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Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids Ermi Girsang; I Nyoman Ehrich Lister; Chrismis Novalinda Ginting; Maulidwina Bethasari; Annisa Amalia; Wahyu Widowati
Molecular and Cellular Biomedical Sciences Vol 4, No 2 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1345.012 KB) | DOI: 10.21705/mcbs.v4i2.90

Abstract

Background: Skin-aging is a progressive changes in the skin combine with cumulative extrinsic factors which are mostly caused by free radicals caused by exposure to lots of free radicals molecules from pollutant, wrongly food intake, or too much sun bathing. These free radicals can be tackled by a treatment using antioxidants. Prevention of aging can be done by escalating antioxidant intake. Protocatechuic acid (PCA) and Ferulic acid (FA) have been known for their scavenging properties on free radicals and antiaging activity. Antioxidant and antiaging activity of both compounds have not been compared comprehensively before. Hence, current study was conducted to compare the potential of PCA and FA for their antioxidant and antiaging activities using various methods.Materials and Methods: Antioxidant analysis of PCA and FA was conducted using H2O2 scavenging assay, 2,2’-azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazil (DPPH), and ferric reducing antioxidant power (FRAP). Meanwhile, antiaging activities of PCA and FA were examined using inhibitory activities of tyrosinase, collagenase, elastase, hyaluronidase and tyrosinase.Results: IC50 of scavenging activity of ABTS were 125.18 µg/mL (PCA) and 35.55 µg/mL (FA), inhibition activity of collagenase were 126.16 µg/mL (PCA) and 52.85 µg/mL (FA) and inhibition activity of tyrosinase were 246.42 µg/mL (PCA), 253.58 µg/mL (FA).Conclusion: In conclusion, FA has better ABTS scavenging and collagenase inhibition activities compared to PCA. Meanwhile, PCA has better activity of tyrosinase inhibition than FA.Keywords: antioxidant, antiaging, ferulic acid, protocatechuic acid
Chemical Constituents of Snake Fruit (Salacca zalacca (Gaert.) Voss) Peel and in silico Anti-aging Analysis Ermi Girsang; I Nyoman Ehrich Lister; Chrismis Novalinda Ginting; Adrian Khu; Butter Samin; Wahyu Widowati; Satrio Wibowo; Rizal Rizal
Molecular and Cellular Biomedical Sciences Vol 3, No 2 (2019)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1926.128 KB) | DOI: 10.21705/mcbs.v3i2.80

Abstract

Background: Skin aging is a condition where skin is unable to retain both its physiological and structural integrity. Plants is the main source of phtytochemicals compound with wide range of biological activities. Through the efforts of ongoing scientific researches, an increasing number of plant extracts and phytochemicals have been showed promising result as anti-aging agent. Snake fruit (Salacca zalacca (Gaert.) Voss) is tropical plant belongs to the palm tree family (Arecaceae) that served as important crop in Indonesia. Despite its utilization, the phytochemical compound available in snake fruit, especially its peel have not been well documented. Present study aimed to elucidate the phytochemical constituent of snake fruit peel and its anti-aging potency.Materials and Methods: Snake fruit peel extract (SPE) was subjected to qualitative phytochemical assay, high performance liquid chromatography, and molecular docking towards protein related in skin aging.Results: The screening showed SPE contained phytochemical compound belong to flavonoid, tannin, phenol, triterpenoid, saponin and alkaloid. Thus, based on the analysis only chlorogenic acid was present in SPE whilst rutin and caffeic acid were not detected. The SPE was contained chlorogenic acid around 1.074 mg/g dry weight. Chlorogenic acid had the high binding affinity towards matrix metalloproteinase (MMP)-1 (-9.4 kcal/mol).Conclusion: Current findings may provide scientific evidence for possible usage of SPE and its compounds as antioxidant and anti-aging agent.Keywords: Salacca zalacca, phytochemical compound, high performance liquid chromatography, anti-aging
An Evaluation of Waste Implementation of Poly Clinic's Outstanding Services with Blueprint Service to Reduce Waiting Time on Kisaran Asahan District Dwi Astuti Manullang; Chrismis Novalinda Ginting; Sri Wahyuni Nasution; Gusbakti Rusip; Mangatas Silaen
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 3 (2022): Budapest International Research and Critics Institute August: In Progress
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.5911

