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All Journal Jurnal Gizi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian JAM : Jurnal Aplikasi Manajemen Journal of Food and Life Sciences Research Journal of Life Science Plantropica: Journal of Agricultural Science Folia Medica Indonesiana Jurnal Farmasi Klinik Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan MPI (Media Pharmaceutica Indonesiana) Jurnal Sains dan Teknologi Pangan IDEAS: Journal on English Language Teaching and Learning, Linguistics and Literature AL ISHLAH Jurnal Pendidikan Majalah Kesehatan FKUB Medical Laboratory Technology Journal Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JMM (Jurnal Masyarakat Mandiri) Jurnal Teknologi Pangan dan Hasil Pertanian Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JURNAL PENDIDIKAN TAMBUSAI Indonesian Journal of Natural Pigments PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Midwifery and Nursing Research (MANR) Journal of Issues in Midwifery Soedirman Economics Education Journal UTAMAX : Journal of Ultimate Research and Trends in Education Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Food Technology and Halal Science Journal Caring : Jurnal Pengabdian Masyarakat New Language Dimensions Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) BAHTRA: Jurnal Pendidikan Bahasan dan Sastra Maternity and Neonatal : Jurnal Kebidanan Jurnal Kebidanan dan Keperawatan Aisyiyah International Journal of Educational Research Excellence (IJERE) Journal of Artificial Intelligence and Digital Business Jurnal Kedokteran Hewan Jurnal Pendidikan Sosial dan Konseling Science And Education Journal (SNEJ) Scientica: Jurnal Ilmiah Sains dan Teknologi SPIKESNAS Nusantara Journal of Multidisciplinary Science Siber Journal of Transportation and Logistics Buletin Literasi Budaya Sekolah Artikula

Sri Winarsih

Departemen Farmasi Fakultas Kedokteran Universitas Brawijaya

Author-ID : 3033615

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PENGARUH PEMBERIAN AIR REBUSAN BIJI ALPUKAT (Persea americana Mill) TERHADAP PERTUMBUHAN JAMUR Candida albicans SECARA IN VITRO Amir, Nayla Nabilla Tahta Avwina; Winarsih, Sri; Rahardjo, Bambang
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2021.005.02.3

The most common cause of patalogis leucorrhoea is infection, one of which is Vulvovaginal Candidiasis (VVC) caused by fungus, while 80% -90% is caused by Candida albicans. Approximately 90% of young women in Indonesia have the potential to experience vaginal discharge because Indonesia is a tropical climate. Alternative treatment for antifungal drugs is needed through the exploration of natural material sources that have the potential as antifungals to deal with this infection safely and easily. The design used in this study was experimental research by in vitro using the dilution method of the tube. Treatment concentrations are 45%; 40%; 35%; 30%; 25%; 20%, 15% and 0% with Candida albicans 104 CFU / ml samples from the microbiology lab of the medical faculty Brawijaya University and repeated 3 times. The result showed that at all concentrations, growth was still obtained in agar media so that it could be denied that the boiled water of avocado seeds had no effect on the growth of Candida albicans fungal colonies in vitro because there were still fungal colonies on the plates.

