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Catechin Isolates from Gambir (Uncaria gambir Roxb) Maintain Glucose Homeostasis in Diabetic Model Rat Rita, Rauza Sukma; Yetti, Husna; Santoso, Putra; Afriani, Nita
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.621

Abstract

The prevalence of diabetes mellitus is rising globally. Oxidative stress, which can result from hyperglycemia in diabetes, might have negative consequences. An antioxidant is needed to prevent hyperglycemia. Cathechin isolates are derived from gambir, which has many antioxidants. This study examines catechin isolates from gambir (Uncaria gambir Roxb.) effect on glucose homeostasis in rats induced by alloxan. For this experiment, 35 male rats were employed. Male rats were given alloxan (150 mg/BW, IP), and after 72 hours, blood glucose levels were assessed. If blood glucose levels exceeded 200 mg/dl, three oral catechin isolates were administered (T1=10 mg/kg/day, T2=20 mg/kg/day, and T3=40 mg/kg/day). Following blood collection on the experiment's last day, fasting blood glucose, glucagon and insulin levels were measured. Catechin isolates decreased blood glucose levels in all treatment groups compared to the positive control group (T1 = 150.750 ± 14.359 mg/dl; T2 = 159.750 ± 15.434 mg/dl, and T3 = 153.375 ± 20.207 mg/dl vs 385 ± 60.989 mg/dl) significantly (p value-0.05). A decrease in glucagon serum level was also observed in the treatment group vs positive control (T1: 193.855 ± 36.009 pg/ml, T2 = 286.689 ± 20.313 pg/ml, and T3 = 319.462 ± 30.060 pg/ml vs  529.825 ± 74.279 pg/ml), significantly. Catechine isolates in the T3 group showed an increase in insulin serum level compared to the positive control group significantly (T3 = 216.640 ± 38.230 µIU/ml vs 69.833 ± 3.071 µIU/ml). In conclusion, catechin isolates from gambir decreased blood glucose levels by reducing glucagon and increasing insulin serum levels.
Pengetahuan dan Sikap Kesehatan Prakonsepsi Calon Pengantin Wanita dalam Pendidikan Pranikah: Studi Quasi Eksperimental Amizuar, Yulia Fauziah; Serudji, Joserizal; Oktova, Rafika; Semiarty, Rima; Karmia, Hudila Rifa; Rita, Rauza Sukma
jitek Vol 12 No 1 (2024): September 2024
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v12i1.1301

Abstract

Maternal and child health challenges have been seen before the process of pregnancy. Improving education, attitudes and behavior of couples is an important part of preconception health. The aimed of this research was to verify the impact of premarital education on enhanced knowledge and attitudes of preconception health on brides. Research method was quasi-experimental, pretest-posttest control group design. Sampling technique was purposive sampling, based on inclusion and exclusion criteria. Time and location of the study September-November 2022 at three Office of religious (KUA Koto Tangah, KUA Kuranji and KUA Padang Utara). The intervention group were given educational material related to marriage law in Islam and preconception health education using lecture and discussion methods. The control group were given education only related to the law of marriage in Islam (religious sphere) with the lecture method. Questionnaires with tested validity and reliability were used to gather data. The results of knowledge intervention group compared the control group (p = 0.00). Prospective bride’s attitudes were not impacted by premarital education in the intervention group compare the control group (p=0.59). In conclusion, it has been proven that premarital education enhance preconception health knowledge, as opposed to women' preconception health attitudes.
Faktor-faktor yang Berhubungan dengan Kadar HbA1c Anggota Klub Prolanis Diabetes Mellitus Tipe 2 Azrimaidaliza Azrimadaliza; Annisa Annisa; Rauza Sukma Rita
Jurnal Ilmu Kesehatan Masyarakat Vol 11 No 01 (2022): Jurnal Ilmu Kesehatan Masyarakat
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikm.v11i01.991

