Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

4.867

P-Index

This Author published in this journals

All Journal HAYATI Journal of Biosciences Media Veteriner Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Sain Veteriner Jurnal Kebidanan Journal of Biomedicine and Translational Research Majalah Obat Tradisional Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Universa Medicina Jurnal Penelitian Kesehatan Suara Forikes Journal Of Vocational Health Studies Jurnal Ilmu Kesehatan Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Medik Veteriner Care : Jurnal Ilmiah Ilmu Kesehatan JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Ovozoa: Journal of Animal Reproduction Heart Science Journal Journal of Marine and Coastal Science Indian Journal of Forensic Medicine & Toxicology Bioscientist : Jurnal Ilmiah Biologi journal of Basic Medical Veterinary Asian Journal of Health Research Indonesian Journal of Cancer Jurnal Kedokteran Hewan Current Biomedicine Journal of Education Technology and Inovation Strada Jurnal Ilmiah Kesehatan (SJIK) JURNAL KEPERAWATAN Medica Majapahit Folia Medica Indonesiana

Widjiati Widjiati, Widjiati

Faculty Of Veterinary Medicine, Universitas Airlangga

Author-ID : 596972

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 105 Documents Claim Missing Document

Claim Missing Document

Articles

4 5 6 7 8

EFEK IBUPROFEN ORAL TERHADAP PERUBAHAN BERAT BADAN PADA MENCIT BETINA Anindya Marcha Angelina Djianto; Tri Hartini Yuliawati; Sri Ratna Dwiningsih; Widjiati Widjiati
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Ibuprofen is one of the most used non-steroidal anti-inflammatory drugs (NSAID) due to its ease of access without the need of prescription. However, ibuprofen may cause side effects associated with gastrointestinal mucosal injury. The discomfort caused when eating may cause nausea and loss of appetite which leads to weight loss. Objective: This study was done to prove changes in body weight after treatment of oral ibuprofen using mice as test subjects. Material and method: This study used pre-test post-test control group design. 33 female BALB/c mice were grouped into 3 groups (P1, P2, P3). P1 is a control group which was given aquadest as placebo, P2 was given 52 mg/kg body weight of oral ibuprofen and P3 was given 104 mg/kg body weight of oral ibuprofen. Treatment lasted for 15 days. Results were analyzed using Kruskal-Wallis test and Mann-Whitney U test in IBM SPSS Statistics 22. Result: 80% of the mice had their body weights decreased with an average decrease of 0.91 g (±2.26) in group P1, average decrease of 2.2 g (±2.15) in P2, and average decreased of 4.11 g (±2.62) in P3. Statistical analysis showed that body weight changes of group P3 has significant difference (p = 0.009) compared to P1 and P2. Conclusion: It can be concluded that 104 mg/kg dose of oral ibuprofen caused a decrease in body weight of female mice.

