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All Journal Jurnal Penelitian Saintek Pharmaciana: Jurnal Kefarmasian Analisis: Jurnal Studi Keislaman Jurnal Pranata Hukum Jurnal Pekommas FIAT JUSTISIA: Jurnal Ilmu Hukum MONOGRAF KOMUNIKE: Jurnal Komunikasi Penyiaran Islam Jurnal Ijtimaiyya WARTA Pharmacon Jurnal Al-Ijtimaiyyah Sosio Konsepsia Proceeding SENDI_U INDONESIAN JOURNAL OF PHARMACY EMPATI : JURNAL ILMU KESEJAHTERAAN SOSIAL Jurnal Pemberdayaan Masyarakat: Media Pemikiran dan Dakwah Pembangunan SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Community Services and Engagement Journal of Nutraceuticals and Herbal Medicine Jurnal Penelitian Sains Teknologi Nurse and Health: Jurnal Keperawatan Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Dakwah Journal of Tropical Marine Science Babul Ilmi Jurnal Ilmiah Multi Science Kesehatan Edification Journal : Pendidikan Agama Islam Journal of Environmental Science and Sustainable Development Masyarakat Berdaya dan Inovasi Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Journal of Global Health research Jurnal At-Taghyir : Jurnal Dakwah dan Pengembangan Masyarakat Desa Medfarm: Jurnal Farmasi dan Kesehatan International Journal of Environmental, Sustainability, and Social Science Yumary: Jurnal Pengabdian kepada Masyarakat Jurnal Pendidikan Bahasa Inggris Proficiency Progress in Social Development Jurnal Rekayasa, Teknologi, dan Sains Jurnal Ekonomi Jurnal Kommunity Online Abdi Psikonomi Jurnal Konstitusi El-Izdiwaj: Indonesian Journal of Civil and Islamic Family Law DEVELOPMENT : Journal of Community Engagement AKADEMIK: Jurnal Mahasiswa Humanis Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Kampus Mengajar Jurnal Farmasi Sains dan Praktis VIVA THEMIS- Jurnal Ilmu Hukum dan Humaniora JUSTICIA SAINS: Jurnal Ilmu Hukum Prosiding University Research Colloquium Abdi Teknoyasa Kajian Ilmiah Hukum dan Kenegaraan Al Itimad: Jurnal Dakwah dan Pengembangan Masyarakat Islam Jurnal Kesehatan Usadha Journal of Pharmacy Engagement: Jurnal Pengabdian Kepada Masyarakat jle Borneo Journal of Pharmacy Epistemé: Jurnal Pengembangan Ilmu Keislaman Journal of Community Services and Engagement: Voice of Community (VOC) Medical Sains : Jurnal Ilmiah Kefarmasian Arsy Al-I'timad: Jurnal Dakwah dan Pengembangan Masyarakat Islam Altifani Journal: International Journal of Community Engagement
Muhtadi Muhtadi
Universitas Muhammadiyah Surakarta
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Optimalisasi Potensi Lokal melalui Pelatihan Pengolahan Ikan Lele menjadi Abon bagi KWT untuk Meningkatkan Kemandirian Ekonomi Perempuan Desa Bogangin, Kacamatan Sumpiuh, Kabupaten Banyumas Qomar, Umi Laelatul; Rahmatullah, Wahyu; Pratama, Wilson Candra Teguh; Sujono, Tanti Azizah; Muhtadi, Muhtadi; Putro, Sartono; Rahmadhani, Wulan; Dewi, Adinda Putri Sari
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 12 (2025): Volume 8 No 12 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i12.23253

