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Pengaruh Usia dan Dosis Terhadap Efek Samping Penggunaan Metformin pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan dan Rawat Inap Purwoko, Bambang; Chasanah, Uswatun
Jurnal Farmasetis Vol 13 No 2 (2024): Jurnal Farmasetis: Mei 2024
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/far.v13i2.2261

Abstract

Pengelolaan Metformin adalah pilihan pertama untuk agen hipoglikemik oral dan sering dikaitkan dengan reaksi obat yang merugikan (ROM) karena efek samping gastrointestinal seperti diare, mual, muntah, dan perut kembung. Efek samping tersebut dapat dipengaruhi oleh usia, dosis, dan cara penggunaan metformin. Tujuan dari penelitian ini untuk mengetahui hubungan antara faktor usia dan dosis terhadap efek samping metformin pada pasien Diabetes Melitus Tipe 2 di RSUD Cilacap. Penelitian ini merupakan penelitian non-eksperimental dengan menggunakan metode cross sectional. Teknik pengambilan sampel secara purposive sampling dengan sampel sebanyak 96 responden yang memenuhi kriteria inklusi. Pengambilan data dilakukan secara retrospektif dari data rekam medis pasien dan wawancara dengan pasien. Hasil penelitian ini menunjukan bahwa karakteristik responden yang memiliki penyakit DMT2 tertinggi adalah pada jenis kelamin perempuan sebesar (55,21%), umur 56-65 tahun sebesar (42,71%), pendidikan SD sebesar (36,46%), dan pekerjaan IRT sebesar (38,54%). Analisis uji chi square tabel 2x2 digunakan untuk menghubungkan dua variabel. Variabel dari penelitian ini adalah usia, dosis, dan terjadinya efek samping penggunaan metformin. Hasil uji chi square menunjukan dosis metformin berpengaruh terhadap risiko efek samping penggunaan metformin dimana nilai (p<0,05) sedangkan faktor usia tidak berpengaruh terhadap efek samping penggunaan obat metformin dengan nilai (p>0,05). Penggunaan metformin dianjurkan diminum sesudah makan dengan dosis awal rendah untuk mengurangi dan menghindari terjadinya efek samping mual dan perut kembung pada penderita diabetes melitus tipe 2.
Dampak Inovasi Produk dan Digital Marketing Pada Pertumbuhan UMKM: Studi Kasus di Sektor Industri Kreatif Fatkhan, Regita Amalia; Chasanah, Uswatun
Socius: Jurnal Penelitian Ilmu-Ilmu Sosial Vol 1, No 12 (2024): July
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.13120398

Abstract

The purpose of this study is to analyze the relationship between product innovation and the expansion of MSMEs in the creative industries through the use of digital marketing strategies. This qualitative study seeks to understand micro, small, and medium-sized enterprises (MSMEs) in the creative sector, their challenges, the impact of digital technology, and the creative approaches they use. This study's findings highlight the significance of e-commerce, data-based decision-making, cooperation, and customer experience as drivers of growth for micro, small, and medium-sized enterprises (MSMEs) in the creative sector. Further, small and medium-sized enterprises (SMEs) in the creative sector might obtain an edge over their competitors by adopting a business innovation strategy and producing one-of-a-kind, new goods and services. New goods and services may be created by MSMEs via the use of digital technology. This can help organizations stay relevant in the market and respond to shifting customer preferences.
Pengaruh Brand Ambassador, Brand Image dan Kehalalan Produk Skincare Terhadap Minat Beli Mahasiswi Universitas Sunan Giri Surabaya Rahmawati, Devi Sinta; Chasanah, Uswatun
Madani: Jurnal Ilmiah Multidisiplin Vol 2, No 9 (2024): September
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.13756750

