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All Journal JURNAL SAINS PERTANIAN EQUATOR Jurnal Pendidikan Sosiologi dan Humaniora Diponegoro Journal of Accounting Jurnal Media Infotama ProNers Jurnal Bahan Alam Terbarukan Jurnal Sosialisasi: Jurnal Hasil Pemikiran, Penelitian dan Pengembangan Keilmuan Sosiologi Pendidikan PROSIDING SEMINAR KIMIA REPOSITORY KIMIA Jurnal Kimia Mulawarman PROFESIENSI Jurnal Kajian Akuntansi JURNAL ATOMIK Regula Fidei : Jurnal Pendidikan Agama Kristen Jurnal Arsir Jurnal Teknik Informatika UNIKA Santo Thomas Gulawentah:Jurnal Studi Sosial INTECOMS: Journal of Information Technology and Computer Science Unes Law Review ComTech: Computer, Mathematics and Engineering Applications Jurnal Ilmiah Fillia Cendekia JURNAL EKSBIS Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Prosiding National Conference for Community Service Project Jurnal Informatika dan Sistem Informasi Community Development Journal: Jurnal Pengabdian Masyarakat Reswara: Jurnal Pengabdian Kepada Masyarakat STUDI PELAKSANAAN SELFMEDICATION PADA PENDERITA DIARE BERDASARKAN TINGKAT PENGETAHUAN MASYARAKAT PESISIR KECAMATAN SOROPIA KABUPATEN KONAWE Shift Key: Jurnal Teologi dan Pengembangan Pelayanan Jurnal Kewarganegaraan Jurnal Pengabdian Masyarakat Indonesia Jurnal Pendidikan PKn Jurnal Sains, Teknologi, Urban, Perancangan, Arsitektur (Stupa) Journal La Multiapp Akasia: Artikel Ilmiah Sistem Informasi Akuntansi Journal Peqguruang: Conference Series TELEIOS: Jurnal Teologi dan Pendidikan Agama Kristen Indo-MathEdu Intellectuals Journal Jurnal Teknik Informatika Unika Santo Thomas (JTIUST) Algoritme Jurnal Mahasiswa Teknik Informatika Jurnal Atma Inovasia ABDINE Jurnal Pengabdian Masyarakat Journal of Student Research Jurnal Natural Innovative: Journal Of Social Science Research The International Journal of Tropical Veterinary and Biomedical Research Enrichment: Journal of Multidisciplinary Research and Development INTERNATIONAL JOURNAL OF HUMANITIES, SOCIAL SCIENCES AND BUSINESS (INJOSS) Journal of Technology Informatics and Engineering IJMI Journal Of Carbazon Daya Nasional: Jurnal Pendidikan Ilmu-Ilmu Sosial dan Humaniora Jurnal Medika Veterinaria Pinisi Journal of Social Science Banking & Management Review Prosiding Dedikasi: Pengabdian Mahasiswa Kepada Masyarakat Jurnal Bisnis Digital dan Enterpreneur (BISENTER) Salaga Journal Peternakan Abdi Masyarakat (PETAMAS) Jurnal Pertanian Agros
Daniel Daniel
Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan alam, Universitas Mulawarman
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Journal : Jurnal Medika Veterinaria

 1 
Screening of Bioactive Compounds of Gambir leaf (Uncaria gambir Roxb) as Antibiofilm Againts the Glucosyltransferase of Streptococus mutans Enzyme Khalid, Idham; Sari, Dea Kurnia; Bakri, Muttaqien; Daniel, Daniel; Frengki, Frengki; Makmur, Ali; Riandi, Lian Varis; Ferdian, Riyan; Amiruddin, Amiruddin
Jurnal Medika Veterinaria Vol 18, No 2 (2024): J. Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i2.43265

