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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan VALENSI Jurnal Kimia (Journal of Chemistry) JURNAL KIMIA SAINS DAN APLIKASI Biotika: Jurnal Ilmiah Biologi Bionatura Indonesian Journal of Applied Sciences Jurnal Ilmu Dasar Jurnal Natur Indonesia Majalah Kedokteran Bandung Cropsaver : Journal of Plant Protection Jurnal Penelitian Hasil Hutan Indonesian Journal of Cancer Chemoprevention Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Indonesian Journal of Science and Technology Dentino: Jurnal Kedokteran Gigi The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Jurnal Bioteknologi & Biosains Indonesia (JBBI) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Al-Kimia Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Communications in Science and Technology Akta Kimia Indonesia Jurnal Kartika Kimia B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Permukiman Jurnal Penelitian Hasil Hutan Journal of Multidisciplinary Applied Natural Science Jurnal Ilmiah Berkala Sains dan Terapan Kimia Denta: Jurnal Kedokteran Gigi Makara Journal of Science Jurnal Ilmiah Sains Molekul: Jurnal Ilmiah Kimia Jurnal Penelitian Hasil Hutan Biodiversitas Journal of Biological Diversity
Unang Supratman
Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Screening and evaluation of antidiabetic activities of endophytic fungi associated with Etlingera elatior LAITA NURJANNAH; AZMI AZHARI; ASRI PENI WULANDARI; SUSENO AMIN; UNANG SUPRATMAN
Biodiversitas Journal of Biological Diversity Vol. 24 No. 6 (2023)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d240645

Abstract

Abstract. Nurjannah L, Azhari A, Wulandari AP, Amin S, Supratman U. 2023. Screening and evaluation of antidiabetic activities of endophytic fungi associated with Etlingera elatior. Biodiversitas 24: 3481-3487. Etlingera elatior (Jack) R.M.Sm. has been well-documented to have antioxidant and antidiabetic properties. Among all medical conditions worldwide, diabetes mellitus is one of the leading causes of death. Therefore, research on the discovery of antidiabetic medicines inhibitory to ?-glucosidase (an enzyme for degrading complex dietary carbohydrates into sugar in the digestive process) is urgently needed. This study aims to isolate and evaluate the potential of the fermentation culture of endophytic fungi associated with E. elatior to inhibit the activity of ?-glucosidase. The endophytic fungi were isolated from various parts of E. elatior. A total of 29 isolates were successfully isolated from the plant's roots, stems, leaves, and flowers. The endophytic fungi were tested for their ability to inhibit ?-glucosidase activity in bioassays. Among those isolates, 8 were inhibitory to such an enzyme, and 2 showed the highest inhibitory activities. Morphotype and molecular identification of those isolates, using their Internal Transcribed Spacer (ITS) regions of ribosomal DNA (rDNA), identified them as Daldinia eschscholtzii isolate CFL 7 and Hypoxylon trugodes voucher YMJ 57, with IC50 values of 738 µg/mL and 825 µg/mL, respectively. That indicates that they are potentially used in preventing or treating diabetic mellitus.
