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Harnessing the power of lemon (Citrus limon) for hypertension: A systematic review of clinical evidence Jayadi, Yusma Indah; Sulaeman, Ahmad; Palupi, Eny; Dewi, Mira; Hardinsyah, Hardinsyah
Diversity: Disease Preventive of Research Integrity Volume 6, Issue 2, February 2026
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/diversity.v6i2.62425

Abstract

Hypertension prevalence and its cardiometabolic complications continue to rise, yet evidence syntheses have not clearly mapped how lemon (Citrus limon) intervention form, dose, and duration relate to blood pressure and biomarker responses, limiting translation into practical dietary guidance. This PRISMA 2020 systematic review synthesized evidence on lemon interventions for systolic/diastolic blood pressure (SBP/DBP) and biomarkers in hypertensive or elevated-blood-pressure populations. Searches of Scopus and PubMed, supplemented by ScienceDirect, relevant platforms, and Google Scholar, were conducted in December 2024–January 2025. Randomized controlled trials of lemon juice, extracts, peel preparations, or essential-oil aromatherapy versus placebo/usual care/other citrus/no intervention were eligible; multi-ingredient regimens containing lemon were extracted but interpreted separately. Screening and extraction used Rayyan, and quality was assessed using the Effective Public Health Practice Project (EPHPP) domains. Thirteen studies met criteria; heterogeneity in formulations, dosing, and outcome reporting precluded meta-analysis, so narrative synthesis was applied. Fresh lemon juice and lemon extracts showed the consistent SBP/DBP reductions, especially with higher doses and durations ≥2–4 weeks, whereas short-term or low-dose regimens more often yielded null results; aromatherapy and peel-powder capsules showed mixed effects. Certainty was limited to moderate due to risk of bias and diversity of interventions. Lemon may be considered a dietary adjunct in lifestyle management, not a replacement for antihypertensive therapy, and may be communicated through halalan thayyiban self-care framing.
Hubungan Antara Konsumsi Pangan dan Tingkat Asupan Gizi dengan Status Gizi Anak Cerebral Palsy Marina Indriasari; Hardinsyah; Lilik Kustiyah; Ferial Hadipoetro
Majalah Kedokteran Indonesia Vol 68 No 6 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.6-2018-60

Abstract

Pendahuluan: Permasalahan gizi pada anak Cerebral Palsy (CP) dapat terjadi karena asupan makanan yang tidak adekuat. Penelitian ini bertujuan untuk mengidentifikasi konsumsi pangan dan kecukupan asupan gizi kaitannya dengan status gizi anak CP di Jakarta, Depok, dan Bogor. Metode: Desain potong lintang pada penelitian ini dilaksanakan di Sekolah Luar Biasa (SLB) dan Yayasan Pembinaan Anak Cacat (YPAC). Subjek sebanyak 45 dipilih secara purposive sampling. Data dikumpulkan melalui pengisian kuesioner, konsumsi pangan dengan metode food record 1 x 24 jam. Status gizi dinilai dari indeks massa tubuh (IMT) berdasarkan umur. Hasil: Frekuensi makan utama sebanyak tiga kali sehari dengan frekuensi makan selingan satu kali mempunyai korelasi positif kuat dengan status gizi anak CP sebesar 0,636. Tingkat asupan zat gizi makro yang terpenuhi hanya protein dengan korelasi positif kuat sebesar 0.729 terhadap status gizi anak CP. Korelasi positif paling kuat sebesar 0,885 pada jenis buah yang dikonsumsi dengan status gizi. Terdapat hubungan yang bermakna antara tingkat asupan seng (p=0,037) dan vitamin C (p=0.008) dengan status gizi. Kesimpulan: Semakin tinggi tingkat kecukupan seng dan vitamin C, semakin baik status gizi anak CP. Semakin banyak frekuensi makanan selingan dan jenis makanan mengandung protein serta buah, semakin baik status gizi anak CP.
Compliance level difference of tele-exercising obese office employee on body weight and body fat Kuswari, Mury; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Dewi, Mira; Gifari, Nazhif
Journal Sport Area Vol 7 No 2 (2022): August
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2022.vol7(2).8917

