Knowledge of a person's health determines behaviour when seeking treatment. Vitamin swamedication is a swamedication activity that uses vitamins needed by the body for normal metabolic processes and growth. This study was conducted to determine the relationship between sociodemographic characteristics and the level of knowledge of vitamin swamedication at Apotek X, Cirebon Regency. The method used is a cross sectional method with a sampling technique of consecutive sampling as many as 80 respondents. The data were analyzed by Spearman test using Statistical Product and Service Solutions (SPSS) version 25. The results showed the sociodemographic characteristics of the majority of respondents aged 26-45 years (44%), female gender (65%), education level SMA/SMK/MA (49%), and 55% of other occupations. Having sufficient knowledge level (63%) and having a relationship between sociodemographic characteristics in the form of education level with knowledge level of vitamin swamedication with p-value = 0.015 (p<0.05). The conclusion of the study is that there is a significant relationship between the level of education and the level of knowledge of vitamin swamedication.