Abstract

Penyakit Diabetes Mellitus (DM) merupakan salah satu penyakit yang dapat menyebabkan kematian. Hasil riset kesehatan menunjukkan adanya peningkatan kejadian DM terutama tipe 2 di Indonesia. Penelitian ini bertujuan untuk mengetahui faktor yang paling berhubungan dengan kadar HbA1c anggota klub prolanis Diabetes Melitus tipe 2. Penelitian ini menggunakan desain studi cross sectional. Populasi penelitian adalah seluruh anggota Klub Prolanis Diabetes Mellitus tipe 2 di Puskesmas Lubuk Buaya dan Puskesmas Ambacang, Kota Padang berjumlah 92 orang. Sampel penelitian adalah anggota Klub Prolanis Diabetes Melitus tipe 2 di Puskesmas Lubuk Buaya dan Puskesmas Ambacang berjumlah 83 orang yang diambil secara simple random sampling. Kuesioner terstruktur dipergunakan dalam menggali informasi tentang asupan makanan, aktifitas fisik dan karakteristik sampel penelitian. Analisis data menggunakan uji chi-square, T-independent dan regresi linier ganda dengan Program SPSS. Hasil penelitian menunjukkan bahwa asupan energi (Pv=0,021), serat (Pv=0,005) dan aktifitas fisik (Pv=0,001) berhubungan secara bermakna dengan peningkatan kadar HbA1C anggota Klub Prolanis Diabetes Melitus tipe 2. Aktifitas fisik merupakan faktor yang paling berhubungan dengan peningkatan kadar HbA1c anggota Klub Prolanis Diabetes Melitus tipe 2 (Pv=0,001; β=-0,425). Perlunya kombinasi antara pengaturan makanan yang seimbang dan aktifitas fisik yang teratur dalam menjaga kadar HbA1c sehingga anggota klub memiliki status kesehatan yang terkontrol.
The Relationship Of Mother’s Knowledge And Educational Level With Triple Elimination Examination Irya, Nada Amelinda; Bobby Indra Utama; Erda Mutiara Halida; Rauza Sukma Rita; Fitrayeni; Laila
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.775-785.2024

Abstract

Introduction: Triple elimination examination can protect mothers and babies from diseases that are transmitted from mother to fetus, namely HIV, Hepatitis B, and Syphilis. Objective: This research aims to determine the relationship between the knowledge and education level of pregnant women and triple elimination examination visits at the Ophir Community Health Center, West Pasaman Regency. Methods: The research design uses analytical research with a cross-sectional method. The population of all pregnant women in the third trimester at the Ophir Community Health Center, West Pasaman Regency in 2023. The total sample was 57 pregnant women taken by total sampling. The data used is primary data using interview and observation methods. The instrument uses a questionnaire sheet. Results: Based on the p-value of the relationship between maternal knowledge and triple elimination examination visits, the p-value was 0.000 (p<0.05). Then, based on the p-value of the relationship between maternal education level and triple elimination examination visits, the result was a p-value of 0.000 (p<0.05). Conclusion: The relationship between knowledge and maternal education level with triple elimination examination visits at the Ophir Community Health Center, West Pasaman Regency.
EDUKASI KESEHATAN DAN PEMERIKSAAN GOLONGAN DARAH PADA MURID SD NEGERI 13 DI DESA TUNGKAL SELATAN KECAMATAN PARIAMAN UTARA Yustini Alioes; Husnil Kadri; Eti Yerizel; Hirowati Ali; Rauza Sukma Rita; Desy Arisanti
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 4 No. 2 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i2.289

Abstract

Elementary school students are consumers who are among those who consume the most food and beverages. Food and drinks sold around the school contain many hazardous substances such as dyes that have been banned from circulating (Rhodamine B in iced drinks, jelly drinks, and so on) and other additives such as formalin which is used as a chewy substance in meatballs sold in carts and restaurants that can cause acute poisonings such as allergies, coughs and chronic poisonings such as cancer of the liver, kidneys and other organs. The purpose of this activity is to increase knowledge about substances in food and an introduction to blood group examination. This activity was carried out at SD Negeri 13 Tungkal Selatan Village in North Pariaman District. The method of activity is in the form of counseling and demonstration. According to the survey before the blood group examination, it turned out that most of the elementary school students did not know their blood type. Before the blood group examination, the students were also given knowledge about determining a person's blood type. After this counseling was carried out, respondents became more aware of the impact of food/snacks on health, and respondents knew their respective blood types. Of the 64 students, there are 22 A, 17 B, 12 AB, 13 O. To avoid problems related to food and blood type. There is a need for continuous health education for elementary school students.
Edukasi Tentang Anemia dan Pemeriksaan Hb pada Ibu Hamil serta Pengobatan pada Masyarakat di Nagari Carocok Anau Kec.Tarusan Kab. Pesisir Selatan Elmatris Sy; Dessy Arisanti; Almurdi Almurdi; Endrinaldi Endrinaldi; Bobby Indra Utama; Dian Pertiwi; Rauza Sukma Rita; Zelly Dia Rofinda; Hasmiwati Hasmiwati; Aswiyanti Asri; Julizar Nazar; Mohamad Reza
Warta Pengabdian Andalas Vol 31 No 3 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.3.591-598.2024