Abstract

ABSTRAK Pemanfaatan potensi lokal menjadi salah satu upaya strategis dalam meningkatkan kemandirian ekonomi masyarakat pedesaan. Desa Bogangin, Kecamatan Sumpiuh, memiliki potensi besar di sektor perikanan air tawar, khususnya budidaya ikan lele. Namun, keterbatasan pengetahuan dan keterampilan masyarakat, terutama kelompok wanita tani (KWT), dalam mengolah hasil perikanan menjadi produk bernilai ekonomi tinggi masih menjadi kendala. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kemampuan anggota KWT dalam mengolah ikan lele menjadi abon sebagai produk olahan yang memiliki daya jual tinggi dan daya simpan panjang. Metode kegiatan meliputi penyuluhan, pelatihan praktis pembuatan abon lele, pendampingan manajemen usaha, dan strategi pemasaran digital. Hasil kegiatan menunjukkan peningkatan pengetahuan dan keterampilan peserta sebesar 85%, serta munculnya inisiatif KWT untuk membentuk usaha bersama dalam skala rumah tangga. Kegiatan ini berkontribusi nyata terhadap pemberdayaan ekonomi perempuan dan penguatan potensi lokal berbasis sumber daya desa. Kata Kunci: KWT, Abon Lele, Pemberdayaan Perempuan, Potensi Lokal, Ekonomi Desa.  ABSTRACT Utilizing local potential is one of the strategic efforts to enhance the economic independence of rural communities. Bogangin Village, located in Sumpiuh Subdistrict, has great potential in the freshwater fisheries sector, particularly in catfish farming. However, the limited knowledge and skills of the community—especially the Women Farmers Group (KWT)—in processing fishery products into high-value economic commodities remain a challenge. This community service activity aims to improve the ability of KWT members to process catfish into shredded fish (abon) as a value-added product with high market potential and long shelf life. The methods used include counseling, hands-on training in making shredded catfish, business management assistance, and digital marketing strategies.The results show an 85% increase in participants’ knowledge and skills, as well as the emergence of an initiative from the KWT to establish a joint household-scale business. This activity has made a tangible contribution to women’s economic empowerment and the strengthening of local potential based on village resources. Keywords: Women Farmers Group (KWT), Shredded Catfish, Women’s Empowerment, Local Potential, Village Economy.
THE CRAB SILVOFISHERY SYSTEM AS A CONSERVATION STRATEGY IN MANGROVE RESTORATION AREA: A CASE STUDY ON THE COAST OF BANYUASIN, SOUTH SUMATRA Apriyanto, Apriyanto; Suwignyo, Rujito Agus; Ulqodry, Tengku Zia; Sarno, Sarno; Aryawati, Riris; Muhtadi, Muhtadi; Purnomo, Herry; Okarda, Beni
Journal of Environmental Science and Sustainable Development Vol. 8, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Anthropogenic activities such as logging and converting mangrove forests into plantations have degraded coastal ecosystems and reduced their ecological stability. Silvofishery is a restoration system that balances the ecological and economic functions of mangroves. In Marga Sungsang Village, South Sumatra, mangrove restoration was integrated with mud crab (Scylla spp.) cultivation through a crab silvofishery system. This study aimed to analyze the contribution of mangrove restoration with a mud crab silvofishery system to mud crab growth. The study was conducted from August 2024 to January 2025. Growth parameters included carapace length, width, and body weight. Analyses covered absolute growth and the correlation between carapace width and body weight. Results showed that in non-mangrove ponds, Scylla tranquebarica males exhibited negative allometry (prominent carapace width), while females showed positive allometry (prominent body weight). Scylla paramamosain showed negative allometry in both sexes. In contrast, in mangrove ponds, both species showed positive allometry for both sexes, indicating higher weight gain. These findings suggest that mangrove vegetation provides optimal habitat conditions by increasing nutrient availability, protecting crabs during molting, and improving substrate quality. The results not only demonstrate the bioecological relationship between mangrove vegetation and mangrove crab growth but also highlight the role of crab silvofishery systems in supporting food security, mitigating climate change, and conserving coastal ecosystems. These results align with the Sustainable Development Goals (SDGs), specifically goal 2 (end hunger, achieve food security and improved nutrition, and promote sustainable agriculture), goal 13 (climate action), and goal 14 (life below water). Although informative, this study was limited by temporal observations conducted only at the start of seed stocking and at harvest. Further research with continuous monitoring and environmental parameter analysis is needed. The findings can support mangrove restoration policies that integrate vegetation recovery with sustainable community-based aquaculture and promote blue economy development.
Konflik Kepentingan Dalam Putusan Mahkamah Konstitusi Nomor 90/PUU-XXI/2023: Adopsi Ketentuan Judicial Disqualification Negara Amerika dan Kanada Komarra, M. Akbar Arri; Ridlwan, Zulkarnain; Muhtadi, Muhtadi
JUSTICIA SAINS - Jurnal Ilmu Hukum Vol 10, No 2 (2025): JUSTICIA SAINS: Jurnal Ilmu Hukum
Publisher : Universitas Sang Bumi Ruwa Jurai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24967/jcs.v10i2.4433