UJI AKTIVITAS SEDIAAN GEL DAN EKSTRAK LENGKUAS (Alpinia galanga) TERHADAP BAKTERI STAPHYLOCOCCUS EPIDERMIDIS SECARA IN VITRO Prihannensia, Maydia; Winarsih, Sri; Achmad, Anisyah
Pharmaceutical Journal of Indonesia Vol 4, No 1 (2018)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Staphylococccus epidermidis dapat menyebabkan berbagai infeksi kulit pada manusia. Terapi yang sering digunakan adalah antibiotik, salah satunya amoksiklav. Antibiotik terkadang menimbulkan efek samping dan resistensi pada beberapa pasien, sehingga diperlukan terapi alternatif bahan alam yakni rimpang lengkuas (Alpinia galanga) yang mengandung flavonoid dan memiliki aktivitas sebagai antibakteri. Untuk menghantarkan senyawa yang terdapat dalam rimpang lengkuas dan mempermudah penggunaan, maka dibentuk sediaan gel. Metode ekstraksi yang digunakan adalah maserasi menggunakan etanol 70%, dan uji antibakteri dengan metode difusi sumuran. Pada uji Kromatografi Lapis Tipis (KLT), ekstrak lengkuas positif mengandung flavonoid. Gel lengkuas dan ekstrak lengkuas dibuat 3 kelompok konsentrasi yaitu 10%, 15% dan 20%. Parameter yang diamati adalah diameter zona hambat gel dan ekstrak lengkuas setelah diinkubasi selama 18-24 jam pada suhu 37oC. Hasil zona hambat menunjukkan semakin tinggi konsentrasi pada gel dan ekstrak lengkuas, maka semakin besar diameter zona hambat bakterinya. (Korelasi Pearson gel lengkuas R=0,958 dan ekstrak lengkuas R=0,979). Hasil uji t-tidak berpasangan menunjukkan tidak terdapat perbedaan siginifikan antara gel dan esktrak lengkuas (p=0,408). Kesimpulan penelitian adalah terdapat hubungan positif antara peningkatan konsentrasi gel dan ekstrak lengkuas dengan peningkatan diameter zona hambat terhadap bakteri S. epidermidis secara in vitroKata kunci: Lengkuas (Alpinia galanga), Staphylococcus epidermidis, Gel, Ekstrak, Â Antibakteri.

PENGARUH WAKTU OKSIDASI ENZIMATIS DAN SUHU PENGERINGAN TERHADAP KUALITAS FISIK DAN ORGANOLEPTIK TEH HITAM-ORTHODOX [The Effect of Enzyme Oxidation Time and Drying Temperature on Physical Quality and Organoleptic of Black Tea-Orthodox] winarsih, sri; Hamida, Maretha; Saati, Elfi Anis; Daely, Brian Fo’era-era
Jurnal Sains dan Teknologi Pangan Vol 7, No 1 (2022): Jurnal Sains dan Teknologi Pangan
Publisher : JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO

The process of enzymatic oxidation and drying was one of the stages of tea processing that distinguished black tea from other types. Both treatments were determinants of the quality of black tea powder. The purpose of this study was to determine the effect of enzymatic oxidation time and drying temperature on the moisture content, yield, and organoleptic of orthodox black tea according to SNI. The method used in the preparation of the research is experimental with quantitative descriptive data discussion. The object of research is tea obtained from PT. Perkebunan Nusantara VIII, Rancabali. Parameters observed were moisture content analysis, yield analysis, and organoleptic analysis (appearance, liquor, and infused leaf). The results obtained were the combination of oxidation time and drying temperature gave different effects on the moisture content, yield, and organoleptic of orthodox black tea. The best treatment for black-orthodox tea is a combination of oxidation time of 120 minutes and drying temperature of 120˚C with moisture content (2,23%), yield (25,5%), and organoleptic; appearance (24), liquor (26), infused leaf (4). Therefore, these research was important to do because there was no research that examines the effect of oxidation time and drying temperature on the moisture content, yield, and organoleptic of orthodox black tea. Proses oksidasi enzimatis dan pengeringan menjadi salah satu tahap pengolahan teh yang membedakan teh hitam dengan jenis lainnya. Kedua perlakuan tersebut merupakan penentu kualitas bubuk teh hitam. Tujuan dari penelitian ini adalah mengetahui pengaruh waktu oksidasi enzimatis dan suhu pengeringan terhadap kualitas fisik dan organoleptik teh hitam orthodox sesuai SNI. Metode yang digunakan dalam penyusunan penelitian yaitu secara eksperimental dengan pembahasan data secara deskriptif kuantitatif. Objek penelitian berupa teh yang diperoleh dari PT. Perkebunan Nusantara VIII, Rancabali. Parameter yang diamati diantaranya, analisis kadar air, analisis rendemen, dan analisis organoleptik (appearance, liquor, dan infused leaf). Hasil yang didapatkan adalah perlakuan kombinasi waktu oksidasi dan suhu pengeringan memberikan pengaruh yang berbeda terhadap kualitas fisik dan organoleptik teh hitam-orthodox. Perlakuan terbaik teh hitam-orthodox yaitu, perlakuan kombinasi waktu oksidasi 120 menit dan suhu pengeringan 120˚C dengan kadar air (2,23%), rendemen (25,5%), dan organoleptik; appearance (24), liquor (26), infused leaf (4). Oleh karena itu penelitian ini penting untuk dilakukan karena belum terdapat penelitian yang mengkaji pengaruh waktu oksidasi dan suhu pengeringan terhadap kualitas fisik dan organoleptik teh hitam orthodox.