Abstract

The quality of health services provided to patients should be observed and addressed as well as possible so that patients as hospital customers can be loyal/loyal to the hospital. In this study, one aspect that needs to be improved is the outpatient service aspect. The outpatient unit is the patient's entry gate to the hospital in addition to the emergency unit. Outpatient visits exceed emergency department visits. The tendency of the community towards polyclinic services is increasing to get practical treatment services that come once and on that day also get complete services (one daycare) (Dewi et al., 2020) Installation of care in the hospital consists of installations inpatient, and outpatient. Outpatient installation is a service used by doctors as a place for consultation, examination, and treatment of patients who require a short time (Ministry of Health, 2012).
An Effect Health Promotion on Acceptance of Covid-19 Vaccine in Communities in the Work Area Sidangkal Puskesmas, Padang Sidempuan Selatan Nerissa Nasriza; Santy Deasy Siregar; Chrismis Novalinda Ginting
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 3 (2022): Budapest International Research and Critics Institute August: In Progress
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.5905

Abstract

Health Promotion is an effort to improve the community's ability to control health factors through learning from by, for, and with the community, so that they can help themselves, and develop community-based activities, according to local socio-cultural and supported by insightful public policies. The purpose of the study was to determine the effect of health promotion on the acceptance of the covid-19 vaccine in the community in the working area of the Sessionkal Public Health Center in 2021. The research used is research that uses a descriptive method with a qualitative approach. The research was conducted in the working area of the Sessionkal Public Health Center in 2021 with 7 core informants. The results of interviews with informants are still many who have not done the covid-19 vaccine. Informants' lack of knowledge about the covid-19 vaccine, lack of promotional media, a lot of slanted news about the covid-19 vaccine, and the lack of health worker outreach activities to the people of South Padangsidempuan. The results showed that there was no effect of health promotion using various promotional media on the acceptance of the covid-19 vaccine in the community in the working area of the Sessionkal Health Center.
Comparison of Antioxidant and Anti-collagenase Activity of Genistein and Epicatechin Geeta,; Widodo, Wahyu Setia; Widowati, Wahyu; Ginting, Chrismis Novalinda; Lister, I Nyoman Ehrich; Armansyah, Adek; Girsang, Ermi
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Skin aging is a complex natural process caused by both intrinsic or genetically programmed aging and extrinsic aging caused by environmental factors, such as free radical. The use of antioxidant and anti-collagenase to prevent the aging proses has been known. Natural compounds from plants are one of the sources of antioxidant and anti-collagenase that has ability to prevent aging. Genistein and Epicatechin are the major phenolic compound found in G. max. Objectives: This research was to evaluate the antiaging potential of genistein and epicatechin through antioxidant activity assay (ABTS-reducing activity assay) and collagenase inhibitory activity assay. Methods: Antioxidant analysis of Genistein and Epicatechin was performed by 2,2’- azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS) reducing activity Assay. Antiaging assay was conducted through inhibitory of collagenase, one of important enzyme in aging process. Results: ABTS- reducing activity assay showed that both compounds had great ABTS-reducing activity in which epicatechin had better activity than genistein. Epicatechin had low value of IC50 ABTS-reducing activity around 14.39 µg/ml better than genistein with IC50 about 43.17 µg/ml. In terms of collagenase inhibitory activity assay, epicatechin had lower value of IC50 (9.08+-3.46 ug/ml), better than genistein (98.74+-4.25 ug/ml). Conclusion: Epicatechin had higher antioxidant and anti- collagenase activity compared to Genistein.
Antioxidant and Elastase Inhibitor Potential of Petals and Receptacle of Rose Flower (Rosa damascena) Mawarni, Evi; Ginting, Chrismis Novalinda; Chiuman, Linda; Girsang, Ermi; Handayani, Rr. Anisa Siwianti; Widowati, Wahyu
Pharmaceutical Sciences and Research Vol. 7, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Free radicals can cause damage to cells or tissues, autoimmune diseases, degenerative diseases, or cancer. Therefore, the body needs important substances, namely antioxidants that can help protect the body by reducing negative effect from free radicals. Rose flower (Rosa damascena) has anthocyanin pigment which belongs to flavonoid group which has a function as antioxidant or free radical scavenger. This study aims to determine antioxidant and anti-elastase potentials of rose petals and receptacles. The method used in this study was a qualitative phytochemical test to determine the compounds contained in the Rose Petal Extract (RPE) and Rose Receptacle Extract (RRE), ABTS ((2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid))-reducing assay to determine antioxidant activity, and antiaging test with anti-elastase assay. RPE and RRE contained flavonoids, phenols, tannins and alkaloids, but did not contain saponins. RPE contained triterpenoids and terpenoids, while RRE contained steroids, but did not contain terpenoids. The inhibitory concentration (IC50) values in the ABTS reducing assay were 4.46 ± 0.34 μg/mL (RPE) and 15.49 ± 0.23 μg/mL (RRE), while the results of the anti-elastase assay were 17.51 ± 1.47 μg/mL (RPE) and 58.91 ± 2.31 μg/mL (RRE). Both RPE and RRE are potent antioxidant and anti-elastase, and RPE is more active than RRE in these assays.
Effectiveness Of Incision Wound Healing Of Pandanus Amaryllifolius Roxb In Wistar Rats Muna Soraya Putri; Ermi Girsang; Linda Chiuman; Chrismis Novalinda Ginting
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 2 (2022): May 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (747.609 KB) | DOI: 10.51601/ijhp.v2i2.33

