriptively. The results showed that on day 7, P1 and P3 many infiltration of inflammatory cells, hemorrhage and edema, on P2 and P4 here more infiltration of inflammatory cells, hemorrhage and edema. On the day 14th of many inflammatory cell infiltration, collagen tissue diffuse very thin on were described P1 and P3, and visible presence of new blood vessels was found on P4. On day 21th infiltration of inflammatory cells still present on (P1), there were a lot of new blood vessels on P2, there has been a process of epithelialization (P3), epidermis formed and collagen tissue spread very densely on P4. Based on the results of this study it can be concluded that administration of ambarella leaf and vaselin can speed up the healing process of burns in rats compared with other treatments.Key words: ambarella leaf, burn, vaselin
EFEK PEMBERIAN MINYAK JELANTAH TERHADAP GAMBARANHISTOPATOLOGIS HATI TIKUS PUTIH (Rattus norvegicus) Siti Aisyah; Hamdani Budiman; Dessy Florenstina BR. G; Dwinna Aliza; M Nur Salim; Ummu Balqis; T. Armansyah
Jurnal Medika Veterinaria Vol 9, No 1 (2015): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v9i1.2989

Abstract

Penelitian ini bertujuan mempelajari gambaran histopatologi hati tikus putih (Rattus norvegicus) akibat mengonsumsi minyak jelantah.  Duapuluh ekor tikus berumur 3 bulan dengan bobot badan ±250 g dibagi atas 4 kelompok perlakuan dan setiap kelompok terdiri at as 5 ekor. Perlakuan K1 (minyak goreng curah), K2, K3, dan K4 (minyak jelantah 3x, 6x, dan 9x pemakaian). Perlakuan dilakukan selama 60 hari, dan pada hari ke 61 dilakukan eutanasia yang dilanjutkan dengan nekropsi. Hati tikus diambil dan difiksasi dalam larutan buffered neutral formaline 10%untuk diproses sediaan histopatologis dan diwarnai dengan hematoksilin dan eosin (HE). Hasil penelitian menunjukkan bahwa hati berwarna coklat kehitaman, bengkak, dan ditemukan nodul multi fokal dengan konsistensi padat. Secara histopatologi terjadi peningkatan kongesti, degenerasi cloudy swelling, dan nekrosis sel
33. Efficacy of Jatropha(Jatrophacurcas L.) Sap Cream in Inflammation Phase of Wound Healing on Mice Skin Hidayati Hidayati; Muhammad Nur Salim; Ummu Balqis; Dian Masyitha; Cut Dahlia Iskandar; Darmawi Darmawi; Abdul Harris
Jurnal Medika Veterinaria Vol 13, No 2 (2019): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v13i2.14565

Abstract

This study aim to know the efficacy of the jatropha sap cream toward the inflammatory phase of wound healing on the skin of mice. This study used 9 male mice, with 25-40 grams weights and 2-3 months old.  Male mice receiveddivided into 3 groups, and3 deuteronomy.The cut is done in the back as 2 cm long. Wound care is done twice a day at 08.00 am and at 18.00 pm for 3 days. The treatment I (PI) cuts smeared a cream base (as a negatif control); treatment II (PII) smeared 10% jatropha sap cream; and the treatment III (PIII) smeared 0.1% sulfadiazine  (as a positive control).Created a skin sample preparation microtechnic stained with hematoxylin-eosin (HE). The result on the number of infiltration of inflammatory cells and neovascular on PI; PII; and PIII were 402,00 ± 7,21 and 14,00 ± 5,57; 248,67 ± 1,53 and 34,67 ± 7,51; and 343,00 ± 8,89 and 28,00 ± 5,00  (P0,01). Based on the result it be concluded the treatment of 10% jatropha sap cream can speed up the process of the inflammatory phase of wound healing in the skin of mice.
Temuan Kejadian Penyakit Tetelo pada Kadaver Unggas yang Dikirim ke Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala Etriwati Etriwati; Muhammad Nur Salim; ummu Balqis; Siti Aisyiah; Nazaruddin Nazaruddin; Aminuddin Aminuddin; Rusli Rusli; Divina Dinda Hayati
Jurnal Veteriner Vol 24 No 3 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.3.313