Invivo Effect Analysis of Rhodomyrtus tomentosa Leaf Ethanol Extract Against Escherichia coli Doris Noviani; Adisty Dwi Treasa; Ade Zakiya Tasman Munaf; Sri Winarsih; Dwi Yuni Nur Hidayati; Mukhamad Nooryanto; Sutrisno Sutrisno
Medical Laboratory Technology Journal Vol. 7 No. 1 (2021): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Puerperium infection contributed 11 percent of 48.17 percent of maternal mortality during the puerperium period; one of the causes of increased risk of puerperium infection was bacteria Gram-negative Escherichia coli. Puerperium infection occurred because bacteria enter through the vagina, wounds on the insertion of the placenta, and other parts spread to blood throughout the body and damage the spleen, liver, and uterus. This research aimed to determine the effect of Rhodomyrtus tomentosa leaves ethanol extract (Rtl-EE) as an antibacterial on the spleen, liver, and uterus of Escherichia coli -induced puerperal infection model mice. Mice in the postnatal treatment group were induced by Escherichia coli bacteria intravaginally and given different doses of ethanol extract of Rhodomyrtus tomentosa leaves. Examination of bacterial colonies growth used pour plate method with EMBA media. The research results showed that the administration of Rtl-EE decreased the growth of bacterial colonies respectively in the liver 1280, 924, 330 CFU/mL; the uterus 1806, 1180, 874 CFU/mL; and the spleen 712, 112, 774 CFU/mL. Colony growth started to decrease at dose 1 of Rtl-EE (100mg/kg BW) of mice model of Escherichia coli -induced puerperal infection. Rhodomyrtus tomentosa leaves contain active compounds - phenols, flavonoids, saponins, tannins, alkaloids, and triterpenoids as antibacterial. Rtl-EE had an antibacterial effect by reducing the number of bacteria on the spleen, liver, and uterus of Escherichia coli -induced puerperal infection model mice. Further research needs to conduct to examine the toxic dose of Rhodomyrtus tomentosa leaves against Escherichia coli bacteria.

Green Tea Extract Increases the Number of Granulosa Cells and E2 Serum Levels of Female Rats Exposed by Cypermethrin Fitria Jannatul Laili; Sri Winarsih; Karyono Mintaroem
Health Notions Vol 2, No 6 (2018): June
Publisher : Humanistic Network for Science and Technology (HNST)

1(CA), 2, 3 1(CA), Indonesia; (Corresponding Author) 2, Indonesia 4, Indonesia ABSTRACT Green tea extract (GTE), Camellia sinensis, known as a very effective antioxidant to repair the damage of organs exposed by stress oxidative. Cypermethrin (CYP) is a harmful substance that can accumulate in the body and cause oxidative stress. This study aimed to demonstrate the effect of GTE in increasing the number of granulosa cells and E2 serum levels. Female rats (Rattus norvegicus) were randomly selected and divided into 5 groups, control group (KN), a group given only CYP 20 mg/kg body weight/day (KP), groups given CYP 20 mg/kg body weight/day and then treated with GTE 7, 14, 28 mg/kg body weight/day (P1, P2, and P3 respectively). Treatment was given for 28 days. The number of granulosa cells was counted by HSel software, E2 serum levels were determined via ELISA ASSAY. Treatment results with GTE 7, 14, and 28 mg/kg body weight/day significantly (p < 0.05) increased the number of granulosa cells and E2 serum levels relative to KN. Administration of GTE 28 mg/kg body weight/day caused the greatest increase in the number of granulosa cells and E2 serum levels. Our result suggests that GTE has potential prevention to stress oxidative by CYP exposure in granulosa cells and E2 serum. Keywords: Cypermethrin, E2, Granulosa Cells, Green tea

