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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) SAINSMAT Jurnal Kedokteran Brawijaya Medula Juke Jurnal Ilmiah Keperawatan Sai Betik JKM (Jurnal Kebidanan Malahayati) Jurnal Ilmu Kedokteran dan Kesehatan Majalah Kedokteran Andalas Jurnal Kesehatan Sarwahita : Jurnal Pengabdian Kepada Masyarakat Malahayati International Journal of Nursing and Health Science JURNAL PENELITIAN PERAWAT PROFESIONAL An-Nadaa: Jurnal Kesehatan Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Journal of Multidisciplinary Applied Natural Science INDONESIAN JOURNAL OF MEDICAL ANTHROPOLOGY Indonesian Journal of Nursing and Health Sciences (IJNHS) Jurnal Farmasetis Majority Holistik Jurnal Kesehatan

Susianti Susianti

Universitas Lampung

Author-ID : 3527023

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Faktor-Faktor yang Berhubungan dengan Status Imunisasi Lanjutan Campak di Wilayah Kerja Puskesmas Labuhan Ratu Kota Bandar Lampung Tahun 2018 Arini Meronica; Roro Rukmi Windi Perdani; Susianti
MAJORITY Vol 10 No 1 (2021): MAJORITY
Publisher : Majority

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Advanced measles immunization is a health program held by the government for ncreasing the level of immunity and extending the period of protection given to children under the age of three and school-age children. The corevage advanced measles immunization at Labuhan Ratu Primary Health Center is the lowest in Bandar Lampung, which is caused by immunization providing behaviour of the mother which is influenced by some factors such as mother's knowledge, mother's attitude, mother's job status, affordability of health services and the role of health workers.This study was an observational study with a cross sectional design. There were 42 respondents which are determined by purposive sampling method. The data was assessed by questionnaire and collected by interview. The data was analyzed univariate and bivariate. Bivariate analysis using chi square test. The results showed 35.7% of respondents received incomplete immunization. Bivariate analysis showed the variables associated with sustainable immunization were knowledge (p value 0.002) and maternal attitudes (p value 0.001). Bivariate analysis also showed that the mother’s employment status (p value 0.47), affordability of the health service place (p value 0.287) and the role of health workers (p value 0.357) were not related. The conclusion is that mother’s knowledge and mother’s attitude were the factors correlated to advanced measles immunization.

Pengaruh Pemberian Ekstrak Kacang Kedelai (Glycine max L.) Terhadap Kadar Eritrosit Mencit (Mus musculus) Jantan Galur Swiss Webster yang Dipapar Natrium Nitrit Tasya Hani Fatwa; Susianti; Anisa Nuraisa Jausal; Sofyan Musyabiq Wijaya4
MAJORITY Vol 12 No 1 (2023): MAJORITY
Publisher : Majority

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Anaemia is defined by the number of red blood cells (erythrocytes) or haemoglobin level is lower than normal. Consumption of food that contained sodium nitrite (NaNO2) could accelerate the breakdown of erythrocytes in the body. Soybean contains iron and protein which trigger the production of new erythrocytes. This study aims to analyze the effect of soybean to the erythrocyte counts of mice induced by sodium nitrite. The method of this study is a post test control only group design with an analytic laboratory experimental type of study. 25 mice were used in this study as the samples which divided into 5 groups. Data analysis was performed by and bivariate analysis with One-Way ANOVA statistical tests. The result of this study indicates that soybean extract has an effect to the increasing of erythrocyte counts on mice induced by sodium nitrite (p=0.000).

The effect of anemia free-club model (CBA) application and giving of blood supplementary tablets (TTD) on knowledge, attitudes, and hemoglobin levels in anemic teenage girls of Senior High School Reni Zuraida; Susianti Susianti; Dian Isti Angraini; Bayu Anggileo Pramesona; Wido Gamani; Catur Ariwibowo; Zakiah Zakiah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 1: March 2023
Publisher : Universitas Aisyah Pringsewu

