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Efek Andrographolide terhadap Gambaran Histopatologi Sel Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karbon Tetraklorida (CCl4): Hasil Penelitian
Sanjaya, Vincent;
Andriani;
Ilmiawan, Muhammad In’am
Cermin Dunia Kedokteran Vol 52 No 10 (2025): Oktober 2025
Publisher : PT Kalbe Farma Tbk.
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DOI: 10.55175/cdk.v52i10.1010
Introduction: Andrographolide is a group of diterpene lactone isolates from the Andrographis paniculata plant with hepatoprotective properties. Andrographolide gives a hydrogen ion to pair with a free electron from a free radical to form a stable chemical compound and thus decrease liver damage. Methods: This experimental research used a post-test only with a control group design. The samples were mouse's liver (Rattus norvegicus).Twenty-four mice (Rattus norvegicus) were divided into 6 groups: a normal group, a curcumin-treated group as a positive control, a carbon tetrachloride-only group as a negative control, and the treatment group with the dose an andrographolide 50 mg/kgBW group, an andrographolide 100 mg/kgBW group, and an andrographolide 200 mg/kgBW group with 4 mice in each group. Mice were induced with carbon tetrachloride on the first day, then treated with curcumin and andrographolide for 7 days. Liver organs were dissected on day 9 to prepare a specimen for assessing hepatocyte damage (necrosis and hydropic degeneration). Results: Andrographolide showed a hepatoprotective effect on hepatocyte damage after induction by CCl4. The injury score in the normal group is 16.84; the negative control group is 34.36; the positive control group is 11.48; the dose 1 group is 24.92; the dose 2 group is 19.96; and dose 3 is 19.52. In the LSD test, the 50 mg/kgBW and 100 mg/kgBW andrographolide dose groups showed significant differences in hepatocyte damage compared to the normal group. There was no significant difference in liver histopathologic injury score between the normal group and the andrographolide 200 mg/kgBW group (ANOVA, p > 0.05). Conclusion: The best hepatoprotective effect was provided by andrographolide 200 mg/kgBW because the degree of damage is similar to that in the normal group.
Produk Tabungan Emas Pegadaian Syariah Sebagai Alternatif Investasi Halal
Irma Niawati;
Andriani
Jurnal Ekonomi Syariah Pelita Bangsa Vol. 10 No. 02 (2025): JESPB Edisi Oktober 2025
Publisher : DPPM Universitas Pelita Bangsa
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DOI: 10.37366/jespb.v10i02.2454
This study aims to examine the Pegadaian Syariah Gold Savings product as a halal investment alternative for Muslims in Indonesia. The background of this study is the increasing public interest in gold investment and the need for sharia-compliant financial instruments. Using a qualitative approach with descriptive methods, this study relies on secondary data from literature, journals, and official sources from Pegadaian Syariah. The study results indicate that Pegadaian Syariah Gold Savings offers various advantages such as guaranteed halal transactions, potential long-term profits, high accessibility, security and transparency, and protection against inflation. This product not only meets investment needs but also supports financial management in accordance with Islamic values. With a sale and purchase agreement (murabahah) and custody mechanism, as well as supervision by the DSN-MUI, Pegadaian Syariah Gold Savings is a halal, inclusive, and sustainable investment solution.
Hubungan Fasiltas Kesehatan Gigi Dan Mulut Dengan Kepuasan Pasien Di Poli Gigi Puskesmas Kecamatan Sukakarya Kota Sabang
Nashwa Juliani;
Andriani
urn:multiple://2988-7828multiple.v3i105
Publisher : Institute of Educational, Research, and Community Service
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Fasilitas pelayanan kesehatan yang memadai merupakan faktor penting dalam menunjang kepuasan pasien terhadap layanan yang diberikan. Namun, Poli Gigi Puskesmas Sukakarya Kota Sabang masih menghadapi kendala berupa ruang tunggu yang sempit, fasilitas yang belum lengkap, dan kebersihan yang kurang optimal, sehingga diperlukan penelitian untuk mengetahui hubungan antara fasilitas kesehatan gigi dan mulut dengan kepuasan pasien. Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross-sectional pada 50 pasien yang dipilih melalui teknik purposive sampling. Data dikumpulkan menggunakan kuesioner dan dianalisis dengan uji Chi-Square untuk menguji hubungan antar variabel. Hasil penelitian menunjukkan bahwa 39 responden (78%) menyatakan fasilitas baik dengan tingkat kepuasan puas, sedangkan 11 responden (22%) menilai fasilitas tidak baik dengan kepuasan tidak puas. Hasil uji Chi-Square menunjukkan nilai p-value = 0,00 (< 0,05), yang berarti terdapat hubungan yang signifikan antara fasilitas kesehatan gigi dan mulut dengan kepuasan pasien. Dengan demikian, semakin baik kelengkapan dan kenyamanan fasilitas yang disediakan, semakin tinggi pula tingkat kepuasan pasien. Oleh karena itu, pihak Puskesmas disarankan untuk melakukan perbaikan dan pemeliharaan fasilitas secara berkala guna meningkatkan kualitas pelayanan kesehatan.