Ekstrak Etanol Teh Hijau (Camellia sinensis) Meningkatkan Kadar Folicle Stimulating Hormone (FSH) dan Jumlah Folikel Antral pada Tikus Betina yang Dipapar Sipermetrin Melati Puspita Sari; Sri Winarsih; Tri Yudani Mardining Raras; Karyono Mintaroem
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v2i2.1559

Latar Belakang: Sipermetrin adalah insektisida jenis piretroid sintetik yang dapat menganggu sistem reproduksi. Sipermetrin juga mampu menghasilkan reactive oxygene species (ROS) sehingga bertanggung jawab menimbulkan terjadinya stres oksidatif. Teh hijau (Camellia sinensis) mengandung polifenol sehingga dapat menghambat radikal hidroksil dan enzim prooksidan. Tujuan: Penelitian ini bertujuan untuk membuktikan pemberian ekstrak etanol teh hijau dapat meningkatkan kadar FSH dan jumlah folikel antral pada tikus betina yang dipapar sipermetrin. Metode: Penelitian yaitu true experimental pada 25 ekor tikus betina galur wistar (Rattus norvegicus) yang dibagi menjadi 5 kelompok; KN: tanpa perlakuan, KP: sipermetrin 20 mg/kgBB/hari, P1: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 7 mg/kgBB/hari, P2: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 14 mg/kgBB/hari, P3: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 28 mg/kgBB/hari per oral selama 28 hari. Kadar FSH diukur dengan metode ELISA dan organ ovarium diambil untuk pemeriksaan jumlah folikel antral dengan metode pewarnaan hematoxylin eosin. Hasil: Kadar FSH dan jumlah folikel antral pada tikus betina menunjukkan hubungan yang positif dan kuat dengan nilai koefisien korelasi 0,742 yang berarti peningkatan kadar FSH diikuti penambahan jumlah folikel antral. Ada perbedaan bermakna pada kadar FSH (p=0,005) dan jumlah folikel antral (p=0,001) antara kelompok kontrol dengan kelompok perlakuan. Kesimpulan: Pemberian ekstrak etanol teh hijau dapat meningkatkan kadar FSH dan jumlah folikel antral pada tikus betina yang dipapar sipermetrin.

Pengaruh Lama Penggunaan Kombinasi ARV (TDF+3TC+EFV) terhadap Jumlah Sel CD4+ Pasien HIV/AIDS Ema P. Yunita; Sri Winarsih; Nisa R. Deasury
Indonesian Journal of Clinical Pharmacy Vol 9, No 3 (2020)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2020.9.3.219

Human Immunodeficiency Virus (HIV) merupakan penyakit yang menyerang sistem imun manusia yaitu sel CD4+ dan dapat berkembang menjadi Acquired Immune Deficiency Syndrome (AIDS) sebagai lanjutan dari penyakit HIV. Prevalensi terjadinya HIV/AIDS di Tulungagung adalah yang terbanyak di Jawa Timur. Data di RSUD Dr. Iskak Tulungagung sampai tahun 2018 menunjukkan jumlah pasien HIV/AIDS sebanyak 2.082 orang dan yang menjalani pengobatan sebanyak 588 orang. Penelitian dilakukan untuk mengetahui pengaruh lama penggunaan kombinasi obat ARV (TDF+3TC+EFV) selama 6–42 bulan terhadap jumlah sel CD4+. Pengambilan data penelitian dilakukan di unit rekam medis RSUD Dr. Iskak Tulungagung pada bulan Agustus–Oktober 2019. Metode yang digunakan pada penelitian ini adalah observasional potong lintang dengan pengambilan data secara retrospektif. Subjek yang memenuhi kriteria inklusi sebanyak 86 pasien HIV/AIDS. Hasil penelitian dengan uji korelasi Pearson menunjukkan bahwa semakin lama pengobatan kombinasi ARV maka jumlah sel CD4+ juga semakin meningkat (p<0,001; r= +0,394). Berdasarkan uji one-way ANOVA, diketahui bahwa peningkatan CD4+ yang signifikan mulai terlihat dengan pengobatan kombinasi ARV minimal selama 18 bulan (p<0,001).Kata kunci: Antiretroviral, CD4+, HIV/AIDS, Tenofovir+Lamivudin+Efavirenz (TDF+3TC+EFV) The Long-term Effect of Using ARV Combinations (TDF+3TC+EFV) on CD4+ Cell Counts of HIV/AIDS Patients AbstractHuman immunodeficiency virus (HIV) is known to attack the human immune system, i.e., CD4 + cells and develops into Acquired Immune Deficiency Syndrome (AIDS) as a continuation of the disease. Furthermore, the prevalence of HIV/AIDS in Tulungagung is recorded as the highest in East Java. The data collected from Dr. Iskak Tulungagung Hospital until 2018, showed that there were 2,082 patients suffering from this disease while 588 of them received treatment. Therefore, this study aims to determine the effect and the use duration of ARV medicines (TDF+3TC+EFV) for 6–42 months on the CD4+ cell counts. The research data was collected from the medical record unit at Dr. Iskak Tulungagung Hospital from August–October 2019. The method used was a cross sectional design and observation retrospective technique. Moreover, 86 HIV/AIDS patients met the inclusion criteria. The results of Pearson correlation test showed that the longer the ARV treatment, the higher the number of CD4+ cells (p<0.001; r= +0.394). From one-way ANOVA test, a significant increase in CD4+ cell was also observed with ARV treatment for at least 18 months (p<0.001).Keywords: Antiretroviral, CD4+, HIV/AIDS, Tenofovir+Lamivudine+Efavirenz (TDF+3TC+EFV)