PENINGKATAN PRODUKTIVITAS SAPI RAKYAT, PEMBUATAN YOGURT, PERMEN SUSU DAN MENINGKATKAN KESEHATAN MASYARAKAT DI KECAMATAN PACET KABUPATEN MOJOKERTO Widjiati Widjiati; Trilas Sardjito; Nenny Harijani
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 1 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Mojokerto Regency is a region with a good economic level. The regency has fertile land and well-preserved Majapahit Kingdom remains. In addition, it has dairy cattle farm located around Pacet Sub-district. Milk produced from this area can support economy in East Java. However, there is no increased milk sale price of dairy processing to be food with high sale price. Dairy cattle community have not been touched by technology of dairy processing to produce high sale priced food such as yoghurt, ice-cream, or dairy candies. Therefore, science and technology are needed by the community in this area to increase their productivity and income in order to create independent economy. The social service is aimed to assist the community in order to increase their income by mastering science and technology in the form of increasing the sale price of milk and creating independent economy by increasing dairy cattle productivity and giving added value of milk to be processed food such as dairy candies or yoghurt. The social service is integrated, in order to give science and technology to the community, to motivate the students and community to keep their health and to take care of their teeth. The target of the activity is to lessen the community’s burden by improving management of cattle caring and dairy cattle productivity, making processed products from milk with higher economic value, creating small scaled industry, and improving public health. The activities conducted were as follows giving trainings to make yoghurt, dairy candies or herbs, giving cattle health service to increase cattle productivity by undergoing cattle fertility examination, treating infertile cattle, doing artificial insemination to cattle in their estrous cycle, giving vitamin to increase cattle appetite, improving cattle feed quality by giving trainings to process cattle feed. Briefing and service on health was given to educate the community in order to live healthily by keeping health and taking care of teeth.The conclusion drawn from the activity conducted in Pacet Sub-district Mojokerto is training on how to make yoghurt and dairy candies is able to give added value for the community in Pacet Sub-district. Many cases on cattle reproductive disorder in Pacet Sub-district are identified, and measurement on Elementary school children’s growth is needed to monitor nutritional status of the children. AbstrakKabupaten Mojokerto merupakan daerah dengan tingkat ekonomi yang baik. Kabupaten ini memiliki lahan subur dan Kerajaan Majapahit yang terpelihara dengan baik. Selain itu, ia memiliki peternakan sapi perah yang terletak di sekitar Kecamatan Pacet. Susu yang dihasilkan dari daerah ini bisa menunjang perekonomian di Jawa Timur. Namun, tidak ada kenaikan harga jual susu olahan susu menjadi makanan dengan harga jual tinggi. Komunitas sapi perah belum tersentuh oleh teknologi pengolahan susu untuk menghasilkan makanan dengan harga jual tinggi seperti yoghurt, es krim, atau permen susu. Oleh karena itu, sains dan teknologi sangat dibutuhkan oleh masyarakat di daerah ini untuk meningkatkan produktivitas dan pendapatannya agar tercipta perekonomian mandiri. Pelayanan sosial ini bertujuan untuk membantu masyarakat dalam rangka meningkatkan pendapatan mereka dengan menguasai sains dan teknologi dalam bentuk kenaikan harga jual susu dan menciptakan ekonomi mandiri dengan meningkatkan produktivitas sapi perah dan memberi nilai tambah susu untuk diolah makanannya. seperti permen susu atau yoghurt. Pelayanan sosial terintegrasi, untuk memberi sains dan teknologi kepada masyarakat, untuk memotivasi siswa dan masyarakat agar tetap menjaga kesehatan dan merawat giginya. Sasaran kegiatan ini adalah mengurangi beban masyarakat dengan meningkatkan pengelolaan produktivitas sapi dan produktivitas sapi perah, membuat produk olahan dari susu dengan nilai ekonomi lebih tinggi, menciptakan industri skala kecil, dan meningkatkan kesehatan masyarakat. Kegiatan yang dilakukan adalah sebagai berikut memberikan pelatihan untuk membuat yoghurt, permen susu atau herbal, memberikan layanan kesehatan sapi untuk meningkatkan produktivitas ternak dengan menjalani pemeriksaan kesuburan ternak, mengobati ternak yang tidak subur, melakukan inseminasi buatan pada ternak dalam siklus estrus mereka, memberi vitamin untuk meningkatkan ternak. nafsu makan, meningkatkan kualitas pakan ternak dengan memberikan pelatihan untuk mengolah pakan ternak. Brieﬁng dan pelayanan kesehatan diberikan untuk mendidik masyarakat agar dapat hidup sehat dengan menjaga kesehatan dan merawat gigi. Kesimpulan yang diambil dari kegiatan yang dilakukan di Kecamatan Pacet Mojokerto adalah pelatihan bagaimana membuat yoghurt dan permen susu mampu memberi nilai tambah bagi masyarakat di Kecamatan Pacet. Banyak kasus gangguan reproduksi ternak di Kecamatan Pacet diidentiﬁkasi, dan pengukuran pertumbuhan anak sekolah dasar diperlukan untuk memantau status gizi anak-anak.

