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Hasmiwati
Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Detection of Ace-1 gene with insecticides resistance in Aedes aegypti populations from DHF-endemic areas in Padang, Indonesia HASMIWATI HASMIWATI; SELFI RENITA RUSJDI; EKA NOFITA
Biodiversitas Journal of Biological Diversity Vol. 19 No. 1 (2018)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d190105

Abstract

Hasmiwati, Rusjdi SR, Nofita E. 2018. Detection of Ace-1 gene with insecticides resistance in Aedes aegypti populations from DHF-endemic areas in Padang, Indonesia. Biodiversitas 19: 31-36. Aedes aegypti is distributed widely in West Sumatra as a primary vector of Dengue hemorrhagic fever, especially in Padang City. Synthetic insecticide control is one currently used method to prevent mosquito-borne diseases. The extensive, long-term application of Temephos along with inappropriate dosages, have resulted in the development of resistance in Ae. aegypti populations. Mutation of the Ace-1 gene, encoding an acetyl cholinesterase, is one of the mechanisms that confer resistance to organophosphate (OP). The Temephos resistance status of Ae. aegypti in Padang city has not yet been studied. This study aimed to investigate the resistance status of Ae. aegypti and identify any possible mutation (s) of the Ace-1 gene in Padang city. Ae. aegypti samples were collected in five population in Padang city (Jati (JT), Gunung Pangilun (GP), Lubuk Minturun (LM), Korong Gadang (KG), and Bandar Buat (BB)). The larval susceptibility to Temephos was tested by larval bioassays with Temephos pestanal at 0.02 mg/L dosages. Larval susceptibility was determined by mortality percentage values. The relationship between Ace-1 genotypes and the resistant phenotype was analyzed by percentage of genotype frequency. Out of five populations, assessed by larval bioassays, JT and GP were resistant to Temephos; LM, KG, and BB were tolerant. A total of 50 individuals from larval bioassays were genotyped for Ace-1 gene. Our findings showed that Ace-1 was 495 bp in length. Mutation was not found in the G119S location but in the T506T location. Three alleles in T506T location were detected, including a wild type allele, TT (65.21%), and two mutant alleles, TA (26.08%), AA (8.69%). The use of Temephos showed that some Ae. aegypti populations were resistant, others were tolerant, but no population was vulnerable to Temephos. A novel mutation was detected as substitution in T506T location (ACT>ACA).
Short Communication: Genotyping of kdr allele in insecticide resistant-Aedes aegypti populations from West Sumatra, Indonesia HASMIWATI HASMIWATI; SUPARGIYONO SUPARGIYONO
Biodiversitas Journal of Biological Diversity Vol. 19 No. 2 (2018)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d190225

Abstract

Hasmiwati, Supargiyono. 2018. Short Communication: Genotyping of kdr allele in insecticide resistant-Aedes aegypti populations from West Sumatra, Indonesia. Biodiversitas 19: 552-558. Aedes aegypti, the primary vector of Dengue fever, is widely distributed in Indonesia including in West Sumatra. Chemical insecticide is an effective way of shedding the chain of Dengue fever transmission. Long-term applications of insecticides have resulted in the development of resistance in Ae. aegypti populations. Knockdown resistance (kdr) allele as a result of point mutations has been found in Voltage-Gated Sodium Channel (VGSC) gene. This study aimed to design allele-specific primers to detect the kdr allele mutations. Ae aegypti samples were collected from several dengue endemic areas in West Sumatra. The susceptibility of adult mosquitos to insecticides was determined by bioassays using impregnation paper test with 0.18% malathion and 0.75% permethrin. In this study, we successfully confirmed that the A. populations have point mutations in the VGSC gene corresponding to S989P and V1016G amino acid substitutions. To genotype S989P and V1016G alleles, we designed kdr allele-specific primers based on the sequence of VGSC gene (NCBI Accession number No. EU399179.1. PCR analysis using the kdr allele-specific primers successfully identified the genotype of Ae. aegypti populations resistant to malathion and permethrin in West Sumatra.
Acetylcholinesterase activity and Ace-1 mutation in Aedes aegypti resistance to temephos YENI ETMA NAZAR; HASMIWATI HASMIWATI; RESTI RAHAYU
Biodiversitas Journal of Biological Diversity Vol. 26 No. 9 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260930

