Article Per Year (5 Year)
p-Index From 2021 - 2026
7.892
P-Index
This Author published in this journals
All Journal Nurse Media Journal of Nursing Medical Journal of Indonesia Indonesian Journal of Urology Gadjah Mada Journal of Psychology The Indonesian Journal of Public Health Majalah Obstetri dan Ginekologi Majalah Kedokteran Sriwijaya The Indonesian Biomedical Journal Sari Pediatri Universa Medicina Paediatrica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Cardiology Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Respirologi Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Oto Rhino Laryngologica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia The New Ropanasuri Journal of Surgery ASEAN Journal of Community Engagement Indonesian Journal of Global Health research Jurnal Ilmu Bedah Indonesia Jurnal Sosial dan Teknologi Narra J Binawan Student Journal Indonesia Journal of Physical Medicine and Rehabilitation Cermin Dunia Kedokteran Indonesian Journal of Public Health Nutrition (IJPHN) The Indonesian Journal of Community and Occupational Medicine Indonesian Journal of Multidisciplinary Science Jurnal Locus Penelitian dan Pengabdian The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of General Procedural Dermatology and Venereology Indonesia IJRETINA - International Journal of Retina Jurnal Muara Medika dan Psikologi Klinis Occupational and Environmental Medicine Journal of Indonesia Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Journal of Indonesian Specialized Nutrition Ophthalmologica Indonesiana
Aria Kekalih
Occupational Medicine Division, Department Community Medicine Faculty Of Medicine Universitas Indonesia
Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 84 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Narra J

 1 
Non-dominant handgrip strength is associated with higher cardiorespiratory endurance and elevated NT-proBNP concentrations in ambulatory male adult outpatients with stable HFrEF Triangto, Kevin; Radi, Basuni; Siswanto, Bambang B.; Tambunan, Tresia FU.; Heriansyah, Teuku; Harahap, Alida R.; Kekalih, Aria; Katsukawa, Hajime; Santoso, Anwar
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1278

Abstract

Understanding the significance of handgrip strength is essential for identifying frailty in heart failure patients. The aim of this study was to identify the association between handgrip strength and cardiorespiratory endurance while highlighting the importance of the musculoskeletal system in cardiac rehabilitation for patients with heart failure. An observational cross-sectional study was conducted at Harapan Kita Hospital, Jakarta, Indonesia, from April 2022 to April 2023, among patients with heart failure with reduced ejection fraction (HFrEF) attributed to cardiomyopathy or coronary artery disease. Patients were classified by a 6-minute walk test (6MWT) distance into <400 meters (low endurance) or ≥400 meters (high endurance). The short physical performance battery (SPPB), handgrip strength, ultrasonographic forearm muscle thickness, left ventricle ejection fraction, tricuspid annular plane systolic excursion, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were measured. Results indicated significant differences in non-dominant handgrip strength, gait speed, and sit-to-stand SPPB scores between patients achieving a 6MWT distance of ≥400 meters and those below this threshold, with values of 31.11±6.88 kg vs 27.66±6.66 kg (p=0.049), 0.52±0.08 m/s vs 0.61±0.13 m/s (p=0.001), and 10.71±2.47 seconds vs 12.85±4.11 seconds (p=0.014), respectively. Stronger non-dominant handgrip strength (>30 kg) was associated with higher endurance (odds ratio (OR): 3.80; 95%CI: 1.35–10.67; p=0.010) and thicker forearm muscles (>1.9 cm) as measured by ultrasonography (AUC: 0.713; 95%CI: 0.585–0.840, p=0.001). In conclusion, a cut-off of ≤30 kg for non-dominant handgrip strength could effectively stratify the male patients into a lower endurance group (6MWT ≤400 meters), which is associated with elevated NT-proBNP levels and reduced forearm muscle thickness.
Effect of the modified Atkins diet on NLRP3, caspase-1, IL-1β, and IL-10 in patients with tetralogy of Fallot undergoing open-heart surgery: A randomized controlled trial Yanuarso, Piprim B.; Djer, Mulyadi M.; Hendarto, Aryono; Pudjiadi, Antonius H.; Rachmadi, Lisnawati; Wibowo, Heri; Advani, Najib; Murni, Indah K.; Kekalih, Aria; Sukardi, Rubiana; Dilawar, Ismail; Susanti, Dhama S.; Supriatna, Novianti
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2138

