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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Marcellus Simadibrata K

Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Central General Hospital, Jl. Diponegoro No.71, Jakarta 10430

Author-ID : 380435

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Articles

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Antibiotic Associated Diarrhea in Hospitalized Adult Patien Marcellus Simadibrata; Lie Khie Chen; Diana Aulia; Ina Sutanto Timan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 1 (2018): VOLUME 19, NUMBER 1, April 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Antibiotic associated diarrhea (AAD) occurs from the first initiation until 2 months of the end of antibiotic treatment. The aims of this study were to know the incidence of AAD, Clostridium difficile infectionand other gastrointestinal symptoms in hospitalized adult patients.Method: The study is a cross sectional study. We studied the antibiotic associated diarrhea (AAD), Clostridiumdifficile infection and other gastrointestinal symptoms in patients who were admited in Cipto Mangunkusumo Hospital. Inclusion were male or female, age 18-75 years old, patients started receiving antibiotics maximal 2x 24 hours prior to hospitalization, gave written informed consent.Results: The incidence of AAD was 11.5%. The incidence of Clostridium difficile infection was 15.4%. The upper gastrointestinal symptom was present on 20 (38.5%) patients. Lower abdominal symptom was present on 10 (19.2%) patients.Conclusion: The Incidence of AAD and Clostridium difficile infection were 11.5% and 15.4% respectively.The clinical manifestations of AAD were diarrhea, other upper and lower abdominal symptoms.

Advanced Gastric Cancer in a Young Patient Ryan Ranitya; Ari Fahrial Syam; Murdani Abdullah; Marcellus Simadibrata; Vera Yuwono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 4, ISSUE 3, December 2003
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/432003100-102

Gastric cancer remains the second most common cancer in the world, and is usually found in men, especially those over 50 years of age. The diagnosis is made by endoscopic biopsy. The high frequency of late diagnosis or advanced stages accounts for the overall poor prognosis for this tumor. Surgery is the most frequently employed modality for both cure and palliation. However, most patients present with advanced disease that is incurable. We reported a rare case of young female patient aged 23 years old with advanced gastric carcinoma. The main clinical features were epigastric discomfort, vomiting, and weight loss. An abdominal mass was palpable on physical examination. Endoscopy showed a giant tumor mass causing gastric outlet obstruction, nodular lesion, ulcerative and hemorrhagic. The histopathologic examination revealed mucinous gastric carcinoma. Palliative resection could not be performed because the tumor tightly adhered to adjacent structures. Jejunostomy was performed to allow enteral nutrition. Best supportive care is very important to improve the quality of life. Keywords: Gastric cancer, young patient

Management of Constipation Toman L Toruan; Ari Fahrial Syam; Marcellus Simadibrata; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 6, ISSUE 1, April 2005
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/61200516-21

Constipation is the most ignored complaint by doctors and unfortunately, it requires urgent management due to the decreased quality of life. Most cases are functional constipation but there is also a great number of constipation due to organic abnormalities. In an attempt to manage the patient properly, we should put our emphasis on excellent knowledge of pathophysiology of constipation.By using the colonic transit time test, we could determine the type of constipation, which would have an effect on therapy. In most cases, constipation has a good response to high fiber diet and additional laxative medication and surgical therapy is seldom required unless complications have occurred. There is also a suggestion for preventing constipation may be caused by opioid usage. Keywords: Constipation, colonic transit time test, high fiber diet, laxatives

The Role of M2 Pyruvate Kinase in the Screening of Bowel Inflammation Ruswhandi -; Marcellus Simadibrata; Irsan Hasan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 16, No 1 (2015): VOLUME 16, NUMBER 1, April 2015
Publisher : The Indonesian Society for Digestive Endoscopy

Background: This is a study to determine if M2 Pyruvate Kinase (M2-PK) can be used to screen the presence of bowel inflammation.Method: The study design being used is diagnostic test. In this study, we recruited 76 participants and performed colonoscopy examination as a gold standard and faecal M2-PK as the examined procedure.Results: From the result of this study, we identified the important role of M2-PK to screen the presence of bowel inflammation with the cut-off point of 1.05 U/mL compared to colonoscopy as gold standard with the sensitivity of 86.2%, specificity 81.8%, positive predictive value 96.6%, and negative predictive value 50%.Conclusion: From the result of this study, we suggested M2-PK examination to screen bowel inflammation in patients with lower gastrointestinal tract problems.