Abstract

The incision is a condition of tissue discontinuity that is commonly encountered with the risk of prolonged healing time, imperfect wound healing, infection, etc. Assessment of the wound healing activity of the incision is the purpose of this research, which includes an examination of wound contraction, the thickness of collagen fibers, and the number of new blood vessels formation. In total, 25 rats will be divided into 5 test groups, each consisting of 5 rats; the control group (cream base treated), standard group (Povidone Iodine), followed by the treated group with 10%, 20%, and 30% pandan leaf extract ointment. The preliminary screening of phytochemical analysisshowed the presence of alkaloids, saponins, flavonoids, tannins, triterpenoids, and steroids and glycosides, with the total content of phenols and flavonoids from the ethanolic extract of Pandan Wangi is 20.95 GAE mg/gram extract, and 23.57 TAE mg/gram extract. Wound contraction examination result showed a significant difference between the treatment groups on day 16 and a sign the pairs of groups after being given the ointment with each concentration (p <0.05), especially in the group with 30% fragrant leaves extract and the standard group. Examination of new blood vessels showed a significant difference (p <0.05), especially with 30% of the leaves extract ointment. There was also a significant difference in collagen density in the group given pandanus ethanol ointment, especially at the 30% pandanus extract content against the group that was only given the ointment base. This research strongly suggests that the fragrant pandan leaf extract ointment is effective in healing incisional wounds and promises the potential for further studies on the pharmacological aspects.
An Evaluation of Factors Related to the Implementation Code Blue System in the Inpatient Room of Hospital Medical Partner Bandar Klippa Arna Fransisca Mp; Chrismis Novalinda Ginting; Sri Wahyuni Nasution; Ali Napiah Nasution
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 3 (2022): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.6604

Abstract

Implementation of the Code Blue System in the Hospital Inpatient Room. Mitra Medika Bandar Klippa is still being found. Constraints that occur are related to human resources (HR), facilities, response time, and Standard Operating Procedures (SPO). This study aims to determine the factors related to the implementation of the Code Blue System in the Hospital Inpatient Room. Mitra Medika Bandar Klippa. The type of research used is descriptive qualitative research with a phenomenological approach. The population in this study was the entire Code Blue team in the Hospital Inpatient Room. Mitra Medika Bandar Klippa and a sample of 9 people. Collecting data with primary and secondary data and analyzed by three interrelated sub-processes, namely data reduction, data display, and conclusion drawing/verification. The results showed that Human Resources (HR), facilities, response time, and Standard Operating Procedures (SPO) were related to the implementation of the Code Blue System at Mitra Medika Hospital Bandar Klippa. The response time factor that is not always on time is due to the distance of the room being too far and the busyness in the ER/ICU at the same time as the code blue activation incident.                                           
An Analysis of Quality Services on Patient Satisfaction Outside at Putri Bidadari Hospital Stabat Langkat Regency Ramadhan Efendi; Ermi Girsang; Ali Napiah Nasution; Chrismis Novalinda Ginting
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 3 (2022): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.6999