Abstract

Purchase interest is consumer behavior where consumers have a desire to choose and consume a product. As an Indonesian society whose majority population is Muslim, it is obligatory to know the halal and haram of a product to be consumed, especially in the beauty/skincare sector. Therefore, this study aims to determine which one influences consumers, especially female students, more towards purchase interest. Do female students see it in terms of Brand Ambassador, Brand Image or see it in terms of the Halalness of the skincare product. In this study, the approach taken by the researcher is quantitative research and uses statistical formulas to be able to analyze the data and facts obtained. With samples taken from female students of Sunan Giri University Surabaya as many as 85 respondents using probability sampling techniques, namely random sampling techniques distributed via google form. The results of data processing carried out by the researcher are that Brand Image and Brand Ambassador have a more significant influence on purchase interest. While the halalness of skincare products does not affect purchase interest
MENINGKATKAN USAHA MIKRO KECIL DAN MENENGAH (UMKM) MELALUI FINTECH SYARIAH PEER TO PEER LENDING : MEKANISME, PELUANG DAN TANTANGAN Jannah, Zahrotul; Agustin, Rizki; Chasanah, Uswatun
ESA : JURNAL KAJIAN EKONOMI SYARIAH Vol 6 No 2 (2024): AGUSTUS
Publisher : SEKOLAH TINGGI ILMU SYARIAH ABU ZAIRI BONDOWOSO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58293/esa.v6i2.100

Abstract

Abstrak Pentingnya peran fintech syariah tidak hanya terbatas pada pengelolaan keuangan, namun membawa dampak positif dalam mendukung kewirausahaan dan Usaha Mikro Kecil dan Menengah (UMKM) yang mengacu pada nilai-nilai syariah. Hal ini membuka peluang yang luas untuk pengembangan sektor UMKM yang memiliki peran sentral dalam perekonomian. Fintech syariah Peer to Peer Lending memiliki peluang yang besar dalam membantu perekonomian negara misalnya Indonesia yang mayoritas penduduknya adalah Muslim. Namun, seiring dengan peluang besar yang dimiliki fintech syariah Peer to Peer Lending, muncul pula beberapa tantangan yang harus dihadapi seperti masih banyak masyarakat yang belum mengetahui bagaimanan mekanisme dari fintech syariah Peer to Peer Lending. Berdasarkan permasalahan tersebut, maka penelitian ini bertujuan untuk mengetahui bagaimana mekanisme, peluang dan tantangan yang harus dihadapi fintech syariah Peer to Peer Lending.  Penelitian pada artikel ini menggunakan metode studi pustaka (library research). Hasil penelitian menujukkan bahwa terdapat peluang dan tantangan yang harus dihadapi fintech syariah Peer to Peer Lending, diantaranya agama, regulasi, literasi, keamanan, persaingan antar kompetitor, sumber daya manusia, dan infrastruktur. Adapun mekanisme fintech syariah Peer to Peer Lending yang terdiri dari tiga subyek hukum, yaitu penyelengara, penerima pembiayaan dan pemberi pembiayaan. Kata Kunci: UMKM, Fintech syariah P2P Lending, Mekanisme, Peluang, Tantangan
An Evaluation of Students’ Readiness to Use E-learning Media in the MBKM Program Humairah, Humairah; Chasanah, Uswatun; Handoyo, Eko
Jurnal Basicedu Vol. 6 No. 3 (2022)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/basicedu.v6i3.2388

Abstract

This study aimed to prepare the readiness of students to use E-learning media in the MBKM (Freedom to Learn – Independent Campus) program at the Faculty of Science, Technology and Education. This was an evaluation research with a quantitative research approach and descriptive method. The data collection technique used lecturer and student questionnaires based on the CIPP evaluation model (context, input, process, product). The samples were 98 students. The results indicated that in terms of readiness and understanding of E-learning-based learning management, the lecturers were included in the high category with a percentage of 87.78%. The score obtained by students based on the understanding of E-learning-based learning was included in the high category with a percentage of 82.16%. The results of the questionnaire showed that the E-learning-based learning activities were carried out well (structured, according to schedule and coordinated).
IMPLEMENTATION OF THE KURIKULUM MERDEKA IN NATURAL AND SOCIAL SCIENCE LEARNING TO STRENGTHEN ELEMENTARY STUDENTS' INDEPENDENCE Fatonah, Siti; Chasanah, Uswatun; Lusiana, Lusiana
Al-Bidayah : Jurnal Pendidikan Dasar Islam Vol. 15 No. 2 (2023): Al-Bidayah : jurnal pendidikan dasar Islam
Publisher : UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/albidayah.v15i2.845