Lama Waktu Tunggu Konsumsi Menurunkan Kandungan Vitamin C Pada Jus Campuran Pepino-Belimbing Ayangsari Cahyaningrum; Sri Winarsih; Yudi Arimba Wani
Jurnal Gizi Vol 6, No 1 (2017): Jurnal Gizi UNIMUS
Publisher : Universitas Muhammadiyah Semarang

Pepino is a fruit that has been widely cultivated in Indonesia. Pepino contains high antioxidants that one of them is vitamin C. Vitamin C can improve endothelial vasodilation and has antihypertensive effect. To improve the taste of pepino need to be mixed with starfruit. Starfruit has been selected because it proved capability of lowering blood pressure. This study aims to determine differences in the content of vitamin C in the juice mixture of pepino and starfruit on juicing and blending processing methods, as well asdifferences in the content of vitamin C in a holding time of 5, 20, 35, 50, and 65 minutes in each of the processing method. This study was an experimental study with completely randomized factorial design. The mixed juice of pepino and starfruit used in this study was pepino (70%):starfruit (30%). Level of treatment used were juicing and blending. Analysis vitamin C using iodometric titration method. The results showed vitamin C (mg/L) in a mixture of pepino and starfruit juice with juicing processing methods on the holding time 5, 20, 35, 50, and 65 minutes respectivelywere 911.7; 863.73; 840.9; 813.6; and 791.5. While, in the processing method of blendingwere 864.1; 528.7; 478; 421.23; and 387.97. The conclusion of this study was no significant difference between the vitamin C content processing method of juicing by blending the holding time of 5 to 65 minutes. As well as a decrease in vitamin C on the processing method of juicing and blending began holding time of 5 to 65 minutes. However, it was not significant in the juicing method (3.45% every 15 minutes) and significant at the blending method (13.03% every 15 minutes). Keywords : vitamin C, pepino, starfruit, juicing, blending, holding time

Deteksi Protein 270 kDa Plasmodium falciparum Isolat Malang pada Membran Eritrosit Penderita Malaria dengan Komplikasi Dewi Indiastari; Sri Winarsih; Loeki Enggar Fitri
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7785

Erythrocyte which is infected by Plasmodium falciparum will have various changes on its architecture, affinity, and biomolecular. Beside that, the infected erythrocyte also forms a knob at its surface. This knob are contained with various parasite proteins, one of them is Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1). Our previous study had been identified a protein with molecular weight 270 kDa at P. falciparum infected erythrocyte from Malang isolate that was playing a role in cytoadherence process. The aim of this study was to detect the possibility of 270 kDa protein expression at complicated malaria falciparum patient erythrocyte membrane. The method that used was immunocytochemistry with polyclonal antibody to 270 kDa protein. The results showed that two (2) erythrocyte samples from healthy people as control had negative reaction, and so did with five (5) erythrocyte samples of uncomplicated malaria patient, but there was positive reaction that shown at two (2) samples of complicated malaria patient erythrocyte. It can be concluded from the results that 270 kDa membrane protein of P. falciparum infected erythrocyte in complicated malaria patient might be a PfEMP-1. This protein can be detected by immunocytochemistry method using polyclonal antibody and can be used for the candidate of complicated malaria diagnostic Keywords: Plasmodium falciparum, 270 kDA protein, immunocytochemistry, polyclonal antibody