Abstract

Cardiopulmonary bypass in tetralogy of Fallot (TOF) corrective surgery induces hyperinflammation by activating NLRP3, caspase-1, and interleukin-1β (IL-1β), subsequently triggering an interleukin-10 (IL-10) response. Despite its known metabolic and anti-inflammatory effects, the impact of the modified Atkins diet (MAD) in pediatric cardiac surgery remains unexplored, with no studies on its use in TOF patients undergoing open-heart surgery. The aim of this study was to assess the effect of MAD on the expression of NLRP3, caspase-1, IL-1β, and IL-10, in TOF patients undergoing open-heart surgery. A double-arm, randomized-controlled trial was conducted with 44 TOF patients. The treatment group (n=22) received the MAD, a low-carbohydrate, high-fat regimen with unrestricted fat and protein intake for at least 14 days preoperatively, while the control group (n=22) followed a standard diet without carbohydrate restriction. Blood plasma and infundibulum heart tissues were collected for analysis. Whole blood samples were collected using a winged infusion needle before the intervention, an Abbocath infusion needle after 14 days of intervention, and a syringe without a needle connected to an arterial line in patients undergoing open-heart surgery at 6, 24, and 48 hours post-surgical correction. Infundibulum heart tissues were collected during the open-heart surgery. This study demonstrated significant differences in NLRP3 protein expression (p=0.015), caspase-1 protein expression (p=0.001), and IL-10 levels between before intervention and 6-, 24-, and 48-hours post-surgery in the MAD group compared to the control group. In contrast, no significant differences in IL-10 levels were observed in the control group between before intervention and 48 hours post-surgery (p=0.654). In conclusion, MAD may modulate perioperative inflammation in TOF patients undergoing open-heart surgery by downregulating NLRP3 and caspase-1 expression while sustaining IL-10 levels. Despite reduced NLRP3 and caspase-1 expression, unchanged IL-1β levels indicate alternative regulatory mechanisms.
Efficacy of N-acetylcysteine and motivational enhancement therapy for nicotine addiction: A randomized clinical trial Nasrun, Martina WS.; Ginting, Tribowo T.; Siste, Kristiana; Pandelaki, Jacub; Kekalih, Aria; Louisa, Melva; Susanto, Agus D.; Utami, Diah S.; Tarigan, Immanuel N.; Trishna, Alya R.; Halim, Kelvin
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2178