Abstract

Abstract. Nazar YE, Hasmiwati, Rahayu R. 2025. Acetylcholinesterase activity and Ace-1 mutation in Aedes aegypti resistance to temephos. Biodiversitas 26: 4598-4605. An organophosphate insecticide called temephos is frequently used to manage Aedes aegypti, the main Dengue Fever (DF) vector. However, prolonged and widespread application has led to resistance in many mosquito. This study aimed to assess temephos resistance in Aedes aegypti larvae from Tanjung Bingkuang, Solok District, West Sumatra, Indonesia, using biochemical and molecular assays, this study sought to ascertain the resistance status of Ae. aegypti larvae collected from Tanjung Bingkuang, Solok District, West Sumatra. The biochemical test results showed that the larvae exhibited a high level of resistance, with an Activity Value (AV) of 1.077 and Acetylcholinesterase (AChE) enzyme activity of 6.65 U/L. Further molecular analysis identified a point mutation at codon T506T in the Ace-1 gene, characterized by a nucleotide change from ACA to ACT. Molecular analysis identified a synonymous mutation (T506T; ACA ? ACT) in the Ace-1 gene, potentially associated with resistance development. These results confirm the emergence of temephos resistance in local Ae. aegypti populations and highlight the importance of incorporating molecular and enzymatic surveillance tools into vector control programs to ensure larvicide efficacy. This study confirms that the use of the organophosphate insecticide temephos is no longer effective in controlling Ae. aegypti larvae in Tanjuang Bingkuang, Solok District, West Sumatra, Indonesia.
EFEKTIFITAS PEMBERIAN SUSU KAMBING FERMENTASI TERHADAP ANTROPOMETRI BAYI BARU LAHIR Ira Suryanis; Hasmiwati Hasmiwati; Nur Indrawaty Lipoeto; Novirman Jamarun
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1834

Abstract

The balance of the gut microbiota during pregnancy is essential for maintaining maternal health and supporting optimal fetal development. Fermented goat’s milk contains naturally occurring probiotics that contribute to microbiota homeostasis and improved maternal nutritional status. This study aimed to evaluate the effect of fermented goat’s milk consumption on newborn anthropometric outcomes. Two group pretest posttest control was applied involving 15 third-trimester pregnant women who met the inclusion criteria. Participants consumed 75 mL of fermented goat’s milk daily for a period of 9–12 weeks. Maternal characteristics and neonatal anthropometric parameters were collected through structured observations and questionnaires. Data were analyzed using paired statistical tests. The findings demonstrated statistically significant improvements (p < 0.05) in neonatal birth weight, body length, and head circumference following the intervention. These results indicate that fermented goat’s milk may positively influence fetal growth without inducing gut microbiota dysbiosis. Further studies employing controlled designs and larger sample sizes are warranted to confirm these findings and elucidate the underlying mechanisms.
Alphabet Letter Recognition Through Letter Pocket Media in Early Childhood Hasmiwati Hasmiwati; Nova Yenti
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 1 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i1.9624

Abstract

Although early childhood literacy has received increasing scholarly attention, research examining the use of concrete and play-based media to support alphabet letter recognition in natural classroom settings remains limited. This study aims to analyze the implementation of alphabet letter recognition through letter pocket media in early childhood education, examine children’s responses to its use, and identify the supporting and inhibiting factors affecting its implementation. A qualitative descriptive design was employed involving 15 group B children aged 5–6 years and one classroom teacher at PAUD/TK Aisyiyah 6 Sulit Air, Solok Regency, West Sumatra, selected through purposive sampling. Data were collected through observation, semi-structured interviews, and documentation, and analyzed using an interactive model comprising data condensation, data display, and conclusion drawing, with validity ensured through source and technique triangulation. The findings show that alphabet letter recognition through letter pocket media was implemented systematically through planning, play-based activities, and evaluation. During the learning process, children actively took letter cards from the pocket, identified letter names and sounds, and matched them with relevant pictures. The use of letter pocket media also increased children’s enthusiasm, attention, confidence, and active participation. This study concludes that letter pocket media provides an effective and developmentally appropriate approach to supporting early literacy learning by offering concrete, manipulative, and interactive experiences aligned with young children’s characteristics. These findings contribute to the strengthening of early literacy practices and imply that teachers and parents should provide consistent literacy stimulation through enjoyable and meaningful learning activities.
Tingkat Pengetahuan, Sikap, dan Perilaku Masyarakat mengenai 3M Plus dan G1R1J dengan Kejadian Dengue di Kelurahan Baru Savira Dewita Junaidi; Hasmiwati; Indra Ihsan
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1344

