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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Marcellus Simadibrata K

Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Central General Hospital, Jl. Diponegoro No.71, Jakarta 10430

Author-ID : 380435

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Dilatation Treatment for Esophageal Strictures Zakiah Zakiah; Ana Mira Lubis; Marcellus Simadibrata; Nurmiati Amir
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 3, December 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/93200898-102

A patient with adjustment disorder and depression had experienced a suicide temptation by ingesting corrosive substance since 6 months before her hospital admission. On the first day care, she only can swallow “soft-fluid diet” which is given very slowly. Subsequently, the patient had a series of dilatation treatment guided by fluoroscopy and demonstrated a very impressive result. On the first dilatation, a 7 mm dilator was used, and then respectively 9, 10, 5, 12, 8 and 14 mm dilator was applied. We needed to perform three sessions of dilatation until the 9 mm dilator can be inserted. After the second dilatation, the patient had started to be able to eat refine porridge and subsequently rice porridge with soft vegetables and side dishes. At the end of treatment, she had already been able to eat normally. The general management of esophageal stricture by using dilator will be discussed in this article. Keywords: stricture, corrosive substance, dilatation treatment, dysphagia

Diagnosis and Management of Gastroenteropathy Asssociated to Non-steroidal Anti-Inflammatory Drugs Stella Ilone; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 2 (2016): VOLUME 17, NUMBER 2, August 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Non-steroidal anti-inflammatory drugs (NSAIDs) is a group of drugs used to treat pain, inflammation, and fever. High consumption of NSAIDs associated with high gastrointestinal side effects. Common complaint from patients, which ranging from mild heartburn to the onset of gastrointestinal bleeding, often complicates the adequate administration of NSAIDs. Various methods have been developed to reduce the likelihood of gastroenteropathy complication. Early diagnosis, appropriate prompt treatment, as well as adequate monitoring will reduce morbidity and mortality from complications due to NSAIDs. This paper will discuss the diagnosis and management of gastro-enteropathy NSAID through approaching the underlying pathophysiology.

The Success Rate of ERCP for Identification and Stenting in Obstructive Jaundice in Cipto Mangunkusumo Hospital October 2004-July 2007 Simon Salim; Daniel Gunawan; Ilham Ahmadi; Marcellus Simadibrata; Achmad Fauzi; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 2, August 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/92200845-47

Background: Obstructive jaundice can be caused by malignant or benign origin. The treatment for these situations includes drainage by biliary stenting. The aim of this study was to evaluate the success rate of Endoscopic Retrograde Cholangiopancreatography (ERCP) in evaluating malignant obstructive jaundice and the success rate of plastic stent placement. Method: We conducted a retrospective study based on data of ERCP in Cipto Mangunkusumo hospital from October 2004 until July 2007. Results: We evaluated 100 patients who had undergone ERCP examination, 92 (92%) of them had clinical diagnosis of obstructive jaundice (direct bilirubin indirect bilirubin). Those with obstructive jaundice were found to have no malignancy in 47 (51.1%) patients, with malignancy in 28 (30.4%) patients, and 17 (18.5%) of them would have further diagnostic evaluation. We had conducted a descriptive study in 36 patients who had tried to have plastic stent placement. Nineteen (52.8%) patients succeed in plastic stent placement; whereas 17 (47.2%) patients had failed. Further evaluation showed that age and sex did not affect stent successfulness, and malignancy was showed to be a factor for stent failure (malignancy: 16 fail and 6 successes (27.3%) vs. non malignancy: 1 fail and 13 successes (92.85%). Conclusion: Cipto Mangunkusumo hospital has acceptable success rate for diagnostic ERCP in obstructive jaundice patients. However, it is relatively lower than other studies, which might be caused by late referral and different standard instruments that were used. Keywords: obstructive jaundice, malignancy, ERCP, stent placement