Antibacterial activities and molecular identification of endophytic fungi isolated from mangrove Avicennia marina YENI MULYANI; ASRI PENI WULANDARI; SISKA ELISAHBET SINAGA; WAHYU SAFRIANSYAH; AZMI AZHARI; SARI PURBAYA; FAJAR FAUZI ABDULLAH; KINDI FARABI; YOSHIHITO SHIONO; UNANG SUPRATMAN
Biodiversitas Journal of Biological Diversity Vol. 24 No. 12 (2023)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d241254

Abstract

Abstract. Mulyani Y, Wulandari AP, Sinaga SE, Safriansyah W, Azhari A, Purbaya S, Abdullah FF, Farabi K, Shiono Y, Supratman U. 2023. Antibacterial activities and molecular identification of endophytic fungi isolated from mangrove Avicennia marina. Biodiversitas 24: 6923-6933. This research explored the antibacterial potential of endophytic fungi from the Avicennia marina's (Forssk.) Vierh leaves, stem bark, and root, located in Blanakan, Subang District, West Java. The screening process for antibacterial activity potential was conducted using the Kirby Bauer disk diffusion method. Subsequently, the molecular screening results of the most promising fungi species were identified using Internal Transcribed Spacer (ITS) markers. The results revealed the isolation of 30 fungal isolates. Among these, seven endophytic fungi exhibited significant antibacterial activity against Staphylococcus aureus ATCC 29213 and Vibrio harveyi ATCC 5339, with inhibition zones ranging from 7.88±1.52 to 23.60±0.77 mm. Through molecular identification, 7 endophytic fungi were identified, including Penicillium chrysogenum, Cladosporium anthropophilum, Trichosporon asahii, Cladosporium sphaerospermum, Fusarium verticillioides, Meyerozyma carpophila, and Penicillium steckii. Notably, C. anthropophilum exhibited the highest inhibition zones against S. aureus and V. harveyi measuring 23.60±0.77 and 21.80±0.26 mm, and showed (Minimum Inhibitory Concentration) MIC values of 15.625±0.98 and 31.25±0.39 ?g/mL, respectively. In this study, endophytic fungi isolated from different parts of A. marina exhibited promising antibacterial activity, with Cladosporium anthropophilum from the stem bark showing the highest potency against S. aureus and V. harveyi, suggesting their potential as a source of antibacterial agents. To the best of our knowledge, this is the inaugural study uncovering the isolation and antibacterial potential of endophytic fungi from the genera Cladosporium, Trichosporon, Fusarium, and Meyerozyma. These fungi were extracted from the bark, leaves, and roots of A. marina, situated within the unique mangrove ecosystem of Blanakan Sub-district, Subang District, West Java, Indonesia.
New Limonoid from Chisocheton macrophyllus: Isolation, Synthesis, Molecular Docking Studies, and Cytotoxicity against Cancer Cells Muhammad Badrul Huda; Nurlelasari Nurlelasari; Faris Hermawan; Wahyu Safriansyah; Unang Supratman; Yudha Prawira Budiman
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.471

Abstract

Dysobinin is a naturally occurring limonoid and a type of triterpenoid, which shows certain efficacy, although its prospects in the field of pharmacology are still limited. Therefore, this study aimed to improve the pharmacological properties of dysobinin through structural rearrangement. A 56% yield was obtained using Selectfluor to convert dysobinin into a novel molecule, specifically 22α-carboxyacid-dysobinin (5). Compared to the other compounds, 22α-carboxyacid-dysobinin (5) exhibited significantly higher cytotoxicity against human epithelial tumor (HeLa) and B16-F10 cancer cells. However, this compound 5 exhibited the lowest cytotoxicity against MCF-7 cancer cells. Subsequently, a docking study showed that compound 5 had binding energies of -9.61, -7.81, and -6.08 kcal/mol for EGFR, Bcl-2, and Tyrosinase, respectively. In the prediction of pharmacokinetic parameters, compound 5 fulfilled the minimum standard parameters for the ADMET properties. Therefore, compound 5 may be considered a promising lead compound for anticancer development, warranting further optimization and validation.
