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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Marcellus Simadibrata K

Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Central General Hospital, Jl. Diponegoro No.71, Jakarta 10430

Author-ID : 380435

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 151 Documents Claim Missing Document

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Articles

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The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening Nur Chandra Bunawan; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 1 (2017): VOLUME 18, NUMBER 1, April 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Colorectal cancer is a malignancy with high incidence and mortality rate. The long carsinogenesis sequence from adenoma unto carsinoma enable early detection and screening as part of the management but until recently the commercialy available test has low sensitivity and specificity. M2-pyruvate kinase (M2-PK), an isomer of glycolisis enzyme involved in aerobic metabolism, is found in high amount in cancerous cell and is shed unto luminal mucosa in colorectal cancer. Quantification of this protein in feces is a promising method to detect malignant lesion of colon. Several studies until recently demonstrate moderate sensitivity and specificity but clearly with better performance than commonly-used gFOBT.

Abdominal Tuberculosis: Diagnostic and Management Problems Noto Dwimartutie; Iskandar A; Marcellus Simadibrata; Ari F Syam; Ceva W Pitoyo; Andri Sulaiman; Tony Loho
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 1, April 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/71200621-27

Abdominal tuberculosis, as one of the manifestations of extrapulmonary tuberculosis, may involve gastrointestinal tract, peritoneum, mesenteric lymph nodes, liver, and also spleen. Most patients have constitutional symptoms of fever, pain, diarrhea, constipation, alternating constipation and diarrhea, weight loss, anorexia and malaise. It also has an insidious course without any specific laboratory, radiological or clinical findings and makes it difficult to diagnosis. Anti tuberculosis treatments with initiation phase for 2 months and continue with continuation phase for 7 months is effective. Steroids may be used to reduce acute inflammation and limit delayed fibrotic complications. We report a male patient with abdominal tuberculosis involving peritoneum, liver, colon, paraaorta lymph nodes, and spleen, which at first suggested as a malignancy. Drug induced hepatitis due to anti tuberculosis drug during treatment was emerged and substituted with other regimen. After given anti tuberculosis treatment and steroid as adjunctive treatment, the clinical condition of patient was improved. Keywords: abdominal tuberculosis, anti tuberculosis treatment, drug induced hepatitis

Endoscopic Variceal Ligation and ß-Blocker Combination Versus Ligation Monotherapy as Variceal Esophagus Bleeding Secondary Prevention Kevin Varian Marcevianto; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 2 (2019): VOLUME 20, NUMBER 2, August 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Variceal esophagus' risk of re-bleeding in the first year is 60-70%. Mortality rate of acute bleeding is 20-35%. Latest guidelines of esophageal rupture suggest endoscopic ligation and Non-selective b-Blocker combination for re-bleeding prevention. However, monotherapy still can be chosen, depends on the clinical judgement and patient preference. The previous meta-analysis still gave inconclusive results on therapy combination effectivity. Moreover, there is no side effect discussion between both treatment choices. Hence, this evidence-based case report analyses the effectivity of combination treatment for esophageal bleeding secondary prevention.Method: Literature searching in Scopus, ProQuest, PubMed, ScienceDirect, and EBSCOhost used keywords and their synonyms. Three articles selected included two meta-analyses and one RCT. Critical appraisal on validity, importance, and applicability based on Oxford Center of EBM 2011 was conducted.Results: Two meta-analysis prove treatment combination is significantly effective decreasing variceal re-bleeding. Ravipati et al. results in RR 0.601 (95% CI 0.44 - 0.82). However, Kumar et al. shows non-significant result. On the other hand, three articles show that therapy combination failed to significantly lower the mortality rates RR 0,786 (95% IK 0,45 - 1,39). This is due to the limitation of treatment combination to prevent cirrhotic progression and other complications. Moreover, this also is due to contraindications and non-suitability of the patients toward non-selective b-Blocker in 30-40% cases.Conclusion: Endoscopic ligation and non-selective b-Blocker combination is recommended for variceal esophagus bleeding secondary prevention, but other treatments are needed to lower the mortality rate1.

