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All Journal International Journal of Electrical and Computer Engineering Torani Journal of Fisheries and Marine Science Lintas Ruang: Jurnal Pengetahuan dan Perancangan Desain Interior Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Ilmiah Mahasiswa FEB Journal of Biomedicine and Translational Research Jurnal Ilmu Kelautan Spermonde JURNAL IPTEKS PEMANFAATAN SUMBERDAYA PERIKANAN Biomedical Journal of Indonesia Sinkron : Jurnal dan Penelitian Teknik Informatika Medical Laboratory Technology Journal Pendas mahakam : jurnal pendidikan dan pembelajaran Sekolah Dasar JURNAL MUQODDIMAH : Jurnal Ilmu Sosial, Politik dan Hummaniora Jurnal Ilmiah Mahasiswa Kedokteran Medisia Jurnal Pendidikan Matematika (JUDIKA EDUCATION) Fair Value: Jurnal Ilmiah Akuntansi dan Keuangan Jurnal Teknologi Sistem Informasi dan Aplikasi JURNAL PENDIDIKAN TAMBUSAI SRIWIJAYA JOURNAL OF MEDICINE ACTIVE: Journal of Physical Education, Sport, Health and Recreation Jurnal Teknologi Terpadu Jurnal Logistik Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Menssana Jurnal Mantik Riyadhoh : Jurnal Pendidikan Olahraga Imajeri: Jurnal Pendidikan Bahasa dan Sastra Indonesia Scientia Psychiatrica Journal of SPORT (Sport, Physical Education, Organization, Recreation, and Training) REMIK : Riset dan E-Jurnal Manajemen Informatika Komputer Jurnal PORKES RESLAJ: RELIGION EDUCATION SOCIAL LAA ROIBA JOURNAL Sriwijaya Journal of Surgery Open Access Indonesia Journal of Social Sciences Sriwijaya Journal of Ophthalmology JURNAL PENDIDIKAN SAINS SOSIAL DAN AGAMA Eureka Herba Indonesia Jurnal Kesehatan Tambusai Jurnal Pengabdian Masyarakat: Humanity and Medicine PRAJA observer: Jurnal Penelitian Administrasi Publik Natural Sciences Engineering and Technology Journal Oikonomia: Jurnal Manajemen Open Access Indonesian Journal of Medical Reviews Indonesian Community Empowerment Journal Jurnal Abdimas Bina Bangsa Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Open Access Indonesia Journal of Social Sciences Arkus Abditeknika - Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat Patikala International Journal of Research and Applied Technology (INJURATECH) Muhasabatuna: Jurnal Akuntansi Syariah Journal of Informatics and Communication Technology (JICT) Journal of Anesthesiology and Clinical Research Journal Of Human And Education (JAHE) Scriptura : Jurnal Ilmiah Sustainability Science and Resources Journal International of Lingua and Technology Proceeding ISETH (International Summit on Science, Technology, and Humanity) Indonesian Journal Computer Science (ijcs) Journal Health Information Management Indonesian Indonesian Research Journal on Education Dikdimas : Jurnal Pengabdian Kepada Masyarakat Jurnal Muara Olahraga Jurnal Multidisiplin Sahombu Jurnal Pengabdian West Science Sinergi International Journal of Communication Sciences Jurnal Sosial, Sains, Terapan dan Riset (Sosateris) Technology and Society Perspectives (TACIT) Scientific Journal of Pediatrics Jurnal Spektrum Komunikasi Sriwijaya Journal of Radiology and Imaging Research Journal of Social Science Utilizing Technology Sriwijaya Journal of Internal Medicine Sriwijaya Journal of Obstetrics and Gynecology Sriwijaya Journal of Otorhinolaryngology Jurnal Pengabdian Sosial Informatics and Software Engineering (ISE) Jurnal Perikanan Terpadu Journal of Informatics and Communication Technology (JICT) Journal of Social Science Utilizing Technology Journal of Industrial Engineering Innovation Acta Psychologia ACTIVE: Journal of Physical Education, Sport, Health and Recreation Communica : Journal of Communication Bambu Laut: Jurnal Pengabdian Masyarakat
RACHMAT HIDAYAT
Department Of Medical Biology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Journal : Sriwijaya Journal of Internal Medicine

 1 
Genetic Predisposition to Cardiac Conduction Defects in a Multi-Ethnic Population: A Case-Control Study in Palembang, Indonesia Hidayat, Rachmat
Sriwijaya Journal of Internal Medicine Vol. 1 No. 2 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.18