Co-Authors - Ruchiyat . Horizon . Susianti Ace Tatang Hidayat Achmad Zainuddin Achmad Zainuddin Ade Akbar Abdilla Ade Kania Ningsih Ade Kania Ningsih, Ade Kania Adel Zamri Agus Safari Agus Safari Agus Safari Agus Safari Agustini, Dewi Meliati Ahmad Darmawan Ahmad Kurniawan Ahmad Kurniawan Ahmad Ramdan Ahmad Yani Nelly Wahyuni Lia Destiarti Akhmad Darmawan Al Arofatus Naini Al Arofatus Naini Al Arofatus Naini Aldo Hartono Almas Widyana Alya Tsamrotul Anas Subarnas Anas Urbanas Anastasya Firdausi Andi Rahim Andre A. Sonda Aneu Wahyuni Anjari, Intan Hawina Aprilia Permata Sari Aprilia Permata Sari Aprina, Lutfia Silva Ari Hardianto Ari Widiyantoro Arif Rahman Hakim Arif Rahman Hakim Arif Rahman Hakim Arif Rahman Hakim Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Suzy Puspa Pertiwi Arto Yuwono Soeroto Asep Supriadin ASRI PENI WULANDARI ASRI PENI WULANDARI Asri Peni Wulandari Astrid Feinisa Khairani Aziiz Mardanarian Rosdianto AZMI AZHARI AZMI AZHARI Azmi Azhari Azmi Azhari, Azmi Azmi, Mohamad Nurul Benny Joy Betry Pujiastuti Budiman, Yudha P. C Hanny Wijaya Celcius Waranmaselembun Christina Marpaung Dadan Sumiarsa Danar Dono Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati, Darwati Deden Indra Dinata, Deden Indra Desi Harnet Desi Harneti Desi Harneti Desi Harneti Desi Harneti Putri Huspa Dewa G Katja Dewa Gede Katja Dewa Gede Katja Dewa Gede Katja Dikdik Kurnia Dimpuulina Erna Mariati Dini Oktaviani Dondin Sajuthi DUDI RUNADI Edi Suanto, Edi Edi Sukmana Edi Sukmana Edi Sukmana Elis Hastuti Elisabeth Krismayanti Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Erina Hilmayanti Erina Hilmayanti Erina Hilmayanti Erina Hilmayanti Euis Julaeha Euis Julaeha Euis Julaeha Evan Hadrian Ezatul Ezleen Kamarulzaman Fadlilah, Gina Faizah Maira Faizal Hermanto FAJAR FAUZI ABDULLAH Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajar, Mohamad Fajar, Mohamad Fani Rahma Yenita Farabi, Kindi Faris Hermawan Fathurachman Fauzan Zein Muttaqien Ferdyan Efza Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Filza Yulina Ade Fizrul Indra Lubis Galih Bayu Pratama Galuga Sinalusur Sari Ghina Izdihar Gilang Muhamad Nur Iqbal Gunawan, Latifah Hadi Kuncoro Hadi Kuncoro Hana Goenawan Hanna Goeanawan Hanna Goenawan Harizon Harizon Harlia Harlia Hasbilla, Raihan Fathurrahman Hasnah Osman Hasnah Osman Hedi Paramita Herdanu Rizqullah Hersa Milawati Hersa Milawati Hersa Milawati Hideo Hayashi Hideo Hayashi Hideo Hayashi Hideo Hayashi Hideo Hayashi Hideo Hayashi Hilmayanti, Erina Huda, Muhammad Badrul Husein Hernadi Bahti Ichsan Nurul Bari Ida Ayu Putu Sri Widnyani Ida Nur Farida Ida Nur Farida Ida Nurfarida Ihsan Rahadian Iis Intan Widiyowati Indri Indriyani Indriyani, Indri Inne Suherna Sasmita Intan Hawina Anjari Intan Rahmayanti Iqbal Musthapa Iqbal Wahyu Mustaqim Isa Mahendra Isramiharti Isramiharti Iwan Setiawan Iwan Setiawan Iwan Setiawan Jamaludin Al-Anshori Jihan Mudrika Rahmi Julia Windi Gunadi Julia Windi Gunadi Julinton Sianturi Julinton Sianturi Kadarusman Kansy Haikal Kansy Haikal Kautsari, Arsi Khadijah Awang Khairunnisa, Shofiyah Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khlaijah Awang KINDI FARABI Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kok Tong Wong Kristin Shinta Dewi Kusumiyati LAITA NURJANNAH Laode Rijai Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah, Lilis Siti Lindung Tri Puspasari M. S. Soedjanaatmadja Maira, Faizah Mantiri, Sisilia A Maryati Maryati Mas