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Efek Protektif Ekstrak Daun Jambu Air (Syzygium Aqueum) terhadap Kerusakan Lambung Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar yang Diinduksi Indometasin Adilla Justisia; Susianti Susianti; Anisa Nuraisa Jausal; Hendri Busman
Malahayati Nursing Journal Vol 7, No 8 (2025): Volume 7 Nomor 8 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i8.21126

Abstract

ABSTRACT The prevalence of peptic ulcers caused by the use of Nonsteroidal Anti-Inflammatory Drugs (NSAID) has increased over the past 10 years. Oxidative stress induced by NSAID can trigger the formation of peptic ulcers. The objective of this research was to determine the protective effect of water apple leaf extract (Syzygium aqueum) on gastric damage of male white rats (Rattus norvegicus) wistar strain induced by indomethacin. This laboratory experimental study with a randomized post-test only control group design involved 24 male Wistar strain white rats divided into 6 groups. Group K(0) was given food and water, K(-) was administered indomethacin at a dose of 30 mg/kgBW, K(+) received vitamin C at a dose of 9 mg/kgBW and indomethacin at 30 mg/kgBW, while P1, P2, and P3 were given water apple leaf extract at doses of 100 mg/kgBW, 300 mg/kgBW, and 900 mg/kgBW, along with indomethacin at 30 mg/kgBW. The results of the Mann-Whitney statistical test analysis showed a significant difference (p0.05) between group K(-), which was administered only indomethacin, and group P2 and P3, which were administered extracts of water apple leaf at doses of 300 mg/kgBW and 900 mg/kgBW along with indomethacin at 30 mg/kgBW. There is an protective effect of water apple leaf extract (Syzygium aqueum) on gastric damage of male white rats (Rattus norvegicus) Wistar strain induced by indomethacin. Keywords: Water Apple Leaf, Syzygium Aqueum, Antioxidants, Indomethacin, Peptic Ulcer  ABSTRAK Prevalensi ulkus peptikum yang disebabkan oleh penggunaan Nonsteroidal Anti-Inflammatory Drugs (NSAID) mengalami peningkatan dalam kurun waktu 10 tahun. Stres oksidatif yang disebabkan oleh NSAID dapat memicu terbentuknya ulkus peptikum. Tujuan penelitian ini untuk mengetahui efek protektif ekstrak daun jambu air (Syzygium aqueum) terhadap kerusakan lambung tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi indometasin. Penelitian eksperimental laboratorik dengan rancangan randomized post-test only control group ini menggunakan 24 tikus putih jantan galur Wistar yang dibagi ke dalam 6 kelompok. K(0) diberikan makan dan minum, K(-) diberikan indometasin 30 mg/kgBB, K(+) diberikan vitamin C 9 mg/kgBB dan indometasin 30 mg/kgBB, serta P1, P2, P3 diberikan ekstrak daun jambu air dengan dosis berturut-turut 100 mg/kgBB, 300 mg/kgBB, 900 mg/kgBB dan indometasin 30 mg/kgBB. Hasil analisis uji statistik Mann-Whitney didapatkan perbedaan bermakna (p0.05) antara kelompok K(-) yang hanya diberikan indometasin dengan kelompok P2 dan P3 yang diberikan ekstrak 300 mg/kgBB dan 900 mg/kgBB serta indometasin 30 mg/kgBB. Ekstrak daun jambu air (Syzygium aqueum) memberikan efek protektif terhadap kerusakan lambung tikus putih (Rattus norvegicus) jantan galur Wistar yang diinduksi indometasin. Kata Kunci: Daun Jambu Air, Syzygium aqueum, Antioksidan, Indometasin, Ulkus Peptikum