Abstract

The purpose of the study was to determine the difference in service quality based on patient safety, effectiveness and efficiency, and patient orientation, as well as patient satisfaction between patients using BPJS and the general public. The study was conducted by as many as 60 respondents consisting of 30 BPJS patients and 30 general patients in out patient care for Hospitsl Putri Bidadari Stabat, Langkat Regency. Analysis of the data used is the independent t-test and then analyzed the effect of the independent variables on the dependent using multiple regression analysis. The results showed that there were significant differences in service quality based on patient safety, effectiveness and efficiency, and patient orientation, as well as patient satisfaction among patients using BPJS and the general public, as well as the influence between patient safety, effectiveness and efficiency, and patient-oriented variables on patient satisfaction. From the results of these equations, it is known that the three independent variables, namely patient safety, effectiveness and efficiency, and patient-oriented services have a positive effect on customer satisfaction. This means that if patient safety, effectiveness and efficiency, and patient-oriented services, the higher patient satisfaction.
An Application of Activity Based Costing Method as Alternative in Determination Hospital Appendictomic Prices the True Partner of Medan Year 2020 Ali Napiah Nasution; Chrismis Novalinda Ginting; Frederick Frederick; Chandra Wilim
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 3 (2022): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.6603

Abstract

The main difference between the traditional system and the activity-based costing system lies in the number of cost drivers used, in determining the cost of goods, the activity-based costing system uses more cost drivers compared to the traditional cost system which only uses one cost driver. by unit. Activity-based costing (ABC) is estimated to be more efficient in determining hospital rates. The purpose of this study was to determine the application of the activity-based costing method as an alternative in determining appendectomy rates at Mitra Sejati Hospital Medan in 2020. This study was quantitative descriptive, the population of this study was all data and files in cases of patients with acute appendicitis at Mitra Sejati Hospital. Medan Year 2020. The results showed that the unit cost of an appendectomy at Mitra Sejati General Hospital Medan using the activity-based costing method was Rp. 21,763,871.7. There is a difference in the cost of appendectomy with the unit cost using the activity-based costing method and by using real cost calculations at Mitra Sejati General Hospital Medan in 2020 with a cost difference of Rp. 2,647.034.7 There is a difference in the cost of appendectomy with the unit cost using the activity-based costing method and by using real cost calculations at Mitra Sejati General Hospital Medan in 2020 with a cost difference of Rp. 2,647.034.7.
Co-Authors Ade Irma Suryani Adek Amansyah Adrian Adrian Adrian Adrian Agatha, Yuti Paramitha Ahmad Faried Alya Mardhotillah Azizah Anditha, Arie Tika Andre, Johannes Anggraini, Jenny Anggraini, Livia Anggraini, Suhelis ANGGREINI, DEVINA Anggriani H, Theresia Angnes, Odri ANITA SARI, DEVI Annisa Amalia Anton Timur Jailani Harahap Aprilia, Shefira Aritonang, Murni Armansyah, Adek Arna Fransisca Mp Astari, Nur Aulia, Makrifatul Aulia, Rumi Awaluddin Ziad Azah, Yunita Wannur Bangun, Chrismas Gideon Bangun, Primta Bawean, Popi Latifah Br Kaban, Karmila Butter Samin