Article Per Year (5 Year)
p-Index From 2021 - 2026
14.163
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Majalah Kedokteran Bandung MEDISAINS Pharmascience BERITA BIOLOGI The Indonesian Biomedical Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Komunitas Buletin Farmatera Indonesian Journal of Medicine SCIENTIA JOURNAL Journal of Humanities and Social Studies Jurnal Kesehatan Unnes Journal of Public Health Media Karya Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Maternitas Kebidanan Jurnal Keperawatan Priority Contagion: Scientific Periodical Journal of Public Health and Coastal Health Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains An-Nadaa: Jurnal Kesehatan Masyarakat Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan INFOKUM Indonesian Journal of Global Health research Jurnal Scientia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Ilmiah METADATA International Journal Of Science, Technology & Management (IJSTM) JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal JURNAL MITRA PRIMA Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal Info Sains : Informatika dan Sains JIDAN (JURNAL ILMIAH KEBIDANAN) Journal of Current Health Sciences International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) Eduvest - Journal of Universal Studies JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Jurnal Pengabdian Masyarakat dan Riset Pendidikan Haga Journal of Public Health (HJPH) Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics Malahayati International Journal of Nursing and Health Science Folia Medica Indonesiana
Ginting, Chrismis Novalinda
Faculty Of Medicine, University Of Prima Indonesia, Medan, North Sumatera, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

Published : 137 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : HAYATI Journal of Biosciences

 1 
Apoptotic Potential of Secretome from Interleukin-Induced Natural Killer Cells toward Breast Cancer Cell Line by Transwell Assay Wahyu Widowati; Diana Krisanti Jasaputra; Teresa Liliana Wargasetia; The Fransiska Eltania; Alya Mardhotillah Azizah; Mawar Subangkit; I Nyoman Ehrich Lister; Chrismis Novalinda Ginting; Ermi Girsang; Ahmad Faried
HAYATI Journal of Biosciences Vol. 27 No. 3 (2020): July 2020
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.27.3.186

Abstract

Breast cancer (BC) is the number one cause of deaths from cancer in women. Metastasis in BC is caused by immunosurveillance deficiency, including impairment of Natural Killer (NK) cell maturation, low NK activity, and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukin 15 (IL15) against BC cells. Human recombinant IL15 was used to induce NK cells. To evaluate the potential of IL15 in inducing NK cells, we measured the activating and inhibiting receptors (NKG2D, NKG2A), apoptotic potency of NK cells on BC cells (MCF7) using transwell assay. The IL15 inducer on the NK cell were measured NKG2D, NKG2A gene expression with quantitative polymerase chain reaction (qPCR), (GzmB) secretion using ELISA, apoptotic gene expression of MCF7 using qPCR. IL15 increased NKG2D expression 4.01-9.13%, but IL15 could not affect toward NKG2A expression on NK cells. IL15-activated NK cells, inhibited BC cells proliferation, induced apoptotic BC cells 25.89-32.19%, induced apoptotic genes of BC cells bax, p53. IL15 increase NK activating receptor (NKG2D), inhibit BC cells proliferation, induce apoptotic percentage and induce apoptotic gene expression.
Screening and Molecular Identification of Endophytic Bacteria from Calamus caesius Blume with Potential as Antioxidant and α-Glucosidase Inhibitors Ginting, Chrismis Novalinda; Lister, Nyoman Ehrich; Girsang, Ermi; Fachrial, Edy
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.599-610