Abstract

Kejadian dengue masih menjadi salah satu masalah kesehatan. Kecamatan Pasar Rebo menjadi daerah dengan kasus dengue yang tinggi di Kota Jakarta Timur dan IR Kelurahan Baru lebih tinggi dibanding dengan Kecamatan Pasar Rebo pada tahun 2018. Tujuan penelitian ini untuk mengetahui gambaran tingkat pengetahuan, sikap, dan perilaku masyarakat mengenai 3M Plus dan G1R1J di Kelurahan Baru. Desain penelitian adalah quasy experiment dengan metode proportionate stratified random sampling dan besar sampel 214 orang. Jumlah total tersebut terbagi menjadi 2 kelompok (kelompok intervensi dan non-intervensi). Hasil penelitian ini menunjukkan bahwa terjadi peningkatan pengetahuan dan perilaku baik pada kelompok intervensi, namun terjadi penurunan sikap baik setelah diberi perlakuan. Kesimpulan bahwa pemberian intervensi memengaruhi peningkatan pengetahuan dan perilaku responden
HUBUNGAN FAKTOR EKONOMI DENGAN PERSEPSI MASYARAKAT TERHADAP FRAKTUR DI KABUPATEN PADANG PARIAMAN Fathimah Fitri Budiman; Rima Semiarty; Hasmiwati fitri; Menkher Manjas; Nelmi Silvia; Elmatris fitri; Lydia Susanti; Taufik Akbar
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 3 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i3.2946

Abstract

Fractures are a health issue that significantly impacts individuals’ quality of life. The Health Belief Model suggests that an individual's perception of disease and their belief in the effectiveness of a particular action will influence their health behavior. Economic factors are among the elements that affect community perceptions. These perceptions will determine how individuals manage fractures. Inappropriate management of fractures can lead to complications such as infections, gangrene, and neglected fractures. This study aims to to investigate the relationship between economic factors and community perception of fractures. The economic factors considered in this study are occupation and income. This study used primary data with analytical observational methods through a cross-sectional approach conducted in Padang Pariaman Regency from November 2023 to March 2024. The population in this study consists of the community in Padang Pariaman Regency, involving 390 respondents. Data analysis was conducted using the chi-square test. The results indicate a relationship between occupation and income factors and community perception of fractures (p=0,000). This study concludes that there is a relationship between economic factors and community perception of fractures in Padang Pariaman Regency.
Detection of Intestinal Protozoa Using Direct Stool Examination in Patients with Colorectal Diseases at Dr. M. Djamil General Hospital, Padang: Intestinal Protozoa in Colorectal Diseases Tazkia Aulia Permata Helena; Selfi Renita Rusjdi; Eka Kurniawan; Hasmiwati Hasmiwati; Dwitya Elvira; Shinta Ayu Intan
Indonesian Journal of Cancer Vol. 20 No. 3 (2026): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i3.1605