Mucus as One of the Defensive Factors in the Stomach Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010107-107

Orocaecal Transit Time in Chronic Diarrhea Marcellus Simadibrata; Paulus Simadibrata; Badriul Hegar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 6, ISSUE 3, December 2005
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/63200567-70

Background: The diagnosis and treatment of chronic diarrhea is sometimes difficult. Orocaecal transit time may explained some pathogenesis mechanism in chronic diarrhea. Methods: Twenty six chronic diarrhea patients and 35 normal adult subjects were included in this study. After fasting for at least 10 hours, subjects were asked to drink 20 ml (13.3 g) lactulose, then performed the breath hydrogen test. If there were an increment of H2 concentration 10 ppm in ½ -1 hour, the subject was considered as rapid transit time. If an increment of H concentration 10 ppm in 1 - 2 hour, the subject was considered as normal transit time. If an increment of H2 concentration 10 ppm in 2 - 3 hour,the subject was considered as delayed transit timeResults: In the chronic diarrhea group, 10 (38.4%) had rapid OCTT, 15 (57.6%) had normal OCTT and only 1 (4%) had delayed OCTT. In the normal adults group, 2 (5.7%) had rapid OCTT, 22 (62.9%) had normal OCTT and 11 (31.4%) had delayed OCTT. The difference was statistically significant (p 0.001). The mean value of OCTT in chronic diarrhea and normal adults were 84.23 + 39.82 min vs. 114.00 + 51.35 min (p = 0.027). Conclusions: The rapid OCTT was more likely to be found in the chronic diarrhea patients compare to normal adults significantly. The mean OCTT in chronic diarrhea was shorter than the mean OCTT in normal adults. Keywords: orocaecal transit time, OCTT, chronic diarrhea

Characteristic Profiles of Parasitic and Fungal Infections in Acute Diarrhea Marcellus Simadibrata; Suzana Ndraha; Tjahjadi Robert Tedjasaputra; Ari Fahrial Syam; Achmad Fauzi; Murdani Abdullah; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Diarrhea has been widely encountered in developing countries, including Indonesia. This study aimed to investigate the incidence of parasites and fungal infections, which also constitutes the etiologies of acute diarrhea. Method: A cross-sectional study was performed involving 93 patients. Patients with chief complaint of acute diarrhea were recruited at five hospitals in Jakarta, Indonesia during the period of November 2008 until May 2009. Acute diarrhea was defined as passing watery or soft stools with frequency of more than three times per day, weighted more 200 g per day, and occurred in less than 15 days duration. They were asked to collect their stool to the laboratory for further parasites and fungal detection. Results: This study showed that 41 out of 93 patients (44.09%) were found to be infected with parasites or fungi. The most common microorganism found was Candida albicans in 18 (19.35%) patients. Other parasites encountered in the stool samples were Blastocystis hominis, Entamoeba histolytica, Entamoeba coli, Giardia lamblia. The presenting clinical symptoms of the patients were fever (44.87%), bloating (41.03%), nausea (39.74%), oliguria (39.74%), cephalgia (35.90%), vomiting (24.36%), and tenesmus (19.23%). Conclusion: The incidence of parasitic and fungal infections in patients with acute diarrhea constitutes nearly half of all cases of infection-caused diarrhea. The most commonly encountered microorganism is Candida albicans. Keywords: parasites, fungi, acute diarrhea

Gastrointestinal Endoscopy in the Time of Covid-19 Pandemic: Current Guidelines and Experience From Indonesian Tertiary Endoscopy Centre Hasan Maulahela; Jaffray DP Rambak; Hilda Nurmalihah; Kaka Renaldi; Achmad Fauzi; Murdani Abdullah; Marcellus Simadibrata; Ari F Syam; Roy Soetikno; Dadang Makmun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Coronavirus disease-19 (COVID-19) is a respiratory disease caused by novel SARS-CoV-2. The disease has become a global pandemic since March 2020. Transmission of the disease is rapid and contagious through droplets and contaminated environments. Meanwhile, gastrointestinal endoscopy is a procedure that has a high risk of transmitting COVID-19. Proper strategies are needed to prevent transmission of the virus in the endoscopic unit. Some literature has published the guidelines for prevent COVID-19 in endoscopic units such as guidelines by AGA, APSDE, ESGE and ESGENA. These guidelines state that strategies for prevent the COVID-19 transmission in endoscopy unit must be done from before the procedure, during the procedure until after the procedure. These strategies must be followed by all patients and health care providers who working in endoscopy units.