Abstract

Penyakit tetelo (Newcastle disease) merupakan penyakit penting yang sangat mudah menular dan menyebabkan kematian tinggi pada unggas rentan. Penelitian ini bertujuan untuk mengetahui kejadian penyakit tetelo pada unggas yang dinekropsi di Laboratorium Patologi, Fakultas Kedokteran Hewan (FKH), Universitas Syiah Kuala (USK), Banda Aceh. Sampel penelitian dikoleksi dari 239 ekor cadaver unggas terdiri dari ayam pedaging/broiler, ayam petelur/layer, ayam kampung/buras dan unggas lainnya yang dinekropsi di Laboratorium Patologi FKH USK periode Juli sampai November 2019. Sampel yang dikoleksi yaitu trakhea, proventrikulus, seka tonsil dan otak. Sampel dipilih berdasarkan perubahan patologi anatomi diduga penyakit tetelo, selanjutnya dibuat sediaan histopatologi dan imunohistokimia dalam parafin blok. Hasil penelitian menunjukkan bahwa unggas yang dinekropsi dan mati akibat penyakit tetelo sebanyak 106 ekor, diduga fowl cholera 52 ekor, infectious bronchitis 25 ekor, avian influenza 22 ekor, colibacillosis 14 ekor, chronic respiratory disease 7 ekor, coccidiosis 5 ekor, infectious laryngotrcheitis 4 ekor, infectious bursal disease 2 ekor dan coryza 2 ekor. Simpulan dari penelitian ini bahwa cadaver unggas yang dinekropsi di Laboratorium Patologi FKH USK periode Juli sampai November 2019 sebanyak 44,4% (106/239) terdiagnosa mati akibat terinfeksi penyakit tetelo.
Phytocompounds of Nigella sativa seeds extract and their neuroprotective potential via EGR1 receptor inhibition: A molecular docking study Kulsum, Kulsum; Syahrul, Syahrul; Hasbalah, Kartini; Balqis, Ummu
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.173

Abstract

Bioactivity of Nigella sativa seed extract has the potential as a neuro-protector, offering its promising utility in the clinical setting for brain injury management. This study aimed to identify the phytocompounds contained in the extract of N. sativa seeds and further screen their respective neuronal anti-inflammatory activities in silico. The extract of N. sativa seeds was prepared through successive maceration using non-polar to polar solvents (n-hexane and ethanol, respectively). The phytocompounds in the ethanolic extract were initially identified through qualitative analysis and further analyzed with gas chromatography-mass spectrometry (GC-MS). The spectral data were compared with the compound library for identification. The identified phytocompounds were then simulated computationally for their binding affinities toward the active pocket of early growth response-1 (EGR1) receptor (PDB: 14r2a). We found that the ethanolic extract of N. sativa seeds were predominantly constituted of hexadecanoic acid, ethyl ester (17.15%); linoleic acid ethyl ester (15.0%); octadecanoic acid (13.26%); and ethyl oleate (10.38%). The binding affinity of the phytocompounds ranged from -7.49 kcal/mol (methyl palmitoleate) to -14.31 kcal/mol (9-hexadecanoic acid, methyl ester), with 12 compounds having binding affinity < -10 kcal/mol. In conclusion, ethanolic extract of N. sativa seeds are rich with fatty acids that have active as anti-inflammatory and may exert neuronal protection by inhibiting EGR1 receptor. Studies using animal models to confirm the activity are warranted.
Oxygen saturation profile in traumatic brain injury animal model after propofol administration Kulsum, Kulsum; Syahrul, Syahrul; Hasbalah, Kartini; Balqis, Ummu; Suryadi, Taufik
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.189