Abstract

The use of natural ingredients in dental care, such as manginang which has become part of the Minang community culture, is considered an alternative dental care that must be created to overcome the negative impacts of dental care made from artificial materials. The core of this study is to change the manginang tradition towards logical verification through screening of bioactive compounds of gambir leaves (Uncaria gambir Roxb.) as antibiofilms against Streptococcus mutans. This study was conducted using an in silico strategy approach with the help of computer programs such as MOE v.09 and Chimera 1.13.1, as well as the Way2Drug site, protein information bank, and protox_ii. This study began with the collection of ligand information from the writing, followed by transformation into 2D and 3D designs. Other antibiofilm actions were decided using the QSAR procedure through the website (http://www.way2drug.com/PASSOnline/predict.php). The selected antibiofilm compounds were then followed by observing their affinity for the receptor (pdb id. 3AIB) using an atomic docking strategy. Finally, the ligand damage profile was observed to anticipate. The results of this study indicate that of the 41 identified gambir leaf compounds, there are 20 compounds that have the potential to have antibiofilm effects with quinnic acid having the highest score (Pa 0.703), while the compound with the strongest affinity for the receptor is chlorogenic acid with an affinity score (Gbinding) of -16.03 kcal/mol and an average of low toxicity (level IV-VI). However, of the 20 bioactive compounds of gambir leaves, only 5 compounds are predicted to have the same potential as the -maltose control.
Antidiabetic Test of Ethanolic Extract of Ant Nest Plants (Myrmecodia sp.) Against the -Glucosidase Enzyme In Vitro Daniel, Daniel; Isa, Muhammad; Hasan, Muhammad; Sari, Wahyu Eka; Rosmaidar, Rosmaidar; Aisyah, Siti; Athaillah, Farida; Frengki, Frengki
Jurnal Medika Veterinaria Vol 18, No 1 (2024): J.Med.Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i1.37431