Abstract

Background: Colorectal diseases are conditions that affect the colon and rectum, impacting both their functional and structural integrity. Colorectal diseases include inflammatory bowel disease (IBD), colorectal polyps, and colorectal cancer, as they have the potential to cause chronic inflammation in the colon and rectum. Chronic inflammation and mucosal disruption may facilitate protozoan colonization and infection, potentially increasing susceptibility to intestinal protozoa. Conversely, intestinal protozoan infections may promote intestinal inflammation and epithelial damage, potentially contributing to the pathogenesis of colorectal disease. This study explores multiple colorectal diseases such as IBD, polyps, and cancer to provide a broader understanding of intestinal protozoan infections within the colorectal spectrum in West Sumatera, where such data have not been previously reported. This study aimed to determine the prevalence of intestinal protozoa detected by direct stool examination among patients with colorectal diseases at Dr. M. Djamil General Hospital Padang. Methods: This study is a descriptive cross-sectional study using primary data from a total of 73 colorectal disease patients, selected through consecutive sampling. Patient diagnoses were obtained from medical records, while intestinal protozoan infections were identified through stool samples via direct stool examination. Fresh stool samples were examined microscopically and then stained with Lugol’s iodine and eosin. Microscopic observations were performed using a binocular light microscope under 100x, 400x, and 1,000x magnifications. The study employed univariate analysis and presented the results in frequency distribution tables. This study was conducted at Dr. M. Djamil General Hospital Padang and the Parasitology Laboratory, Faculty of Medicine, Andalas University, between December 2023 and February 2024. Results: Among the 73 patients, 79,5% had colorectal cancer, 19.2% had IBD, and 1.4% had colorectal polyps. Intestinal protozoan infections were most frequently observed in patients with colorectal cancer. Most patients were male (60.3%), with the highest prevalence in the 51-60 and > 60 age groups (31.5%). Intestinal protozoan infections were detected in 52.1% (38/73) of colorectal disease patients, with Cryptosporidium sp. found in 52.6% and Blastocystis sp. in 47.4% of cases. The infection rate was higher in the 51-60 age group (36.8%) and predominantly found in males (65.8%). The dominant type of infection was single infection (89.5%). Conclusions: The prevalence of intestinal protozoan infections was found to be relatively high, particularly in colorectal cancer patients. The most frequently detected species were Blastocystis sp. and Cryptosporidium sp. Patients should undergo screening and receive antiparasitic treatment if necessary, along with education on disease prevention related to intestinal protozoan infections.  
Effects of Moringa oleifera Leaf Extract on Serum 8-OHdG Levels in Alloxan-Induced Diabetic Rats Yuhendri Putra; Arni Amir; Eti Yerizel; Hasmiwati
Journal of Public Health and Pharmacy Vol. 6 No. 3 (2026)
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v6i3.11226