Abstract

The school curriculum in Indonesia is constantly changing. It is currently a transitional period between the 2013 curriculum and the Kurikulum Merdeka. This study aims to analyze the implementation of the Kurikulum Merdeka in science learning to strengthen the learning independence of grade 4 elementary students. This research used a descriptive qualitative approach. The subjects in this study were the grade 4 teacher and students at Muhammadiyah Elementary School (MES) Kadisoka Yogyakarta. The data collection techniques used were interviews, observation, and documentation. The data analysis technique in this study used the data condensation, data display, and conclusion. The results of this study indicate that MES Kadisoka uses the Kurikulum Merdeka, but it has not been implemented in all classes, only in grade 1 and grade 4, whereas other classes are still implementing the 2013 Curriculum; Science learning seeks to provide understanding to students of how to identify various problems and find solutions to achieve a sustainable learning goal of training students' independence. Natural and social sciences aim to train students to think critically, have high curiosity, and try to realize the Project of Pancasila Student Profile Strengthening (PPSPS) in the Kurikulum Merdeka; The teacher's role in science learning is not only teaching and educating but also being a facilitator and evaluator, providing guidance, and encouraging creativity to maximize students' abilities.
Formulation of Serum Using a Combination of Tamanu Oil and Tea Tree Oil as Antiacne Ermawati, Dian; Cahyani, Pradina Zustrian; Shahnaz, Ifa; Juniarty, Amelya; Mahardhika, Chandra Leony; Chasanah, Uswatun
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6570

Abstract

Acne is a chronic inflammation of the skin caused by bacteria. Tamanu oil contains neoflavonoids and tea tree oil contains terpenes-4-ol, both of which have good antibacterial agents. The combination of Tamanu oil and tea tree oil will produce a preparation synergistic in inhibiting bacterial growth. This study was to determine the best formula for serum preparations with good characteristics and stability against bacteria without irritating the skin. Serum formulation in three different concentrations of Tamanu oil is 0.5%, 0.75%, and 1%, each combined with 2% tea tree oil. Then the characteristics test (organoleptic, homogeneity, viscosity, dispersibility, and pH), stability test (organoleptic, homogenous, and pH) using cyclic temperature stress testing, and antibacterial test against Staphylococcus aureus and Propionibacterium acnes using well-diffusion method and irritation test using Hen’s egg test chorioallantoic membrane (HET-CAM) were carried out. The results showed that the overall viscosity, spreadability, and pH matched the specification, were stable, and had no irritation effect. Serum formulation containing Tamanu oil 1% and tea tree oil 2% is the best antibacterial activity which zones inhibition of 12.5 mm on Propionibacterium acnes and 11.6 mm on Staphylococcus aureus.
A Study progress on moringa seed oil with microemulsion: bibliometrics analysis of year 2012-2023 chasanah, Uswatun; Lalu Muhammad Irham; Nining Sugihartini; Sapto Yuliani
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 1 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i1.28978

Abstract

Transdermal drug delivery systems increase the effectiveness of a drug substance, and one of them is a microemulsion. Moringa oil has anti-inflammatory, antioxidant, and antibacterial activity. The purpose of this study is to conduct a bibliometric analysis research on moringa oil formulated as microemulsions. A total of 5 English articles from the Scopus databases from 2012 to 2023 US sources were used in the bibliometrics analysis of Moringa oleifera seeds oil related to microemulsions. The bibliometrics analysis shows research trends, including the most used keywords depicted in visualizations using the VOSViewer application, article publishers, affiliations, and the author's country of origin. The most used keywords are microemulsions, microemulsion, Moringa oleifera, antioxidant activities, and antioxidants. The most publishers are Key Engineering Materials, the most affiliated are Chiang Mai University and Thamasat University, and most authors are from Thailand. The study of microemulsion formulations of Moringa seed oil has yet to be widely carried out but has been cited by other researchers.
Development microemulsion formulation combination of citronella and red ginger essential oil Chasanah, Uswatun; Wardhani, Ellen Kusuma; Ermawati, Dian
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 2 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i2.35039