Abstract

The majority of people of Nagari Carocok Anau Kec. Tarusan Kab. Pesisir Selatan worked as a fisherman, farmer, a small number of civil servants and market traders, as well as a housewife. Pregnant women in Nagari Carocok Anau, most of whom are housewives, still do not receive health checks such as haemoglobin (Hb) checks. This activity aims to increase knowledge among the public and health cadres regarding anaemia and Hb examination in pregnant women, as well as treatment. The health of pregnant women is checked by checking blood pressure, Hb and medication. This Hb examination is an effort to minimize abnormalities that can occur in pregnant women and fetuses due to low Hb when the mother is pregnant. The examination results showed that more than half of the pregnant women (71.43%) who attended were in the age range 18 – 35 years. Nearly half (42.86%) of pregnant women had Hb levels below the normal limit (11 mg/dl). For a more valid diagnosis, it is necessary to carry out quantitative analysis from the hospital laboratory so that follow-up can be carried out. Education about anaemia and Hb examinations in pregnant women can increase people's knowledge so that preventive measures can be carried out early. Health checks on the general public (blood pressure, Hb) and treatment were also carried out, it was found that the Hb results were within normal limits.
Parental Resilience Determinants in Children with Cancer in Indonesia: A Path Analysis Novrianda, Dwi; Jamil, Mohd.; Rita, Rauza Sukma
Nurse Media Journal of Nursing Vol 14, No 3 (2024): (December 2024)
Publisher : Department of Nursing, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nmjn.v14i3.54943

Abstract

Background: Determining parental resilience in children with cancer is essential to ensuring parents’ involvement in caring for children in hospitals. Existing quantitative research evaluates factors influencing resilience in mothers but has not fully explored the determinants of resilience in parents of children with cancer. Studying parents more broadly is essential, as contemporary caregiving roles increasingly involve both mothers and fathers, offering a more comprehensive understanding of family dynamics.Purpose: This study aimed to analyze the determinants of parental resilience in children with cancer.Methods: Correlational research with a cross-sectional design was conducted in the pediatric ward of a tertiary hospital in Indonesia. A total of 102 parents of children with cancer were recruited using consecutive sampling. Data were collected using a demographic questionnaire, the 10-item Connor Davidson Resilience Scale (10-item CDRC), the Hert Hope Index (HHI), the International Personality Item Pool – Big Five Factor Markers 50 (IPIP-BFM-50), Parenting Stress Index (PSI), and the Survey of Family Environment (SFE). Quantitative data were analyzed using path analysis.Results: The results showed that the mean (SD) of the resilience score was 27.20 (5.79), personality 102.44 (19.11), hope 24.80 (6.04), parenting stress 39.22 (10.15), coping 39.84 (9.81), and family environment 84.57 (21.87). Resilience was directly influenced by hope (p=0.000), family environment (p=0.001), and coping (p=0.051). Personality indirectly influenced resilience (p=0.004). Path analysis revealed a Chi-square value of 0.000, a Root Mean Squared Estimate of Approximation (RMSEA) of 0.286, and values for the Normed Fit Index (NFI), Comparative Fit Index (CFI), Incremental Fit Index (IFI), and Goodness-of-Fit Index (GFI) were nearly close to 1, indicating the model had a nearly good fit.Conclusion: Parental resilience was determined by hope, family environment, and coping. Strengthening these factors can enhance resilience and support better outcomes for families and children with cancer. 
CORRELATION BETWEEN NEURON-SPECIFIC ENOLASE (NSE) SERUM LEVEL AND TRAUMATIC BRAIN INJURY SEVERITY Pitra, Dian Ayu Hamama; Syafrita, Yuliarni; Susanti, Rika; Rita, Rauza Sukma
Nusantara Hasana Journal Vol. 5 No. 1 (2025): Nusantara Hasana Journal, June 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i1.1498

Abstract

Traumatic brain injuries (TBIs) are a health and socio-economic problem worldwide, both in low- and high-income countries, that affects all age groups. Computed Tomography (CT) is a diagnostic modality that can be used to assess brain damage. However, there are some limitations in the use of CT in TBIs. Therefore, biomarkers are expected to be a solution to identify brain injuries. Neuron-Specific Enolase (NSE) is a more practical and cheaper alternative. It does not require patient mobilization, especially for patients with severe TBIs, to accompany clinical examinations and CT. Methods: A cross-sectional design was used to determine the correlation between Neuron Specific Enolase (NSE) serum levels and the severity of TBIs at RSUP Dr. M. Djamil, Padang. Results: The study found that most patients were 23 men (76.7%), consisting of adults (40.0%). The majority of patients had mild traumatic brain injury (GCS 13-15) in 18 people (60.0%). The cut-off point for serum NSE was 6.6 ng/ml using the ROC curve. There was a negative correlation between serum NSE levels and the severity of TBI (r=-0.211). Conclusion: The correlation of serum NSE levels with the severity of TBI was very weak.
Protective Effects of Java Plum (Syzygium cumini) Leaf Extract on Serum Biomarkers in Lead-Exposed Rats Ansori, Fachrurrazi Al; Rita, Rauza Sukma; Almurdi, Almurdi
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403345