Abstract

Decision Number 90/PUU-XXI/2023 is very problematic how the Constitutional Court Judges in their authority actually handle cases that should be returned by the lawmaking body (open legal policy) and have made new norms. The inconsistency of interpretation into the realm of open legal policy and the doctrine of the Constitutional Court as a negative legislator is also evident in Constitutional Court Decision Number 29-51-55/PUU/XXI/2023, which needs to be analyzed from the independence and impartiality of the judiciary. This research method refers to normative research conducted by conducting a study of the principles and applicable laws and regulations relating to the legal issues to be discussed. The research was accompanied by literature studies in the form of books, journals, and decisions as reference materials for research. Data analysis uses descriptive analytics to describe legal phenomena that occur in society through analysis obtained through deductive data to be concluded specifically. The results showed that the conflict of interest that accompanied the Constitutional Court Decision Number 90/PUU-XXI/2023 reduced the quality of the Constitutional Court's independence and the impartiality of its judges. The legal events that the author found in such a way contradict the initial spirit of the establishment of the Constitutional Court. The independence of the Constitutional Court institutionally is considered to have exceeded the limits of authority by handling the case of the age limit of the presidential and vice presidential candidates, which should be owned by the lawmaking body, as well as the inconsistency of previous decisions that create new norms without any clear disadvantages. Conflict of interest was also present in the judicial process, where the composition of the judges changed instantly when Anwar Usman attended the RPH, which was originally the majority of judges refused to partially grant.
Tindak Pidana Pemalsuan Ijazah Dalam Perspektif Kuhp Dan Undang-Undang Sistem Pendidikan Nasional Sari, Linda; Siswanto, Heni; Muhtadi, Muhtadi; Fardiansyah, Ahmad Irzal; Rosidah, Nikmah; Firmansyah, Ade Arif
JUSTICIA SAINS - Jurnal Ilmu Hukum Vol 10, No 2 (2025): JUSTICIA SAINS: Jurnal Ilmu Hukum
Publisher : Universitas Sang Bumi Ruwa Jurai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24967/jcs.v10i2.4240

Abstract

Forgery of diplomas is a criminal offense that not only damages the integrity of the education system, but also threatens public trust in educational institutions and government. Although diploma forgery has been regulated, the practice of forgery still occurs frequently due to the lack of synchronization between the two regulations. This research aims to analyze the relevance and synchronization between the Criminal Code and the National Education System Law in handling the criminal act of diploma forgery so as to provide a comprehensive understanding of more effective law enforcement. The method used is normative- juridical research with statute approach and conceptual approach. Data is sourced from primary legal materials in the form of provisions in the Criminal Code and the National Education System Law, as well as secondary legal materials such as journals, legal literature, and related court decisions, namely district court decision Number 43/Pid.B/2021/Pn. Liw and the analysis is done descriptively-qualitatively. The results show that the regulation of diploma forgery in the Criminal Code is still general in nature through Article 263 on forgery of letters, while the National Education System Law only emphasizes administrative aspects without clear regulation of criminal sanctions. This has led to dualism in the application of the law and the potential for a legal vacuum in practice
Role of BAMUIS BNI in Empowering the Poor Based on Had Kifayah through the BMUK Programme Herlinda Mendrofa; Muhtadi, Muhtadi
Ijtimaiyya: Jurnal Pengembangan Masyarakat Islam Vol. 18 No. 2 (2025): Ijtimaiyya: Jurnal Pengembangan Masyarakat Islam
Publisher : Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/ijpmi.v18i2.28868