Abstract

N-acetylcysteine (NAC) is known to enhance neuroplasticity and help reduce smoking addiction by modulating brain metabolites. The use of magnetic resonance spectroscopy (MRS) in smokers receiving NAC as an adjuvant to motivational enhancement therapy (MET) represents a novel approach to understanding how this combination therapy influences brain chemistry. By utilizing MRS, the effectiveness of NAC can be quantitatively assessed by analyzing changes in smoking-affected brain metabolites. The aim of this study was to evaluate the efficacy of NAC combined with MET for nicotine addiction, using MRS to assess neurochemical alterations associated with treatment response. A stratified, randomized, parallel-group clinical trial was conducted, comparing NAC and MET combination to MET only among smokers. The study analyzed the effectiveness of NAC by evaluating glutamate-glutamine (Glx) to creatine ratio (Glx/creatine ratio) and N-acetylaspartate (NAA) to creatine ratio (NAA/creatine ratio) in the nucleus accumbens, bilateral cerebellum, medial prefrontal cortex, ventromedial prefrontal cortex, and bilateral precuneus. Our data indicated that the Glx/creatine ratios for the intervention versus control groups were as follows: nucleus accumbens (0.68 vs 0.43), bilateral cerebellum (0.68 vs 0.43), left medial prefrontal cortex (1.11 vs 0.82), ventromedial prefrontal cortex (0.32 vs 0.86), and bilateral precuneus (0.75 vs 0.58). The NAA/creatine ratios for the intervention versus control groups were as follows: nucleus accumbens (3.55 vs 8.35), bilateral cerebellum (7.82 vs 4.02), left medial prefrontal cortex (5.47 vs 5.20), ventromedial prefrontal cortex (3.55 vs 7.46), and bilateral precuneus (4.73 vs 4.00). Our analysis indicated that the Glx/creatine ratio was higher in the intervention group than in the control group in the medial prefrontal cortex (p=0.02), while the NAA/creatine ratio was higher in the intervention group than in the control group in the bilateral cerebellum (p<0.001). The reported side effects were mild to moderate discomfort and well-tolerated across both groups. These findings highlight the potential of NAC and MET combination in promoting neuroplasticity and supporting nicotine addiction treatment.
Co-Authors Achmad Fauzi Kamal Addin Trirahmanto Adiningsih Sri Lestari Afrionaldi Suparman Agi Satria Putranto Agiananda, Feranindhya Agus D. Susanto Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Ahmad Aulia Ahmad Fuadi Ahmad Syafiq Aldri Frinaldi Aleddin, Rommel Alexander AW Peters Alida Roswita Harahap Alma Thahir Pulungan Ambari, Ade Meidian Amendi Nasution Amilya Agustina Amir Shidik Amir Shidik Amitya Kumara Amitya Kumara Andrijono Angela BM Tulaar Aninditha, Tiara Anis Karuniawati Anita Ratnawati Anitasari Kusumawati Antonius H. Pudjiadi Anwar Jusuf Anwar Santoso Aprilya, Dina Arthur Garson Aryono Hendarto Asmarinah Astri, Setia Wati Astrid Sulistomo Aziza G. Icksan Badriul Hegar Badriul Hegar Bambang Budi Siswanto Bambang Pontjo Priosoeryanto Bambang Supriyatno Basrowi, Ray Wagiu Basuni Radi Batubara, Jose Benjamin Ngatio, Benjamin Betharia Sonata Butarbutar Bethy Suryawathy Hernowo Bondan Harmani Bondan Harmani Boy Hidayat Budhi Antariksa Budi Sampurna Budi Wiweko Budiman Bintang Prakoso Canintika, Anissa Feby Cepi Teguh Pramayadi Chaidir Arif Mochtar Cut Putri Samira Damayanti Rusli Sjarif Danny Rasjiid Garna Darmawan, Irene Darwis, Patrianef Deni Noviana Denta Aditya Episana Desandri, Dwita Rian Dewi Friska Dewi Friska Dewi Sumaryani Soemarko Dewi Yunia Fitriani Dialika Dialika Dilawar, Ismail Dwiputra, Bambang Effendi, Haikal Elisna Syahruddin Elisna Syahruddin Elvioza Elvioza Elvioza Elvioza Endang Parahyanti Erlina Burhan Etty Rekawati Fachruddin, Ismi Irfiyanti Faisal Yunus Faisha Rahma, Melly Faraby Martha Feni Fitriani Ferdy Nurhadi Ferius Soewito Ferry Sandra Fitri Octaviana Fitriyadi Kusuma Gatot Purwoto Gede Wirya Kusuma Duarsa Ginting, Tribowo T. Halim, Kelvin Hanny Nilasari Hansen Angkasa Harahap, Alida R. Harahap, Alida Rosita Hardjono, Indra Hariyono Winarto Harsono, Hasto Hartanto, David Dwiadiputra Hartono Gunardi Hartono