- Musik Mozart Memiliki Ekspresi Brain Deriverd Neurotrophic Factor Tertinggi Pada Serebrum dan Serebellum Rattus norvegicus Dibandingkan Dengan Gamelan Jawa, Sunda Dan Bali Selama Kehamilan Virki Widoyanti; Hermanto Tri J; Widjiati Widjiati
coba Vol 8 No 2 (2020): Mei 2020
Publisher : Akademi Keperawatan Dharma Husada Kediri

Introduction: Music can affect the parasympathetic nervous system or the automatic nervous system, both directly and indirectly. The exposure of Mozart's music, Javanese, Sundanese and Balinese gamelan influences neurotropic factors in the brain. Methods: This study was an experimental laboratory with a random post-test design only in the design of the control group used by Rattus norvegicus as a model. Results: There were significant differences in brain deriverd neurotrophic factor expressions in Rattus norvegicus children between groups with p = 0.018 (mean 1.60 ± 0.42 for the control group, 4.00 ± 1.85 for the mozart music group, 3.00 ± 0.96 for Javanese gamelan groups, 2.48 ± 0.68 Sundanese Gamelan groups, and 2.16 ± 1.27 in Balinese Gamelan groups) also in the cerebellum with p = 0.022 (average 1, 44 ± 0 , 29 for the control group, 3.92 ± 1.81 for the Mozart event, 3.04 ± 0.94 Javanese gamelan groups, 2.92 ± 0, 41 Sundanese gamelan groups, and 2.57 ± 1,053 Balinese gamelan groups). Discussion: There are differences in the expression of brain derived neurotrophic factors in the cerebrum and Rattus norvegicus cerebellum between those exposed to Mozart music, Javanese, Sundanese, Balinese gamelan and control.. Key words : Mozart, Javanese Gamelan, Sundanese Gamelan, Balinese Gamelan, Brain Deriverd Neurotrophic Factor

The Suppression Effect of Kebar Extract on Endometriosis Lesion MDA and TNF -a Independent to VEGF A Study in Endometriosis Mice Mode: Efek Supresi Ekstrak Kebar terhadap Lesi Endometriosis, MDA dan TNF-a, tidak Bergantung pada VEGF: Studi pada Model Tikus Endometriosis Yuli Trisetiyono; Noor Pramono; Syarief T. Hidayat; Widjiati Widjiati
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 1 January 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Background: The pathogenesis of endometriosis remains unclear, and involves multifactorial etiologies. The increase in oxidative stress is known to be associated with this disease. Oxidative stress increases angiogenesis and supports the proliferation of endometriosis tissue in the peritoneal cavity. Kebar grass, a medicinal plant, is expected to increase antioxidant defense resulting in decreased oxidative stress, inflammation, angiogenesis, and reduced endometrial tissue implants. Objective: To investigate the effects of Kebar grass extract administration to MDA serum levels, TNF-a and VEGF expression, and the extension of the endometriotic lesions in mice model. Methods: This study was experimentally designed. It was conducted in the Department of Obstetrics Gynecology, Faculty of Medicine Diponegoro, University and Faculty of Veterinary Medicine, Airlangga University. Twenty-one mice were divided into three groups: the first group is control of 7 untreated endometriosis mice model, the second group consisted of 7 mice injected with leuprolide acetate 1mg/kgBB single dose, and the last group consisted of 7 mice fed with Kebar grass extract 3mg/day for 14 days. MDA serum level was measured by spectrophotometry, TNF-a and VEGF expression by IHC using Rammele Scale Index (ImmunoReactive Score), whereas the extension of the endometriotic lesions was measured using computerize tracing. Results: Both Kebar grass extract and leuprolide acetate administration significantly decrease MDA serum levels in endometriosis mice model, compare with the control group, (0.09Â±0.02 nmol, 0.11Â±0.07 nmol, and 0.30Â±0.06 nmol, respectively; p=0.001). TNF-Î± expression of the group treated with Kebar grass extract was lower than leuprolide acetate and control group (2.43Â±1.521 %, 4.86Â±0.458 %, and 7.26Â±2.898 %, respectively; p=0.002). However, there was no significant difference in VEGF expression among study groups (4.34Â±2.40 %, 5.11Â±1.95 %, and 7.40Â±3.49 % respectively; p=0.116). Finally, the extension of the endometriotic lesions of the mouse models administered with Kebar grass extract and leuprolide acetate was smaller than the control group (0 mm2, 4.54Â±7.75 mm2, and 34.80Â±13.09 mm2 respectively; p=0.005). Conclusion: Kebar grass extract has the effect of decreasing MDA serum levels and reducing TNF-Î± expression, resulted in smaller endometriotic lesions in mice, even though it does not affect VEGF expression. Keywords: malondialdehyde, tumour necrosis factor alpha, vascular endothelial growth factor, endometriotic lesion, kebar grass extract, endometriosis mouse