One-year Survival Rate of Pancreatic Cancer and the Mortality Affecting Factors Alexander Michael Joseph Saudale; Marcellus Simadibrata; Rino Alvani Gani; Cleopas Martin Rumende
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 2 (2020): VOLUME 21, NUMBER 2, August 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Pancreatic cancer is the fourth leading cause of death associated with malignancy in the United States, and is thought to be the second leading cause of death in 2030 in the United Kingdom. In Asia, pancreatic cancer is the most fatal cancer with the lowest survival of all malignancies, 25-30% survival five years after surgery. Indonesia has no data on the survival of pancreatic cancer and the factors that affect it. The aim of this study is knowing the 1-year survival of pancreatic cancer and its influencing factors in Cipto Mangunkusumo Hospital, Jakarta.Method: A retrospective cohort study was performed using data from the medical records of pancreatic cancer patients dr. Cipto Mangunkusumo Hospital between January 2012 - December 2016. Factors age, sex, metastasis, stage, comorbid and treatment were analyzed bivariate and multivariate using Cox Proportional Hazards Regression to obtain Hazard Ratio (HR) for each prognostic factor. The cumulative survival of 1 year after diagnosis is expressed by the Kaplan-Meier curve.Results: Of 83 subjects the proportion of males was 62.7%, age ≥ 50 years 68.7%, with age range 33-79 years, and 55 years on average. In bivariate analysis, there was a statistically significant relationship of survival with comorbid variables (HR = 2,116, 95% 953 1,335-3,513, p 0,002), metastasis (HR = 3,802, 95% CI: 1,995-7,249, p 0.001), palliative treatment (HR = 2,108 , 95% CI: 1,077-4,125, p = 0,029) and group without treatment (HR = 2,924, 95% CI: 1,496-5,716, p = 0,002). Multivariate analysis showed that metastasis provided the greatest risk of death with HR = 4.306 (95% CI: 2.125-8.724, p 0.001). Palliative group HR was 2.510 (95% CI: 1,245-5,061 p = 0.010) while the group without treatment gave HR 2,535 (95% CI: 1,277-5,032 p = 0,008). The 1-year survival rate is 14%, with a median survival of 6 months.Conclusion: The overall survival of one year of pancreatic cancer patients was 14%, with a median survival of 6 months. The presence of metastasis and not the curative therapy of Whipple surgery in patients with pancreatic cancer in dr. Cipto Mangunkusumo Hospital is the main factor that negatively affect the survival of 1 year

Eosinophilic Esophagitis T Yuli Pramana; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8 ISSUE 2 August 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/82200748-52

The frequency of eosinophilic esophagitis (EE) cases is increasing along with increased understanding among doctors about EE. In the beginning, EE is mostly found in children population. It was first reported in adults by Landres on 1978. The prominent EE symptoms in adults are dysphagia and solid food impaction. Endoscopic examination reveals mucous ring of esophagus, white plaque on the mucosa. The diagnosis is supported by positive result of eosinophils, which forms infiltration on the mucosaof 20 eosinophils/ high power field in the distal or middle esophagus. Treatment by using diet and corticosteroid, either topical or systemic, shows adequate results. Immunomodulator treatment is promising, but it needs further investigation with larger sample. No consensus have been reached for EE, therefore it may affect the diagnosis, treatment and epidemiology data. Keywords: esophagus, eosinophil, dysphagia, ring of esophagus