Efek Antibakteri Ekstrak Daun Katuk (Sauropus androgynus) terhadap Pertumbuhan Salmonella Typhi secara In Vitro Sri Winarsih; Danik Agustin Purwantiningrum; Anastasia Shinta Wardhani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2015): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v15i2.3755

Daun Katuk biasa digunakan sebagai obat tradisional terhadap berbagai macam penyakit termasuk mengobati diare. Kandungan daun Katuk yang diperkirakan berperan sebagai antibakteri adalah saponin, flavonoid dan tannin. Penelitian ini bertujuan untuk mengetahui efek antibakteri dari ekstrak daun Katuk secara in vitro. Metode yang digunakan adalah dilusi tabung yang terdiri dari dua tahap yaitu tahap penentuan Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM). Konsentrasi ekstrak daun Katuk yang digunakan adalah 10%, 15%, 20%, 25% dan 30%, sedangkan konsentrasi S. typhi adalah 106 CFU/ml. Hasil menunjukkan bahwa KHM ekstrak daun Katuk terhadap S. typhi sebesar 25% dan KBM nya sebesar 30%. Uji Anova menunjukkan bahwa ekstrak daun Katuk secara signifikan menghambat pertumbuhan S. typhi (p = 0.000). Uji korelasi menggunakan regresi menunjukkan terdapat korelasi negatif antara konsentrasi ekstrak daun Katuk dengan jumlah koloni S. typhi (p = 0,000; r = - 0,800). Dapat disimpulkan bahwa ekstrak daun Katuk memiliki efek antibakteri terhadap S. Typhi. Semakin tinggi kosentrasi ekstrak daun Katuk, semakin rendah jumlah koloni.Katuk (Sauropus androgynus) leaves is used as a traditional medicine against various diseases include diarrhea. The estimated antibacterial substances of Katuk leaves are saponin, flavonoid and tannin. The aim of this research is to know antibacterial effect of Katuk leaves extract against Salmonella typhi in vitro. Antibacterial effect is determined by tube dilution method, which consists of two steps, namely the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericide Concentration (MBC). The concentrations of Katuk Leaves extracts are 10%, 15%, 20%, 25%, and 30%. The concentration of S. typhi is 106 CFU/ml. The result shows that MIC and MBC of the Katuk leaves extract are 25% and 30% respectively. Anova test shows that Katuk leaves extract significantly inhibits the growth of S. typhi (p = 0,000). Correlation test by using regression shows that there is a negative correlation between the Katuk leaves extract concentration and the amount of S. typhi colony (p= 0,000; r = - 0,800). The conclusion is that Katuk leaves has antibacterial effect against S. typhi. The higher concentration of Katuk leaf extract, the lower the number of colonies