Abstract

The problem of overnutrition and obesity tend to increase year by. Office employee are susceptible to physical inactivity and obesity. In context of current pandemic, exercising via online media, termed ‘tele-exercise’ may be an effective alternative intervention. However, the effect of compliance and timing of exercise on overall health-related output are still not often discussed. The purpose of the study is to compare the effect of tele-exercise done during working hours vs. after working hours on obese office employee’s weight loss and improvement of body fat percentage, as well as their relation to compliance level. The design of this study is quasi-experimental design, with obese office employee as participants, which then grouped into after work exercise (AW, n = 36, 1-hour duration) and mid-work exercise (DW, n = 21, 30-minute duration). Total sampling was used since the target population were under 100 people. Exercises were done 3 times/week for 12 weeks. Data collected were sample characteristics, bodyweight, and percentage of body fat. Both timing of intervention is effective on reducing body weight significantly (p<0.05). Significant reduction (p<0.05) on percentage of body fat is only occurring in DW group. Compliance level for AW and DW group are 63.75% and 61.23%, respectively, and being insignificant to each other (p>0.05). The contribution of compliance in shorter exercise/DW on body fat loss and weight loss is 23.1% and 20.9%, respectively; while the contribution of compliance in longer exercise/AW is 11.3% on body weight loss. A short, mid-working exercise have the similar or even better effect than 1-hour after-work exercise session on weight loss and body fat loss. We recommend tele-exercising during working hours for at least 30 minutes to achieve significant body weight and body fat loss.
Mineral Content, Vitamin Profile, and Dietary Fiber Fractions of Aqueous Leaf Extracts from Four Sundanese Traditional Vegetables in Indonesia Leny Eka Tyas Wahyuni; Hardinsyah Hardinsyah; Budi Setiawan; Nur Rezky Khairun Nisaa; Putri Anggreini
Media of Health Research Vol. 4 No. 2 (2026): Media of Health Research, May 2026
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/mohr.v4i2.433

Abstract

Lalapan, the traditional Sundanese raw vegetable salad of Indonesia, is a significant component of the daily diet for millions of Indonesians; however, the nutritional composition, particularly the mineral, vitamin, and dietary fiber fractions of its constituent leafy vegetables, remains insufficiently characterized in the scientific literature. Objective This study aimed to determine the mineral content (calcium, potassium, iron, and magnesium), β-carotene, vitamin C, and dietary fiber fractions (soluble, insoluble, and total) in aqueous leaf extracts of four lalapan vegetables: gandaria (Bouea macrophylla), kemangi (Ocimum americanum), pohpohan (Pilea melastomoides), and selada (Lactuca sativa). Methods: Fresh leaves were subjected to aqueous maceration extraction as described. Mineral analysis was performed by atomic absorption spectrophotometry (AOAC 975.03), β-carotene by HPLC (AOAC 45.1.34), vitamin C by titration (AOAC 967.21), and dietary fiber by the enzymatic-gravimetric method. Data are presented as mean ± SD from triplicate analyses. Results: Pohpohan exhibited the highest calcium (1697.05 ± 11.70 mg/100 g) and magnesium (1990.11 ± 6.01 mg/100 g) content, while selada contained the highest potassium (8709.03 ± 34.36 mg/100 g). Kemangi demonstrated the greatest β-carotene concentration (7.69 ± 0.13 mg/100 g), and Gandaria the highest vitamin C (59.66 ± 3.53 mg/100 g). Pohpohan also recorded the highest total dietary fiber (22.11 ± 1.40%) with a predominance of soluble fiber (12.24%). Conclusion: All four lalapan species are nutritionally valuable, with pohpohan and kemangi demonstrating exceptional mineral and vitamin profiles. These findings support promoting lalapan as a functional food component in Indonesian dietary guidelines.
Evaluation of physicochemical properties and functional potential of analog rice based on commercial flours of porang tuber and gembili as an alternative carbohydrate food source Salma Widya Azhari; Sri Anna Marliyati; Hardinsyah Hardinsyah
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2476