Clinical Profile and Outcome of Non-Variceal Upper Gastrointestinal Bleeding in Relation to Timing of Endoscopic Procedure in Patients Undergoing Elective Endoscopy Lianda Siregar; Abdul Aziz Rani; Chudahman Manan; Marcellus Simadibrata; Dadang Makmun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Endoscopy is the most accurate method for diagnosing the source of upper gastrointestinal bleeding. This study was aimed to evaluate the correlation between the timing of elective endoscopy and the length of hospital stay, the amount of transfusion given and incidence of recurrent bleeding or patient mortality. Method: A retrospective study was conducted in all patients with non-variceal upper gastrointestinal bleeding who had experienced elective endoscopy at Cipto Mangunkusumo Hospital between January 2007 and August 2008. Identification of clinical risk using clinical Rockall score was performed at the emergency room. Persistent bleeding, recurrent bleeding, surgical treatment and death were the outcome variables. Statistical analysis was performed using Chi-square/fisher exact test and linear regression. Results: There were 40 eligible cases with mean age of 53 ± 13 years; the greatest occurrence was at the age group of 50-59 years (12%), male (52.5%) and those who had clinical symptom of melena (52.5%). Twenty seven (67.5%) patients had Rockall score of 1-3 points and 13 (32.5%) had 4-6 points. There was only one patient who had adherent clots (Forrest grade II B). Endoscopy results revealed that the most common cause of bleeding was gastric ulcer, which occurred in 12 (30%) patients. There was no correlation between the timing of endoscopic procedures and outcome variable; however the length of hospital stay had a significant correlation with timing of endoscopic procedures. Conclusion: Elective endoscopy does not affect the variables of mortality and recurrent bleeding; however, it affects the length of hospital stay. Further prospective studies are required to find causal relation between them. Keywords: non-variceal upper gastrointestinal bleeding, Rockall score, elective endoscopy, outcome variables

Randomized Double-blind Controlled Trial: Benefits of Lactobacillus reuteri in Chronic Functional Constipation Patients Taolin Agustinus; Marcellus Simadibrata; Irsan Hasan; Hamzah Shatri
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 16, No 3 (2015): VOLUME 16, NUMBER 3, December 2015
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Chronic functional constipation is a common problem that affects between 15-25% of the population and cause symptoms and disorders that creates discomfort, morbidity, and high costs for health care. Recently, the consumption of probiotics in treating chronic constipation in adults have been investigated. However, there are still limited and controversial evidences available from controlled trials. The aim of this study was to evaluate the effects of Lactobacillus reuteri (L. reuteri) in improving the Agachan constipation score, the number of L. reuteri in the feces and the fecal pH in the patients with chronic functional constipation.Method: A double-blind, placebo randomized controlled trial (RCT) was conducted in 40 adults (12 males/28 females with mean age 45.95 ± 16 years) affected by chronic functional constipation according to Rome III criteria. Patients were randomly assigned to receive a supplementation of L. reuteri or placebo for 4 weeks.Results: At week 4, the decrease in Agachan constipation score was from 17.00 to 8.00 with p 0.001, the increase number of L. reuteri was from 6.80 x 107 to 2.12 x 108 with p 0.001 and the decrease of pH feces was from 5.44 (SD 0.70) to 4.78 (SD 0.56) with p 0.001 in the L. reuteri group, otherwise in the placebo group there were no significant results in Agachan constipation score, the number of L. reuteri and fecal pH assessed.Conclusion: L. reuteri is more effective than the placebo group in improving the Agachan constipation score, increasing the number of L. reuteri in the feces and decreasing the fecal pH in adult with chronic functional constipation.

Detection Of Helicobacter Pylori Infection With Stool Antigen: Comparison With Other Techniques Paulus Simadibrata; Rudolf Simadibrata; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 3, NUMBER 2, August 2002
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/32200246-49

Helicobacter pylori has been known as a cause of chronic gastritis, a predisposition to gastric and duocenal ulcers, and a class I gastric carcinogen. Throughout the world, H. pylori infection is very common, reaching 40% -50% of the population in developed nations and 80% – 90% of the population in developing nations. Several techniques have been used to detect H. pylori infection, such as the urea breath test, rapid urease test, serological test, as well as biopsies of gastric or duodenal tissues for culture and histopathology. In this review article, we will discuss a relatively new method to detect H. pylori antigen in stools with enzyme immunoassay, and comparisons with other standard techniques. However, the H. pylori stool antigen test is not yet commercially available in Indonesia. Key words: Helicobacter pylori - stool antigen - enzyme immunoassay.