Abstract

This study aims to analyze the role of Yayasan Baitulmal Ummat Islam Bank Negara Indonesia (BAMUIS BNI) in empowering the poor based on Had Kifayah through the Small Business Capital Assistance Program (BMUK) in Pasar Rebo District, East Jakarta. The research focuses on how BAMUIS BNI applies the Had Kifayah concept in determining mustahik eligibility and to what extent the institution contributes to improving beneficiaries’ living standards. A descriptive qualitative approach was employed through in-depth interviews, observation, and documentation. The findings reveal that BAMUIS BNI carries out four main roles: facilitative, educative, representative, and technical. These roles contribute to increasing mustahik income, business skills, and economic independence, although challenges remain in business management, motivation, and market adaptation. This study provides a theoretical contribution to the discourse on zakat-based empowerment and a practical contribution for philanthropic institutions in designing more effective and sustainable economic empowerment strategies.
Pemberdayaan masyarakat Desa Kaligentong berbasis olahan produk singkong kingkong Muhtadi Muhtadi; Suranto Suranto; Pramudya Kurnia; Chandra Wisnu Utomo
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 4 (2024): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i4.28132

Abstract

AbstrakKegiatan pengabdian masyarakat dilakukan di desa kaligentong dengan melibatkan mitra sasaran yaitu mitra-1 Kelompok Tani Marsudi Utomo, Mitra-2 Kebun Bibit Desa (KBD) Suharno dan Mitra-3 Ibu-Ibu PKK di Desa Kaligentong. Permasalahan yang dihadapi Mitra-1 keterbatasan perluasan lahan, sulitnya pengairan pembibitan, pengembangan pemasaran bibit. Untuk mitra-2 hasil pertanian masih dijual bahan baku mentah, petani singkong belum menjadi pilihan usaha, ketrampilan pasca panen masih rendah. Mitra-3 dengan masalah ketrampilan pengolahan bahan singkong masih rendah, kemampuan pengemasan produk yang dihasilkan masih lemah, rendahnya kentrampilan dalam pemanfaatan diversifikasi produk oalahan. Tujuan pengabdian ini membantu dalam pemanfaatan dan pengelolaan potensi unggulan lokal bagi pengembangan desa sntra produksi olahan singkong menuju swasembada pangan dan ekonomi. Adapun metode yang digunakan adalah Community Development, sebagai pendekatan pemberdayaan berorientasi pada pengembangan masyarakat sebagai subyek pembangunan, dan keterlibatan secara langsung dalam berbagai kegiatan pengabdian yang akan dilaksanakan. Tahapan pemberdayaan: sosialisasi, pelatihan, implementasi teknologi, pendampingan pemberdayaan dan keberlanjutan. Adapun sasaran mitra memiliki potensi yang dapat dikembangakan, dimana KDB Suharno memiliki peluang untuk meningkat dalam pengadaan bibit dan penjualan bibit berbagai singkong dan bibit tanaman lainnya, demikian pula mitra-2 memiliki potensi pemanfaatan lahan yang luas untuk tanaman singkong dan olahan aneka singkong dan budidaya tanaman lainnya. Mitra-3 Ibu ibu PKK memiliki potensi dalam peningkatan ekonomi, ketahanan pangan dan wirausaha mandiri pengadaan aneka olahan berbasis singkong yang menjadi desa wisata, desa produk olahan singkong. Hasil kegiatan telah dicapai permasalahan mitra dapat diselesaikan, melalui tahapan yang dilaksanakan, mulai bibit meningkat jumlahnya, ekonomi kelompok petani meningkat dan olahan diversifikasi produk dapat dikembangkan. Kata kunci: pemberdayaan, masyarakat; singkong kingkong; budidaya; olahan. AbstractCommunity service activities were carried out in Kaligentong village involving target partners, namely partner-1 Marsudi Utomo Farmers Group, Partner-2 Suharno Village Nursery (KBD) and Partner-3 PKK Women in Kaligentong Village. The problems faced by Mitra-1 are limited land expansion, difficulty in irrigation of nurseries, development of seed marketing. For partner-2 agricultural products are still sold as raw materials, cassava farmers have not yet become a business option, post-harvest skills are still low. Mitra-3 has problems with skills in processing cassava ingredients which are still low, the ability to package the products produced is still weak, and skills in utilizing diversified processed products are still low. The aim of this service is to assist in the utilization and management of local superior potential for the development of villages in the center of processed cassava production towards food and economic self-sufficiency. The method used is Community Development, as an empowerment approach oriented towards community development as the subject of development, and direct involvement in various service activities that will be carried out. Empowerment stages: socialization, training, technology implementation, empowerment assistance and sustainability. The target partners have potential that can be developed, where KDB Suharno has the opportunity to increase in the procurement of seeds and sales of various cassava seeds and other plant seeds, likewise partner-2 has the potential to utilize large areas of land for cassava plants and various processed cassava and plant cultivation other. Mitra-3 PKK mothers have the potential to improve the economy, food security and independent entrepreneurship in procuring various cassava-based products which can become tourist villages and villages for processed cassava products. The results of the activities have been achieved, partner problems can be resolved, through the stages implemented, starting from the number of seeds increasing, the economy of farmer groups increasing and processed product diversification can be developed. Keywords: community empowerment; kingkong cassava; cultivation; processed
Phytochemical Insights into Rhizophora stylosa: pH-Dependent Extraction, Antioxidant Activity, and Enzyme Inhibition Potential Dwi Bagus Pambudi; Muhtadi Muhtadi; Maryati Maryati
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.11158