Buulolo, Sukriston Calvin, David Chandra Wilim Chintya Darma, Gladys Chiuman , Linda Chiuman, Linda Chiuman, Veranyca Daniel Prem Raj Pandid Datitha Alodia Br Kaban, Karina Dewi Riastawati DEWI SARTIKA Dewi Sartika Dewi, Silvi Tiara Diana Krisanti Jasaputra Duha, Sonya Marsela Pieta Dwi Astuti Manullang Dwight Mahaputera Marulitua Hutapea Edy Fachrial Eliani, Eliani Elis Anggeria Emilia Laia, Maria Erika Erika Ermi Girsang Ermi Girsang Ernes, Audrina Eva Latifah Nurhayati Fadhilla, Jeni Putri Fentia, Lia Ferdinand, Sahna Feri irawan Fiska Maya Wardhani Frederick Frederick gan, claris cyntha deninta Geeta, Ginting, Astriani Natalia Br Ginting, Sahna Ferdinand Girsang, Ermi Guk Guk, Marissa Hardayati Br Raja Gultom, Hanawita Gultom, Yohania Premita Gusbakti Rusip Hafifah Hafifah Halim, Michael Handayani, Rr. Anisa Siwianti Handoko, Erwin Handriani, Wita Hanna Sari Widya Kusuma Harahap, Viora Rezky Harmileni Hasibuan, Nasyidah Hannum Hasya, Muhammad Nawal Hermansyah, Mhd. Farhans Hia, Arman Hondo, Alfarikus Hsb, Khairiyani Asri Hutabarat, Yohana Candra Andini I Nyoman Ehrich Lister I Nyoman Ehrich Lister IKHTIARI, REFI Iksen, Iksen Irwan Irwan irza Haicha Pratama Johannes Bastira Ginting Kartika, amalia Laurenxius, Vanessa Sinana Linda Chiuman Lister, I Nyoman Ehrich Lister, I Nyoman Ehrich Lister, Nyoman Ehrich Lumbanraja, Dhea Rebeca Lumbantobing, Salomo Lydia Ernawati Rahayu Makdalena, Makdalena Manalu, Andika Prianto Mangatas Silaen Manik, Rayani Manurung, Grace Nathasya Mariana Mariana Masryna Siagian Maswarni Matondang, Windri Mutiara Maulidwina Bethasari Mawarni, Evi Mendrofa, Gusmina Mendrofa, Leli Angelita Mendrofa, Trisman Basri Mendrofa, Tuho Konsultasi Merrina Arts, Tricya Mucmaini, Rica Muhammad Hidayat Muna Soraya Putri Murni, Faradila Mustika, Rani Mutia, Maya Sari Nabila, Siti Napiah, Ali Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Nasution, Sri Lestari Ramadhani Nasution, Sriwahyuni Nella Vista Purba, Agnes Nerissa Nasriza Noflita, Noflita Noviawati Noviawati Nurhayati, Evalatifah Oni Fatmala, Cut Panggabean, Dini Desita Panjaitan, Dian Permata Khaira, Azzuhra Pesta Ria, Anna Maria Pinem, Sabriela Br Piska, Finna Pulungan, Ica Yulianti Purba, Deborah Angelin Puspita, Nadia Enjelika Putranto Manalu Rahanum, Dewi Rahayu Rahayu Rahmadani, Rani Raif, Martinus Ahmad Ramadhan Efendi Rapael Ginting Razoki, Razoki Rica Tri Septinora Rizal Rizal Rizky, Muhammad Irvan Rosari, Anita Rotua, Margaretia Yenni Sahna Ferdinand Ginting Sahna Ferdinand Ginting Santy Deasy Siregar saragih, jean Sari, Laura Kartika Satri, Endah Juni Satrio Wibowo Sembiring, Lidia Henni Siagian, Masryna Siahaan, Destri Safhira Siahaan, Nurisa Tri Ayu Sianturi, Reksaudi Sihombing, Bungaran Sihombing, Nadia Deva Sihura, Belinda Putri E. Silaen, Mangatas Simanungkalit, Jeny Angelica Karolina Sinaga, Widya Oktaviani Siregar, Reza Arfan Siti Hardianti, Siti Sri Mulyati Sri Ulina, Evita Sri Wahyuni, Devi Subangkit, Mawar SUHARTOMI . Sunarti Suriani Suriani Suyono, Tan Syahputra, Hariyadi Dharmawan Syahrian, Muhammad Faridz Telaumbanua, Rizky Anditino Teresa Liliana Wargasetia The Fransiska Eltania Tiarnida Nababan Tjiawi, Midoro Tobing, Madeline Angeline Tresun Br Turnip, Malna Umar, William Vera Estefania Kaban vera vera, vera Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wardhani, Fiska Maya Wau, Herbert Widodo, Wahyu Setia Widya Yanti Sihotang Widyastari, Elisa Wienaldi, Wienaldi Wijaya, Johanna Fransiska Wijaya, Winny Winda Sari Yanti, Ratmi Yolanda Eliza Putri Lubis Yuliansyah, Jeri Yulita, Emi Yulizal, Ok Yusmaini, Yusmaini Zamili, Effendi Zebua, Sawato Zendrato, Desi Haryanti Zerry All Vindo Tarigan