Abstract

Traumatic brain injury (TBI) is a traumatic that often leads to death due to untreatable cerebral hypoxia, indicated by oxygen saturation of <90%. Cerebral hypoxia is rarely monitored and thereby often overlooked as a cause of mortality and monitoring oxygen saturation is an accurate method to detect the condition. Propofol, an anesthetic agent, is commonly used in the management of TBI; however, its effect on brain tissue and cerebral hypoxia in TBI cases is not well understood. The aim of this study was to evaluate the profile of oxygen saturation in TBI animal model after propofol administration. A laboratory experimental study was conducted, involving 18 male Rattus novergicus rats (aged 4–8 weeks with weight between 150–200 grams) divided into three different treatment groups (non-TBI, TBI without propofol, and TBI with propofol). Oxygen saturation was measured regularly from day 1 to day 8 using pulse oximetry. The oxygen saturation percentages were compared between the TBI rats with and without propofol administration using independent Student t-rest. The results revealed significant reductions of oxygen saturation levels of animals within propofol-treated TBI group compared to that of the untreated-TBI group (p<0.05), with the average oxygen saturation ranging from 80.8%±6.96% vs 86.8%±5.48%. This finding suggests a reducing effect of propofol administration on oxygen saturation levels in rats with TBI and this potentially causes cerebral hypoxia.
Co-Authors . Azhar . Darmawi . Darmawi . Darmawi . Darniati . Fakhrurrazi . Ismail . Muthmainnah . Muttaqien . Nurliana . Rasmaidar Abdul Harris Abdul Harris Abdul Harris Abdul Harris Abdullah Hamzah Abdullah Hamzah Adi Firmansyah Afifah Nur Oriyasmi Aminuddin Aminuddin Amiruddin Amiruddin Amiruddin Amiruddin Ananda Putri Lestari Angreini, Meliyantika Annisa, Aiza Aprilia Wardana Aprilia Wardana Arman Sayuti Arman Sayuti Astri Wulandari Awaluddin Awaluddin Ayu Agita Ginting Azhar Azhar Azhar Azhar Azhar Azhar Azhari Azhari Azmi Zul Bagus Dwijayanti bakti suganjar Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto budianto panjaitan Connie Januari Cut Dahlia Iskandar Cut Mentari Fatihah Amran Cut Nila Thasmi Cut S. Utami Cut Syeila Utami Darmawi . Darmawi D Darmawi D Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Denny Irmawati Hasan Dessy Florenstina BR. G Dian Masyitha Dian Masyitha dian masyithah Didik T Subekti divina dinda hayati Doly Ihsan Siregar Dwina Aliza Dwinna Aliza Dwinna Aliza Dwinna Aliza Eko Karunia Friyan Eliawardani Eliawardani Elsa Mariane Ramadani Erdiansyah Rahmi Erdiansyah Rahmi Erina Erina Erina Erina Erina Erina Erwin Erwin Erwin Erwin Erwin Erwin Erwin Erwin Etriwati E EVA FITRIYANINGSIH Eva Fitriyaningsih Fachriyan H Pasaribu Fachriyan H Pasaribu Fachriyan H. Pasaribu Fachriyan H. Pasaribu Fachriyan Hasymi Pasaribu Fachriyan Hasymi Pasaribu Fadli A Gani Faisal Mustafa Farida Athaillah Farida Athaillah Farida Athaillah Farida Athaillah Febiola Rama Sari Febiola Rama Sari febri ramadana Fera Febrina Ferdian, Riyan Fitriani Fitriani Fitriani Fitriani Fitriani Fitriani Gholib Gholib Ginta Riady Hamdan Hamdan Hamdani Budiman Hamdani Budiman Hamny Sofyan Hasan, Denny Irmawati Hasan, Desi Salwani Hasbalah, Kartini Helmi, T. Zahrial Henni Vanda Hidayati Hidayati Ismail Ismail Ismail Ismail Juli Melia Kulsum Kulsum, Kulsum laksmita patma ningrum M Aman Yaman M Daud AK M Jalaluddin M Nur Salim M Nur Salim M. Hanafiah M. Hasan M. Nur Salim Mahdi Abrar Maimun Syukri, Maimun Marwiyah M Maryam Maryam Maryam Maryam Masda Admi Mirna Safrani Fauzi Muhammad Fathur Ridho Muhammad Hambal Muhammad Hambal Muhammad Hambal Muhammad Hanafiah Muhammad Jalaluddin Muhammad Jalaluddin Muhammad Nur Salim Mulyadi Adam Mulyadi Mulyadi Muslim Akmal Muslina Muslina Muslina Muslina Mustafa Sabri Muttaqien Bakri Muttaqien Muttaqien Muttaqien Muttaqien N. Nazaruddin NA, Zuhrawaty Nabila Latifa Hafizsha Nabilah Putroe Agung Nanda Afrizan Nauval Gibran Lubis Nazaruddin Nazaruddin Nazaruddin Nazaruddin Nora Usrina Nur rachmatika Nur Salim Nurjannah Annah Nurliana Nurliana Nurul Fitria Nuzul Asmilia Nuzul Asmilia Rachmad Suhanda Rahmat Nazif Rasmaidar R Rastina Rastina Raudia Tuzzahra Razali Daud Razali Daud Razali Daud resti aulia putri Retno D Soejoedono Retno D Soejoedono Retno D. Soejoedono Retno D. Soejoedono Retno Damayanti Soejoedono Rhoza Indra Rinidar Rinidar Rinidar Rinidar Risa Tiuria rizki nurliyanti siregar Rosmaidar Rosmaidar Rosmaidar Rosmaidar Rosmaidar Rosmaidar Roza Dea Silvina Rusli Rusli Rusli Rusli Samadi Samadi sariati latif Siti Aisyah Siti Aisyah Siti Aisyah Siti Aisyiah sri yuliati Sugito - Sugito Sugito Sugito Sugito Sukma, Zahwa Tamara Syafruddin Syafruddin Syafruddin Syafruddin Syahrul Syahrul T Armansyah TR T. Armansyah T. Armansyah T. Armansyah TR T. Fadrial Karmil T. Fadrial Karmil T. Reza Ferasyi T. Zahrial Helmi Tapielaniari - Taufik Suryadi, Taufik Teuku R. Ferasyi Triva Murtina Lubis Utami, Cut Suraiya Wahyuni Vinky Claudya Fransiska viola erian Wahyuni, Sri Widya Wati winaruddin winaruddin Winaruddin Winaruddin Yudha Fahrimal Yudha Fahrimal Zainuddin Zainuddin Zainuddin Zainuddin Zamzami, Rumi Sahara zena fisdiora Zico, Hanifa Zuhrawati NA Zuhrawati Zuhrawati Zuraidawati Zuraidawati