Gunardi Haswinzky, Rose Amalia Hatibie, Mendy Juniaty Helda Khusun Helda Khusun Helena Turnip Hendriko Heri Suroto Heri Wibowo Herman Mulijadi Herqutanto - Herwanto Herwanto Hesti Lestari Hidayat, Boy I Gusti Lanang Sidiartha I Nyoman Murdana Ibrahim Basir Ida Parwati Idqan Fahmi Ika Citra Susanti Ika Karlina Idris Imam Subekti Ina Susianti Timan Indah S. Widyahening Indiarto Wityawan Inne Yuliawati, Inne Iqbal, Mochamad Irfan Wahyudi Iris Rengganis IRWANTO Isbaniah, Fathiyah Isep Supriyana Ismail Hadisoebroto Dilogo Ismet, Mohamad F. Iwan Dwiprahasto Iwan Dwiprahasto Jeo, Wifanto S. Jeo, Wifanto Saditya Johan, Anita Judith N. Anastasia Junaiti Sahar Kamil, Radhita F. Kanadi Sumapradja Karnasih, Artasya Kartika, Emiliana Katsukawa, Hajime Kayika, I Putu Gede Kemal N. Siregar Kreshanti, Prasetyanugraheni Kurniawan, Kristian Kusmarinah Bramono Kusnadi, Dana S. Laila Nuranna Latifah , Suci Lesmana, Elvira Levina Chandra Khoe Liem Jen Fuk Lisnawati Lisnawati Rachmadi Luh Ade Wiradnyani Luh K Wahyuni Luh Karunia Wahyuni, Luh Karunia M Ilyas M. Dio Syaputra M. Sidik Marcellus Simadibrata Marsen Isbayu Putra Maulanisa, Sinta C. Maulia Fitra Purnama Maulia Fitra Purnama Meilania Saraswati Meilinda, Astrid Melva Louisa Mila Maidarti Mochamad Iqbal Moretta Damayanti Muchtaruddin Mansyur Muhamad Sidik Muhammad Ilyas Muhammad Ilyas Muhammad Sidik Muhammad Soffiudin Mulyadi M. Djer Mulyantara, Irwan Murdhana, Nyoman Murni, Indah K. Najib Advani Nasrun, Martina WS. Natadisastra, Raden Muharram Novia Rahayu Nur Ahlina Damayanti Nuraini I Susanti Nuri Dyah Indrasari Nuri Purwito Adi Nuri Purwito Adi Nurjati Chairani Siregar Nurmiati Amir Nury Nusdwinuringtyas Nury Nusdwinuringtyas Nury Nusdwinuringtyas Oktavia, Nikken Rima Ova Emilia Pandelaki, Jacub Paulus Daniel Sahanggamu Piprim B. Yanuarso, Piprim B. Ponco Birowo Pramaningasih, Maelissa Prasandhya Astagiri Yusuf Pratama, Dennis W. Prayangga, Regina Primariadewi Rustamadji Purba, Herdiman Bernard Puspaseruni, Putri Air Puspita Eka Wuyung Putra, M. Arza Putranto, Agi S. R. Muharam Rachmanto, Ary Rachmawati, Elvie Zulka Kautzia Raden Muharam Natadisastra Radiana Dhewayani Antarianto Raditya Pratama Rahadiani, Nur Raharja, Putu Angga Risky Rahayu, Tri Rahmanofa Yunizaf Rahyussalim Ratna Dwi Restuti Restuti, Ratna Dwi Retno Asti Werdhani Retno Wibawanti Reynaldo Reynaldo Reynaldo Reynaldo, Reynaldo Riani Dwianasari, Riani Rilanda, Risa Rini Andriani Rini Andriani Rini Sekartini Risky Dwi Rahayu Rita Hadi Widyastuti Riza Sahyuni Rizky Humairah , Inas Rosa Tatun Roscoe, Roscoe Roy Dwi Indra Rubiana Sukardi, Rubiana Rusli, Noer Triyanto S. Soemarko, Dewi Saleha Sungkar Sali Rahadi Asih Salmarezka Dewiputri Samjunanto, Achmad Sandra Widaty Sari, Siti Maulidya Saunar, Rofi Y. Sawitri Darmiati Seala Septiani Selly C Anggoro Shidik, Muhammad Sinabutar, Klara Siregar, Sun Parkuseg Siskawati, Yulia Siste, Kristiana Sri L. Menaldi Sri Linuwih Susetyo Wardhani, Sri Linuwih Susetyo Sri Wahdini Sugeng Supriadi, Sugeng Sugiharto, Bobby Suhartono, Raden Suhendro Suhendro Sujudi, Yufanti Sukasah, Chaula Luthfia Sulistomo, Astrid Sulistomo, Astrid Sunarjo, Peggy Supriatna, Novianti Suratih, Ni Made Desy Susanti, Dhama S. Susanti, Nuraini I Susanti, Nuraini I Susyana Tamin Syahrial MH Syntia Nusanti Syntia Nusanti Syntia Nusanti Syntia Nusanti Syska Widyawati Syska Widyawati Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Tamin, Susyana Tarigan, Immanuel N. Teuku Heriansyah, Teuku Tirza Z Tamin Tjhin Wiguna Toar JM Lalisang Tran Thi Hai Tresia Fransiska Uliana Tambunan Tresia Fransiska Ulianna Tambunan Tri Mawanti, Wening Tri Rahayu Tri Rahayu Triangto, Kevin Trinovita Andraini Trishna, Alya R. Tukimun, Suci Tria Meirisa Utami, Diah S. Vanto, Yoni Velyani, Dyani Pitra Viscanita Viscanita W. Roestam, Ambar Wahmurti, Tuti Wahyu Widodo Wardhani, Rizky Kusuma  Wibisono, Sasanto Wibowo, Suryo Widianto, Eri Widjajalaksmi Kusumaningsih, Widjajalaksmi Widura Imam Mustopo, Widura Imam Widya Utami, Tofan Winata, Vera Wresti Indriatmi B. Makes Yayi Suryo Prabandari Yefta Moenadjat Yoga Devaera Yundari, Yundari Yunizaf, Rahmanofa Yusra Yusra Yusra  Sugiarta,  Iwan