Recurrent Acute Pancreatitis as A Manifestation of Sphincter of Oddi Dysfunction Ira Laurentika; Ari Fahrial Syam; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Recurrent acute pancreatitis (RAP) is defined as two or more occurance of acute pancreatitis with no evidence of underlying chronic pancreatitis. Prevalence of RAP varied from 10-30%. One of the postulated mechanism of this condition is sphincter of Oddi dysfunction (SOD) which is a clinical biliary pain syndrome or acute pancreatitis (AP) due to pancreatobiliary obstruction at the level of sphincter of Oddi. We reported a 29-year-old female patient who came to Cipto Mangunkusomo Hospital regarding upper quadrant abdominal pain with previously well documented history of AP in the last six months before admission. Laboratory findings showed elevated pancreatic enzyme level which was consistent with AP. The patient underwent magnetic resonance cholangio-pancreatography (MRCP) and endoscopic ultrasound (EUS) examination and both of the results showed dilatation of pancreatic duct which suggested SOD. Due to the lack of further diagnostic modality, manometry was not performed on this patient. However, after excluding other possible etiology of SOD, the patient underwent endoscopic retrograde cholangio-pamcreatograhy (ERCP) and sphincterotomy was performed. The signs and symptoms of AP was relieved after sphincterotomy and not yet recurred.

Hematochezia in Young Patient Due to Crohn’s Disease Anna Mira Lubis; Marcellus Simadibrata; Dadang Makmun; Ari F Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 2, August 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/72200654-56

Crohn’s disease encompasses a spectrum of clinical and pathological patterns, affecting the gastrointestinal (GI) tract with potential systemic and extraintestinal complications. The disease can affect any age group, but the onset is most common in the second and third decade. Lower GI bleeding is one of its clinical features. Surgical intervention is required in up to two-thirds of patients to treat intractable hemorrhage, perforation, obstruction or unresponsive fulminant disease. We reported a case of Crohn’s disease in young male who suffered from severe lower GI bleeding (hematochezia) as the clinical features. Lower GI endoscopy revealed ulceration at the distal ileum surrounded by fibrotic tissue as a source of bleeding and a tumor mass at mesocolon. Upper GI endoscopy was unremarkable. Histopathologyc examination concluded multiple ulceration with chronic ischemic condition, appropriate to Crohn’s disease. The patient underwent emergency surgical intervention (subtotal colectomy and ileustomy), and his condition was improved. Keywords: hematochezia, young male, Crohn’s disease, surgery

Approach for Diagnostic and Treatment of Achalasia Andree Kurniawan; Marcellus Simadibrata; Prima Yuriandro; Lie Khie Chen
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 2, August 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Achalasia is a rare motor disorder of the esophagus and lower esophageal sphincter. The incidence is approximately 1/100,000 per year and the prevalence rate is 10/100,000. Achalasia is quite difficult to establishbecause the symptoms might be insidious and therefore not many people come to seek medical attention until it deteriorates to final stage of the disease. There are several modalities that can be used as diagnostic toolssuch as manometry, barium esophagogram, esophagoduodenoscopy, esophageal CT-scan, until the recent one, high-resolution manometry that can classify achalasia into three different types. The treatment options are the pharmacologic intervention, endoscopic treatment, minimal invasive surgery, and radical surgery.We reported a case of 20 year old female with achalasia who came with dysphagia symptom since three years before. The diagnosis was made by historytaking, physical examination and barium meal and esophagogastroduodenoscopy. The patient underwent pneumatic dilatation and since then the symptom was relieved.Keywords: achalasia, diagnostic, treatment

Obesity as a Risk Factor of Erosive Gastroesophageal Reflux Disease Hotmen Sijabat; Marcellus Simadibrata; Ari Fahrial Syam; Endang Susalit; Djulzasri Albar; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 2, August 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/112201061-65