Introduction: The prevalence of anemia among teenage girls in senior high schools in Lampung Province is still quite high. A more comprehensive coping model is needed to improve this situation, such as applying the CBA (Anemia Free Club) model, which consists of nutrition education and the supervisory role of mothers and teachers. This study aims to analyze the effect of applying the CBA model and administering blood supplementary tablets on knowledge, attitudes and hemoglobin levels in anemic teenage girls of high school students in South Lampung Regency. Methodology: Quasi-experimental research with a non-randomized control group pretest–posttest design. The research was conducted in February-May 2022 using the consecutive sampling technique by dividing into two groups: the intervention group of senior high school and the control group of senior high school. The Anemia Free-club model was applied for anemic teenage girls, and supplementary tablets were given for six weeks. The analytical test used was the paired t-test using the SPSS program and was considered to have a significant effect if p less than 0,05. Results: After implementing the Anemia Free-club model and giving iron supplements, in the intervention group, there was an increase in the nutrition knowledge (up 45.33 points), the nutritional attitude (up 9.8 points) and the Hb level (up 1,06 mg/dL). Conclusion: It showed a significant effect between the application of the CBA model and the administration of blood supplementary tablets on nutritional knowledge, nutritional attitudes, and Hb levels (p less than 0,05) in the intervention group.

HUBUNGAN FAKTOR LINGKUNGAN FISIK, SOSIAL EKONOMI KEJADIAN TUBERKULOSIS PARU BERBASIS ANALISIS SPASIAL DI WILAYAH KERJA PUSKESMAS PANARAGAN JAYA Cana, Arla Erit Siktia; Rengganis Wardani, Dyah Wulan Sumekar; Susianti, Susianti
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 2 (2024): Volume 11 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i2.13246

Abstrak: Hubungan Faktor Lingkungan Fisik, Sosial Ekonomi Kejadian Tuberkulosis Paru Berbasis Analisis Spasial Di Wilayah Kerja Puskesmas Panaragan Jaya. Tuberculosis (TBC) adalah penyakit menular yang disebabkan oleh Mycobacterium tuberculosis, yang dapat menyerang paru dan organ lainnya. Pada tahun 2022 Kementerian Kesehatan bersama seluruh tenaga kesehatan berhasil mendeteksi TBC di Indonesia sebanyak lebih dari 717.941 kasus. Berdasarkan data laporan Puskesmas Panaragan Jaya selama tahun 2020-2022 kasus TBC terus mengalami peningkatan. Tujuan dari penelitian ini adalah untuk menganalisis hubungan faktor lingkungan fisik (akses ke pelayanan Kesehatan dan cakupan rumah sehat) dan sosial ekonomi (kepadatan penduduk dan keluarga pra sejahtera) dengan kejadian TBC berbasis analisis spasial di wilayah kerja puskesmas Panaragan Jaya Tahun 2020 - 2022. Penelitian ini terbagi menjadi dua jenis yaitu sub penelitian 1 yang membahas tentang hubungan lingkungan fisik sosial ekonomi secara individu dan merupakan penelitian Case-control dan sub penelitian ke 2 membahas tentang analisis spasial dengan wilayah persebaran penyakit TBC. Penelitian ini dilakukan di wilayah kerja puskesmas panaragan jaya yang memiliki 8 kelurahan. Pelaksanaan Penelitian dilakukan pada bulan agustus - november tahun 2023. Hasil penelitian yang telah dilakukan diwilayah kerja puskesmas panaragan jaya menunjukkan bahwa faktor lingkungan fisik, sosial ekonomi yang berhubungan dengan penyakit TB paru adalah rumah sehat, kepadatan hunian , pendapatan perkapita dengan nilai p value < 0,05 sedangkan faktor yang tidak berhubungan dengan penyakit TB paru adalah akses ke pelayanan Kesehatan. Hasil analisis spasial persebaran Kasus TB paru tertinggi tahun 2020-2022 berada di kelurahan Panaragan Jaya dengan jumlah 49 kasus.

Hubungan Rinosinusitis Kronis dengan Tingkat Kekambuhan Asma Pada Anak Andriansah, M.; Susianti, Susianti; Angraini, Dian Isti
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.953

Asthma is one of the health problems that the world is fighting against, according to WHO in 2019 the global prevalence of asthma sufferers reached 262 million people with high mortality, causing 455,000 deaths. Apart from the high mortality rate, asthma also has a high morbidity rate. One of the reasons for the high morbidity rate in asthma is the high recurrence rate of asthma, which affects the productivity of asthma sufferers. In 2020, the asthma recurrence rate in adults was 40.7% and in children the asthma recurrence rate was divided into two groups based on age, namely in the under 18 age group it was 42.7% and in the under 5 year age group it was 52. 9%. There are many factors that influence the rate of asthma recurrence, namely allergic and non-allergic factors. One non-allergic factor that can trigger an asthma recurrence is an infection in the sinuses or sinusitis. The aim of this study was to determine the relationship between chronic rhinosinusitis and the rate of asthma recurrence in children. The method used was a review article by searching for articles using the keywords rhinosinusitis, asthma, asthma recurrence rate via Google Scholar and Pubmed, then the articles were reviewed and analyzed. The results of this review article are that there is a relationship between chronic rhinosinusitis and the rate of asthma recurrence in children, especially influencing the degree of asthma attacks in children.