Identifikasi Kromosom Ikan Nila (Oreochromis Niloticus) Strain Merah Jatimbulan dan Larasati yang Diambil dari Lokasi Berbeda Laksmi Sulmartiwi; Syifa Fauziyah; Widjiati Widjiati
Journal of Marine and Coastal Science Vol. 9 No. 2 (2020): June
Publisher : Universitas Airlangga

Ikan nila merah Jatimbulan dan ikan nila Larasati merupakan hasil rekayasa genetik dari dua lokasi yang berbeda. Ikan yang berasal dari lokasi yang berbeda mempunyai karakter yang berbeda karena adanya pengaruh interaksi antara genetik dan lingkungannya. Lingkungan merupakan salah satu faktor pembatas dari tiap populasi ikan dari segi morfometrik ataupun genetik. Perbedaan suhu, cahaya, nutrisi dan faktor lingkungan lain memiliki dampak perbedaan kromosom pada setiap strain ikan. Dalam upaya mendapatkan informasi mengenai hal tersebut, maka penelitian ini akan membahas bagaimana gambaran kromosom dari dua strain ikan nila merah yang dibudidayakan di lokasi yang berbeda. Penelitian ini bertujuan untuk mengetahui gambaran kromosom (jumlah kromosom, bentuk kromosom dan susunan kromosom) ikan nila merah Jatimbulan dan ikan nila Larasati. Hasil dari penelitian ini menunjukkan jumlah kromosom ikan nila merah Jatimbulan dan ikan Larasati adalah 44 pasang (2n=44). Bentuk dan susunan kromosom (karyotipe) ikan nila merah Jatimbulan adalah 4 pasang sub metasentrik, 9 pasang sub telosentrik dan 9 pasang telosentrik (4SM-9ST-9T), sedangkan kromosom dari ikan nila Larasati adalah 3 pasang sub metasentrik, 14 pasang sub telosentrik dan 5 pasang telosentrik (3SM- 14ST-5T).

PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN, DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP KEPADATAN DENDRIT DI CEREBELLUM Rattus norvegicus BARU LAHIR Ancha Ayu Amishinta; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar

Indonesia is categorized as middle humandevelopment index. One of the causes is the fluentignorance of brain growth and development during1000 days of life period. This period is the bestopportunity to give proper stimulations to increase themaximal brain growth and development. Exposure toclassical music such as Mozart, Beethoven, andChopin music can increase the wave of brain activity.During pregnancy, Mozart music is proven to increasethe dendritic density. Analyzing the difference ofdendritic density of cerebrum and cerebellum ofnewborn baby of Rattus norvegicus that are exposedto the Mozart, Beethoven, and Chopin music, and thatis not exposed to music during pregnancy. Laboratoryexperimental research, posttest-only control groupdesign. Subjects were female pregnant Rattusnorvegicus, grouped into 4 random groups: 1 controlgroup and 3 treatments groups; with 6 samples each.Subjects were super ovulated, and 65 dB intensity ofmusic was played for an hour at 20.00-21.00 on thesubjects on 10th day of pregnancy. On 20th day ofpregnancy, the mothers were dissected usingcaesarean section. 2 heaviest newborn babies ofRattus norvegicus were taken, and their brain tissueswere taken as samples. The dendritic density ofcerebrum and cerebellum were observed using GolgiCox method of silver impregnationprocedure.Statistical test concluded there weresignificant differences of dendritic density of cerebrumand cerebellum of newborn babies of Rattusnorvegicus among the exposure to Mozart,Beethoven, and Chopin music, and without theexposure to music with value of p=0,004 (<0,05) incerebrum and p=0,003 (<0,05) in cerebellum. Thedendritic density of cerebrum and cerebellum ofnewborn babies of Rattus norvegicus that wereexposed to Mozart music during pregnancy werehigher than that are exposed to Beethoven andChopin music and that were not exposed to music. Itis recommended for the next research to do furtherresearch to prove the dendritic density caused by themusical stimulation during pregnancy when Rattusnorvegicus grows up.

PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN, DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP INDEKS APOPTOSIS SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR Dessy Hidayati Fajrin; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar

The efforts that can be done to improvebrain cells in the prenatal period is the provision ofnutrients and good stimulation. Exposure to classicalmusic such as Mozart, Beethoven, and Chopinmusic can increase the wave of brain activity. Duringpregnancy, Mozart music is proven to decrease theapoptosis of neuronal.Analyzing the difference of apoptosisneuronal of cerebrum and cerebellum of newbornbaby of Rattus norvegicus that are exposed to theMozart, Beethoven, and Chopin music, and that isnot exposed to music during pregnancy.Laboratory experimental research, posttestonly control group design. Subjects were femalepregnant Rattus norvegicus, grouped into 4 randomgroups: 1 control group and 3 treatments groups;with 6 samples each. Subjects were super ovulated,and 65 dB intensity of music is played for an hour at20.00-21.00 on the subjects on 10th day ofpregnancy. On 20th day of pregnancy, the motherswas dissected using SC technique. 2 heaviestnewborn babies of Rattus norvegicus were taken.Statistical test concluded there wassignificant differences of apoptosis neuronal ofcerebellum of newborn babies of Rattus norvegicusamong the exposure to Mozart, Beethoven, andChopin music, and without the exposure to musicwith value of p=0,033 in cerebellum.In conclution, the exposure of Mozart’smusic during pregnancy perform expression ofBDNF cerebellum in the offspring-rat was higherthan exposed Beethoven’s music, Chopin and notexposed to music.

PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP JUMLAH SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR Herlina Alvianti N; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar

Efforts could be made to improve humanresources that have intelligence required apositive relationship between health and goodeducation quality, one of the efforts to improvehuman resources requires good brain qualitysince the phase of conception. Classical musichas been shown to boost brain function andhuman intellectual optimally believed to have thebest stimulating effect on babies. Cellularexposure to Mozart affects the number of moreneuronal cells. Analyze the number of cerebrumand cerebellum neuronal cells of newborn Rattusnorvegicus between the exposed to Mozart music,Beethoven, Chopin and not exposed to musicduring pregnancy. This research was anexperimental research with posttest only controlgroup design. The sample was divided into fourgroups randomly, non-exposed, Mozart musicexposure group, Beethoven music exposuregroup, Chopin music exposure group, exposed for1 hour during the night after Rattus norvegicuswas pregnant on day-10 with an intensity of 65 dBand a distance of 37 cm from the rat cage. On the20th day of the pregnant mother of Rattusnorvegicus was sacrificed and selected two ofRattus norvegicus's babies with the greatestweight and then the brains of Rattus norvegicus'sbabies were decapitated and brain dissection tocount the number of neuronal cells withHemotoxyln-Eosin staining. The statistical resultsshowed that the number of neurons of cerebellumcells in the Mozart group differed significantly fromBeethoven, Chopin and not exposed to music withp <0.05. The number of neuronal cells ofcerebellum of the newborn Rattus norvegicus whoexposed to Mozart music during pregnancyproved higher than that exposed to Beethovenmusic, Chopin and not exposed to music.

PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP EKSPRESI BRAIN DERIVED NEUROTROPHIC FACTOR DI CREBELLUM RATTUS NORVEGICUS BARU LAHIR Pitria Permatasari; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar

r 2015 was ranked 113 out of 188 countries.Education would be needed to raise HDI’s rank. Oneprinciple component of education is the quality of thebrain. BDNF expression in the brain was affected bymany stimuli. Mozart classical music had aneurobiological effect which had ability to increaseBDNF. Whereas, other classical musics such asBeethoven and Chopin had never been studied. Thisstudy aims to cerebellum’s BDNF expression in theoffspring of Rattus norvegicus that ere exposed tothe Mozart , Beethoven, Chopin during pregnancy.The method used is pure laboratoryexperiment with posttest only control group design.The variables measured were BDNF expression inthe brain. The samples were divided into 4 groups ofeach 6 rats.The results showed that significantdifferences in BDNF expressions between controlgroup and Mozart (p=0,023; p<0,05), betweenMozart group and Chopin (p=0,003). There were nostatistically detected differences between controlgroup and Beethoven (p=0,256), control group andChopin (p=0,684), Mozart group and Beethoven(p=0,092) and Beethoven group and Chopin(p=0,292). Based on the above results it can beconcluded that the exposure of Mozart’s musicduring pregnancy had a higher expression of BDNFin the offspring-rat’s cerebellum compare to thosewhich exposed by Beethoven and Chopin’s music.

Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model Laili Muninggar; Widjiati Widjiati; Indra Yuliati; Brahmana Askandar; Poedjo Hartono
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.