Abstract

Acne vulgaris is a skin health problem. Citronella oil contains citronellal, geraniol, geranial, β-citronellol, and neral, which have antibacterial properties. Meanwhile, red ginger oil contains gingerol, which has anti-inflammatory properties. These two ingredients are suitable for treating acne vulgaris. The aim of this study are to develop microemulsion formulation combination of citronella and red ginger essential oil. In this experimental study, a microemulsion combination of citronella essential oil and red ginger essential oil was made using Tween 80 as a surfactant and Transcutol® as a co-surfactant, with variations of S-mix (surfactant:cosurfactant) of 3:3, 4:2, and 4.5:1.5 ratios. As an oil carrier, isopropyl myristate is used. The microemulsions are formulated using a titration method. The microemulsion was then tested for characteristics and stability. The results show that the most optimal microemulsion formula was obtained with an S-mix ratio of 4:2 with a globule size of 21.64 nm, a Polydispersion Index of 0.15, and a zeta potential of -3.82. Its pH and viscosity meet the required specifications and are stable.
Characterisation and Antibacterial Activity of Green Tea Extract-Enriched Solid Goat’s Milk Soap Chasanah, Uswatun; Ermawati, Dian; Utami, Dwi Putri; Hayati, Angela Nora
Pharmaceutical Sciences and Research Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Solid goat’s milk soap is organic and beneficial for the health and appearance of the skin. One of the components in green tea known to display antibacterial activities is epigallocatechin gallate (ECGC). In this study, the effects of solid goat’s milk soap containing 1%, 2%, and 4% green tea extract on the growth of Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis were examined. The soap was characterized for its organoleptic, pH, free fatty acid, alkalinity, water content, foam stability, and hardness. In addition, an in vitro antimicrobial test was performed utilising the well-diffusion method. The findings revealed that all the soap formulas matched the SNI 3533-2016 standards for water content, free fatty acid content, and free alkali content, and that they also had similar pH, foam stability, and hardness. The solid goat’s milk soap showed antibacterial activities against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, but the effect of the green tea extract on the soap did not increase these.
Co-Authors Abdul Majid Abdul Rochman Abror, Sirojuddin Adrian, Firman Ardi Afandi, Nihro Afifah, Rahayu Nur AFIFI MUTIARANI Agil Dzikrullah, Ach. Agung Prabowo Agung Trisnawa, Vindy Agus Triyono Agustin, Rizki Agustina, Isnaeni Ahmala, Majidatun Ahyar Ismail Aini, Dewi Nur Aisyah, Mutiara Akhmad Fauzi Alfatiyah, Rini Ali Murtadho Ali, Ramsah Alihan Satra, Alihan Aliyah, Nelud Darajaatul Amiruddin, Muh Amrullah, A. Afif Amrullah, Ahmad Afif Ananta, Aldan Dwi Andani, Herika Juli Andi Prastowo Andriani, Vifi Anggelina, Riska Arif Rachman Putra Asih, Ria Arista Asmaul Lutfi Marufah Aulia, Hani Ridha Auliyah, Khusnul Ayuningrum, Firda Azizah, Salma Nur Bambang Purwoko Bambang Purwoko BR Ginting, Alifa Humairah Budiningsih, Tri Hastuti Cahyani, Pradina Zustrian Dahniar, Tedi Damat, Damat Daraini, Nur Sa’adatut Devi Dwi Siskawardani Dian Ermawati Didit Darmawan Dyah Fajarsari Dyah Rahmasari Eko Handoyo El Gufri, Lutfi Mushonif Eli Masnawati Elyta, Erminda Katon Emawati, Sita ENDANG PURBANINGRUM Endarwati, Tri Marya Erik Aditia Ismaya Erna Yayuk Esti Hendradi