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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Marcellus Simadibrata K

Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Central General Hospital, Jl. Diponegoro No.71, Jakarta 10430

Author-ID : 380435

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 151 Documents Claim Missing Document

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Articles

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Ghrelin Level in Syndrome Dyspepsia Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 16, No 1 (2015): VOLUME 16, NUMBER 1, April 2015
Publisher : The Indonesian Society for Digestive Endoscopy

Diagnosis and Treatment of Refractory Gastroesophageal Reflux Disease (GERD) Selfie -; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 16, No 3 (2015): VOLUME 16, NUMBER 3, December 2015
Publisher : The Indonesian Society for Digestive Endoscopy

Gastroesophageal reflux disease (GERD) was a damage in mucosal layer caused by gastric acid reflux. GERD was found about 10-20% in Western Countries and less in Asia, about 2,6-6,7%. Among different type of GERD, refractory GERD was a problem found in daily clinical practice. This terminology was used in patients with regurgitation and heartburn symptoms which is not responsive to 8 weeks proton pump inhibitor (PPI) therapy. There were several mechanisms underlying the etiology and pathophysiology of refractory GERD. In general, refractory GERD diagnosis was based on clinical findings, objective endoscopic examination, ambulatory reflux monitoring, and response to antiacid-secretion therapy. Reevaluation of patients compliance should be the first step in refractory GERD management. A further treatment strategies could be started, consist of medical and surgical therapies. A basic clinical knowledge of refractory GERD would help clinician in deciding the best approach for diagnosis and therapy.

Management of Duodenal Ulcer with Gastroesophageal Reflux Disease (GERD) with Intravenous Pantoprazole Ari Fahrial Syam; Murdani Abdullah; Marcellus Simadibrata; Dadang Makmun; Chudahman Manan; Daldiyono Hardjodisasto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 4, NUMBER 1, April 2003
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/41200326-28

Proton pump inhibitors (PPIs) are the most effective anti secretory drugs available for controlling gastric acid acidity and volume. They are the drug of choice in the treatment for gastro esophageal reflux disease (GERD), Helicobacter pylori eradication, peptic ulcer and non steroidal anti-inflammatory drug (NSAID) gastropathy: For acute cases, an intravenous PPI is needed, especially for hospitalized patient. Recently, intravenous pantoprazole represents an alternative to intravenous histamine-2 receptor antagonists. We observed 2 patients who were treated with pantoprazole for duodenal ulcer, where one case had a complication of bleeding with a history of long term use of NSAID. After two weeks of treatment with pantoprazole, significant lesion healing from endoscopy findings was achieved in both cases. Keywords: peptic ulcer, upper gastrointestinal bleeding, proton pump inhibitors, pantoprazole

A 17-Years Old Man of Colitis Tuberculosis with Fistula Perianal Paulus Kusnanto; Marcellus Simadibrata; Ari Fahrial Syam; Achmad Fauzi; Murdani Abdullah; Dadang Makmun; Chudahman Manan; Daldiyono Daldiyono; Abdul Aziz Rani; Ening Krisnuhoni
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 3, December 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/932008103-106

Tuberculosis (TB) remains to be one of the most common problems in developing countries such as Indonesia. It can involve many organs including gastrointestinal tracts. Colonic tuberculosis is an ancient disease and has long been recognized. However, it is sometimes difficult to make early diagnosis due to its nonspecific signs and symptoms. Perianal granulomas or perianal fistula presents some degree of diagnostic difficulty. A spectrum of diseases can produce granulomas in perianal region and perineum. Most are infectious or inflammatory diseases. Standard histological diagnosis often less significant to clarify the etiology and treatment will vary from one to another disease entity. In this report, we present a case 17-years old man with colitis TB and fistula perianal, in which the initial diagnostic workup suggested Crohn’s disease. Mantoux test, Acid Fast Bacilli test on fecal examination and polymerase chain reaction analysis revealed negative result. The chest X-ray was normal; while the fistulography X-ray: revealed 2 orifices in rectosigmoid area. The colonoscopy revealed mucosa edema with ulceration in rectosigmoid and pedincular polyp in the caecum. Initial colonoscopy diagnosis was Crohn’s disease with differential diagnosis colitis ulcerative, colitis TB, colitis infection. results of direct or post homogenizes examination (Ziel–Nielsen staining) revealed that no acid-fast bacilli was found. Multiple biopsies were done, which indicated mucosa edema with ulceration in rectosigmoid area, pedincular polyp in the caecum, and surrounded by fistula perianal; while histopathological examination showed inflammatory-caseating-epithelioid-granulomas and giant cells (Langhans datia cell) caused by tuberculosis. It highlights the need for awareness of intestinal TB along with the differential diagnosis of chronic intestinal disease. Standard regimen of antituberculosis treatment was given and the patient showed good clinical response. Keywords: Crohn’s disease, caseating epithelioid granuloma, giant cell, colitis TB, perianal fistula