Complicated Benign Peptic Stricture of the Esophagus Mulia Mulia; Jeffry Beta Tenggara; Murdani Abdullah; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 2, August 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1122010100-105

Peptic esophageal stricture secondary to gastroesophageal reflux is an important cause of esophageal stenosis and dysphagia. Symptoms of peptic strictures are usually insidious but progressive beginning with dysphagia to solids followed by dysphagia to liquids. It was estimated to occur in up to 20% of untreated patients, which has decreased significantly since the era of proton pump inhibitor therapy. The presence of esophageal reflux stricture is typically diagnosed by means of a barium esophagogram, although endoscopy may have both diagnostic and therapeutic value. Treatment usually involves dilation combined with acid- suppressive therapy. We reported a 43-year-old patient with complicated benign peptic stricture of the esophagus that finally underwent esophageal resection, a rarely therapeutic option. Keywords: gastroesophageal reflux disease, benign peptic esophageal stricture, dysphagia, esophageal dilatation, surgical treatment

Lower Gastrointestinal Bleeding due to Multiple Polyps in Ileum Ivo Novita Sah Bandar; Ari Fahrial Syam; Chudahman Manan; Marcellus Simadibrata; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 3, NUMBER 3, December 2002
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/33200299-101

The causes of lower gastrointestinal bleeding (hematochezia) are amyloidosis, anal fissure, angiodysplastic lesions, coagulation disorder, colitis, colon cancer, colorectal polyps, Crohn’s disease, diverticulitis, haemorrhoids, etc. This was a case of lower gastrointestinal bleeding due to colonic inflammatoric polyp. This inflammatoric polyps were caused by infection/inflammation and improved after antibiotic and NSAID therapy. Key Words : Colonic inflammatoric polyp, hematochezia.

Specific Subjective Symptoms for Gastroesophageal Reflux Disease in Ulcer Like Dyspepsia Poerniati Koes Andrijani; Chudahman Manan; Marcellus Simadibrata; Parlindungan Siregar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 5, ISSUE 1, April 2004
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/5120047-14

Background: The Aim of study is to identify specific subjective symptoms for gastroesophageal reflux disease (GERD), GERD proportion in ulcer like dyspepsia and the correlation between specific subjective symptoms for GERD and endoscopic examination Result in ulcer like dyspepsia Methods: A cross-sectional study was conducted in 67 patients with ulcer like dyspepsia. The patient’s history of illness was taken, and physical and endoscopic examinations were performed. A questionnaire on dyspepsia symptoms was completed. Data analysis was performed to identify the correlation between subjective symptoms and endoscopic examination results using chi-square test. T test was performed to determine the correlation between dyspepsia scores and endoscopic results. Result: Subjective symptoms that correlated with endoscopic results were severe epigastric pain (p=0.080) and the absence of bloating (p=0.055). Dyspepsia scores did not correlate with endoscopic examination results (p=0.725). Conclusion: Specific subjective symptoms for GERD in clinical dyspepsia-like ulcer were severe epigastric pain and absence of bloating. The proportion of such symptoms in ulcer like dyspepsia could assist clinical diagnosis of GERD. Keywords: GERD, symptom, dyspepsia