Background: Gastroesophageal reflux disease (GERD) is a pathological condition of esophagus caused by reflux of gastric content or gastric juice with multifactorial etiologies. Some complications may occur such as: ulcer, bleeding, stricture, Barret’s esophagus and esophageal adenocarcinoma. One of risk factors that currently taken into concern is obesity. Our study aimed to identify obesity and abdominal obesity as the risk factor in the development of erosive GERD and to recognize that abdominal obesity is more important factor compared to obesity itself as the risk factor on the incidence of erosive GERD.. Method: Our study was a cross-sectional study. Data was obtained from eligible patients at Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia between June and September 2009 Results: Samples were 74 patients with mean age of 48.61 ± 8.64 years. The proportion of female patients was larger than male (60.81% vs. 39.19%). The endoscopic assessment of upper gastrointestinal tract based on Los Angeles Classification included: Grade A esophagitis: 27.03%, Grade B: 16.21%, Grade C: 4.05%, Grade D: 1.35%. Obesity (odds ratio (OR) 17.160; 95% confidence interval (CI) 5.219 – 56.418, p = 0.000) and abdominal obesity (OR 10.371, 95% CI 3.260 – 32.915; p = 0.000) has been proven as risk factors in the development of erosive GERD. Conclusion: There is a correlation between obesity and abdominal obesity as risk factors on the development of erosive GERD. Obesity becomes a more important factor compared to abdominal obesity as the risk factor on the development of erosive GERD. Keywords: erosive gastroesophageal reflux disease, obesity, abdominal obesity, risk factor

The Pathophysiology Gastroesophageal Reflux Disease Bradley Jimmy Waleleng; Marcellus Simadibrata; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 3, December 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/83200784-90

ABSTRACT The incidence of Gastroesophageal Reflux Disease (GERD), especially in Indonesia, is increasing with the change of community life-style. Also, the doctors’ perception in understanding clinical manifestation of GERD is alike in addition to the development of diagnostic facilities such as endoscopy in Indonesia. The GERD incidence in Indonesia is as high as the incidence in developed countries. Esophageal reflux develops in physiological condition, which may be found in normal individual. GERD development is caused by anatomical and physiological disorders such as hereditary or acquired factor; and other factors that may be categorized into offensive factors such as gastric acid, pepsin, bile acid, trypsin and disturbance in defensive factors such as hypotensive Lower Esophageal Sphincter (LES), Transient Lower Esophageal Sphincter Relaxations (TLESR), hiatal hernia, disrupted saliva production, esophageal peristaltic disorder; as well as other factors such as genetic, diet, or certain drugs. Imbalance of such factors may cause pathological repeated esophageal reflux which may damage esophageal mucosa and lead to GERD development including all of complications. Keywords: esophageal reflux, GERD, LES

Hospital-based Survey on Knowledge and Attitude toward Colorectal Cancer Screening among Indonesian Population Murdani Abdullah; Achmad Fauzi; Ari Fahrial Syam; Dadang Makmun; Marcellus Simadibrata; Chudahman Manan; Joseph JY Sung; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 2, August 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/102200951-55

Background: Several western countries have recommended colorectal cancer (CRC) screening, however the yield of CRC screening is still low. The acceptability of CRC screening is influenced by people’s knowledge and attitude. This study was conducted to evaluate the knowledge and attitude of Indonesian people toward CRC screening. Method: Adult Indonesian population aged 19–65 years was recruited in this hospital-based survey. Knowledge and attitude toward CRC screening were assessed by using structured questionnaires consisting of nine chapters. Result: There were 614 respondents recruited in this study. Most respondents (36.2%) incorrectly pointed out abdominal pain or pain around anus as the symptom of bowel cancer. Regarding CRC risk factors, eating fruits or vegetables rarely was the most frequent answer (28.5%) encountered. Only one-third (28%) of respondents mentioned colonoscopy as the Method for CRC screening. There were 38.1% of respondents who believed that CRC screening test might be harmful to the body. Up to 70.8% of the respondents agreed and strongly agreed that CRC screening test might cause physical discomfort. Two fifth (41.5%) of respondents believed that CRC screening test was embarrassing. More than half (58.8%) of respondents were afraid of having the CRC screening test. The test was too expensive according to 79.5% of respondents. Conclusion: The knowledge on CRC symptoms, risk factors, and screening tests is still low among Indonesian population. Our study result indicates that the lack of knowledge and the discouraging attitude among Indonesian population will be the major barriers to implement CRC screening in Indonesia. Keywords: colorectal cancer, screening, knowledge, attitude