Abstract

The use of plants, one of the biological sources, as an alternative medicine for degenerative diseases is increasingly being studied. Usually, the biological effects of these plants come from the secondary metabolite components contained therein. Ant nest is one of them which is reported to contain compounds belonging to the class of flavonoids, tannins, and polyphenols. This research was conducted in vitro by observing the antidiabetic potential of the ethanolic extract of ant nests against the -glucosidase enzyme following the modified "Wako Pure Chemical Industries Ltd., Japan" protocol. The results showed that the inhibitory power of -glucosidase of the extract was stronger than that of the quercetin control with IC50 values of 10.59 g/mL and 38.09 g/mL, respectively. These results proved that the ethanolic extract of ant nest had very strong -glucosidase inhibitory property. Predictive analysis of the pharmacokinetics and toxicity of the bioactive compounds contained in the ant nest extract showed that rutin has similar characteristics to acarbose as a first-line anti-diabetic drug of choice through an -glucosidase inhibitor mechanism, so rutin is worthy of consideration for development as an anti-diabetic candidate.
Co-Authors A An Arief Jusuf Abdul Hamid A. Yusra Abdul Latief Abdurizal Arsyad, Syech Geopandu Adi Suyatno Adu, Desmon Ayub Agatha, Septian Ahmad Ridha Akbar, Fath Ali Al Hidayah, Riama Amin, Abdul Rachmad Zahrial Amiruddin Amiruddin Amrazi Zakso ANDI ACO AGUS Andi Muhammad Fadhal Hiqh.T Pangera Andreas Saputra, Andreas Angelita, Maya Anggunadi, Angelica Anis Chariri Annisa Purbasari, Annisa Aritonang, Ramona Athaillah, Farida Batan, Alfrida Bihairi Hadi, Ricky Lutfi Br Ginting, Survina Osalia C. Pickerling Cahya, Lisye Mareta Cendana, Colleen Chairul Saleh Chandra Wijaya Christiyanto, Laurensius Erdin Christopher, Arvin Damanik, Justin Gamaliel Danut, Yohana Dedhi Yustendi Dewantara, Jagad Aditya Dewi, Camelia Eugenia Dewi, Ezra Shandra Dhita Wahyu Anggraeni, Dhita Wahyu Dwi Agustina Ermawati Ermawati Erwin Erwin Eva Marliana, Eva Farhana, Siti Farhany, Farhany Fathurrohman, Reza Fazhar Sumantri febriyanti febriyanti Feliciana, Anastasia Fellyanto, Fellyanto Ferdian, Riyan Ferdian, Ryan Fila Sasmita Firmansyah, Muchammad Ravi Fredy Purnomo Frengki Frengki, Frengki Gaanty Pragas Maniam, Gaanty Pragas Halim, Grace Suriadi Harahap, Hanna Meyrani Harefa, Kasieli Hartono, Eric Hasibuan, Serepina Yoshika Hasriati Hasriati, Hasriati Hendrawan Armanto Hermanto Hermanto Hidayat, Farah Amalia Hiyahara, Irfan Ashari Hutabarat, Rugun Romaida Idham Khalid Imran Imran Indra Riyana Rahadjeng Indra, Natal Ismiyani, Nining Isyana Emita Iwan Ramadhan Jap Tji Beng Jonatan, Jonatan Juliana, Eva Junianto Wika Adi Pratama Justin, Justin Kirana, Stephani Nindya Kumahara, Wien Kurniati, Triani Larosa, Setiaman Latumahina, Bill Samuel Lelunu, Sapta Leslivania, Monika Liangga, David Liku, Yeli Oktaviana Liku Lukman Hakim M Ezar Al Rivan M. Hasan Magdaleni, Agustina R. Magdaleni, Agustina Rahayu Makmur, Ali Malina, Khaira Manisha, Manisha Margareta, Serlen Marpaung, Franky Hadinata Maswadi - Maygusten, Maygusten Maylina, Ajeng Chandra Meiliana, Evita Melyani Melyani, Melyani Meriyani, Susi Michael Michael Mochammad Imron Awalludin Moron, Maria Selvi Mufid, Zainul Muhammad Fachrurrozi Bafadal Muhammad Hasan Muhammad Isa Muhammad Jalaluddin, Muhammad Muhammad Nadir Mulyono, Romi Kurniawan Agni Muttaqien Bakri, Muttaqien Naibaho, Lamhot Nataniel Tandirogang Naufaludin, Ahmad Noni Zakiah Noor Hindryawati, Noor Nora Usrina Nugrahanto, Cornelius Septian Nurhidayah, Annisa Nurleni, Nurleni NURLIANA NURLIANA Nurmadewi, Dita Nurmawan, Mardatungga Octa Maria Sihombing Octavianus Octavianus, Octavianus Okianna Okianna Olivia, Nia Panannangan, Josua K. Partomuan Simanjuntak Parulian Hutajulu, Josua Pentagon, Pentagon Pontan, Darmawan Prancisca, Stella Pranita, Widya Pratama, Ellen Putri, Andini Amelia Putri, Erika Ardya Mesia Rachmat, A. Khafifah Dwi Rachmat, Zul Rafik, Ahmad RAHMAT GUNAWAN Rahmawati, Rahmawati Rakhmad, Rakhmad Ramadhan, Yanuar Rantung, Dyoys Anneke Ravensca, Irene Riandi, Lian Varis Rindawati, Novi Riska Riska Rismawati Rismawati Riyanto, Rahmat Fajar Rizkiana Karmelia Shaura Rosalina Putri, Kesia Roslizawaty Roslizawaty, Roslizawaty Rosmaidar Rosmaidar, Rosmaidar Rustiyarso, Rustiyarso Ryn Pratiwi, Djihan Saibun Sitorus Sandra, Putri Ayu Sanjaya, Regi Sara Ruhghea Sari, Dea Kurnia Sari, Wahyu Eka SATRIYAS ILYAS Sebastian, Novianto Sembiring, Rinawati Seputri, Merryana Sigit, Miarsono Sikwan, Agus Silvia Monica Sisilia, Desy Siti Aisyah Sitompul, Citra Uli Sitti, Nur Faridah Situmorang, Aspriska R. Solidah, Sindi Nur Soma, Yolanda V. A Sormin, Hendro Jatmiko Subagyono, R.R. Dirgarini Julia Nurlianti Subur P Pasaribu Sucipto, Rakhmat Hadi Sudrajat Sudrajat Sumeru, Indrawati Suriyanisa, Suriyanisa Suteja, Mekar Sari Sutrisno, Marshela Suzzana Winda Artha Mustika Swastika, Rahayu Syafrida, Yuni Tandjung, Muhammad Akbar Thomy Sastra Atmaja Toibah Umi Kalsum TONE, KAMARUDDIN Tony Tony Torro, Supriadi Trisna Fajar Prasetyo Variani, Joanna Rika Vedro, Vedro Vera Methalina, Vera Vincent Tristan, Radick Vincentia, Meyshela Viny Christanti M Wardhani, Lailia Dwi Kusuma Wardoyo, Arif Wasino Wasino Widiastiani, Nindry Sulistya Wirya, Wirya Yaputri, Leticia Yenni Yusriani Yohanes Bahari Yonas, Yonas Yudhistira Oscar Olendo Yulita, Wita Yunita, Risna Zulkifli Zulkifli Zulkifli, Baidillah Zuri Astari