Co-Authors -, Selfie -, Selfie A.A. Ketut Agung Cahyawan W Aan Santi Aan Santi Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Rahman M ACHMAD FAUZI Achmad Fauzi Achmad Fauzi Adang Bachtiar Adeputri Tanesha Idhayu Aditya Rachman Aditya Rachman Aditya Rachman, Aditya Aditya Wardhana Adityo Susilo, Adityo Adiwinata, Sheila Adjeg Tarius Afistianto, Muhammad Fikri Agi Satria Putranto Agustinus, Taolin Ahmad Fauzi Ahmad Soefyani Alexander Michael Joseph Saudale Ali Djumhana Ali Imron Yusuf Alida Roswita Harahap Amanda P Utari, Amanda P Amanda Pitarini Utari Ana Mira Lubis Andhika Rachman Andi Asadul Islam Andree Kurniawan Andri Sanityoso Andri Sulaiman Angga Pramudita Anna Mira Lubis Anthony Eka Wijaya Anthony Eka Wijaya Anwar Jusuf Ardhia Fefrine Indarta Ari F Syam Ari F Syam Ari Fahrial Syam Ari Wijayanti Aria Kekalih Arief Hakiki Armen Armen Arnold Hasahatan Harahap Arshita Auliana Arya Govinda Aulia Rizka, Aulia Axel, Benvenuto Ayundini, Gratcia Aziz Rani Badriul Hegar Badriul Hegar Bambang Sutopo Bastomy Eka Rezkita Batara Bisuk Benedicta Mutiara Suwita, Benedicta Mutiara Benvenuto Axel Benvenuto Axel Bisuk, Batara Bona Adhista Bradley Jimmy Waleleng Bradley Jimmy Waleleng Budi Tan Oto Budiman Sudjatmika Budimutiar, Felix Budimutiar, Felix Aloysius Budu - Bukhari, Agussalim C Rinaldi A Lesmana Ceva W. Pitoyo Chatarina Umbul Wahyuni Christophorus Simadibrata Chudahman Manan Chudahman Manan Chudahman Manan Cleopas Martin Rumende Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Daniel Gunawan Daniel Martin Simadibrata Daniel Martin Simadibrata Daniel Martin Simadibrata Dasril Nizam David Reinhard Sumantri Samosir Deborah Theresia Budimutiar Deddy Gunawanjati Deka Larasati Deskian Kostermans Deskian Kostermans, Deskian Dharmika Djojoningrat Diah Rini Handjari Diah Rini Handjari Diana Aulia Diana Aulia Diantha Soemantri Diany N Taher Dicky Levenus Tahapary Didi Kurniadhi Didi Kurniadhi Dina Ikawari Djulzasri Albar Dolly Dolven Kansera Dono Antono Drupadi Harnopidjati Singh Dillon Dyah Purnamasari Dyah Ratna Budiani E Mudjadid E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edi Mulyana Edi Mulyana Edi Mulyana, Edi Ekowati Rahajeng Ekowati Rahajeng Elizabeth Merry Wintery Elli Arsita Elli Arsita Em Yunir, Em Emerson Patulahon Simatupang Endang Susalit Endang Susalit Ening Krisnuhoni Enrik John Aguila Epistel Pangujian Simatupang Erni J. Nelwan, Erni J. Esa, Dekta Filantropi Evy Yunihastuti Fauzi Ahmad Muda Felix Aloysius Budimutiar Ferry Sandra Fiastuti Witjaksono FJW Ten Kate Fransiska Hardi G. N.J. Tytgat Gerie Amarendra GNJ Tytgat Gratcia Ayundini Guno, Tri Hapsoro Guntur Darmawan Guntur Darmawan Halimkesuma, Christopher Christian Haloho, Raja Mangatur Haryanto Rahardjo Haryanto Surya Hasan Maulahela Hayatun Nufus Helsi Helsi Herdiman T Pohan Heri Wibowo Hery Djagat Purnomo Hery Djagat Purnomo Hilda Nurmalihah Hotmen Sijabat Ibrahim Labeda Ida Parwati Ikawari, Dina Ikhwan Rinaldi Ilham Ahmadi Ilhamjaya Patellongi Ilone, Stella Ina Susianti Timan Ina Sutanto Timan Indah S. Widyahening Indira Kemalasari Indra Kurniawan Indra Marki Indra Marki