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All Journal SAINSMAT bionature Jurnal Nalar Pendidikan BIOTROPIA - The Southeast Asian Journal of Tropical Biology Unnes Science Education Journal Jurnal Pendidikan Biologi Jurnal Penelitian Pendidikan IPA (JPPIPA) UNM Journal of Biological Education Biology Teaching and Learning Jurnal IPA Terpadu Jurnal Biologi Tropis Pendas : Jurnah Ilmiah Pendidikan Dasar Biosel: Biologi Science and Education Anterior Jurnal JFL : Jurnal Farmasi Lampung JISIP: Jurnal Ilmu Sosial dan Pendidikan Jurnal Biotek Jurnal Mangifera Edu UNM Environmental Journals Biopendix: Jurnal Biologi, Pendidikan dan Terapan Best Journal (Biology Education, Sains and Technology) Jurnal Biogenerasi Community Development Journal: Jurnal Pengabdian Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Journal of Community Service and Empowerment Indigenous Biologi JIHAD : Jurnal Ilmu Hukum dan Administrasi Bioeduca : Journal of Biology Education Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Kepada Masyarakat Patikala EDUBIOLOCK Stigma : Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Journal of Innovation and Research in Primary Education Indonesian Journal of Fundamental Sciences Journal of Biological Science and Education Biocaster : Jurnal Kajian Biologi Filogeni: Jurnal Mahasiswa Biologi Nanggroe: Journal Of Scholarly Service Seminar Nasional Hasil Penelitian LP2M UNM Ininnawa: Jurnal Pengabdian Masyarakat Nanggroe: Journal of Scholarly Service Prosiding Seminar Nasional Dies Natalis Universitas Negeri Makassar Abdi Kimia : Jurnal Pengabdian Masyarakat Jurnal Abdi Negeriku Bionature Sempugi: Journal of Community Service and Empowerment Jurnal Biosilampari: Jurnal Biologi
Yusminah Hala
Department Of Biology, Faculty Of Science And Mathematics, Makassar University, Makassar 90221, Indonesia
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Pemanfaatan CRISPR-Cas9 pada Antibodi Monoklonal untuk Terapi HIV Adhytama S, Ryan Putra; Hala, Yusminah
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January (In Progress)
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.843

Abstract

HIV infection remains a global health challenge with high rates of new infections and low levels of viral suppression, especially in middle-income countries. Antiretroviral therapy (ART) has significantly reduced morbidity and mortality, but has not been able to eliminate latent reservoirs so lifelong therapy remains necessary. In the last decade, monoclonal antibodies, particularly broadly neutralizing antibodies (bNAbs), as well as CRISPR-Cas9 gene-editing technology have emerged as innovative therapeutic approaches with long-term remission potential. bNAbs is able to neutralize a broad spectrum of HIV strains and activate immune effector mechanisms, including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, but cost limitations, viral resistance, and duration of effects limit its use as a substitute for ART. In parallel, CRISPR-Cas9 has demonstrated the ability to target HIV proviruses in the host cell genome and enable the engineering of immune cells to stably produce therapeutic antibodies. Pre-clinical studies show that B-cell engineering with CRISPR-Cas9 can maintain immune memory, perform isotype switching, and somatic hypermutation, thus creating "programmed immunity". The combination approach of bNAbs and CRISPR-Cas9 is considered promising because it is able to neutralize circulating viruses while removing latent proviruses, increasing the potential for functional cure. However, biological risks such as off-target effects, Cas9 immunogenicity, limitations of the delivery system, and the emergence of escape mutants remain challenges. This review shows that the integration of monoclonal antibodies with CRISPR-Cas9 opens up a new paradigm of HIV therapy, with the potential to improve efficacy, duration of protection, and decrease reliance on ART. Further research, including advanced phase clinical trials, is needed to ensure its safety, effectiveness, and feasibility of application in human populations.
DNA Barcoding sebagai Inovasi Bioteknologi untuk Identifikasi dan Konservasi Tanaman Lokal: Suatu Tinjauan Sistematis Syahriani; Hala, Yusminah
Biosel Biology Science and Education Vol. 15 No. 1 (2026): BIOSEL (Biology Science and Education: Jurnal Penelitian Sains dan Pendidikan)
Publisher : INSTITUT AGAMA ISLAM NEGERI AMBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33477/bs.v15i1.12116

