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The Effect of Ethanol Extract of Phaleria macrocarpa Fruit Combined with Deferiprone on Peripheral Blood Counts in Iron-Overloaded Rats Rahma, Rahma; Estuningtyas, Ari
Pharmaceutical Journal of Indonesia Vol. 10 No. 1 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.010.01.4

Abstract

Iron overload poses health risks due to its role in reactive oxygen species (ROS) formation. We evaluated the efficacy of ethanol extract of Phaleria macrocarpa Fruit (PM) against deferiprone-induced alterations in hematological parameters in iron-overloaded rats. Six groups were studied: control, iron-overloaded (IO), deferiprone (D), PM, and two combination groups (DPM-1 and DPM-2). Hematological parameters were assessed at baseline (week-3) and post-treatment (week-8), including total white blood cell count (WBC), lymphocytes (LYM), granulocytes (GRAN), platelet count (PLT), red blood cell count (RBC), hemoglobin (Hb), mean corpuscular volume (MCV, mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). Iron overload induced mild changes, with significant increases in MCV, alongside non-significant increasing trend in LYM and decreasing trends in other parameters. Deferiprone led to significant decreases in RBC and Hb, with non-significant increases in MCV and non-significant decreases in other parameters. PM group showed significant decreased in PLT, RBC, and Hb, and a significant increase in MCV and MCH, accompanied by non-significant increase in MCHC and non-significant decreasing trends in WBC, LYM, and GRAN. Combination treatment of ethanol extract of Phaleria macrocarpa fruit with deferiprone at usual dose (DPM-1) resulted in significant changes, including decreases in GRAN, RBC, Hb and MCHC and increasing MCV, accompanied by non-significant increase in MCH and non-significant decrease in other parameter. The magnitude of parameter changes appears smaller when the dose of deferiprone is reduced in the combination group (DPM-2) compared to the DPM-1 group. PM alone exhibited minimal effects on hematological parameters compared to deferiprone (except for PLT), indicating the need for further research to elucidate the specific cellular and molecular pathways influenced by these treatments to support the use of PM as adjunct therapy in patients with iron overload.
Co-Authors AA Sudharmawan, AA Abd Farid Lewa Abdullatif, Ahmad Afidah, Andi Nisa Fathimiyah Agian Jeffilano Barinda Agustia, Putri Lestari Alauddin, Andi Alfi Rahmi, Alfi Alrefi, Alrefi Amanda Anatasya Aminuyati Amir, Rahma Melati Andi Ahmad Chabir Galib Andi Dian Angriani, Andi Dian Andi Saifah Anisaturrahmi, Anisaturrahmi Annisa Annisa Ardiputra, Muh Akbar Ari Estuningtyas, Ari Arif, M Asriadi Asriadi Astri Astri, Astri Astuti, Serli Widia Azis, Andi Mattotoran Bambang Sardi BIDJAI, TOMI Burhamzah, Muftihaturrahmah Choirun Niswah, Choirun Christin Rony Nayoan Dasril Daud, Dasril DEWI FITRIANI Djayadin, Chairunnisa Dona, Fikhrenia Rima Dwi Wahyuni Hamka ELIHAMI, ELIHAMI Ernawati, Dwi Wiwik Fadjriah, Rasyika Nurul Failur Rahman Faisal Faisal Faridah Faridah Fatma Zuhra Fatrika, Fitria Firmansyah Firmansyah Fitriani Nur, Fitriani Gina Andyka Hutasoit Gina, Gina Guli, Musjaya Haerani harun Hafiz, Abdul Halim, Fauziatul Hartono Hartono Hasibuan, Rabitah Hanum Hendrik, Deny Hepriyanti, Lisa Herlian, Herlian Husnidar, Husnidar I Gusti Nyoman Surya Utama I Putu Fery Immanuel White Ibtisam Ibtisam, Ibtisam Ika Parma Dewi Imtihanah Amri Inayah, Faidul Irsyadunas, Irsyadunas Irwan Irwan Ismaya Ismaya Jannah, nurjannah Jaya, Asman Jayawarsa, A.A. Ketut Joharlinda, Joharlinda Junita Ratna Sari Karianti, Ni Ketut Kasinyo Harto Ladaka, Laraswati S Laendatu Paembonan Liestiany, Elly Lilianti, Lilianti Lisa Lisa, Lisa Lopo, Christian Lopo, Wigia Hanalia Lusia Salmawati Lusty Firmantika M. Sabir, M. Sabir Maningtyas, Diva Mardeli Mardeli Marinawati Ginting Marniati Marniati, Marniati Marsuki, Andika Masfufah Masfufah, Masfufah Masnah, Masnah Matda Yunartha Maulana , Raditya Alvin Merli, Merli Miftahul Jannah Miranti Miranti Missouri, Randita Mochammad Hatta Mochammad Imron Awalludin Muhammad Indar Pramudi Muhammad Syukur Munkizul Umam Kau Musdayati, Musdayati Nadirah Rasyid Ridha, Nadirah Rasyid Nasir Nasir Nasir, A. Muhajir Ngatijo Ngatijo Ngatimin, Dachruddin Nova Nova Novianti Novianti Nur Fahri Tadjuddin Nur Hasan Nuranbiya, Audry Nurhaliza, Dinda Nurhijatina, Haviva Patoding, Seprinus Poku, Asraty Prawiro, Sumarno Reto Puji, Puji Putra, Dodi Pasila Putri, Ayu Sekarani Damana Putri, Monica Rachmawaty Rachmawaty, Rachmawaty Rahmawati, Nurul Dina Ramadanil Pitopang RAMADHAN, SYAIFUL Rasid, Rasid Rasyid, Riyadh Retno Sari Reva, Reva Riadhus Sholihin Ridwan, Madinatul Munawwarah Ririk, Ririk Rizandri, Dhavi Rizki, Sari Rosa Dwi Wahyuni Rosmiati Rosmiati RR. Ella Evrita Hestiandari Safarati, Nanda Safaruddin Sahrul Salingkat Saipul Annur Salam, Fadlillah Salam, Salam Salingkat, Sahrul Sarah Nadiya Sariwulan, Taty Sartika Arifin Satrio Junaidi Sawitry, Maryanti Setiadi, Kusno Siti Khaulah, Siti Khaulah Siti Patimah Siti Zubaidah Sobirin Sobirin srimarjayanti, srimarjayanti St. Nur Humairah Halim Stang Stang Sudin, Sudin Suharti Sukatin, Sukatin Sulaeman Miru Suryadi Hadi Sutari Sutari Syahdan Syahdan, Syahdan Syamsuriyawati, Syamsuriyawati Syarifuddin Syarifuddin Tahir, M. Yusuf Takdir Takdir, Takdir Tallesang, Mukthar Tri Wahyudi Udin, Fitra Ulva, Maria Veryawan, Veryawan Wahyudi, R.Firdaus Wan Prala, Hendri White, I Putu Ferry Immanuel White, IPFI Widajandja, I Nyoman Yovi, Arsil Yuniar Yuniar Yusdiana, Yusdiana Zaiyad Zubaidi Zulkifli Makkawaru Zulkipli Lessy