Abstract

Indonesia is one of the countries that produces porang and gembili tubers that can be processed into value-added food products. One innovation that can be developed is the analog rice made from these two tubers. Porang and gembili tubers are known to contain bioactive compounds and dietary fiber that provide functional benefits, such as lowering blood glucose levels, improving lipid profiles, and improving digestive tract health. This study aimed to evaluate the physical and proximate qualities of three analog rice formulations using commercial porang and gembili flours. The experimental design used was a Completely Randomized Design (CRD) with two replications, conducted from August to December 2024 at the Technopark Laboratory (Faculty of Agricultural Technology) and Nutrition Analysis Laboratory (Department of Community Nutrition, FEMA IPB). The formulations had porang and gembili ratios of F1 (75:25), F2 (50:50), and F3 (25:75). Data were analyzed using One-Way ANOVA preceded by variance homogeneity testing, followed by DMRT multiple range test. The results showed that cooking time and bulk density differed significantly between F1, F2, and F3. The expansion ratio, degree of breakage, and hardness differed significantly among F3, F1, and F2. F3 exhibited the highest brightness (L*) value. Proximate analysis revealed significant differences in ash, moisture, protein, fat, and carbohydrate contents among all formulations. The F3 formulation, which had a higher proportion of gembili, demonstrated the greatest potential as a staple carbohydrate source. However, further sensory and consumer acceptability improvements are needed.
Co-Authors . Nurrohmah A'immatul Fauziyah Agus Firmansyah Agus Riawan Agus Sumule Agus Sumule Ahmad Sulaeman Ahmad Sulaeman Aida Vitayala Aida Vitayala S. Hubbeis Al Khairiyah, Hanifah Alamsyah, Putri Rahmah Ali Khomsan Amini Nasoetion Andi Rahmad Anik Djuraidah Ansarullah, Alfia Arin Tria Agustin ASEP SAEFUDDIN Aslis Wirda Hayati Astri Ayu Novaria Astriningrum, Eka Puspita Atika Primadala Amrin Atmarita . Atmarita ., Atmarita Aviani Harfika Bachti Alisjahbana Bambang Sumantri Budi I. Santoso Budi Iman Santoso Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Bunga Ch Rosha Cesilia M Dwiriani Chairunita Chairunita Clara M Kusharto Clara M Kusharto Clara M Kusharto Dadang Sukandar Dadi Hidayat Maskar Dadi Hidayat Maskar, Dadi Hidayat Dasmasela, Maya Klementina Dede Kusmana Dede Kusmana Dewa K.S. Swastika Dewa Ketut Sadra Swastika Dewi Anggraini Dewi Angraini, Dewi Dewi Permaesih Dewi, Mira Dewi Dhea Marliana Salsabila Dhiya Fadhila Rahmah Diah Krisnatuti Dijaya, Rendy DIMAS ANDRIANTO Dionysius Subali Dodik Briawan Drajat Martianto Dwi Juliani, Kurnia Edtripany, Gebby Dwi Eliza Halim Elya Sugianti Eny Palupi Erry Yudhya Mulyani Euis Sunarti Evi Damayanti Evy Damayanthi Fachruddin