Co-Authors Ade Yonata Adilla Justisia Aditya Kusumaningtyas Hudisaputeri Aditya Permana Agusta Saraswati Agustyas Tjiptaningrum Ahmad Farizan Radhitya Ahmad Syah Putra Ainin Aniah, Pratiwi Ajeng Defriyanti Pusparini Akuba, Nanda Nurrohim Aldo Fatejarum Ambarwati, Yuli Andhini, Friska Andi Setiawan Andrian Rivanda Andriansah, M. Anggi Setiorini Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Anisa Nuraisa Jausal Anisa Nuraisa Jausal Arif Setiawansyah Arini Meronica Arninda Rahman Atmajaya, Yudhi Audya Pratiwi Putri Riyanda Ayu Ningsih Ayu Tiara FItri Azkiya Bahren Nortajulu Balqis Mezzaluna D'Azzuri Bara Ade Wijaya Suprayitno Bayu Anggileo Pramesona Betta Kurniawan betta kurniawan Betta Kurniawan, Betta Buana, Faris Agung Cana, Arla Erit Siktia Catur Ariwibowo Catur Ariwibowo Damayanti, Putri Daulay, Suryani Agustina Dedi Hermawan Devi Rahmadiani Diah Septia Liantari, Diah Septia Dian Isti Angraini Dian Isti Angraini Dyah Wulan Sumekar Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Endro Prasetyo Wahono Ersa, Rakhmigasti Citra Ety Apriliana Ety Apriliana Ety Apriliana Eva Lusina, Septia Evi Kurniawati, Evi Evi Kurniawaty Exsa Hadibrata Fahrezi Fathilla Farida Hakim Lamuhammad Fatriyadi Suwandi, Jhons Febrianti, Arlin Fendi Setiawan Fitri Sofiatin Fitria Saftarina Gemayangsura Gemayangsura Gemayangsura, Gemayangsura Giok Pemula Giska Tri Putri Hadibrata, Exsa Hana Muthi'a Putri Handayani Dwi Utami Hanna Mutiara, Hanna Happy, Terza Aflika Hardiansyah, Ridwan Hendra Tarigan, Sibero Hendri Busman Hendri Busman Hijami, Nurul 'Afifah Ibnu Fadilah Indri Windarti Intan Kusumaningtyas Intanri Kurniati Irawan Budi Waskito Irma Liani Ismunanto, Aziza Regina Kinasih Isvari, Gusti Ayu Made Prathita Iswandi Darwis Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi John Hendri Joni, Agnesia Priskila Justisia, Adilla Kamalia, Avissa Medina Khairun Nisa Khairun Nisa Kinanti Rahmadhita Kurniawaty, Evi Lanang Rachmadi M. Ridho Ulya M. Yusran Mallarangeng, Andi Nafisah Tendri Adjeng Marcellia, Selvi Maya Ganda Ratna Mayasari, Diana Mela Liberti Octoriani Simaremare Merry Indah Sari Muhamad Yogie, Fadli Muhammad Ariq Naufal Muhammad Yogie, Fadli Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Nabila Shafira Naufal, Muhammad Ariq Ni Luh Gede Ratna Juliasih Ni Putu Sari Widiyani Nisa Karima Nisa Karima Novianty, Detty Novita Carolia Novita Carolia Nurhasanah Nurhasanah Oktadoni Saputra, Oktadoni Oktafany Oktafany Ovalia, Nora Wilya Pemula, Giok Peni Ahmadi Pratiwi, Ainin Aniah Putri, Najwa Naraniya Putu Ristyaning Ayu R Supriyanto Rachel Junita Sitepu Ramadhana Komala Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Ratri Mauluti Larasati Reimma Emily Rachman Rengganis Wardani, Dyah Wulan Sumekar Reni Zuraida Rianto, Muhamad Arif Rie Dahniar Marissa Marpaung Rika Lisiswanti Rika Oktaria Rinawati Rinawati Risal Wintoko Riski Pangestu Risti Graharti Rizki Hanriko Rodiani Rodiani Rodiani, Rodiani Roro Rukmi Windi Perdani, Roro Rukmi Rosbhaiti Chodijah Rudianto, Waluyo Rudiyanto, Waluyo Ruslani, Nada Oktista Sangging, Putu Ristyaning Ayu Septia Eva Lusina Septiani, Linda Siti Raqiya Rasyid Smith Imanuel Saputra Sofyan Musyabiq Wijaya Soraya Rahmanisa Soraya, Yeni Sri Agustina Suharmanto Suharmanto Suharmanto Sulthan Alam Yasyfa Surriandari, Latifah Dwi Suryadi Islami Suryani Agustina Daulay Sutarto Sutarto Sutarto Sutopo Hadi Sutyarso Sutyarso Sutyarso Sutyarso Sutyarso Syafira Alifia Audiani SYAIFUL BAHRI Syaiful Bahri Syazili Mustofa Tara Aulianova Tasya Hani Fatwa Tri Umiana Soleha Tutik Ernawati Victoria Hawarima W, Dyah Wulan Sumekar R. W., Dyah Wulan Sumekar R. Waluyo Rudianto Waluyo Rudiyanto Wardani, Dyah Wulan Wawan Abdullah Setiawan Wido Gamani Worocahyo, Avis Meyvika Yadika, Adilla Dwi Nur Yolanda Fratiwi Yudhi Atmajaya Yudho Prabowo, Arif Yunianto, Andi Eka Yuningrum, Hesti Zahra, Aulia Jannatuz Zakiah Zakiah