Abstract

Introduction: Oxidative stress contributes to the pathogenesis and complications of diabetes mellitus through excessive production of reactive oxygen species, which can lead to oxidative DNA damage. Serum 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) is widely used as a biomarker of oxidative DNA damage. Moringa oleifera leaves contain various antioxidant compounds that may help modulate oxidative stress under diabetic conditions. This study aimed to evaluate the effects of Moringa oleifera leaf extract on serum 8-OHdG levels in alloxan-induced diabetic rats. Methods: This exploratory, randomized, post-test-only experiment included 25 male Wistar rats allocated to five groups (n = 5/group): non-diabetic control, alloxan-exposed diabetic control, and alloxan-exposed groups receiving Moringa oleifera leaf extract at 250, 500, or 1000 mg/kg body weight orally once daily for 14 days. Alloxan monohydrate was administered intraperitoneally at 150 mg/kg body weight. A fasting glucose level ≥200 mg/dL at 72 hours defined eligibility for the diabetic groups. Serum 8-OHdG was measured by enzyme-linked immunosorbent assay (ELISA), and group means were compared using one-way ANOVA with p < 0.05 as the significance threshold. Results: Serum 8-OHdG did not differ significantly among groups (F(4,20) = 1.55; p = 0.227). The 500 mg/kg group had the numerically lowest mean (0.367 ± 0.036 ng/mL), but this observation did not establish a treatment effect or an optimal dose. The diabetic control mean (0.416 ± 0.073 ng/mL) was not higher than the non-diabetic control mean (0.468 ± 0.108 ng/mL). Conclusion: This exploratory study did not demonstrate a statistically significant effect of Moringa oleifera leaf extract on serum 8-OHdG under the tested conditions. The observed numerical variation should be interpreted cautiously and does not establish antioxidant efficacy or an optimal dose. Larger, adequately powered studies with standardized extract characterization, longitudinal glycemic assessment, and additional oxidative stress markers are warranted.
Co-Authors Abdiana Abdiana, Abdiana Adrial Adrial Adrial Adrial Adrial Adrial Adrial, Adrial Afriwardi Afriwardi Afrizal Afrizal Agustini, Cynthia Aisha, Fahra Audina Aisyah Suci Ayudya Alioes , Yustini Almurdi Almurdi Amir, Arni Andani Eka Putra Ariadapa Rahadi, Didan Ariadi, Ariadi Arina Widya Murni Arni Amir Arni Amir Arni Amir Aswiyanti Asri Aswiyanti Asri Aulia, Febby Beni Indra, Beni Bobby Indra Utama Cimi Ilmiawati, Cimi Citra Manela Daan Khambri Dahelmi Dahelmi Deddy Saputra Delmi Sulastri Desmawati Desmawati Desmiwarti Dessy Arisanti Dessy Arisanti Dessy Arisanty Dewi Asmawati Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Diandra K., Puti Reno Dwiharyani, Yuli Dwitya Elvira, Dwitya Effy Huriyati Efrida Efrida Eka Kurniawan Eka Nofita EKA NOFITA Eka Novita Ellyza Nasrul Elmatris fitri Elmatris Sy Endrinaldi Erizal Zaini Erlina Rustam Erlina Rustam Eryati Darwin Eti Yerizel Fadrian, Fadrian Faisaelia, Rezka Nanda Fathimah Fitri Budiman Fatma Sri Wahyuni Fauzan, Rezky Firdawati Firdawati Fortuna, Fory Gestina Aliska Ginting, Desi Scorpinasari Gusti Rati Hardisman Hendriani, Intania Dwiputri Hendriati, Hendriati Henmaidi Henmaidi Henny Herwina Herman, Deddy Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Husnil Kadri Husnil Wardiyah Huvaid, Sevilla Ukhtil Ida Rahmah Burhan Ilmiawati, Ilmiawati Indra Ihsan Intan, Shinta Ayu Ira Suryanis Janra, Muhammad Nazri Julizar Julizar Julizar Nazar Karmia, Hudila Rifa Kevin Bryan Alghifari Kharisma Putra Kharisma Putra D Lestari, Rahmi Linosefa Linosefa Luois Joseph Joseph Lydia Susanti, Lydia Mairawita, Mairawita Malinda Meinapuri Maria Dona Octavia Marwin, Fikri Alhafizd Masnadi, Nice Rachmawati Masrul Djalal Menkher Manjas Mohamad Reza Mohamad Reza Muhamad Diva Caesar Muhammad Abi Ghoffari Siregar Muhammad Ilham Nabila Priscilla Putri Nelmi Silvia Nesa Pratiwi Nice Rachmawati Masnadi Nita Afriani Nora Harminarti Nova Yenti Noverika Windasari Novirman Jamarun Noza Hilbertina, Noza Nur Afrainin Syah Nur Indrawaty Lipoeto Nurhalimah Juneldi Nurhayati Nurhayati Nurhayati Nurhayati Nurhayati Nurhayati, Nurhayati Nursyirwan Effendi, Nursyirwan Nurul Badriyah Nuzulia Irawati Oktavia, Sri Olivia, Ivonne Puti Reno Diandra K. Putra, Fachri Putri, Nabila Priscilla Putri, Salsa Utami Raden Mohamad Herdian Bhakti Rahmatini . Ramadhan, Mario Arya Ratu Fawwaz Efendi Rauza Sukma Rita Resti Rahayu Restu Susanti Revila, Gusti Reza, Mohamad Rifa, Farras Zahra Rika Susanti Rima Semiarty Rizanda Machmud Rizka Karima Husfa Rosfita Rasyid Roslaili Rasyid Roza Silvia Rozi Sastra Purna Rustam, Rony Savira Dewita Junaidi Savitri, Melvinia Selfi Renita Rusdji Selfi Renita Rusjdi Selfi Renita Rusjdi Selfi Renita Rusjdi, Selfi Shinta Ayu Intan Siti Nurhajjah Sri Oktavia Suchitra, Avit Suharti , Netti Sukri Rahman SUPARGIYONO SUPARGIYONO Syamel Muhammad Taufik Akbar Taufik Ramadhani Tazkia Aulia Permata Helena Tiya Taslisia Tofrizal Tofrizal Tofrizal Trisuliandre, Muhammad Rizki Vaulline Basyir Vilza Maharani Syahnel Wirsma Arif Harahap Wirsma Arif Harahap YENI ETMA NAZAR Yenita . Yenita Yenita Yoseph De Nachs Yuhendri Putra Yulistini, Yulistini Yuniar Lestari Zelly Dia Rofinda Zurayya Fadila