Abstract

The solvent properties, including pH, highly influence the extraction efficiency of these bioactive compounds. This study investigated the effect of pH modulation in the ethanol solvent on the recovery of antioxidants from Rhizophora stylosa. Ethanolic extraction was performed on R. stylosa samples using solvents adjusted to varying pH levels (4, 8, 9, 10, and 12). The total phenolic content (TPC) and total flavonoid content (TFC) of the extracts were quantified using standard colorimetric assays. The antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The inhibitory activity against carbohydrate-digesting enzymes was assessed through α-amylase and α-glucosidase inhibition assays. Additionally, data mining of established natural product databases (KNApSAcK and IMPPAT) and literature was conducted to identify and catalog the known bioactive constituents of R. stylosa. The results demonstrated a significant correlation between the pH of the extraction solvent and the yields of phenolic compounds, flavonoids, and the resulting antioxidant activity. Extract obtained at pH 10 yielded the highest TPC and exhibited the strongest antioxidant activity, whereas the highest TFC was observed at pH 4. Furthermore, enzymatic inhibition assays revealed that the pH 10 extract displayed moderate α-amylase inhibitory activity (IC₅₀ = 76.7 µg/mL) but substantially weaker α-glucosidase inhibition (IC₅₀ = 190 µg/mL), demonstrating a selective inhibition profile though less potent than that of acarbose. These findings establish pH-modulated extraction as a targeted strategy to produce potent, phenolic-rich antioxidant extracts from R. stylosa, highlighting its potential for nutraceutical and pharmaceutical applications.
Rapid and Controlled: Microflow Reactor-Assisted Synthesis of Cinnamaldehyde and Ethyl Cinnamate along with Their Cytotoxic Activity Against Several Cell Lines Nindita Fransiska Rahmawati; Muhtadi Muhtadi; Andi Suhendi; Ahmad Fauzi; Didin Mujahidin; Ahwan Ahwan; Agustono Wibowo
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.11781