Abstract

Calamus caesius, traditionally used in Asian medicine for managing diabetes mellitus, is a promising source of endophytic bacteria due to its bioactive potential. This study aims to identify the potential of endophytic bacteria isolated from “Pakkat” (Calamus caesius Blume), a traditional food of North Sumatra, as a source of α-glucosidase inhibitors. These inhibitors, such as acarbose, are used to manage type 2 diabetes mellitus but have significant gastrointestinal side effects. This study focuses on isolating and characterizing endophytic bacteria that can produce natural inhibitors, potentially safer alternatives. Twenty endophytic bacterial isolates were successfully isolated, of which five were excluded due to hemolytic activity. Antioxidant activity was determined using the DPPH method, and isolates with the highest activity proceeded to α-glucosidase inhibitor testing. Molecular identification of potential isolates was performed through 16S rRNA gene amplification, and genomic DNA sequencing utilized the Oxford Nanopore Technologies platform. Secondary metabolite analysis was performed using antiSMASH, and gene cluster comparison with CAGECAT. Of 15 isolates, LTUP1.3 (Bacillus cereus) exhibited 86.6% α-glucosidase inhibitor activity, close to the positive control (88%). Although in Bacillus cereus LTUP1.3 no secondary metabolites were found that act as α-glucosidase inhibitors, three enzymes have similarities with enzymes found in Actinoplanes that play a role in acarbose biosynthesis namely dTDP-glucose 4,6-dehydratase RffG, glucose-1-phosphate thymidylyltransferase rmIA and glucose-1-phosphate adenylyltransferase glgC. These results suggest that Bacillus cereus strain LTUP1.3 has a potential biosynthetic pathway similar to the acarbose biosynthetic pathway in Actinoplanes. However, further confirmation is required to establish its overall acarbose production capability.
Co-Authors Ade Irma Suryani Adek Amansyah Aditya Kurnia, Muhammad Adrian Adrian Adrian Adrian Afni Kartika, Ajeng Agatha, Yuti Paramitha Agnes Agnes Ahmad Faried Alya Mardhotillah Azizah Anditha, Arie Tika Andre, Johannes Anggraini, Livia Anggraini, Suhelis Anggriani H, Theresia Angnes, Odri ANITA SARI, DEVI Annisa Amalia Annissa Fadhila Ainy, Al Anton Timur Jailani Harahap Aprilia, Shefira Aritonang, Murni Armansyah, Adek Arna Fransisca Mp Astari, Nur Atma Negara, Rama Aulia, Rumi Awaluddin Ziad Azah, Yunita Wannur Bangbang Buhari Bangun, Chrismas Gideon Bangun, Primta Bawean, Popi Latifah Butter Samin Calvin, David Chandra Wilim Chintya Darma, Gladys Chiuman , Linda Chiuman, Linda Chiuman, Veranyca Daniel Prem Raj Pandid Datitha Alodia Br Kaban, Karina Deasy Siregar, Santy Dessy Series Ulina Ginting Dewi Riastawati Dewi Sartika DEWI SARTIKA Dewi, Silvi Tiara Diana Krisanti Jasaputra Duha, Sonya Marsela Pieta Dwi Astuti Manullang Edy Fachrial Eliani, Eliani Elis Anggeria Eliza Putri, Yolanda Emi Girsang Emilia Laia, Maria Erika Erika Ermi Girsang Ermi Girsang Ernes, Audrina Eva Latifah Nurhayati Fentia, Lia Ferdinand, Sahna Feri irawan Finna Piska Fiska Maya Wardhani Frederick Frederick gan, claris cyntha deninta Geeta, Gemmi Deseva, Frisca Ginting, Sahna Ferdinand