Rizky A.A. Syamsunarno Max R.J Runtuwene Max R.J Runtuwene Mayshah Purnamasari MEGANTARA, SANDRA Melanie Melanie Milawati, Hersa Moelyono Moektiwardoyo Mohamad Fajar Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurul Azmi bin Mohamad Taib Mohamad Nurul Azmi Mohamad Taib Mohamad Nurul Azmi Mohamad Taib Mohamed Ashraf Ali Mohd. Zaheen Hassan Mohd. Zaheen Hassan Muchlis, Handi Nugraha Muhamad Nurul Azmi Muhamad Nurul Azmi Muhammad Badrul Huda Muhammad Hanafi Muhammad Hanafi Muhammad Hanafi Muhammad Solehin Abd Ghani Muhammad Solehin Abd Ghani Murtihapsari . Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Muttaqin, Fauzan Zein Nadia Mohamed Yusoff Nadya Thufaila Nafiah, Mohamad Azlan Naini, Al Arofatus Nasrudin Nasrudin Nayla Haraswati Noor Rain Abdullah Noor Rain Abdullah Nova Sylviana Nova Sylviana Nunung Kurniasih Nunung Kurniasih Nunung Kurniasih, Nunung Nur Insani Amir Nur Muhammad Miftah Nurabi Ferdiana Nurlelasari Nurlelasari Nurlelasari Nurlelasari Nurlelasari Nurlelasari Nurlelasari Okta Wismandanu Paramita, Hedi Ponis Tarigan Prasetyo, Wibowo Budi Pratama, Galih Bayu Prayudi Santoso Primahana, Gian Purbaya, Sari Purnama Purnama Purnama Purnama Purnama Purnama Purwoko, Agus Puspita Sari Putri, Ghesta Alifka Rahmawati Rahmawati Rani Maharani Rani Maharani Rani Maharani Rani Maharani Rani Maharani Ratu Safitri Ray, Hamidie Ronald Daniel Rejeki, Purwo Sri Revan Hardiawan Richa Mardianingrum Ricson Pemimpin Hutagaol Rika Meliansyah Risyandi Anwar Riza Apriani Rizky Abdulah Rizky Abdullah Romundza, Febbry Ronauli Fitriana Ronny Lesmana Ronny Lesmana Roosje Rosita Oewen, Roosje Rosita Roro Wahyudianingsih Rudi Hendra Rurini Retnowati Rymond Jusuf Rumampuk Safri Ishmayana Safriansyah, Wahyu Salam, Supriatno Salam, Supriyanto Samuel San Parulian Sandra Amalia Riyadi SARI PURBAYA Sari Purbaya Sari Purbaya Sari, Aprilia Permata Satwika Nandiwardhana Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Shabarni Gaffar Shiono, Yoshihito Sianturi, Julinton Sinaga, Siska Elisahbet Sisilia A Mantiri SISKA ELISAHBET SINAGA Siska Elisahbet Sinaga Siska Mulya Octavia Siska Mulya Octavia Siti Hani Pratiwi Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Srikandi, Srikandi Steffi Triany Arnov Subekti Mauluddin Sudarjat Sudarjat Sunarjati Sudigdoadi Supriatno Supriatno Salam Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriyatna Supriyatna Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna, - Suruwaky,, Amir SUSENO AMIN Suseno Amien Susianti Susianti Susianti Susianti Susianti Susianti, Susianti Tati Herlina Tati Herlina Tati Herlina Tati Herlina Tati Herlina Tati Herlina Tati Herlina Teddy Budiyansyah Thaigarajan Parumasivam Tiara Prima Amalya Tjandrawati Mozef Toto Subroto Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Tri Reksa Saputra Tri Reksa Saputra Tri Reksa Saputra, Tri Reksa Vicki Nishinarizki Vidia Afina Nuraini Vita Murniati Tarawan Vita Murniati Tarawan W.C. Taylor WAHYU SAFRIANSYAH Wahyu Safriansyah Wahyu Safriansyah Wahyu Syafriansyah Wahyuni, Aneu Wawan Hermawan Wawan Hermawan Winda Sukmawati Winda Sukmawati Witriany Rayapratiwi YENI MULYANI Yeni Mulyani Yenny Febriani Yun Yenny Febriani Yun Yenny Febriani Yun, Yenny Febriani Yeong Keng Yoon Yessi Permana YOSHIHITO SHIONO Yoshihito Shiono Yoshihito Shiono Yoshihito shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yudha Prawira Budiman Yum Eryanti Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yusup Hidayat