Fadilah, Maulidia Ilham Faizah, Dian Nur Fajar, Rizki Nur Fatkhan, Regita Amalia Fikri Imadudin, Muhammad Firmansyah , Muhibuddin Fitria Prabandari Gerry Anugrah Dwiputra, Gerry Anugrah Ghozali, Solchan Halim, Muhammad Abi Sofian Abdul Handjani, Hany Hariani, Mila Haris , Abdul Haryadi, Madep Hasanah Setyowati Hawa, Alifya Nur Hayati, Angela Nora Hayati, Feb Amni Hidayah, Ian Fii Barril Humairah Humairah Ida Zahara Adibah, Ida Zahara Imam Mawardi Imam Sofi’i Imaniar Purbasari Irsalina, Siti Isbir, Moh. Ismah, Khoirul Issalillah, Fayola Istiningsih, Istiningsih JANNAH, ZAHROTUL Jauharoti Alfin Juhaeni Juhaeni Juhaeni, Juhaeni juhaeri, Juhaeri Junaidi.S , Agus Juniarty, Amelya Juraifa, Syalwa Anindya Juwanti, Risma Diah Kencana, Putri Nilam Khayru, Rafadi Khan Khoiriyatin, Vilda Zahrotul Kurniati, Edy Dwi Kurniyawati, Shobiroh Ulfa Kusmayati, Nindya Kartika Kustriyani, Menik Kusuma, Elmia Nidha Nata LAILY PURNAWATI, LAILY Lalu Muhammad Irham Latifatun, Latifatun Lidia Lilik Wahyuni P Lukia Zuraida Lusiana Lusiana Machfud, Nailul Ulah Al Chumairoh Madlazim, M Mahardata, W. Dika Pradana Mahardhika, Chandra Leony Makhillah, Makhillah Makhyaruddin, Makhyaruddin Marufah, Asmaul Lutfi Maspupah, Ima Mathori, Muhammad Mayasari , Fransiska Dian Maylina Ilhami Khurniyati Meidawati, Neni Mohammad Syaifuddin Muchlisin, M. Artabah Mudasetia Hamid Mufatihatut Taubah, Mufatihatut Muhayarotun, Siti Muktamar Cholifah Aisiyah Mulawarman Mulawarman Munadjat, Baliyah Munawir Munawir Mutiuddin, Ach. Muhandis Muzizah, Lita Fitroh Ardianti Nabila, Aisya Safira Nasikhah, Atiun Nasrul Fuad Erfansyah Nia Shohaya, Jihan Nikmah, Uswatun Ningsih, Utami Nining Sugihartini Nisrina, Khalda Novita Sari Novitasari, Tharisma Noviyanti, Iis Nugroho, Haris Dwi Nur ‘Azah Nurfauziya, Ahada nursoleh, nursoleh Nursyifa, Aulia Nurwijayanti Nur’aini, Fitri Octavia, Devi Ristian Otari, Widiati Hairina Pamungkas, Puthut Rakyan Pangestu, Dimas Prayogo Permatasari, Ayudya Rizky Prasetiyo, Didit Eko Prasetyo, Agung Slamet Priharyanti Wulandari, Priharyanti Priyanto Priyanto Priyastiwi, Priyastiwi Purwoko Purwoko Puspita Zahra, Mayang Putri Rizki Amalia, Putri Rizki Putri Yunita, Putri Putri, Dyah Puspitasari Sunaryo Putri, Millenia Yulanda Putri, Sakia Amanda Deviana Raditya Weka Nugraheni Rahayu Mardikaningsih Rahayu, Afiyah Wildah Rahayu, Utami Rahma Suci, Tiara Rahmawati, Devi Sinta Ramdhani, Aris Nur Ratifah . Ridho Kamal, Muhammad Rizki Amalia Kinanthi, Imas Rosidi, Ayep ROUDLOTUL JANNAH Ruhansah, Vina Inayati Sabrina, Salwa Safaruddin Safaruddin Safira, Mirza Elmy Sahrupi, Sahrupi Salsabila, Zuha Prisma Sapto Yuliani Sapto Yuliani Sari, Cindy Kartika Seno Nurrohman, Aryo Septiana, Ervina Sermi, Sermi Setyaningsih, Reni Shahnaz, Ifa Shofiyah, Roidatus Sidqi Nurmida, Ahmad Sihabudin Sihabudin, Sihabudin Sinaga, Yumelin Adelina Sinambela, Ella Anastasya Siti Fatonah Solihah, Maratun Sri Afira Tuhyadi, Siti Ghaida Sri Setyowati Sri Sumarsih Supriani, Supriani Suwarno Suwarno Suwito Su’eb, Mochammad Talib, Uswatun Saidah A. Taufik Taufik Ta’in, Anas Tjahjono, Achmad Tryana, Tryana Tugiyono Tugiyono Ulfiana, Vina Ulwiyatin, Uul Uswatun Hasanah Utami, Dwi Putri Ventura, Raghusfi Bhuena Vita Sari, Nurul Vitrianingsih, Yeni Wahyudi, Kalvin Edo WARDANI, WINDY GUSTIA Wardhani, Ellen Kusuma Wati, Ayu Fera Widayani, Hartanti Wijiati Wijiati Winarti, Andirana Yatmi, Yatmi Yudi Wahyudin Yulianis, M. Sifa Fauzi Yuliastutik, Yuliastutik Yusuf, Ujang Zaenal Abidin Zalfa, Khulaimata Zuliastuti, Vivi Zumirddat, Wa Ode