Co-Authors . AULANI’AM Achmad Salman Achmad Salman Faridz, Achmad Salman Achmad Yunus Adi Setyawan Prianto Agung Budianto Achmad, Agung Budianto Agus Sulistyono Agustina Hidayati Agustina Mar'atus Sholichah Agustina, Widayati Ahmad Rukhani Lutfi Alfiah Hayati Ali Madinah Ali Medina Ali Medina Aliyah, Suhartatik Amila, Ukhti Mukminah ilmi Ancha Ayu Amishinta Andita Hapsari Anike Rachmawati Anike Rachmawati Anindya Marcha Angelina Djianto Anna Surgean Veterini Annis Catur Adi Annise Proboningrat Anwar Fauzi Ardy, Carolina Arief Boediono Arimbi Askandar Tjokroprawiro Aswin, R. Haryanto Aty Widyawaruyanti Aucky Hinting Ayu Putri Yani Azami D Azinar Bambang Poernomo Bambang Purwanto Bambang Sektiari Lukiswanto Bambang Wahjuprajitno Berlina, Cyrcilia Relita Binta Dwi Novitasari Boedi Setiawan Budi I Santoso Budi Prasetyo Budi Santoso Budi Santoso Budi Santoso Budi Susetyo Pikir Budi Susetyo Pikir Budi Utomo Budi Utomo Budi Wicaksono Budi Wicaksono Chairul Anwar Darsono, Roesno Desak Ketut Ayu Aryani Desi Wulansari Desi Wulansari Dessy Hidayati Fajrin Dewita Dewita Dhesy Kartikasari Dian Sukmawati Diana Estu Rumahastuti Dina Helianti Dwi Gustin, Mandasari Dwi Nurdi Puspita Sari Dwi Puji Wijayanti Eighty M Kurniawati Eighty Mardiyan K, Eighty Eka Nasrur Maulana Eka Pramyrtha Hestianah, Eka Pramyrtha Endang Setyaningsih endra, priawasana Epy Muhammad Luqman Erma Safitri Ermawati Ermawati Erry Gumilar Dachlan, Erry Gumilar Dachlan, Erry Gumilar Exma Mu'tatal Hikmah Faizah, Zakiyatul Fauzan Djunaidi Fedik A Rantam Fedik Abdul Rantam Fitria Desky Gandul Atik Yuliani Gatut Hardianto, Gatut H.M Bahkriansyah Hamdani Lunardhi Hana Eliyani Hani Plumeriastuti Hany Aryani Puspita Hari Basuki Notobroto Hari Paraton Hariadi, Mas'ud Harry Mangasi Binsar Panjaitan Haspita Rizki Syurya Handini Hendy Hendarto HENI RACHMAWATI HERAWATI, LILIK Herlina Alvianti N Herlina Puji Angesti Hermanto Hermanto Hermanto Hermanto Hermanto T Joewono Hermanto TJ Hermanto Tri J Hermanto Tri Joewono Hermanto Tri Juwono Heru Santoso Wahito Nugroho Hidajati, Nove Hidayatullah, Amiruddin Ika WAHYUNI Imam Mustofa IMAM MUSTOFA INDRA YULIATI, INDRA Inu Mulyantoro Iwan Sahrial Hamid Jeanita, Winny Jimmy Yanur Annas Jojor Sihotang Joseph Chandra Relmasira Kartikasari, Dhesy Khasanah, Rima Nur Kuncorojakti, Suryo Kurniawati, Sepvian Dewi Kusumawardani, Emi Laba Mahaputra Laili Muninggar Laksmi Sulmartiwi Lilik Maslachah Machmudia, Ainun Mafruchati, Maslichah Masyitah Hamidah Meitria Syahadatina Noor Meles, Dewa Ketut Mikra Latisfian Mikra Latisfian Mikra Latisfian Muhammad Miftahussurur Mulyanto Mulyanto Mulyanto Mulyanto Muninggar, Laili MY Ardianta W N Cininta M Nasrul Wahdi Nenny Harijani Ngakan Made Rai Widjaja Ngakan Made Rai Widjaja Ningrum, Nyna Puspa Noor Pramono Noor Pramono Noor Pramono Noor Pramono Noerpramana Nur Anindya Syamsudi Nur AR Widiatmoko Nur Cholila Nur Laila Faizah Nurbayatin, Anita Nursadida, Milla Nurvy Alief Aidillah Nusdianto Triakoso Nyna Puspa Ningrum Oktoria Indrapraja Pardede, Sabrina Melisa Pardede, Sabrina Melisa Paulus Liben Paulus Sugianto, Paulus Permatasari, Dian Ayu Pipit Sri Estuning Rahayu Pitria Permatasari Poedjo Hartono Poetranto, Emmanuel Djoko Portia Sumarsono, Portia Pudji Srianto Rachmad Suhanda Rahadyan, Raihan Alif Rahayu, Pipit Sri Estuning Rahmaniabdi, El Roy Achmad Rao, Sherbrina Bai Seenivasa Ratriana Via Parasti Raudatul Hikmah Rehatta, Nancy Margarita Relly Yanuari Primariawan, Relly Yanuari Rimayanti R Rimayanti R, Rimayanti Rimayanti Rimayanti RINA YUDIWATI BM, RINA Risna Y, Dyah Ayu Roro Rochmah Kurnijasanti Romi Ermawan Romi Ermawan, Romi Rusyawardani, Aldis Ingrid S.Pd. M Kes I Ketut Sudiana . Salmon Charles Pardomuan Tua Siahaan Sami, Abdul Sari, Gadis Meinar Sarmanu, Sarmanu Sarudji, Suryanie Seindy Glamour Shabira, Zahra Siti Nur Kholifah Siti Nur Kholifah Siti Nur Kholifah SOETJIPTO Sofiyanti Miftakhurohmah Sri Mulyati Sri Mulyati Sri Mumpuni Sri Mumpuni Sri Pantja Madyawati Sri Pantja Madyawati, Sri Sri Pantja Madyawati, Sri Pantja Sri Ratna Dwiningsih Subijanto Marto Soedarmo Suherni Susilowati Sulistiawati Sulistiawati Sutiman Bambang Sumitro Suwarno . Suzanita Utama Syarief T. Hidayat Syarief Thaufik Hidayat Syifa Fauziyah Tias, Eriza Putri Ayu Ning Tinta Julianawati Tita Damayanti Lestari Tjuk Imam Restiadi Tri Hartini Yuliawati Tri HS Hadi Tri Purwanti Tri Wahyu Suprayogi Trilas Sardjito TRINIL SUSILOWATI Tyasningsih, Wiwiek Ukhti Mukminah ilmi Amila Varianida Veterini Virki Widoyanti Viski Fitri Hendrawan Wahyuni, Retno Sri Wicaksono, M Galih Widodo Jatim P Widya Paramita Lokapirnasari Windhu Purnomo Wiranata, Try Ardhi Wurlina, W Yaner, Nurul Ramadhani Yeni Dhamayanti Yoes Priyatna Dachlan Yudhana, Aditya Yudi Her Oktaviono Yudi Her Oktaviono, Yudi Her Yuli Trisetiyono Yulia Putri Permatasari Yulianna Puspitasari

Title

Found 105 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 105 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 105 Documents
Search