Abstract

Lead (Pb), a heavy metal recognized as a hazardous environmental toxin, triggers oxidative stress by catalyzing oxidation reactions that produce free radicals, ultimately leading to cell death. Liver cell damage due to lead can decrease serum albumin levels, while kidney damage can increase serum uric acid levels. To counteract this oxidative stress, the intake of exogenous antioxidants is necessary. Java plum (Syzygium cumini) leaves are abundant in natural antioxidants, including flavonoids and phenolic compounds. The compounds possess antioxidant potential by scavenging free radicals. The purpose of this study was to determine the effects of an extract of S. cumini on serum albumin and uric acid in rats induced with lead acetate. All treatments lasted 30 days. Testing for serum albumin and uric acid was performed using the DiaSys method. One-way ANOVA followed by the Bonferroni post hoc test revealed significant differences (p < 0.05) in serum albumin levels among the groups: the normal group (4.13 g/dL), the positive control (2.86 g/dL), and the treatment group (3.93 g/dL). Similarly, significant differences were observed in serum uric acid levels: the normal group (1.47 mg/dL), the positive control (3.14 mg/dL), and the treatment group (1.64 mg/dL). These results indicate that S. cumini extract helps mitigate the adverse effects of lead exposure on serum albumin and uric acid levels in rats. A p-value of less than 0.05 indicates that the observed differences are statistically significant and unlikely due to chance.
SYNERGISTIC COMBINATION OF JAVA PLUM (SYZYGIUMCUMINI(L.) SKEELS) LEAF EXTRACT AND VITAMIN C ON ASPARTATE AMINOTRANSFERASE AND ALANINE AMINOTRANSFERASE LEVELS IN LEAD ACETATE-INDUCED RAT Ikhsan, M; Rita, Rauza Sukma; Elmatris, Elmatris; Alioes, Yustini; Mahata, Liganda Endo; Almurdi, Almurdi
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1708