Chronic Pancreatitis Indira Kemalasari; Murdani Abdullah; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 2 (2018): VOLUME 19, NUMBER 2, August 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Chronic pancreatitis is a progressive inflammation in pancreas results in fibrosis and irreversible damage lead to loss of exocrine and endocrine function. Mortality and complication rate is high. Appropriate management of chronic pancreatitis begin from accurate diagnosis to adequate treatment. Diagnosis is still a challenge for clinician, mostly in early-stage disease. Several diagnostic modalities such computed tomography scan, magnetic resonance cholangiopancreaticography, endoscopic ultrasound, endoscopic retrograde cholangiopancreaticography, and direct-indirect pancreatic function test help diagnosis establishment. Endoscopic approach has an important role, both during diagnosis and treatment.

The Use of Immunochemical Fecal Occult Blood Test as Colorectal Cancer Screening Tool in Asymptomatic Population in Indonesia Murdani Abdullah; Hayatun Nufus; Ari Fahrial Syam; Dadang Makmun; Marcellus Simadibrata; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 15, No 1 (2014): VOLUME 15, NUMBER 1, April 2014
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Colorectal cancer is the fourth leading cause of cancer-related mortality worldwide. Earlydetection of colorectal cancer is necessary in term of increasing survival. Immunochemical fecal occult bloodtest (I-FOBT) is one of the simple and inexpensive screening modality that can be used widely. No data has been available yet regarding the usage of I-FOBT in Indonesia. This study is a prevalence study of I-FOBT in asymptomatic population in Indonesia. Method: A cross sectional study was conducted in asymptomatic population visiting five public health service centers in Depok district, West Java, Indonesia. This study was performed from January to March 2012. Casereport form and I-FOBT kit were used to assess and screen the patients. Statistic analysis was performed usingChi-square test. Results: The prevalence of positive I-FOBT was almost equally distributed among age group. Femaledominated whole patients 202 (72.7%). Most of them had middle to low education level 116 (41.7%). As manyas 50.7% patients had normal body mass index. We had 11 (4%) patients with positive result of I-FOBT. Conclusion: Prevalence of positive result of I-FOBT in asymptomatic population in Indonesia was 4%.Further studies were needed to confirm sensitivity and specifity of I-FOBT in Indonesia.Keywords: colorectal cancer, immunochemical fecal occult blood test (I-FOBT), early detection

Colitis Tuberculosis Budi Tan Oto; Ahmad Fauzi; Ari Fahrial Syam; Marcellus Simadibrata; Murdani Abdullah; Dadang Makmun; Chudahman Manan; Abdul Aziz Rani; Daldiyono Daldiyono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010143-149

Tuberculosis (TB) is a significant public health problem worldwide. Indonesia is a country with the third highest prevalence of TB in the world after China and India. TB infection can attack all organs of the human body. TB in digestive system is one of the extrapulmonary TB manifestations and comprises of 3- 16% of all extrapulmonary TB cases. This type of TB may affect digestive system, peritoneum, mesentery lymphatic glands, liver, and spleen. Digestive system is affected in 66-75% of patients with abdominal TB. The ileocaecal region is most commonly affected. The manifestation of abdominal TB is not specific. Precise diagnostic approach and supporting results are needed to determine final diagnosis. However, there is no single examination adequate enough to diagnose abdominal TB. If the diagnosis can be established early, this disease could then be managed with conventional anti-TB drugs. Treatment for both 6-9 months period and 18-24 months period has been proven effective in management of extrapulmonary TB. In countries with high abdominal TB prevalence, initiation of anti-TB therapy is allowed if there are the clinical features present. Diagnosis can be determined when the patient has therapeutic response against the the anti-TB treatment. Keywords: tuberculosis, colitis, extrapulmonary, antituberculosis drugs