Girsang, Ermi Gultom, Yohania Premita Gusbakti Rusip Hafifah Hafifah Halim, Michael Handayani, Rr. Anisa Siwianti Handoko, Erwin Handriani, Wita Hanna Sari Widya Kusuma Harahap, Viora Rezky Harmileni Haryani, Novita Hasibuan, Nasyidah Hannum Hasya, Muhammad Nawal Hondo, Alfarikus Hsb, Khairiyani Asri Hutabarat, Yohana Candra Andini Hutapea, Dwight Mahaputera Marulitua I Nyoman Ehrich Lister I Nyoman Ehrich Lister Ias Natanael, Glorio IKHTIARI, REFI Iksen, Iksen Irania, Feby Irwan Irwan irza Haicha Pratama Johannes Bastira Ginting Karmila Br. Kaban Laurenxius, Vanessa Sinana Leksmana, Oki Lestari Ramadhani Nasution, Sri Lestari Ramadhani, Sri Lilies Lingkaran Linawaty, Linawaty Linda Chiuman Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, Nyoman Ehrich Lumbanraja, Dhea Rebeca Lumbantobing, Salomo Lydia Ernawati Rahayu Makdalena, Makdalena Manalu, Andika Prianto Mangatas Silaen Manik, Rayani Marcelino, Nico Mariana Mariana Maricella, Adrianie Masryna Siagian Maswarni Maulidwina Bethasari Mawarni, Evi Maywinsih Jauhari, Mutia Mendrofa, Leli Angelita Mendrofa, Trisman Basri Mendrofa, Tuho Konsultasi Merrina Arts, Tricya Mucmaini, Rica Mustika, Rani Mutia, Maya Sari Nabila, Siti Napiah Nasution, Ali Napiah, Ali Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Nasution, Sriwahyuni Nasution, Zahrah Fadhillah Nella Vista Purba, Agnes Nerissa Nasriza Nirman Waruwu Noflita, Noflita Noni Rokaya Pasaribu Noviawati Noviawati Nurhayati, Evalatifah Oni Fatmala, Cut Panggabean, Dini Desita Panjaitan, Dian Permata Khaira, Azzuhra Pertiwi Br. Sembiring, Rima Pesta Ria, Anna Maria Pinem, Sabriela Br Pulungan, Ica Yulianti Purba, Deborah Angelin Putra Nasution, Pratama Putranto Manalu Putri, Muna Soraya Rahayu Rahayu Rahmadani, Rani Raif, Martinus Ahmad Ramadhan Efendi Rapael Ginting Raveli , Kalvin Razoki, Razoki Rica Tri Septinora Rizal Rizal Rizky, Muhammad Irvan Rosari, Anita Rotua, Margaretia Yenni Rya Sianturi , Agnes Sahna Ferdinand Ginting Sahna Ferdinand Ginting Santy Deasy Siregar Santy Siregar saragih, jean Sari Mutia, Maya Sari, Laura Kartika Satrio Wibowo Siagian, Masryna Siahaan, Destri Safhira Siahaan, Nurisa Tri Ayu Sianturi, Reksaudi Sihombing, Bungaran Sihombing, Nadia Deva Silaen, Mangatas Silalahi, Yosiana Sinaga, Widya Oktaviani Siregar, Reza Arfan Siti Hardianti, Siti Soekardi, Adi Soraya, Annisa Sri Lestari Ramadhani Nasution Sri Mulyati Sri Ulina, Evita Sri Wahyuni, Devi Subangkit, Mawar Suhartomi Sunarti Suriani Suriani Suyono, Tan Syahputra, Hariyadi Dharmawan Syahrian, Muhammad Faridz Syahrullah Pohan, Muhammad Telaumbanua, Rizky Anditino Teresa Liliana Wargasetia The Fransiska Eltania Tiarnida Nababan Tjiawi, Midoro Tobing, Madeline Angeline Tresun Br Turnip, Malna Umar, William Vera Estefania Kaban vera vera, vera Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wahyuni Nasution, Sri Wardhani, Fiska Maya Wau, Herbert Widodo, Wahyu Setia Widya Yanti Sihotang Widyastari, Elisa Wienaldi, Wienaldi Wijaya, Johanna Fransiska Wijaya, Winny Winda Sari Winvi, Feli Clarisa Yanti, Ratmi Yolanda Eliza Putri Lubis Yolanda Eliza Putri Lubis Yuliansyah, Jeri Yulita, Emi Yulizal, Ok Yusmaini, Yusmaini Zebua, Sawato Zerry All Vindo Tarigan