Pengaruh Pemberian Minyak Jelantah 1,5 mL/Hari Selama 14 Hari Terhadap Histopatologi Hepar Rattus norvegicus Jantan Ersa, Rakhmigasti Citra; Susianti, Susianti; Kurniawaty, Evi; Mustofa, Syazili
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1088

Using cooking oil multiple times can caused bad effect on health one of them is liver damage. Free radical content in reused cooking oil trigger oxidative stress then disturb the cellular respons in liver. This study aimed to determine the effect of giving reused cooking oil for 14 days on rats (Rattus norvegicus) liver histopathology. This study was a true experimental using 10 rats (Rattus norvegicus) and were devided by 2 groups, which are normal group (KN) and treatment group (KP) that was given 1,5 mL reused cooking oil per day. After 14 days of treatment, rats were terminated and the liver were taken. To observe rats liver histopathology, cloudy swelling scoring were used on 5 field of view. Score 0: there was no cloudy swelling and necrosis found, score 1: there was 1-20% cloudy swelling and necrosis found, score 2: there was 21-50% cloudy swelling and necrosis found, score 3: there was 51-75% cloudy swelling and necrosis found, and score 4: there was more than 75% cloudy swelling and necrosis found.It was found a minimal cloudy swelling on KN with average liver damage score was 0,04. In group KP it were found cloudy swelling degeneration on all over the liver with average liver damage score was 4. Mann-Whitney test showed a significant difference between groups. Giving reused cooking oil 1,5 ml/day for 14 days caused damage on male rats liver histopathology.

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN DISFUNGSI EREKSI PADA PASIEN BENIGN PROSTAT HIPERPLASIA DI RS YUKUM MEDICAL CENTRE Kamalia, Avissa Medina; Hadibrata, Exsa; Susianti, Susianti; Sutyarso, Sutyarso
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1116

Benign Prostate Hyperplasia (BPH) is the second most common urology’s disease in Indonesia. This disease occurs due to hyperplasia of stromal cells and epithelial cells of the prostate. The clinical manifestations of this disease consist of obstruction symptoms, irritation symptoms, and post void symptoms. People with BPH often complain about the decrease of their quality of life. One of the factor that Impaired to their quality of life is erectile dysfunction. This study aims to identify the factors that impact the incidence of erectile dysfunction in BPH patients at Yukum Medical Centre Hospital. There were 67 men with bph was obtained from Yukum Medical Centre Hospital in January-September 2021. Data were collected with International Index of Erectile Function-5 questionnaire and medical records. Data were analysis with chi-square test using SPSS and a p-value (<0,05 was considered significant). The result showed that 39 BPH patients had erectile dysfunction. Mean age of BPH patiens with erectile dysfunction was 66,74 (SD±6,51) and mean IIEF-5 scores of the BPH patients was 19,41 (SD±4,23). Age and prostate volume had significant impact with p-value 0,004 and 0,002 respectively. Treatment and medication didn’t have significant impact with p-value 0,193, and 0,856 respectively. Age and prostate volume have a significant impact on the incidence of erectile dysfunction in BPH patients. However, treatment and the type of medication doesn’t impact the risk of incident erectile dysfunction in BPH patients.

Determinan Pemeriksaan Triple Eliminasi pada Ibu Hamil di Wilayah Operasional Puskesmas Pagar Dewa dan Puskesmas Kibang Budi Jaya Kabupaten Tulang Bawang Barat Andhini, Friska; Susianti, Susianti; Pramesona, Bayu Anggileo
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 11, No 1 (2024): AN-NADAA JURNAL KESEHATAN MASYARAKAT (JUNI)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v11i1.13799