Indrasari, Nuri Dyah Ira Laurentika Irfan Maulani Iris Rengganis Irsan Hasan Iskandar A Ivo Novita Sah Bandar Iwan Ariawan Jacobus Albertus Jaffray DP Rambak Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Joseph JY Sung Juferdy Kurniawan Julwan Pribadi Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Kevin Varian Marcevianto Kharia Utia Khie Chen Kie Chen Kumalawati, July L A Lesmana L. A. Lesman Laras Budiyani, Laras Laura A Siahaan, Laura A Laurentika, Ira Laurentius Lesmana Laurentius Lesmana Leonard Nainggolan Lianda Siregar Lianda Siregar Lies Luthariana Loli J Simanjuntak Lusy Erawati Lusy Erawati Luthfi, Muhammad Lydia D Simatupang M Purnomo Isnaeni Maharani, Shabrina Marcevianto, Kevin Varian Mauna, Alesia Prillya Maureen Irawati Meilania Saraswati Mesanti, Oska Moch Ikhsan Mokoagow Mochammad Hatta Muh. Nasrum Massi MUHAMMAD SYAFIQ Mulia Mulia Murdani Abdulah Murdani Abdullah Mustika, Rita Mustikarani, Dewi Mutiara, Rizka Nadia Ayu Mulansari, Nadia Ayu Nata Pratama Hardjo Lugito Nisan Soeheri Noto Dwimartutie Novie Rahmawati Zirta Nur Chandra Bunawan Nur Chandra Bunawan Nur Rahadiani Nur Rasyid Nur Rasyid Nurmiati Amir Nurmiati Amir Oska Mesanti Pamela Abineno Pangestu Adi Parhusip, Santi Sumihar Rumondang Parlindungan Siregar Parlindungan Siregar Paulus Kusnanto Paulus Simadibrata Paulus Simadibrata Poerniati Koes Andrijani Prihantono Prihantono Prima Yuriandro Primariadewi Rustamadji Puspadina, Shafira Putra Nur Hidayat Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi Raja Mangatur Haloho Raja Mangatur Haloho Ralph Girson Gunarsa Randy Adiwinata Randy Adiwinata Randy Adiwinata, Randy Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Riadi Wirawan Riadi Wirawan Riahdo Saragih Rina Masadah Rinda Nariswati Rino A Gani Rizka Mutiara Rizki Yaruntradhani Rolan Sitompul Rosdiana Natzir Rose Feri Roy Soetikno Rudi Putranto Rudolf Simadibrata Rudy Hidayat Rumagesan, Djahalia Rustam, Musfardi Ruswhandi - Ruswhandi - Ruswhandi -, Ruswhandi Ryan Ranitya Salius Silih Saskia Aziza Nursyirwan Sedijono Sedijono Selfie - Selfie Selfie Selfie, Selfie Seri Mei Maya Ulina Sheila Adiwinata Siahaan, Billy Stinggo Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Simatupang, Emerson Patulahon Simon Salim Siti Setiati Stella Ilone Stephanie Chandra Stephanie Chandra, Stephanie Steven Irving Steven Sumantri Sugita, Peter Suhendro Suhendro Suhendro Suhendro Suryantini Suryantini Suryantini Suryantini Susanto, Liana W Suzana Ndraha Suzanna Ndraha Syahrizal Syahrizal Syarif Hidayat Syarif Hidayat T Yuli Pramana Tahir, Andi Cahaya Tandan, Manu Taolin Agustinus Teguh Karyadi Tengku Riza Zarzani N Timan, Ina Sutanto Tjahjadi Robert Tedjasaputra Tjahjadi Robert Tedjasaputra Toman L Toruan Tommy P Sibuea Tony Loho Tri Hapsoro Guno Tri Juli Edi T Unggul Budihusodo Vera D Yoewono Vera Yuwono Veronica, Raja Merlinda Virly Nanda Muzelina Virly Nanda Muzellina Wijaya, Anthony Eka Willy Brodus Uwan Willy Brodus Uwan, Willy Brodus Wismandari Wisnu Witri Abriya Yohannessa Wulandari Yundari, Yundari Yusra Yusra Zakiah Zakiah

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