Proportion and Factors Associated with Zinc Deficiency in Acute Diarrhea Patients Budi Tan Oto; Marcellus Simadibrata; Drupadi Harnopidjati Singh Dillon; Siti Setiati
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Zinc may affect the intestinal immune response. No data has been available on zinc deficiency in adult patients with diarrhea, especially for Indonesian population. Zinc metabolism, etiologies, pathogenesis and clinical course of diarrhea may have various effects on zinc concentration in different population. This study aimed to determine the proportion of zinc deficiency in patients with acute diarrhea, including its associated factors. Method: A cross-sectional study was conducted in patients with acute diarrhea at outpatient clinics and emergency wards of four hospitals between August 2010 and March 2011. A serum zinc concentration of 10.7 µmol/L was set as cut-off value for zinc deficiency. Data was analyzed by using Chi-square test. Results: There were 101 subjects, 54.5% were female, the median age was 26 years, median duration of acute diarrhea was 5 days, and the median frequency was 6 times/day. About 95% patients had nutritional status of subjective global assessment (SGA) A and the mean value of body mass index was 19.3 ± 0.70 kg/m2. Approximately 88.1% patients had severe infective diarrhea based on hydration status. About 69.3% patients were zinc deficient with the mean serum zinc concentration of 9.26 ± 2.95 µ mol/L. We found a significant correlation between the severity of diarrhea and zinc deficiency in patients with acute diarrhea. Conclusion: The proportion of zinc deficiency in acute diarrhea patients was quite large although the mean serum zinc level was still below the National Health and Nutrition Examination Survey (NHANES) reference value. The severity of diarrhea has been proven to be significant that affects zinc deficiency in acute diarrhea patients. Keywords: zinc deficiency, acute diarrhea, adult

The Role of Vitamin D in Inflammatory Bowel Disease Pathogenesis and Management Randy Adiwinata; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 1 (2017): VOLUME 18, NUMBER 1, April 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Vitamin D is widely recognized in maintaining bone metabolism and health. However, recent studies indicated that vitamin D also play important role in regulating immune system. Patients with inflammatory bowel disease (IBD) is commonly found to be vitamin D deficiency; whether it served as risk factor of IBD or as the consequence of disease activity are still debatable. Growing evidences showed that supplementation of vitamin D for IBD patients to achieve normal or optimal serum level may suppress the inflammatory process, reduce disease severity, maintaining remission status, and improving quality of life.

Through-the-scope Polyethylene Balloon Dilations in Benign Corrosive Esophageal Stricture Complicated with Temporomandibular Joint Dislocation Elli Arsita; Achmad Fauzi; Jeffri Gunawan; Kaka Renaldi; Ari Fahrial Syam; Murdani Abdullah; Marcellus Simadibrata; Dadang Makmun; Chudahman Manan; Abdul Aziz Rani; Daldiyono Daldiyono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Esophageal dilation is a non-surgical management for anatomic and functional abnormalities causing both benign and malignant esophageal stricture. The basic goals of stricture dilation include safe and efficacious lumenal enlargement plus prevention of restenosis. These could be achieved using through- the-scope (TTS) balloon dilations, ranged in diameter of 4 to 40 mm, they will allow dilation of previously inaccessible strictures in the esophagus, stomach, small bowel, and colon. There are 5,000–15,000 cases of stricture due to ingestion of corrosive substances in United States every year. The following case would demonstrate a 28-year-old male with depressive disorder who attempted a suicide by ingesting corrosive substances two months before admission. Subsequently he started having difficulty in swallowing even soft foods. The complaint was gradually increasing until a month before admission he went through endoscopic examination and a corrosive esophageal stricture found. Hence after, he underwent dilation using Savary bouginage with fluoroscopy and through-the-scope (TTS) balloon dilations. The patient underwent a series of dilation treatment and demonstrated vigorous improvement. Problems raised as the patient was complicated with temporomandibular joint (TMJ) dislocation due to traumatic injury after ingesting corrosive substances. The consideration in management of esophageal stricture with complications will be discussed further in this article. Keywords: esophageal stricture, corrosive substances, dysphagia, temporomandibular joint dislocation, through-the-scope polyethylene balloon dilation