Survival of Pancreatic Cancer Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 2 (2019): VOLUME 20, NUMBER 2, August 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Co-Authors -, Selfie -, Selfie A.A. Ketut Agung Cahyawan W Aan Santi Aan Santi Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Rahman M Achmad Fauzi Achmad Fauzi ACHMAD FAUZI Adang Bachtiar Adeputri Tanesha Idhayu Aditya Rachman Aditya Rachman Aditya Rachman, Aditya Aditya Wardhana Adityo Susilo, Adityo Adiwinata, Sheila Adjeg Tarius Afistianto, Muhammad Fikri Agi Satria Putranto Agustinus, Taolin Ahmad Fauzi Ahmad Soefyani Alexander Michael Joseph Saudale Ali Djumhana Ali Imron Yusuf Alida Roswita Harahap Amanda P Utari, Amanda P Amanda Pitarini Utari Ana Mira Lubis Andhika Rachman Andi Asadul Islam Andree Kurniawan Andri Sanityoso Andri Sulaiman Angga Pramudita Anna Mira Lubis Anthony Eka Wijaya Anthony Eka Wijaya Anwar Jusuf Ardhia Fefrine Indarta Ari F Syam Ari F Syam Ari Fahrial Syam Ari Wijayanti Aria Kekalih Arief Hakiki Armen Armen Arnold Hasahatan Harahap Arshita Auliana Arya Govinda Aulia Rizka, Aulia Axel, Benvenuto Ayundini, Gratcia Aziz Rani Badriul Hegar Badriul Hegar Bambang Sutopo Bastomy Eka Rezkita Batara Bisuk Benedicta Mutiara Suwita, Benedicta Mutiara Benvenuto Axel Benvenuto Axel Bisuk, Batara Bona Adhista Bradley Jimmy Waleleng Bradley Jimmy Waleleng Budi Tan Oto Budiman Sudjatmika Budimutiar, Felix Budimutiar, Felix Aloysius Budu - Bukhari, Agussalim C Rinaldi A Lesmana Ceva W. Pitoyo Chatarina Umbul Wahyuni Christophorus Simadibrata Chudahman Manan Chudahman Manan Chudahman Manan Cleopas Martin Rumende Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Daniel Gunawan Daniel Martin Simadibrata Daniel Martin Simadibrata Daniel Martin Simadibrata Dasril Nizam David Reinhard Sumantri Samosir Deborah Theresia Budimutiar Deddy Gunawanjati Deka Larasati Deskian Kostermans Deskian Kostermans, Deskian Dharmika Djojoningrat Diah Rini Handjari Diah Rini Handjari Diana Aulia Diana Aulia Diantha Soemantri Diany N Taher Dicky Levenus Tahapary Didi Kurniadhi Didi Kurniadhi Dina Ikawari Djulzasri Albar Dolly Dolven Kansera Dono Antono Drupadi Harnopidjati Singh Dillon Dyah Purnamasari Dyah Ratna Budiani E Mudjadid E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edi Mulyana Edi Mulyana Edi Mulyana, Edi Ekowati Rahajeng Ekowati Rahajeng Elizabeth Merry Wintery Elli Arsita Elli Arsita Em Yunir, Em Emerson Patulahon Simatupang Endang Susalit Endang Susalit Ening Krisnuhoni Enrik John Aguila Epistel Pangujian Simatupang Erni J. Nelwan, Erni J. Esa, Dekta Filantropi Evy Yunihastuti Fauzi Ahmad Muda Felix Aloysius Budimutiar Ferry Sandra Fiastuti Witjaksono FJW Ten Kate Fransiska Hardi G. N.J. Tytgat Gerie Amarendra GNJ Tytgat Gratcia Ayundini Guno, Tri Hapsoro Guntur Darmawan Guntur Darmawan Halimkesuma, Christopher Christian Haloho, Raja Mangatur Haryanto Rahardjo Haryanto Surya Hasan Maulahela Hayatun Nufus Helsi Helsi Herdiman T Pohan Heri Wibowo Hery Djagat Purnomo Hery Djagat Purnomo Hilda Nurmalihah Hotmen Sijabat Ibrahim Labeda Ida Parwati Ikawari, Dina Ikhwan Rinaldi Ilham Ahmadi Ilhamjaya Patellongi Ilone, Stella Ina Susianti Timan Ina Sutanto Timan