Abstract

Lead (Pb) is a toxic metal that is used to trigger oxidative stress. Oxidative stress causes damage to organs, especially the liver increasing aspartate aminotransferase (AST) and alanine aminotransferase (ALT). This study aims to determine the synergistic effect of antioxidant as Java plum leaf extract and vitamin C together on lead-induced levels of AST and ALT in rats.This type of research is true experimental research with a randomized posttest-only-control group design. The study used 20 male white rats which were divided into 4 groups. The treatment was carried out for 30 days. The examination for AST and ALT levels using the Micro Lab 300 with the Sample Star method. Data analysis was performed by using One-way Anova and Post Hoc-Turkey HSD.In this study, The results were obtained in the form of a decrease in AST and ALT levels in rats that had been induced lead acetate 40 mg/KgBW by administration of Java plum leaf extract dose 75 mg/KgBW and vitamin C dose 35 mg/KgBW as well as the administration of Java plum leaf extract at a dose of 150 mg / KgBB and vitamin C dose of 75 mg / KgBB with significant influence at the lower dose (p=0,01).It can be concluded that administrating of Java plum leaf extract dose 75 mg/KgBB and vitamin C dose 35 mg/KgBB was effective to protect the liver based on the decrease of AST and ALT levels in rats that had been induced lead acetate dose 40 mg/KgBB
Co-Authors Abdiana Abdiana, Abdiana Adilla Oktariza Zarwin Afi Putra Perdana Nurullah Afni, Fauza Afriani, Nita Agustianov, Indah Ahmad Muhtar Al Farisy, Alexandria Firdaus Aldi Tamara Rahman Alhamda, Nadhiyatul Alimuddin Tofrizal Almurdi Almurdi Ambulani, Nur Amel Yanis Amizuar, Yulia Fauziah Amriza, Muhammad Zidan Ananda Fitriana Annisa Annisa Annisa Rusdi Annisa, Nadia Rizki Ansori, Fachrurrazi Al Ari Setiawan Ari Susanti Arif Sabta Aji Ariyani, Farida Arlen Defitri Nazar Arum Putri Rahayu Asih Dewi Setyawati Astiena, Adila Kasni Aswiyanti Asri Aswiyanti Asri Azahra, Azizah Firda Azmi, Yudia Azrimaidaliza Azriz, Helena Bobby Indra Utama Budi Witjaksana Cesar, Afifah Raudhati Delmi Sulastri Desmawati Desmawati Dessy Arisanti Dessy Arisanti Dessy Arisanty Desy Arisanti Desy Arisanti Desy Nofita Sari Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Didi Sudrajat Dwi Novrianda Eka Fithra Elfi Eka Nofita Eliza Anas Elly Usman Elmatris Sy Elmatris Sy Endrinaldi Erda Mutiara Halida Eryati Darwin Eti Yerizel Etriyel Etriyel Fadli Fadli Faishal Arif Kurniawan Fajri, Rahmi Eka Farida Ariyani Fathiyyatul Khaira Fathiyyatul Khaira, Fathiyyatul Febby Arrahmi Febrian, Wenny Desty Feby Larasati Feni Andriani Firdawati Firdawati Fitrayeni Fitrayeni Fitrayeni Fitria, Henni Gestina Aliska Ghifari Aulia Dzakwan Ginting, Kevin Hizkya Hanum, Fathiya Juwita Hardisman Hasmiwati Havriza Vitresia Hayyumahdania Reswan Helti Lestari Sitinjak Henni Fitria Hervina Winerti Hindun Mila Hudzaifah Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Husni Husni Husnil Kadri Husnil Kadri Ibrahim, Raihan Syah Ida Rahmah Burhan Iffah, Uliy Iffah, Ully Ilmiawati Ilmiawati, Ilmiawati Indah Fajarwati Irya, Nada Amelinda Isnindiah Koerniati Ivan Petrovsky Jamil, Mohd. Jihan Aprilia Nawawi Julizar Julizar Julizar Nazar Karmia, Hudila Rifa Kurniawan, Faishal Arif laila Laila Laras Surakusuma Lathifah Arief, Lathifah Lili Irawati M Ikhsan Mahata, Liganda Endo Maiyani Lestari Maliza, Rita Mas'ud Muhammadiah Masrul Djalal Maulana, Rafi Mellina Rahmi MIftah Irrahmah Miftah Irrahmah Miftah Irramah Miranie Safaringga Mohamad Reza Mohamad Reza Muflihah Isnawati Muhammad Abi Ghoffari Siregar Muhammad Bhagus Andina Putra Muhammad Samudra Ilham Muhammad Toat Muhammad Zidan Amriza Mulono Apriyanto Nada Amelinda Irya Nidya Ikha Putri Nisriinaa Yurensi Nora Harminati Novilla, Arina Nur Afrainin Syah Nur Indrawaty Lipoeto Nur Indrawaty Lipoeto Nur Rohmah Nursal Asbiran Nurullah, Afi Putra Perdana Nuzulia Irawati Pitra, Dian Ayu Hamama Putra Santoso Putri, Biomechy Oktomalio Rafika Oktova Rahmaddiansyah, Refa Rahmadini Aulia Rahmadini Faricha Hakim Rahmatini . Rahmawati, Lailia Rahmi, Wahida Ramadhani, Dhea Amaliya Refa Rahmaddiansyah Refa Rahmaddiansyah Refa Rahmaddiansyah Resy Nirawati Reviandari Widyatiningtyas, Reviandari Reza, Mohamad Rika Susanti Rima Semiarty Rina Gustia Ririn Marta Sari Rizal, Wadratul Jannah Rizaldi, Fajri Roza Silvia Rusti, Sukarsi Sabrina Herfika Putri Sabrina, A`thifa Santika, Annisa Yulia Selfi Renita Rusjdi Selfi Renita Rusjdi Serudji, Joserizal Sihite, Perdana Liansyah Sisca Dwi Yarni Sri Mulyanti Sri Suparni Suharni Suharni Sukarsi Rusti Sulthani, Muhammad Zhorif Syafruddin Ilyas Syandrez Prima Putra Tofrizal Ulfa Farrah Lisa, Ulfa Farrah Ulya Uti Fasrini Umi Fahmida Utami, Riezka Putri Wahida Rahmi Wahida Rahmi Westi Permata Wati Yanni, Mefri Yanti Rahayu Yanti Setianti Yulia, Dwi Yuliarni Syafrita Yulistini, Yulistini Yulizawati Yulizawati . Yulizawati, Yulizawati Yuniar Lestari Yurensi, Nisriinaa Yusrawati Yusrawati Yustini Alioes Zelly Dia Rofinda Ziadati Shoulhuna Zulfan Zulfikar Zulham Zulham Zurayya Fadila Zurrahmi Wirda