Co-Authors -, Selfie -, Selfie A.A. Ketut Agung Cahyawan W Aan Santi Aan Santi Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Rahman M ACHMAD FAUZI Achmad Fauzi Achmad Fauzi Adang Bachtiar Adeputri Tanesha Idhayu Aditya Rachman Aditya Rachman Aditya Rachman, Aditya Aditya Wardhana Adityo Susilo, Adityo Adiwinata, Sheila Adjeg Tarius Afistianto, Muhammad Fikri Agi Satria Putranto Agustinus, Taolin Ahmad Fauzi Ahmad Soefyani Alexander Michael Joseph Saudale Ali Djumhana Ali Imron Yusuf Alida Roswita Harahap Amanda P Utari, Amanda P Amanda Pitarini Utari Ana Mira Lubis Andhika Rachman Andi Asadul Islam Andree Kurniawan Andri Sanityoso Andri Sulaiman Angga Pramudita Anna Mira Lubis Anthony Eka Wijaya Anthony Eka Wijaya Anwar Jusuf Ardhia Fefrine Indarta Ari F Syam Ari F Syam Ari Fahrial Syam Ari Wijayanti Aria Kekalih Arief Hakiki Armen Armen Arnold Hasahatan Harahap Arshita Auliana Arya Govinda Aulia Rizka, Aulia Axel, Benvenuto Ayundini, Gratcia Aziz Rani Badriul Hegar Badriul Hegar Bambang Sutopo Bastomy Eka Rezkita Batara Bisuk Benedicta Mutiara Suwita, Benedicta Mutiara Benvenuto Axel Benvenuto Axel Bisuk, Batara Bona Adhista Bradley Jimmy Waleleng Bradley Jimmy Waleleng Budi Tan Oto Budiman Sudjatmika Budimutiar, Felix Budimutiar, Felix Aloysius Budu - Bukhari, Agussalim C Rinaldi A Lesmana Ceva W. Pitoyo Chatarina Umbul Wahyuni Christophorus Simadibrata Chudahman Manan Chudahman Manan Chudahman Manan Cleopas Martin Rumende Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Daniel Gunawan Daniel Martin Simadibrata Daniel Martin Simadibrata Daniel Martin Simadibrata Dasril Nizam David Reinhard Sumantri Samosir Deborah Theresia Budimutiar Deddy Gunawanjati Deka Larasati Deskian Kostermans Deskian Kostermans, Deskian Dharmika Djojoningrat Diah Rini Handjari Diah Rini Handjari Diana Aulia Diana Aulia Diantha Soemantri Diany N Taher Dicky Levenus Tahapary Didi Kurniadhi Didi Kurniadhi Dina Ikawari Djulzasri Albar Dolly Dolven Kansera Dono Antono Drupadi Harnopidjati Singh Dillon Dyah Purnamasari Dyah Ratna Budiani E Mudjadid E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edi Mulyana Edi Mulyana Edi Mulyana, Edi Ekowati Rahajeng Ekowati Rahajeng Elizabeth Merry Wintery Elli Arsita Elli Arsita Em Yunir, Em Emerson Patulahon Simatupang Endang Susalit Endang Susalit Ening Krisnuhoni Enrik John Aguila Epistel Pangujian Simatupang Erni J. Nelwan, Erni J. Esa, Dekta Filantropi Evy Yunihastuti Fauzi Ahmad Muda Felix Aloysius Budimutiar Ferry Sandra Fiastuti Witjaksono FJW Ten Kate Fransiska Hardi G. N.J. Tytgat Gerie Amarendra GNJ Tytgat Gratcia Ayundini Guno, Tri Hapsoro Guntur Darmawan Guntur Darmawan Halimkesuma, Christopher Christian Haloho, Raja Mangatur Haryanto Rahardjo Haryanto Surya Hasan Maulahela Hayatun Nufus Helsi Helsi Herdiman T Pohan Heri Wibowo Hery Djagat Purnomo Hery Djagat Purnomo Hilda Nurmalihah Hotmen Sijabat Ibrahim Labeda Ida Parwati Ikawari, Dina Ikhwan Rinaldi Ilham Ahmadi Ilhamjaya Patellongi Ilone, Stella Ina Susianti Timan Ina Sutanto Timan Indah S. Widyahening Indira Kemalasari Indra Kurniawan Indra Marki Indra Marki