In Lampung Province, a 100% completion rate for triple elimination exams was the projected goal for 2022. Nevertheless, the collected data shows that the achievement—at 84.1%—is less than the goal. Comparably, the accomplishment rate in Tulang Bawang Barat Regency is at 83.1%. In the Tulang Bawang Barat working region, Kibang Budi Jaya and Pagar Dewa Public Health Center only obtained 62% and 52.4%, respectively. The purpose of this study is to determine the variables that pregnant women in Tulang Bawang Barat Regency's working regions of Pagar Dewa and Kibang Budi Jaya Health Center perceive influence their intention to undergo triple elimination. Cross-sectional design, analytical survey research methodology is used. Proportional random sampling was used to conduct the study in Pagar Dewa and Kibang Budi Jaya Health Center, Tulang Bawang Barat Regency, from September to October 2023. Tests for reliability and validity were carried out using Cronbach's alpha and the Pearson product moment. SPSS was used to perform univariate, bivariate, and multivariate data analysis. According to the findings, pregnant women who are well educated (46%), have a positive attitude (50.7%), have support from family/husband and healthcare professionals (51.5%), and live close to Health Center (51.2%) are more likely to have triple elimination exams. In multivariate analysis, the primary element is the attitudes of the respondents. The report makes recommendations for improving communication campaigns for healthcare providers to encourage increased involvement of pregnant women in triple elimination exams, as well as training in HIV/AIDS, syphilis, and hepatitis B counseling.

Predisposing, enabling, and reinforcing factors for the success of antiretroviral (ARV) treatment among people living with HIV Atmajaya, Yudhi; Wardani, Dyah Wulan Sumekar Rengganis; Susianti, Susianti
Holistik Jurnal Kesehatan Vol. 18 No. 6 (2024): Volume 18 Nomor 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v18i6.321

Background: The Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) epidemic is now growing rapidly and becoming one of the biggest challenges, despite various efforts to control and suppress its transmission. Globally, HIV/AIDS is a health problem that can cause a multidimensional crisis. The HIV/AIDS control program is aimed at reducing morbidity and hospitalization rates, mortality due to AIDS, and improving the quality of life of HIV sufferers. Purpose: To determine the effect of predisposing, enabling, and reinforcing factors on the success of antiretroviral (ARV) treatment in people with HIV/AIDS. Method: A Quantitative research of cross-sectional analytical survey conducted at the Bandar Lampung City Health Center for 2 months in January-February 2024. The number of samples in this study was 122 respondents taken using purposive sampling technique. The instrument used was a questionnaire that had been declared valid in the validity and reliability tests. Data analysis used univariate and bivariate chi-square tests with confidence intervals (CI), significance level p <0.05. Results: Several factors that influence success include clinical stage (p-value=0.014), comorbidities (p-value=0.000), and treatment adherence (p-value=0.000). Conclusion: There is a significant influence between clinical stage, comorbidities, and adherence to the success of ARV treatment. Meanwhile, there is no significant relationship between the duration of ARV treatment and the combination of ARV therapy with the success of treatment. In increasing the success of treatment, people with HIV/AIDS must maintain their health so that opportunistic infections (HIV comorbidities) do not occur and remain in the early clinical stage. Keywords: Antiretroviral (ARV); Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS); People Living with HIV (PLHIV); Threatment. Pendahuluan: Epidemi Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) kini semakin berkembang cepat dan menjadi salah satu tantangan terbesar, meskipun telah dilakukan berbagai upaya untuk mengendalikan serta menekan penularannya. Secara global HIV AIDS merupakan masalah kesehatan yang dapat menyebabkan krisis multidimensi. Program pengendalian HIV/AIDS ditujukan untuk menurunkan angka kesakitan dan rawat inap, angka kematian yang berhubungan dengan AIDS, dan meningkatkan kualitas hidup orang terinfeksi HIV. Tujuan: Untuk mengetahui pengaruh faktor predisposing enabling dan reinforcing terhadap keberhasilan pengobatan ARV pada ODHIV. Metode: Penelitian kuantitatif survei analitik cross sectional yang dilakukan di Puskesmas Kota Bandar Lampung selama 2 bulan pada bulan Januari-Februari 2024. Jumlah sampel pada penelitian ini sebanyak 122 responden yang diambil menggunakan teknik purposive sampling. Instrumen yang digunakan berupa kuesioner yang telah dinyatakan valid pada uji validitas dan reliabilitas. Analisis data yang digunakan univariat dan bivariat uji chi square dengan confidence interval (CI), tingkat kemaknaan p<0.05. Hasil: Beberapa faktor yang memengaruhi keberhasilan antara lain, stadium klinis (p-value=0.014), penyakit penyerta (p-value=0.000), dan kepatuhan pengobatan (p-value=0.000). Simpulan: Terdapat pengaruh yang bermakna antara stadium klinis, penyakit penyerta, dan kepatuhan terhadap keberhasilan pengobatan ARV. Meskipun tidak terdapat hubungan yang bermakna antara lama pengobatan dan paduan terapi ARV dengan keberhasilan pengobatan. Dalam meningkatkan keberhasilan pengobatan ODHIV harus menjaga kesehatan agar tidak terjadi infeksi oportunistik (penyakit penyerta HIV) dan tetap pada stadium klinis awal. Kata Kunci: Antiretroviral (ARV); Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS); Pengobatan.