Epstein-Barr Virus Infection as One of the Predisposition Factor for Colorectal Cancer Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Co-Authors -, Selfie -, Selfie A.A. Ketut Agung Cahyawan W Aan Santi Aan Santi Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Rahman M Achmad Fauzi Achmad Fauzi ACHMAD FAUZI Adang Bachtiar Adeputri Tanesha Idhayu Aditya Rachman Aditya Rachman Aditya Rachman, Aditya Aditya Wardhana Adityo Susilo, Adityo Adiwinata, Sheila Adjeg Tarius Afistianto, Muhammad Fikri Agi Satria Putranto Agustinus, Taolin Ahmad Fauzi Ahmad Soefyani Alexander Michael Joseph Saudale Ali Djumhana Ali Imron Yusuf Alida Roswita Harahap Amanda P Utari, Amanda P Amanda Pitarini Utari Ana Mira Lubis Andhika Rachman Andi Asadul Islam Andree Kurniawan Andri Sanityoso Andri Sulaiman Angga Pramudita Anna Mira Lubis Anthony Eka Wijaya Anthony Eka Wijaya Anwar Jusuf Ardhia Fefrine Indarta Ari F Syam Ari F Syam Ari Fahrial Syam Ari Wijayanti Aria Kekalih Arief Hakiki Armen Armen Arnold Hasahatan Harahap Arshita Auliana Arya Govinda Aulia Rizka, Aulia Axel, Benvenuto Ayundini, Gratcia Aziz Rani Badriul Hegar Badriul Hegar Bambang Sutopo Bastomy Eka Rezkita Batara Bisuk Benedicta Mutiara Suwita, Benedicta Mutiara Benvenuto Axel Benvenuto Axel Bisuk, Batara Bona Adhista Bradley Jimmy Waleleng Bradley Jimmy Waleleng Budi Tan Oto Budiman Sudjatmika Budimutiar, Felix Budimutiar, Felix Aloysius Budu - Bukhari, Agussalim C Rinaldi A Lesmana Ceva W. Pitoyo Chatarina Umbul Wahyuni Christophorus Simadibrata Chudahman Manan Chudahman Manan Chudahman Manan Cleopas Martin Rumende Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Daniel Gunawan Daniel Martin Simadibrata Daniel Martin Simadibrata Daniel Martin Simadibrata Dasril Nizam David Reinhard Sumantri Samosir Deborah Theresia Budimutiar Deddy Gunawanjati Deka Larasati Deskian Kostermans Deskian Kostermans, Deskian Dharmika Djojoningrat Diah Rini Handjari Diah Rini Handjari Diana Aulia Diana Aulia Diantha Soemantri Diany N Taher Dicky Levenus Tahapary Didi Kurniadhi Didi Kurniadhi Dina Ikawari Djulzasri Albar Dolly Dolven Kansera Dono Antono Drupadi Harnopidjati Singh Dillon Dyah Purnamasari Dyah Ratna Budiani E Mudjadid E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edi Mulyana Edi Mulyana Edi Mulyana, Edi Ekowati Rahajeng Ekowati Rahajeng Elizabeth Merry Wintery Elli Arsita Elli Arsita Em Yunir, Em Emerson Patulahon Simatupang Endang Susalit Endang Susalit Ening Krisnuhoni Enrik John Aguila Epistel Pangujian Simatupang Erni J. Nelwan, Erni J. Esa, Dekta Filantropi Evy Yunihastuti Fauzi Ahmad Muda Felix Aloysius Budimutiar Ferry Sandra Fiastuti Witjaksono FJW Ten Kate Fransiska Hardi G. N.J. Tytgat Gerie Amarendra GNJ Tytgat Gratcia Ayundini Guno, Tri Hapsoro Guntur Darmawan Guntur Darmawan Halimkesuma, Christopher Christian Haloho, Raja Mangatur Haryanto Rahardjo Haryanto Surya Hasan Maulahela Hayatun Nufus Helsi Helsi Herdiman T Pohan Heri Wibowo Hery Djagat Purnomo Hery Djagat Purnomo Hilda Nurmalihah Hotmen Sijabat Ibrahim Labeda Ida Parwati Ikawari, Dina Ikhwan Rinaldi Ilham Ahmadi Ilhamjaya Patellongi Ilone, Stella Ina Susianti Timan Ina Sutanto Timan Indah S. Widyahening