Abstract

Limitations in accurate and efficient species identification techniques at various stages of development and sample conditions are major problems in the conservation of local plants. Conventional morphology-based identification approaches often encounter obstacles due to phenotypic variation and diagnostic character limitations. This study aims to examine the potential of DNA barcoding as a biotechnology innovation in supporting the identification and conservation of local plants. The research method used was a systematic literature study of national and international scientific articles published between 2020 and 2025. Data sources were obtained from the PubMed, Scopus, ScienceDirect, and Google Scholar databases, then analyzed thematically by grouping findings based on the type of genetic marker, identification procedure, and relevance to plant conservation. The results of the study show that DNA barcoding is a species identification technique carried out through the analysis of deoxyribonucleic acid sequences from specific standard marker genes. In plant taxonomy, chloroplast genes commonly used as genetic markers include ribulose bisphosphate carboxylase large chain, maturase K, and internal transcribed spacer. The genetic sequences obtained are then compared with a global database to accurately determine species suitability. This technique has been proven to provide fast and reliable species identification under various sample conditions. With these advantages, DNA barcoding has great potential as a key supporting tool in local plant conservation efforts. Keywords: DNA Barcode, Biotechnology, Plant Conservation
Co-Authors . Hasrah, . . Hijriah, . ., Hardiyanti ., Syafiuddin A. Irma Suryani A. Mushawwir Taiyeb, A. Mushawwir Abd Muis Adhytama S, Ryan Putra Adnan Adnan Adnan Adnan Ahmad Fudhail  Majid Akida Akida Alimuddin Ali Am, Septian Dwi Cahyo. Amalia, Riska Dina Amelia, Nila Andi Asmawati Azis Andi Asmawati Aziz Andi Bida Purnamasari Andi Faridah Arsal Andi Mu’nisa Andi Nurfaizah Yusuf Andi Rahmat Saleh Andri Adi Mustika Andri Adi Mustika, Andri Adi Angraeni, Andi Tirta Anisa Oktobianti , Andi Antonius Suwanto Aqilah Fauziyah MF AR, Mira Arhamar, A. S. Muhammad Arif, Armin Arifah Novia Arifin, Arifah Novia Arifin, Arifah Novia Ariya, A Aida Arni Arni Arsad Bahri Asdaniar, Asdaniar Asham Bin Jamaluddin Asmirah, Nurul Asnir Andriani Usman Astuti S, Dewi Atira, Aynun Azazi, Amalia Nur Citra Sakinah Dirawan, Gufron D Elsa Erlin, Charisniaty Ernawati Ernawati Fatmawati, Fatmawati Firdaus Daud Fitriani Fitriani Gufran D. Dirawan Gufran D. Dirawan, Gufran D. Hafsan, Hafsan Halifah Pagarra Hammado, Nururrahmah Hartati, A. Hartina Harjuna Hartono Hartono Hasniar Hasniar, Hasniar Herlina Rante Hilda Karim I Ketut Suada Idris, Irma Suryani Ismail Ismail Jamaluddin, Nurbina Septiani Khatimah, Khusnul Latif, Rahmawati Lodang, Hamka M. Nur, Risna Majid, Anna Marsa, Marsa Masrida, Masrida Mu'nisa, A. Muh. Junda Muh. Wahyudi Jasman Muhammad Arsyad Muhammad Danial Muhammad Farid Muhammad Junda Muhammad Wiharto MUHAMMAD ZAIRIN Jr. Muhiddin Palennari Muis, Sahribulan Muliana Mulianti Muliyati M Mulyadi, Hasnidah Munandar, Wahidatul Mushawwir Taiyeb Muthmainna, Nur Muthmainnah, Thiara Adzkia Nani Kurnia Nani Kurnia, Nani Nur Aida, Nur Nur Veryani, Andi Nur wahidah Nurlia Nurlia Oslan Jumadi Oslan Jumadi Pagarra, Halifah Rachmawaty Rachmawaty Muchtar Rachmawaty Muchtar, Rachmawaty Rachmawaty Rachmawaty, Rachmawaty Rachmawaty, Rachmawaty Rahmawati, Rahmawati Ramadani, Rani Ramlawati Ramlawati Rauf, Asnaeni Razak, Muliana Resti Handayani, Resti RIDWAN AFFANDI Risma Syam Rivai, Andi Tenri Ola Rosdiana Ngitung Ruli, Fitha Febrilia Sadriani, Andi Sahodding, Sahodding Sahribulan Saleh, Andi Rahmat Saniah, St Sirniawan, Sirniawan Sitti Saenab Sitti Saenab, Sitti Sri Wahyuni St. Fatmah Hiola Suradi Tahmir, Suradi SURIYANTO Syahriani Syamsiah, Syamsiah Syamsul Tahmir, Suradi Taiyeb A. Mushawwir Taiyeb, Andi Mushawwir Tenri Ampa Nurfitria Papada, Andi Tenri Lalla, Putri Pati Widiana, Riska Dina Wiji Astuti, Wiwik Wirna Arsyad Wulandari R, Wulandari R Yeheskiel, Wini Yuliana Yuliana Yundari, Yundari Yusuf, Syahriani Yusuf, Yusnaeni Zulkarnaen Zulkarnaen