Hubungan Pemberian Susu Formula Dengan Karies Gigi Pada Anak Usia 4-6 Tahun Di TK Latifa Kecamatan Baiturrahman Banda Aceh
Intan Wardyna;
Andriani
urn:multiple://2988-7828multiple.v3i105
Publisher : Institute of Educational, Research, and Community Service
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Karies gigi merupakan salah satu masalah kesehatan mulut yang sering terjadi pada anak usia dini dan dipengaruhi oleh berbagai faktor, termasuk pola pemberian susu formula yang tidak tepat. Penelitian ini bertujuan untuk mengetahui hubungan antara pola pemberian susu formula dengan kejadian karies gigi pada anak usia 4–6 tahun di TK Latifa Kecamatan Baiturrahman, Banda Aceh. Penelitian ini menggunakan desain analitik dengan pendekatan cross sectional dan melibatkan 33 anak yang dipilih melalui teknik simple random sampling. Pengumpulan data dilakukan menggunakan kuesioner untuk mengetahui pola pemberian susu formula dan pemeriksaan indeks def-t untuk menilai tingkat keparahan karies. Analisis data dilakukan menggunakan uji chi-square dengan tingkat signifikansi α = 0,05. Hasil penelitian menunjukkan bahwa sebagian besar anak memiliki pola pemberian susu formula yang kurang baik (54,5%) dan tingkat karies sangat tinggi (51,5%). Berdasarkan hasil uji statistik diperoleh nilai p = 0,003 yang menunjukkan adanya hubungan signifikan antara pola pemberian susu formula dengan kejadian karies gigi pada anak. Dengan demikian, dapat disimpulkan bahwa pola pemberian susu formula yang tidak sesuai berkontribusi terhadap peningkatan risiko karies gigi pada anak usia dini, sehingga diperlukan edukasi kepada orang tua mengenai praktik pemberian susu yang benar untuk menjaga kesehatan gigi anak.
A Review of Adolescent Behavior Against Lesbian, Gay, Bisexual, Transgender (LGBT) Behavior at SMA Negeri 5 Pekanbaru
Hamidah Sari Batubara;
Andriani
International Journal of Public Health Excellence (IJPHE) Vol. 2 No. 1 (2022): June-December
Publisher : PT Inovasi Pratama Internasional
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DOI: 10.55299/ijphe.v2i1.247
LGBT behavior is a form of negative behavior because this behavior is seen as inconsistent with the norms prevailing in society. On average, a lesbian is aware of his homosexuality since he was a teenager. In his research, three general factors were found in the formation of sexual identity in adolescents. This study aims to describe the behavior of adolescents towards lesbian, gay, bisexual, transgender (LGBT) behavior in SMA Negeri 5 Pekanbaru in 2018. Type of quantitative research with a descriptive design. The population in this study were all 829 students at SMA Negeri 5 Pekanbaru with a sample of 89 people. The data was collected using the stratifield proportional random sampling method. The data were processed in a univariate way. The results obtained from the knowledge of the majority of adolescents have sufficient knowledge, amounting to 68 people (76%), the attitude of the majority of adolescents is negative 56 people (63%) and the majority of adolescent actions do not do 71 people (80%). For future researchers to be able to carry out further research such as factors that influence adolescent behavior or quantitative research with analytic designs at SMA Negeri 5 Pekanbaru.
The Relationship of Episiotomy to Perineal Tears in Labor Women
Andriani;
Linda Suryani;
Eva Santi H.
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 1 (2023): June-December
Publisher : PT Inovasi Pratama Internasional
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DOI: 10.55299/ijphe.v3i1.412
Episiotomy is a rupture made in the perinea between the vaginal open and the anus to release the baby. Episiotomy is not recommended because it may lead to an increase in the amount of blood lost. The number of events in the field of obstetrics around the world in 2009 accrued 2.7 million cases of perineal rupture wounds in mothers. The purpose of this research was to determine the relationship of episiotomy in labor to the incidence of perineal rupture in the maternal mother at the Ernita maternity clinic. This research is quantitative research with analytical design. The population in this research is all maternal mothers at Ernita maternity hospital as many as 95 people. The sampling technique used in this research is the total population that is sampling from all mother maternity data. The results showed that of 54 people (57%) who performed the episiotomy action in the majority of labor perineal rupture that is as many as 35 people (37%). Chi-square test results there is a relationship between episiotomy in labor to the incidence of perineal rupture in the maternal maternal mother where the p value is 0.040 <0.05. It is desirable for midwives to reduce the action of episiotomy by doing proper labor delivery.