Perdana Fahmi Abdul Hamid Faisal Anwar Fasli Jalal Fauziah, A'immatul Ferial Hadipoetro Fitrah Ernawati Ghaida Yasmin Gifari, Nazhif Gina Apriani Gulardi Gulardi Guspri Devi Artanti Hadi Riyadi Hadi Riyadi Hadipoetro, Ferial Hardiansyah, Angga Harianto . Hendratno Tuhiman Hermanto Siregar Heryudarini Harahap Hidayat Syarief Hidayat Syarief Hidayat Syarif Himarwan, Aditya Hotmuda Simarmata Humayrah, Wardina Husaini . I Gusti Bagus Wiksuana I MADE ARTIKA Ibrahim, Nur Susan Iriyanti Ida Mariati Hutabarat Ikeu Ekayanti Ikeu Tanziha Ikeu Tanziha Ikeu Tanziha Imam Effendi Indah Irma Maharani Indah Ratikasari Indah Yuliana Indrayana, Indrayana John Letsoin John Letsoin Joko Hermanianto Jus'at, Idrus Karina Indah Pertiwi Karina Rahmadia Ekawidyani Katrin Roosita Khoirul Anwar Kholik Kholik Kudang Boro Seminar Laksmi Nur Fajriani Leily Amalia Leny Eka Tyas Wahyuni Lilik Kustiyah M. Aries, M. M. Djemdjem Djamaludin Made Astawan MADE ASTAWAN Made Mita Dwi Saraswati Mahani Mahani Marhamah . Marhamah Marhamah Marina Indriasari Marissa Indreswari Meitycorfrida Mailoa Mewa Ariani Mimin Aminah Mira Dewi Mokhamad Fahrudin Muhamad Rizal Martua Damanik Muhammad Aries Muhammad Rivai Muhilal . Muhilal ., Muhilal Mukhlidah Hanun Siregar Mury Kuswari Mustafa Kamal Mustafa Kamal Nadiya Mawaddah Nadya Rizki Fadilah Naufal Muharam Nurdin Netta M. Putri Netti Herawati Neysa Rucita Ni Made Putria Sukma Febriyani Noorwati Sutandyo Novitasari, Putri Nunuk Januwati Nur Rezky Khairun Nisaa Nurdin . Nurfi Afriansyah Nurul Maqfira Nurwati, Yuni Parlindungan Siregar Parlindungan Siregar Picauly, Intje Ploeger, Angelika Pudji Muljono Pusparini Pusparini Pusparini Pusparini Putra, Felicia Kartawidjaja Putri Anggreini Putri Rialdi, Athifah Rahman, Listhia Hardiati Rahmawati Rahmawati Rahmawati, Rahmawati Ramadhani Fitri Ratna Megawangi Ratu S. Hanifah Retnaningsih Retnaningsih Rian Adi Pamungkas Rian Diana Rif’atul Amini Rimbawan , Rimbawan Rimbawan Riza, Ras Adiba Rizal M. Damanik Rohmaeni, Yeni Rosemiarti, Tria Salma Widya Azhari Seprianto Sherry A Tanumihardjo, Sherry A Silvia Mawarti Perdana Siswahyudianto Siti Aida Adha Taridala Siti Madanijah Siti Madanijah Siti Madanijah Siti Madanijah Siti Nuryati Siti Nuryati Soekirman Soekirman Soeryo Adiwibowo Sri Anna Marliyati Sri Hartati R. Suradijono Sri Rihati Kusno Sudung O. Pardede Sudung O. Pardede, Sudung O. Sukati Saidin Sukati Saidin Suparman Suparman Suparman Suparman Suprihatin Guhardja Teguh Jati Prasetyo Tessa Winandita Titik Sumarti Tiurma Sinaga Tjahjono, Erinna Tria Rosemiarti Trina Astuti Tutik Wresdiyati Umi Fahmida Wahyuni, Leny Eka Tyas Wichitra Yasya Winata, Grace Marlina Windardi, Ika Puspa Wirawanti, Ika Wirya Wirna Zulianti Yahdiana Harahap Yayuk Farida Baliwati Yekti Hartati Effendi Yeni Rohmaeni Yongky Yongky Yunindyawati Yunindyawati Yusma Indah Jayadi Zulaikhah ., Zulaikhah