Co-Authors Abd. Haris Abd. Rasyid Syamsuri Ade Zakiya Tasman Munaf Adisty Dwi Treasa Ahmad Alim Bachri Aisha Rifda Palastri Ajeng Budi Purwati Ajeng Maharani Putri Akbariyanto, Fahrizal Akhid Yulianto Alfatah, Abu Hasan Alfian Wika Cahyono Alluza, Hamid Hunaif Dhofi Almira, Rehan Amelia, Putri Nurhidayati Amir, Nayla Nabilla Tahta Avwina Anastasia Shinta Wardhani Anggawirya, Arin Mantara Anggita Maharani Anisyah Achmad ANISYAH ACHMAD Ardaleni Frista Ariel, Dio Giovanni Arif Widagdo Arsy Arundina Aulanni'am, Aulanni'am Aulia, Aida Salsabila Ayangsari Cahyaningrum Ayuk Lawuningtyas Hariadini Azzahra, Ika Prima Bambang Rahardjo Burhan, M. Cahyaningtyas, Tita Dwi Cahyono, Alfian Wika Caska - Celsy Citra Septiana Daely, Brian Fo’era-era Danik Agustin Purwantiningrum, Danik Agustin Derisna, Anak Agung Dewi Indiastari Dhany Efita Sari Dio Giovanni Ariel Doris Noviani Dwi Yuni Nur Hidayati Elfi Anis Saati Ema Dianita Mayasari Ema P. Yunita Ema Pristi Yunita Ema Pristi Yunita, Ema Pristi Erwan, Nabila Erina Eviana Norahmawati Eviana Norahmawati Febriani, Amelia Dwi Fitria Febriliani Putri Fitria Jannatul Laili Florensy Sauhenda, Angla Frenty Hadiningsih, Eka Hamid Hunaif Dhofi Alluza Hamida, Maretha Hanif Alamudin Manshur Hariyani, Tintin Hastuti, Nur Aini Retno Heidir, Hilwa Huwae, Thomas Erwin C.J I Nengah Kundera Iin Tri Marlinawati Ika Ratnaningrum Insania, Chika Kalsumy, Umi Kana Mardhiyyah Kartika, Bintang Karyono Mintaroem Kesuma, Suryanata Kinasih, Anggraini Lenggana, Rinaldi Lia Sawitri Loeki Enggar Fitri Louise Panggabean, Helena Maemunah Majid, Muhammad Abdul Mardhiyyah, Kana Marni Bawawa Marnina Marnina Maulota, Sally Inggrid Mayasari, Ema Dianita Melati Puspita Sari Muchammad Subali Noto Mukhamad Nooryanto Munayarokh Munayarokh, Munayarokh Murdiono, Jatmiko Murtiningsih Murtiningsih Nabila Erina Erwan Nabilah, Aviana Zuhrotun Narahawarin, Margaretha F Narahawarin, Margaretha F. Nashi Widodo Nikmawati, Nuril Nisa R. Deasury Noorhamdani Novanda, Shabilla Caesar Nugraha, Rivo Yudhinata Brian Nur komalasari Nuraida Fara Rahmani Nurhakim Nurhakim Nurul Istiqomah Oktavia Rahayu Adianingsih Pande Made Dwijayasa Prawiro, Sumarno Reto Prihannensia, Maydia Purwantiningrum, Danik Agustin Putri Ardela, Mayasari Putri, Ajeng Maharani Putri, Fitria Febriliani Rahman, Chientya Annisa Ratnasari, Aprilya Seruni Retty Ratnawati Ribkha Itha Idhayanti Rinaldi Lenggana Riny Natalina Ririn Handayani Rista, Nadia Rivo Yudhinata Brian Nugraha Rosalia Sanarto Santoso Sani, Indra Santoso, Putu Adi Saputra, Hendriek Farhan Saputra, Ridwan Cahya Saputra, Wahyu Joko Sarnita Setyono Yudo Tyasmoro Shafira, Hanna Sijabat, Survey Siti Candra Windu Baktiyani Siti Candra Windu Baktiyani Siti Chunaeni Siti Nurhidayah Sri Andarini Sri Poeranto, Sri Sri Sukasih, Sri Sulistiyani Sulistiyani Sultanah Zahariah Sumarno Reto Prawiro SURYANTI Susanto Nugroho Susanto Nugroho Sutrisno Sutrisno Tamara Gusti Ebtavanny Tatit Nurseta Tatit Nurseta Tatit Nurseta Tatong Harijanto, Tatong Thomas Erwin Christian Junus Huwae Tita Hariyanti Tri Ardyati Tri Yudani Mardining Raras Triana, Salma Ayuning VALENTINA YURINA Wachid, Moch. Wahyuniar Wardhani, Anastasia Shinta Wibowo, Fiska Almayda Widayanti, Isyania Widya, Reta Anggraeni Wiyasa, I Wayan Arsana Yogi Sugito Yohanes Kristantyo Yudhistira Ardana, Yudhistira Yudi Arimba Wani Yulistiani Yulistiani, Yulistiani Zahariah, Sultanah

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