Integrating The Network Pharmacology and Molecular Docking Confirmed with In Vitro Toxicity to Reveal Potential Mechanism of Non–Polar Fraction of Cyperus rotundus Linn as Anti-Cancer Candidate Susianti Susianti; Syaiful Bahri; Sutopo Hadi; Arif Setiawansyah; Lanang Rachmadi; Ibnu Fadilah; Maya Ganda Ratna
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.228

Cyperus rotundus Linn is a plant that is historically used in traditional medicine with anti-cancer potential. Despite the evidence of C. rotundus anti-cancer effect on various human carcinoma cell lines, its pharmacological mechanism remains unclear, particularly its non-polar fraction. This study was employed to provide mechanistic insight regarding the anti-cancer properties of C. rotundus non-polar fraction by integrating in silico and in vitro approach. The network pharmacology study was used to observe the molecular targets of n-hexane fraction of C. rotundus, confirmed by molecular docking simulation using Autodock 4.2. The in vitro toxicity using BSLT method was used to strengthen the in silico result. The network pharmacology investigation revealed several core targets including PI3K, MAPK1, mTOR, RAF1, and NF-κB in the potential anti-cancer mechanism of C. rotundus. The molecular docking study illustrated that compound 3 (Isopetasol) and compound 9 (alpha-cyperone) as the most promising compound in n-hexane fraction of C. rotundus, with free binding energies consistently less than -7 kcal/mol in all targets. The in vitro BSLT signified the in silico results, highlighting the highest toxicity of fraction 3 exhibited among others. Integrating the network pharmacology and molecular docking simulation along with in vitro toxicity have provided evidence of the anti-cancer potential of n-hexane fraction of C. rotundus. Specific compounds and the molecular targets responsible for its anti-cancer properties have been identified, warranting further investigations.

Co-Authors Agusta Saraswati Ahmad Syah Putra Ajeng Defriyanti Pusparini Andhini, Friska Andrian Rivanda Andriansah, M. Anggi Setiorini Anggraeni Janar Wulan Anisa Nuraisa Jausal Arif Setiawansyah Arini Meronica Atmajaya, Yudhi Ayu Ningsih Bahren Nortajulu Balqis Mezzaluna D'Azzuri Bara Ade Wijaya Suprayitno Bayu Anggileo Pramesona Betta Kurniawan Cana, Arla Erit Siktia Catur Ariwibowo Dedi Hermawan Devi Rahmadiani Diah Septia Liantari, Diah Septia Dian Isti Angraini Dian Isti Angraini Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Ersa, Rakhmigasti Citra Ety Apriliana Exsa Hadibrata Fitri Sofiatin Giok Pemula Hadibrata, Exsa Ibnu Fadilah Indri Windarti Irawan Budi Waskito Irma Liani Jhons Fatriyadi Suwandi Kamalia, Avissa Medina Khairun Nisa Kinanti Rahmadhita Kurniawaty, Evi Lanang Rachmadi M. Yusran Maya Ganda Ratna Mela Liberti Octoriani Simaremare Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Nabila Shafira Ni Putu Sari Widiyani Nisa Karima Nisa Karima Nurhasanah Nurhasanah Pemula, Giok Putu Ristyaning Ayu R Supriyanto Rengganis Wardani, Dyah Wulan Sumekar Reni Zuraida Rinawati Rinawati Rizki Hanriko Roro Rukmi Windi Perdani, Roro Rukmi Sangging, Putu Ristyaning Ayu Siti Raqiya Rasyid Smith Imanuel Saputra Sofyan Musyabiq Wijaya Sri Agustina Suharmanto Suharmanto Sutarto Sutopo Hadi Sutyarso Sutyarso Sutyarso Sutyarso Syaiful Bahri Syazili Mustofa Tasya Hani Fatwa Wido Gamani Yolanda Fratiwi Yudhi Atmajaya Zakiah Zakiah

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