Abstract

Cinnamaldehyde is a major aromatic compound utilized in the pharmaceutical industry due to its diverse biological activities, including anticancer potential. This study aims to develop a rapid and controlled synthesis method for cinnamaldehyde and ethyl cinnamate using microflow reactor technology, followed by structural elucidation and cytotoxic evaluation against HeLa, MCF-7, and T47D cancer cell lines. The synthesis of cinnamaldehyde was performed via aldol condensation of benzaldehyde and acetaldehyde (1.3:1 molar ratio) at 70°C, while ethyl cinnamate was synthesized through a two-step process involving Pinnick oxidation and Fischer esterification. The results demonstrated that microflow synthesis achieved a cinnamaldehyde yield of 52% with high purity (100% based on HPLC relative area), and ethyl cinnamate with 99% purity. In cytotoxic assays, synthesized cinnamaldehyde exhibited moderate activity, most notably against HeLa cells with an IC₅₀ of 95 µg/mL, whereas ethyl cinnamate showed lower potency (IC₅₀ > 200 µg/mL). Although the synthesized compounds were less potent than the standard cinnamaldehyde (IC₅₀ 1.56 µg/mL) and Doxorubicin control, this study confirms that microflow reactor technology is a highly effective and time-efficient method for producing high-purity cinnamate derivatives.
Penerapan Aplikasi LARASKIA (Layanan Rekam Stunting dan Informasi Kesehatan Ibu dan Anak) Pada Kader Posyandu di Desa Bogangin, Kacamatan Sumpiuh, Kabupaten Banyumas Umi Laelatul Qomar; Wahyu Rahmatullah; Wilson Candra Teguh Pratama; Tanti Azizah Sujono; Muhtadi Muhtadi; Sartono Putro; Wulan Rahmadhani; Adinda Putri Sari Dewi
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 2 (2026): Volume 9 Nomor 2 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i2.24053

Abstract

ABSTRACT Stunting is a chronic nutritional problem that has serious implications for health outcomes and human resource quality. One of the main challenges in stunting prevention at the village level is the limited system for recording, monitoring, and disseminating maternal and child health information, which is still predominantly conducted manually. This Community Service Program (Pengabdian kepada Masyarakat/PKM) aimed to enhance the capacity of Posyandu cadres in stunting monitoring through the implementation of the LARASKIA application (Stunting Recording and Maternal and Child Health Information Service) in Bogangin Village, Banyumas Regency. The program employed socialization, application usage training, mentoring, and evaluation as its implementation methods. The results demonstrated that the application of LARASKIA significantly improved the knowledge and skills of Posyandu cadres in recording toddlers’ nutritional status, monitoring maternal and child health, and delivering health information in a more effective and systematic manner. This program contributes to strengthening digital-based stunting prevention efforts at the village level. Keywords: Stunting, LARASKIA, Posyandu Cadres, Maternal and Child Health, Digital Health.  ABSTRAK Stunting merupakan permasalahan gizi kronis yang berdampak serius terhadap kualitas kesehatan dan sumber daya manusia. Salah satu kendala utama dalam upaya pencegahan stunting di tingkat desa adalah keterbatasan sistem pencatatan, pemantauan, dan penyampaian informasi kesehatan ibu dan anak yang masih dilakukan secara manual. Kegiatan Pengabdian kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan kapasitas kader Posyandu dalam pemantauan stunting melalui penerapan aplikasi LARASKIA (Layanan Rekam Stunting dan Informasi Kesehatan Ibu dan Anak) di Desa Bogangin, Kabupaten Banyumas. Metode pelaksanaan meliputi sosialisasi, pelatihan penggunaan aplikasi, pendampingan, serta evaluasi. Hasil kegiatan menunjukkan bahwa penerapan aplikasi LARASKIA mampu meningkatkan pengetahuan dan keterampilan kader Posyandu dalam pencatatan status gizi balita, pemantauan kesehatan ibu dan anak, serta penyampaian informasi kesehatan secara lebih efektif dan sistematis. Program ini berkontribusi dalam mendukung upaya pencegahan stunting berbasis digital di tingkat des Kata Kunci: Stunting, LARASKIA, Kader Posyandu, Kesehatan Ibu Dan Anak, Digital Health.
In Silico Evaluation of Cinnamaldehyde and Its Analogues as Potential Alpha-Glucosidase Inhibitors for Antidiabetic Therapy Ahwan Ahwan; Muhtadi Muhtadi; Rima Munawaroh
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.622