Indah S. Widyahening Indira Kemalasari Indra Kurniawan Indra Marki Indra Marki Indrasari, Nuri Dyah Ira Laurentika Irfan Maulani Iris Rengganis Irsan Hasan Iskandar A Ivo Novita Sah Bandar Iwan Ariawan Jacobus Albertus Jaffray DP Rambak Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Joseph JY Sung Juferdy Kurniawan Julwan Pribadi Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Kevin Varian Marcevianto Kharia Utia Khie Chen Kie Chen Kumalawati, July L A Lesmana L. A. Lesman Laras Budiyani, Laras Laura A Siahaan, Laura A Laurentika, Ira Laurentius Lesmana Laurentius Lesmana Leonard Nainggolan Lianda Siregar Lianda Siregar Lies Luthariana Loli J Simanjuntak Lusy Erawati Lusy Erawati Luthfi, Muhammad Lydia D Simatupang M Purnomo Isnaeni Maharani, Shabrina Marcevianto, Kevin Varian Mauna, Alesia Prillya Maureen Irawati Meilania Saraswati Mesanti, Oska Moch Ikhsan Mokoagow Mochammad Hatta Muh. Nasrum Massi MUHAMMAD SYAFIQ Mulia Mulia Murdani Abdulah Murdani Abdullah Mustika, Rita Mustikarani, Dewi Mutiara, Rizka Nadia Ayu Mulansari, Nadia Ayu Nata Pratama Hardjo Lugito Nisan Soeheri Noto Dwimartutie Novie Rahmawati Zirta Nur Chandra Bunawan Nur Chandra Bunawan Nur Rahadiani Nur Rasyid Nur Rasyid Nurmiati Amir Nurmiati Amir Oska Mesanti Pamela Abineno Pangestu Adi Parhusip, Santi Sumihar Rumondang Parlindungan Siregar Parlindungan Siregar Paulus Kusnanto Paulus Simadibrata Paulus Simadibrata Poerniati Koes Andrijani Prihantono Prihantono Prima Yuriandro Primariadewi Rustamadji Puspadina, Shafira Putra Nur Hidayat Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi Raja Mangatur Haloho Raja Mangatur Haloho Ralph Girson Gunarsa Randy Adiwinata Randy Adiwinata Randy Adiwinata, Randy Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Riadi Wirawan Riadi Wirawan Riahdo Saragih Rina Masadah Rinda Nariswati Rino A Gani Rizka Mutiara Rizki Yaruntradhani Rolan Sitompul Rosdiana Natzir Rose Feri Roy Soetikno Rudi Putranto Rudolf Simadibrata Rudy Hidayat Rumagesan, Djahalia Rustam, Musfardi Ruswhandi - Ruswhandi - Ruswhandi -, Ruswhandi Ryan Ranitya Salius Silih Saskia Aziza Nursyirwan Sedijono Sedijono Selfie - Selfie Selfie Selfie, Selfie Seri Mei Maya Ulina Sheila Adiwinata Siahaan, Billy Stinggo Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Simatupang, Emerson Patulahon Simon Salim Siti Setiati Stella Ilone Stephanie Chandra Stephanie Chandra, Stephanie Steven Irving Steven Sumantri Sugita, Peter Suhendro Suhendro Suhendro Suhendro Suryantini Suryantini Suryantini Suryantini Susanto, Liana W Suzana Ndraha Suzanna Ndraha Syahrizal Syahrizal Syarif Hidayat Syarif Hidayat T Yuli Pramana Tahir, Andi Cahaya Tandan, Manu Taolin Agustinus Teguh Karyadi Tengku Riza Zarzani N Timan, Ina Sutanto Tjahjadi Robert Tedjasaputra Tjahjadi Robert Tedjasaputra Toman L Toruan Tommy P Sibuea Tony Loho Tri Hapsoro Guno Tri Juli Edi T Unggul Budihusodo Vera D Yoewono Vera Yuwono Veronica, Raja Merlinda Virly Nanda Muzelina Virly Nanda Muzellina Wijaya, Anthony Eka Willy Brodus Uwan Willy Brodus Uwan, Willy Brodus Wismandari Wisnu Witri Abriya Yohannessa Wulandari Yundari, Yundari Yusra Yusra Zakiah Zakiah

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