Indrasari, Nuri Dyah Ira Laurentika Irfan Maulani Iris Rengganis Irsan Hasan Iskandar A Ivo Novita Sah Bandar Iwan Ariawan Jacobus Albertus Jaffray DP Rambak Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Joseph JY Sung Juferdy Kurniawan Julwan Pribadi Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Kevin Varian Marcevianto Kharia Utia Khie Chen Kie Chen Kumalawati, July L A Lesmana L. A. Lesman Laras Budiyani, Laras Laura A Siahaan, Laura A Laurentika, Ira Laurentius Lesmana Laurentius Lesmana Leonard Nainggolan Lianda Siregar Lianda Siregar Lies Luthariana Loli J Simanjuntak Lusy Erawati Lusy Erawati Luthfi, Muhammad Lydia D Simatupang M Purnomo Isnaeni Maharani, Shabrina Marcevianto, Kevin Varian Mauna, Alesia Prillya Maureen Irawati Meilania Saraswati Mesanti, Oska Moch Ikhsan Mokoagow Mochammad Hatta Muh. Nasrum Massi MUHAMMAD SYAFIQ Mulia Mulia Murdani Abdulah Murdani Abdullah Mustika, Rita Mustikarani, Dewi Mutiara, Rizka Nadia Ayu Mulansari, Nadia Ayu Nata Pratama Hardjo Lugito Nisan Soeheri Noto Dwimartutie Novie Rahmawati Zirta Nur Chandra Bunawan Nur Chandra Bunawan Nur Rahadiani Nur Rasyid Nur Rasyid Nurmiati Amir Nurmiati Amir Oska Mesanti Pamela Abineno Pangestu Adi Parhusip, Santi Sumihar Rumondang Parlindungan Siregar Parlindungan Siregar Paulus Kusnanto Paulus Simadibrata Paulus Simadibrata Poerniati Koes Andrijani Prihantono Prihantono Prima Yuriandro Primariadewi Rustamadji Puspadina, Shafira Putra Nur Hidayat Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi Raja Mangatur Haloho Raja Mangatur Haloho Ralph Girson Gunarsa Randy Adiwinata Randy Adiwinata Randy Adiwinata, Randy Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Riadi Wirawan Riadi Wirawan Riahdo Saragih Rina Masadah Rinda Nariswati Rino A Gani Rizka Mutiara Rizki Yaruntradhani Rolan Sitompul Rosdiana Natzir Rose Feri Roy Soetikno Rudi Putranto Rudolf Simadibrata Rudy Hidayat Rumagesan, Djahalia Rustam, Musfardi Ruswhandi - Ruswhandi - Ruswhandi -, Ruswhandi Ryan Ranitya Salius Silih Saskia Aziza Nursyirwan Sedijono Sedijono Selfie - Selfie Selfie Selfie, Selfie Seri Mei Maya Ulina Sheila Adiwinata Siahaan, Billy Stinggo Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Simatupang, Emerson Patulahon Simon Salim Siti Setiati Stella Ilone Stephanie Chandra Stephanie Chandra, Stephanie Steven Irving Steven Sumantri Sugita, Peter Suhendro Suhendro Suhendro Suhendro Suryantini Suryantini Suryantini Suryantini Susanto, Liana W Suzana Ndraha Suzanna Ndraha Syahrizal Syahrizal Syarif Hidayat Syarif Hidayat T Yuli Pramana Tahir, Andi Cahaya Tandan, Manu Taolin Agustinus Teguh Karyadi Tengku Riza Zarzani N Timan, Ina Sutanto Tjahjadi Robert Tedjasaputra Tjahjadi Robert Tedjasaputra Toman L Toruan Tommy P Sibuea Tony Loho Tri Hapsoro Guno Tri Juli Edi T Unggul Budihusodo Vera D Yoewono Vera Yuwono Veronica, Raja Merlinda Virly Nanda Muzelina Virly Nanda Muzellina Wijaya, Anthony Eka Willy Brodus Uwan Willy Brodus Uwan, Willy Brodus Wismandari Wisnu Witri Abriya Yohannessa Wulandari Yundari, Yundari Yusra Yusra Zakiah Zakiah

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