Abstract

Diabetes mellitus (DM) is a chronic disease that can impact the health and well-being of patients in the long term. According to the International Diabetes Federation (2025), DM sufferers in Indonesia numbered 20.4 million in 2024. This figure is expected to increase to 28.6 million in 2050, DM treatment by inhibiting the alpha-glucosidase receptor. Cinnamaldehyde compounds have antidiabetic activity. This in silico study aims to determine the potential of cinnamaldehyde compounds and their analogs against alpha-glucosidase receptors as antidiabetics. Data on cinnamaldehyde compounds and their analogs were collected through the PubChem database and the alpha-glucosidase structure from the PDB database with the code 3TOP. This study evaluated cinnamaldehyde and its six analogs using molecular docking simulations on alpha-glucosidase receptors with tools such as PyRx 0.8, AutoDockTools-1.5.6, and Biovia Discovery Studio 2024, as well as pharmacokinetic and toxicity predictions using the pkCSM web tools and Lipinski's Rule of Five. The Lipinski's Rule of Five prediction results indicate that acarbose does not meet Lipinski's criteria. In contrast, cinnamaldehyde and its derivatives meet these criteria. Docking analysis shows that acarbose (7.1 kcal/mol) has the highest binding affinity for α-glucosidase, but cinnamaldehyde and its analogs (6.0–6.4 kcal/mol) still exhibit strong interactions at the enzyme's active residues. The ADMET profile supports the potential of cinnamaldehyde as an antidiabetic candidate with a broader systemic action range and a better pharmacokinetic profile than acarbose.
Co-Authors A Anifatussaa'dah A.A. Ketut Agung Cahyawan W Aan Sofyan ABDUL ROKHMAN Adinda Putri Sari Dewi Aditya Naova Sofyan Agus Triono Agus Triyono Agustina, Vinda Agustono Wibowo Agustono Wibowo Ahmad Fauzi Ahmad Saleh Ahmad Syofyan Ahwan Ahwan Aida Vitayala S Hubeis Aji Astuti, Winata Al Fikri, Muhammad Sidiq Alfiyatul Azizah Alyonni, Alvin Amalia, Hanisa Amalinda Ayu Faroska Ambarwati Amna, Amna Andi Faisal Bakti & Venny Eka Meidasari Andi Suhendi Andi Suhendi Anggara, Alvin Anggun Ella Indriyani Anisah, Salma Nur Annida Karimah Anandhi Annissa, Yanis Nur Apriyanto, Apriyanto Ardalia Rinanda Oktaviani Arikarani, Yesi Ariyani, Herda Ashari Rachmanisa Aulia Ayu Fatkhurrohmah Wiyono Awaludin, Aditiya Ayu Annisa Gharini Budiyono Budiyono Bunga Sawitri, Novelia Burhanudin Ichsan Cast Torizellia Chairani, Hanifah Chandra Wisnu Utomo Choirunnisa, Indah Chusniatun Decky, Radha Aulia Putri Deden Mauli Darajat, Deden Mauli Dewi, Adinda Putri Sari Dhany Efita Sari Diah Ayu Wulandari, Diah Ayu Didin Mujahidin Dudi Iskandar Dwi Bagus Pambudi Dwi Linna Suswardany Dwi Sarbini Dyera Forestryana Dzaki Fikri Firdaus Bakri Efendi, Muhammad Alief Farezi Em Sutrisna Eni Setyowati Erindyah Retno Wikantyasning Erlina, Mega Erna Dewi . Erna Herawati Euis H. Hakim Eva Diahayu Wardani Fachry Abda El Rahman Fadhilla Tri Nugrahaini Fahmi, Muhammad Zaini Fahriza Mei Trihatmoko Fahrun Nur Rosyid Fardiansyah, Ahmad Irzal Fari Adi Prasetya Faridita khoirun Nisa' Faroska, Amalinda