Indira Kemalasari Indra Kurniawan Indra Marki Indra Marki Indrasari, Nuri Dyah Ira Laurentika Irfan Maulani Iris Rengganis Irsan Hasan Iskandar A Ivo Novita Sah Bandar Iwan Ariawan Jacobus Albertus Jaffray DP Rambak Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Joseph JY Sung Juferdy Kurniawan Julwan Pribadi Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Kevin Varian Marcevianto Kharia Utia Khie Chen Kie Chen Kumalawati, July L A Lesmana L. A. Lesman Laras Budiyani, Laras Laura A Siahaan, Laura A Laurentika, Ira Laurentius Lesmana Laurentius Lesmana Leonard Nainggolan Lianda Siregar Lianda Siregar Lies Luthariana Loli J Simanjuntak Lusy Erawati Lusy Erawati Luthfi, Muhammad Lydia D Simatupang M Purnomo Isnaeni Maharani, Shabrina Marcevianto, Kevin Varian Mauna, Alesia Prillya Maureen Irawati Meilania Saraswati Mesanti, Oska Moch Ikhsan Mokoagow Mochammad Hatta Muh. Nasrum Massi MUHAMMAD SYAFIQ Mulia Mulia Murdani Abdulah Murdani Abdullah Mustika, Rita Mustikarani, Dewi Mutiara, Rizka Nadia Ayu Mulansari, Nadia Ayu Nata Pratama Hardjo Lugito Nisan Soeheri Noto Dwimartutie Novie Rahmawati Zirta Nur Chandra Bunawan Nur Chandra Bunawan Nur Rahadiani Nur Rasyid Nur Rasyid Nurmiati Amir Nurmiati Amir Oska Mesanti Pamela Abineno Pangestu Adi Parhusip, Santi Sumihar Rumondang Parlindungan Siregar Parlindungan Siregar Paulus Kusnanto Paulus Simadibrata Paulus Simadibrata Poerniati Koes Andrijani Prihantono Prihantono Prima Yuriandro Primariadewi Rustamadji Puspadina, Shafira Putra Nur Hidayat Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi Raja Mangatur Haloho Raja Mangatur Haloho Ralph Girson Gunarsa Randy Adiwinata Randy Adiwinata Randy Adiwinata, Randy Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Riadi Wirawan Riadi Wirawan Riahdo Saragih Rina Masadah Rinda Nariswati Rino A Gani Rizka Mutiara Rizki Yaruntradhani Rolan Sitompul Rosdiana Natzir Rose Feri Roy Soetikno Rudi Putranto Rudolf Simadibrata Rudy Hidayat Rumagesan, Djahalia Rustam, Musfardi Ruswhandi - Ruswhandi - Ruswhandi -, Ruswhandi Ryan Ranitya Salius Silih Saskia Aziza Nursyirwan Sedijono Sedijono Selfie - Selfie Selfie Selfie, Selfie Seri Mei Maya Ulina Sheila Adiwinata Siahaan, Billy Stinggo Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Simatupang, Emerson Patulahon Simon Salim Siti Setiati Stella Ilone Stephanie Chandra Stephanie Chandra, Stephanie Steven Irving Steven Sumantri Sugita, Peter Suhendro Suhendro Suhendro Suhendro Suryantini Suryantini Suryantini Suryantini Susanto, Liana W Suzana Ndraha Suzanna Ndraha Syahrizal Syahrizal Syarif Hidayat Syarif Hidayat T Yuli Pramana Tahir, Andi Cahaya Tandan, Manu Taolin Agustinus Teguh Karyadi Tengku Riza Zarzani N Timan, Ina Sutanto Tjahjadi Robert Tedjasaputra Tjahjadi Robert Tedjasaputra Toman L Toruan Tommy P Sibuea Tony Loho Tri Hapsoro Guno Tri Juli Edi T Unggul Budihusodo Vera D Yoewono Vera Yuwono Veronica, Raja Merlinda Virly Nanda Muzelina Virly Nanda Muzellina Wijaya, Anthony Eka Willy Brodus Uwan Willy Brodus Uwan, Willy Brodus Wismandari Wisnu Witri Abriya Yohannessa Wulandari Yundari, Yundari Yusra Yusra Zakiah Zakiah

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