Etika Kerja Islami dan Retensi dalam Kinerja Dosen IAIN Kediri
Andriani;
Binti Mutafarida;
Ilyas Adhi Purba
Istithmar Vol. 7 No. 2 (2023): Istithmar : Jurnal Studi Ekonomi Syariah
Publisher : Program Studi Ekonomi Syariah Fakultas Ekonomi dan Bisnis Islam Universitas Islam Negeri Syekh Wasil Kediri
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DOI: 10.30762/istithmar.v7i2.978
Kinerja dan etika karyawan yang baik menjadi tolak ukur bagi perusahaan untuk mempertahankan atau melepaskan karyawannya. Kondisi ini disebabkan oleh kinerja karyawan yang baik sehingga perusahaan dapat berjalan cepat dalam mencapai tujuan yang ditetapkan. Penelitian ini bertujuan untuk mengetahui hubungan antara etika kerja Islam dan retensi terhadap kinerja dosen IAIN Kediri. Penelitian ini menggunakan pendekatan kualitatif deskriptif, yaitu penelitian yang bertujuan untuk mengetahui fenomena yang terjadi pada subjek. Data diperoleh dengan melakukan wawancara terstruktur dan menyebarkan kuesioner dengan dosen yang berstatus PNS di IAIN Kediri. Penelitian ini diolah dengan menggunakan metode Structural Equation Model (SEM). Hasil penelitian ini menjelaskan bahwa etika kerja Islami yang lebih baik dapat meningkatkan retensi tubuh. Indikator etika kerja Islami yang memberikan kontribusi terbesar dalam meningkatkan retensi adalah transparansi, tercermin dalam kreativitas kerja, yang merupakan sumber kebahagiaan dan kesuksesan. Lembaga dengan etika kerja Islami yang baik akan mengamalkan nilai-nilai, berupa: kejujuran, menepati janji, keadilan, menghargai orang lain, integritas, loyalitas, akuntabilitas, kepedulian terhadap sesama, dan tanggung jawab.
Strategi Inovatif untuk Meningkatkan Minat Siswa dalam Pembelajaran Teori Musik Pada Pendidikan Dasar
Andriani;
Yusna;
Achmad Mieka Husaeini Pinem;
Yamonaha Halaw;
Anita Satriani
Jurnal Pendidikan Dasar Islam Vol. 1 No. 3 (2023): September
Publisher : putrapublisher.org
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DOI: 10.58540/jurpendis.v1i3.497
This research aims to find and apply new methods to increase students' interest in learning music theory. This is because students' interest in music theory has decreased. This research uses a qualitative approach with a literature review type of research. Data sources come from research results, books and websites that are relevant to the research. The data analysis used is content analysis. The research results show that the application of innovative strategies increases students' interest in learning music theory. Strategies that combine interactive and contextual elements have the greatest influence in increasing students' interest in music theory. This study provides music educators with important insight into the importance of change and innovation in teaching. Recommendations for educational practice and future research emphasize the need for approaches that better suit the needs and desires of today's students. These results add to the music education literature by demonstrating a useful method for addressing the problem of teaching music theory in modern schools.
LEARNING TO WRITE POETRY TEXT BASED ON ACROSTIC MODEL WITH WORD CARDS THROUGH WORDWALL MEDIA
T. Muntazar;
Asmaul Husna;
Andriani
International Journal of Social Science, Educational, Economics, Agriculture Research and Technology (IJSET) Vol. 2 No. 1 (2022): DECEMBER
Publisher : RADJA PUBLIKA
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DOI: 10.54443/ijset.v2i1.696
This study discusses the effectiveness of learning to write poetry based on the acrostic model with word cards through Wordwall media. The acrostic model is used to help students compose poetry more systematically, while word cards function as a guide in selecting relevant vocabulary. The integration of Wordwall media aims to create more interactive and interesting learning. The method used in this study is a literature study that examines various sources related to learning to write poetry. The results of the study indicate that this approach is able to increase creativity, understanding of the concept of acrostic poetry, and students' motivation in writing. In addition, the use of Wordwall as an interactive learning medium allows students to more easily explore ideas and improve critical thinking skills in writing poetry. Therefore, this strategy is recommended as an innovative alternative in learning literature in schools.
FORMULASI FLAKES TEPUNG MOCAF (Modified Cassava Flour) DAN TEPUNG UBI JALAR KUNING (Ipomoea batatas L.) SEBAGAI ALTERNATIF SARAPAN PENDERITA DIABETES MELLITUS
wati, Rachma;
Mardhatillah;
hadi, abdul;
andriani
JURNAL SVASTA HARENA RAFFLESIA Vol 4 No 1 (2025): SHR Volume 4, Nomor 1, Juni 2025
Publisher : Poltekkes Kemenkes Bengkulu
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DOI: 10.33088/shr.v4i1.1032
Diabetes mellitus (DM) is a global health problem with increasing prevalence in Indonesia. Dietary regulation based on glycemic index (GI) is an important strategy. Mocaf flour and yellow sweet potato which have medium GI and high fiber have the potential as functional food ingredients. This study aims to develop low-glycemic flakes as an alternative healthy breakfast for people with DM. The study was conducted experimentally with a Completely Randomized Design (CRD), 3 treatments and 3 replications. Data were analyzed using ANOVA and Duncan's further test. The results showed that the treatment had a significant effect on color and taste, but not on aroma and texture. The best formulation was 70% mocaf: 30% yellow sweet potato. The results of the proximate test showed that the protein and carbohydrate levels met SNI standards. It was concluded that the addition of flour had a significant effect on color, taste, and nutritional content (P <0.05). Keywords: Flakes, Mocaf Flour, Yellow Sweet Potato Flour, Organoleptic Test, Chemical Test.