Ayu Fathimah Muyassaroh Fatulloh, M. Rizki Felita, Safira Fharadilla, Niken Fidhia Nur Rifaini Firmansyah, Ade Arif Fitria, Aziza Gafrila Fani Eka Saputri Gazi, Gazi Gumelar, Rizki Elang Guntur Nurcahyanto Gutimigo, Zelta Pratiwi Hafiz Ramadhan Hafiz Ramadhan Haliza Arzeti Nurseptiria Hamsiri, Hamsiri Handayani, Eka Wuri Hanifa Adityarahma Hanum, Lifya Afrianti Hari Widada, Hari Harun Joko Prayitno Haryoto Haryoto Haya Nabilah Utama Helandri, Joni Heni Siswanto Herlina, Lenni Herlinda Mendrofa Herry Purnomo Hidayah Karuniawati Hieronymus Soerjatisnanta Himmatun Ulya, Azka Humaidi, Lutfi Ida Maesaroh Iffat Rifdah Rosyid Iffat Rosyid Ihwan Susila Indah Suryawati Isa Ayu Fatimah Islamiyah, Putri Robiatul Istiqomah, Nur Fajar Izzuwana, Fadilah Jalifah Latip Junita Dwi Wardhani Kamarudin, Anna Permatasari Kamarusdiana, Kamarusdiana Khusnul Khotimah Kiky Rizky Komarra, M. Akbar Arri Kun Harismah Kusnindyasita, Anisa Kussudyarsana Kuswaji Dwi Priyono Laila Dzafira Lia D. Juliawaty Liliyana Lina Ayu Kusumastuti Listiana Masyita Dewi M. Syukri Ghozali Mahasri Shobahiya Mariska Sri Harlianti Maroni Maroni Marsilia Rosa Sinensis HI Maryati Maryati Meiliana, Sherin Isna Muhammad Andya Nurpatria Muhammad Fahmi Johan Syah Muhammad Fakih Muhammad Zaini Fahmi Mujani, Sahril Mulyanti, Amelia Nur'afni Munajat Tri Nugroho Murodi Murodi Musdhalifah Husna Firdausi Muslih, Imam Muyassaroh, Fathimah Naufal Ishartono Ngimadudin Nia Istiana Nikmah Rosidah Nindita Fransiska Rahmawati Ninuk Purnaningsih Novandi, Idham Nur Afifah Mustikasari Nur Hidayati Nurcahyanti . Nurhidayat Nurhidayat Nurul Latifatul Inayati Okarda, Beni Palindo, Ahmad Dempo Peni Indrayudha Pramudya Kurnia Pratama, Wilson Candra Teguh Pudji Muljono PUJI LESTARI Putri Sulistiawati Putri, Citra Mutiara Putri, Yunisha Dena Qurtubi, Muhammad Raafika Studiviani Rahardian Surya Basusena Rahmatya Nurmeidina Rahmayuni, Dewi Rifki Febriansah Rima Munawaroh Rinaldy Amrullah Rini Fathonah, Rini Riris Aryawati Rizki Ainun Fitriani Romadhon, Sahri Rosidah, Wilda Rozirwan . Rujito Agus Suwignyo Rusdin Rauf Rustiono, Dedy Sabtanti Harimurti, Sabtanti Saifuddin Saifuddin Saifudin Saifudin Saputri, Gafrila Fani Eka Sari, Linda Sarno Sarno Sartono Putro Sativa, Wieke Rachma Sayyidah Nurul Muslihah Septian Hendra Wijaya Setiawan, Arief Tri Sherin Isna Meiliana Sjamsul A. Achmad Soepatini Sofyan Anif Sri Anggraeni Sudirman, Ade Suharjo Suharjo Sulistiawati, Putri Suparti Suparti Suranto Suranto Suranto Suranto Suranto Suranto Suratmi Suratno, Geri Sutama Tantan Hermansah, Tantan Tanti Azizah Tanti Azizah Tanti Azizah Sujono Tengku Zia Ulqodry Tia Mella Citra Tisnanta, H. Soerya Tista Ayu Fortuna Totok Budi Santosa, Totok Budi Totok Suwanda umi laelatul qomar Umi Laelatul Qomar Utami Ningrum Utaminingsih, Dwi Sri Vitania Marsya Wahyu Rahmatullah Wahyu Rahmatulloh Wahyudi, Arie Wilson Candra Teguh Pratama Wulan Rahmadhani Wulan Rahmadhani, Wulan Yana M. Syah Yanis Nur Annissa Yanis, Tryan Zaki Aulia Yuninda Shanti Pangestuti Yusdiyanto Yusnadi, Alja Zakariya, Luqman Zaman, Chairil Zen, Muhammad Hilmy Zulkarnain Ridlwan