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Winda Sari
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Pertumbuhan dan Perkembangan Ilmu Komunikasi Haykal, Muhammad; Zuhra, Nabila; Effendi, Erwan; Sari, Winda; Nafidza, Selfa; Najmullah, Anwar
Da'watuna: Journal of Communication and Islamic Broadcasting Vol. 4 No. 3 (2024): Da'watuna: Journal of Communication and Islamic Broadcasting (In Press)
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/dawatuna.v4i3.617

Abstract

The aim of this study is to learn how the ancient growth and development of the communication sciences made such a widespread development in the present era. The study employed a library study method by conducting a qualitative study method using a descriptive method. The study gathered data available from journals and books associated with the growth and development of communication sciences. The technique employed in this data collection involves recording and summarizing a number of obvious data sources. Analysis in this data collection suggests that the growth and development of communication sciences go through many processes in the stages of its development. The results of this study suggest that the growth and development of the communications science are constantly changing over the years and is thus growing rapidly and broadly in the present era.
The Evolving Paradigm of Acne Vulgaris Management: A Systematic Review Emphasizing Evidence-Based Combination Therapy, Antimicrobial Stewardship, and Patient-Reported Outcomes Cici Wulandari; Winda Sari; Sherli Wahyuni
The Indonesian Journal of General Medicine Vol. 20 No. 1 (2025): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/9zftvn36

Abstract

Introduction: Acne vulgaris (AV) is a highly prevalent, chronic inflammatory dermatosis that necessitates sophisticated, long-term management strategies to optimize physical clearance, minimize permanent scarring, and address the substantial psychosocial impact on patients.1 This systematic review aimed to critically synthesize recent, high-certainty evidence informing the comparative efficacy, safety, and durability of therapeutic interventions for AV, specifically focusing on the public health imperative of antimicrobial stewardship and the mandatory utilization of patient-reported outcomes (PROs).2 Methods: We conducted a systematic search for randomized controlled trials (RCTs) and systematic reviews published in major databases up to the current date, adhering to the PRISMA 2020 guidelines.4 Inclusion criteria focused on studies addressing treatment efficacy (topical combinations, systemic antibiotics, hormonal therapy, oral retinoids, and physical modalities) for patients aged 9 years and older.3 Methodological quality was assessed using the Cochrane Risk of Bias (RoB 2.0) tool.6 We prioritized the synthesis of ten distinct outcomes, including lesion count reduction (LCR), Investigator Global Assessment (IGA) success, discontinuation rates, specific adverse events (AEs), durability (relapse rates), and changes in the Dermatology Life Quality Index (DLQI).2 Results: Data were synthesized from 17 representative studies or data analyses. Topical combination therapies were significantly superior to monotherapy, with fixed-dose Adapalene 0.3%/Benzoyl Peroxide 2.5% achieving a 68.7% reduction in inflammatory lesions and a 68.3% reduction in non-inflammatory lesions by week 12.7 For systemic management, Spironolactone demonstrated robust objective efficacy in adult women, showing a sixfold increase in the odds of treatment success compared to placebo (Odds Ratio (OR) 6.59; 95% CI 3.50–12.43), a finding validated by Trial Sequential Analysis.6 Conversely, temporal analysis revealed a significant positive correlation (R=0.69) between time and rising C. acnes resistance to Erythromycin, escalating from 10% in 2008 to 44% in 2024, highlighting a critical failure of antimicrobial stewardship.8 Furthermore, a statistically moderate correlation was observed between physician-assessed IGA improvement and patient-reported QoL improvement (DLQI) (r=0.516, P < 0.001), suggesting a significant discrepancy in current success metrics.2 Physical modalities were primarily characterized by a high overall risk of bias due to lack of blinding.9 Discussion: The evidence mandates a paradigm shift toward non-antibiotic systemic interventions and combination therapy as the first-line standard for all disease severities. The demonstrated high certainty of Spironolactone efficacy 6 makes it the preferred systemic agent for adult female AV, mitigating the public health crisis of antimicrobial resistance fueled by historical over-prescription.8 The weak correlation between IGA and DLQI necessitates the routine incorporation of PROs as primary endpoints in future trials to accurately capture therapeutic benefit from the patient's perspective.2 Conclusion: Effective, safe, and durable AV management relies on the early and mandatory use of combinations of topical retinoids and Benzoyl Peroxide, strict limitation of systemic antibiotic duration, and aggressive utilization of non-antibiotic systemic agents. Future clinical research must focus on validating physical modalities through low-bias RCTs and standardizing QoL metrics as core outcome measures.
Co-Authors Abdul Fattah Nasution Abdullah, Hasbi Achmad Daeng GS Aci Murhad Agistia, Nesa Agus Jayadi Agusta, Rini Agustian, Bayu Ahmad Darlis Ahmad Tohir Aini, Azizah Alam Bakti Keloko Alda Alda Alfarezi, M Alief Harahap, Tondini Alif Ringga Persada Alpatiqa, Silviana Lufti, Siti Hizra Amir, Sulaiman Muhammad Andy, Safria Aprilia, Maya Apriliani, Lusia Ar-Rifa'i, Ahmad Aravik, Havis Arfathan Arina Denggan Munthe Arlina Armon Fernando Azra, Abdi Al Azra, Muhammad Haykal Bambang Karnain P Batubara, Fadhilah M. Beauty, Veronica Bunyamin yafid Chiuman, Linda Choiriyah Choiriyah Choiriyah Choirunnisak, Choirunnisak Cici Wulandari Damanik, Agusman Daulay, Sholihatul Hamidah David Kaluge Desi Fitriyani Dina Dinata Dina Rombot Dina Syahfitri Diniayuningrum, Anggie Dodi Irawan Dongoran, Faisal Rahman Dwi Noviani Eddy Syahrial Effendi, Erwan Elfrida Ratnawati Erwina Azizah Hasibuan, Erwina Azizah Faizal, Moh. Fathonah Nur Imamah Febrianty Febrianty Ferdy Firmansyah Fita Delia Gultom Fitra Arsil Fitri Wardani, Erika Fitri, Yunie Amelia Ghina Dhaniyah Salsabil Ginting, Chrismis Novalinda Ginting, Siti Aisha Gultom, Marwan Gusnedi Gusnedi H. Abdul Halim Hafizhoh, Syariah Hariyani, Widya Hasibuan, Ahmad Nasir Hasibuan, Mhd. Amin Haykal, Muhammad Hefriza Putri Henlani, Sopy Amelia Hidayah, Nurul Iman Hijril Ismail, Hijril Humaira Humaira Husada, Hindiana Sava Ifaya, Mus Ikmawati Ikmawati Ilham Ilham Imamah, Fathonah Nur Innek Safitri Irma Sulistia Silaen Irwandi Irwandi Ismail Nasution Iyone E. T. Siagian Jasmawati, Jasmawati Jauhari Syamsiyah Jeffi Mutiara Jeshinta Olivia Fentari Kabbani, Safa Hisham Kadarman, Achmad Kartika, Chandra Kartika Kurniawan Kurniawan Kusaeri, Akhmad Laudy Livianti Machfudloh, Machfudloh Maharani, Andi Deswita Mahmud, Razkiah Makmur, Nandar Manik, Gilang Ramadhan Manik, Kresna Ningsih Marlini Marlini Maryunita, Dinda Maulana, M. Rizki Mohammad Hussien Muhammad Anwar Muhammad Ilham Muhammad Noer Fadlan Muhammad Yunus Lubis Mujahidin Mujahidin Murtiani Murtiani Mutiara Intan Arini Nababan, Irene Ardyani Nafidza, Selfa Nainggolan, Dormariati Najmullah, Anwar Nasrul Syakur Chaniago Nasution, Lina Marlina Sari Nasution, Nurmahari Nasution, Yassir Arafat Ngurah, Yosua nila, arma Nofriyanti Nofriyanti Novita, Vivian Nurhasanah Nurhasanah Nurhastuti, Nurhastuti Nurika Khalila Daulay Nurul Afni Nurul Insi Syahruddin Nutrisia Aquariushinta Sayuti, Nutrisia Aquariushinta Panggabean, Ilham Paralihan, Hotmatua Puspandari, Hendriana Putri Lestari, Putri Putri, Mozha Pramesti Rahma, Indah Lutfianti Rahma, Rizqia I’zza Rahman, Yosi Solidatul Rahmiatul Zuhro Rani Septiawati Ratna Sari Dewi Reni Anggainy Rima Rahmaniah Rina Dewi Ritonga, Alwi Dahlan Rizka Amelia Rizqiana Ayu Safitri Rosa Aprilia Rosmawati, Rhona Rustam Pakpahan Sadam Husein Saefuddin Saefuddin Safira, Yola Safitri Safitri Sahna Ferdinand Ginting Sai, Yong Heng Sandi Sandi Saputra, Angga Aldi Saputri Fatahna Nurjanah Saqina, Azalia Putri Sherli Wahyuni Siahaan, Hasnah Sihombing, Rosdiana Siregar, Imel Agustin Sitanggang, Cokro Malik Siti Nurani Siti Raihanah Siti Romlaini Sitorus, Ghazy Muhammad Syuja Solly Aryza Sugiharto Sugiharto sukmo, ketut puji Sumaiga, Henny Sumarno . SUNARTO Suprianik Suryono Suryono Syaharuddin Syaharuddin Syahruddin, Nurul Insi Syilfia Hasti Tasya Zanuarista Topo Santoso Ulul Azmi Vera Mandailina, Vera Widi, Miranti Yulia Setyarini, Yulia Yunita, Isma Yustina Yustina Yusuf, Moh Deni Kurniawan Yuwanti, Bening Yuzaidi, Yuzaidi Zahra, Anggraini Zhafirah, Rafika Zuhra, Nabila Zul Anwar Zulfarina Zulfarina