Abstract

Introduction: Cardiac conduction defects (CCDs) represent a significant global health burden, contributing to morbidity and mortality. While environmental and lifestyle factors are recognized contributors, genetic predisposition plays a crucial role in their development. This study aimed to investigate the association between specific genetic variants and CCDs in the diverse multi-ethnic population of Palembang, Indonesia. Methods: A case-control study was conducted involving 200 cases with CCDs (atrioventricular block, bundle branch block, sick sinus syndrome) and 200 age- and sex-matched controls from Palembang, Indonesia. Participants underwent detailed clinical evaluations, electrocardiography, and genotyping for selected single nucleotide polymorphisms (SNPs) previously associated with CCDs. These SNPs were located in genes encoding ion channels (SCN5A, KCNQ1, KCNH2), connexin proteins (GJA1, GJA5), and transcription factors (NKX2-5, TBX5). Logistic regression analysis was performed to assess the association between SNPs and CCDs, adjusting for potential confounders such as age, sex, hypertension, diabetes mellitus, and smoking status. Results: Several SNPs showed significant associations with CCDs in the Palembang population. The SCN5A rs1805124 variant was associated with an increased risk of atrioventricular block (OR 1.85, 95% CI 1.12-3.05, p=0.016). The KCNQ1 rs1801252 polymorphism was linked to a higher risk of bundle branch block (OR 2.10, 95% CI 1.30-3.40, p=0.002). Additionally, the GJA5 rs10453535 variant was associated with an increased risk of sick sinus syndrome (OR 1.72, 95% CI 1.05-2.82, p=0.031). These associations remained significant after adjusting for potential confounders. Conclusion: This study provides evidence for the genetic predisposition to CCDs in the multi-ethnic population of Palembang, Indonesia. Specific SNPs in SCN5A, KCNQ1, and GJA5 genes were associated with increased risks of various CCDs. These findings contribute to our understanding of the genetic basis of CCDs and may have implications for risk stratification and personalized management strategies.
Activated Growth Factor (AGF): An Advanced Modality of Platelet-Rich Plasma as a New Biological Agent for the Treatment of Degenerative and Traumatic Conditions Hidayat, Rachmat; Kemas Abdul Mutholib Luthfi; Maria Margareth Wilson; Shina Abdulkadir
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.168

Abstract

Platelet-rich plasma (PRP) has emerged as a promising therapeutic modality for various medical applications, particularly in regenerative medicine and wound healing. This is largely attributed to its rich concentration of growth factors (GFs) that play pivotal roles in tissue repair and regeneration. However, the inherent limitations of PRP, such as the variable GF concentrations and short-lived release kinetics, have spurred the development of advanced modalities to enhance its therapeutic efficacy. Activated growth factor (AGF) represents one such advancement, aiming to optimize the release and bioavailability of GFs from platelets. This comprehensive review delves into the biological mechanisms underlying AGF, its preparation methodologies, preclinical and clinical evidence supporting its use, and its potential applications in treating degenerative and traumatic conditions. Furthermore, it explores the advantages of AGF over conventional PRP and discusses future directions for research and clinical translation.
Overview of the Cardiac Conduction System: A Narrative Literature Review Hidayat, Rachmat
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.206

Abstract

The conduction system of the cardiac initiates and coordinates the electrical signals that cause rhythmic and synchronous contraction of the atria and ventricles. This literature review aims to describe the electrophysiology of the cardiac conducti on system. Electrical impulses usually arise in the sinoatrial (SA) node. The SA node is innervated by sympathetic and parasympathetic nerves. Each act ion potential moves rapidly from cell to cell and through the myocardium of the atria, onto the atrioventricular node (AV node), and causes both atria to contract and begin systole. The AV node, located on the right atrial wall superior to the tricuspid valve and anterior to the coronary sinus ostium, conducts action potentials into the ventricles. From the AV node, the conducting fibers converge t o form the bundle of His (atrioventricular bundle) within the posterior border of the interventricular septum.
Co-Authors Abdul Mahatir Najar Abdulwahab Hakimi Abu Bakar Abu Bakar Abudarda, Andi Risda Fitrianti Achmar Mallawa Adnindya, Msy Rulan Agus Indra Jaya Agus Junaidi Agus Junaidi Agustian, Kresnawidiansyah Ahadi Aulia Rahman Ahmad Ahmad Ahmad Fatoni Ahmad Salim, Ahmad ahmad yani Ahmad Zain Sarnoto Ahmad, Arfandi Aji, Muhammad Pramono Alhan, Khusni Alif Tunru, Andi Alvian, M. Andri Anang Tribowo Andayani, Nurfitri Andiani, Lia Andres Andres Andriana, Nadila Andronias Siregar Annisa Wimaulia Azlin Anuar, Arman Bin Aprilyanti, Cindy Apriwandi . Arifin, Nurdin Arindi Maretzka Aryanto, Hermawan Noval Ayeshah A Rosdah Azakhia, Yolanda Citra Baharuddin Baharuddin Bainamus, Putri Milanda Bella Stevanny Bemba, Tonia Buchari Buchari Budi Pratiti Carla R Marchira Catherine Christine, Debbie Cinthya Callathea Dahlan, Dadang - Dariyanto, Erwin Debby Handayanti Harahap Dessa, Rima Djoko Widodo Edith Humries edy susanto Ella Amalia, Ella Ellya Verawati Elsa Iskandar Erizka Rivani Erma Agusliani Ester G Pansserga Fahcreza Faisal Syahputra, Faisal Fajarwati, Lia Fathonah, Andina Nur Fatmawati Fatmawati Fatmawati Fildzah Hashifah Taufiq Fiona Widyasari Firjatullah, Andhika Fauziana Griselda Griselda Hadi, Dudi Abdul hadi, marwan Handayani, Lisa Hani Subakti Haryanto Haryanto Herman Paninggiran Hermansyah Hermansyah Hermansyah Herry Hasnawi HUSNUL KHOTIMAH Ichsan, Amirul Ika Kartika Ikrima Ikrima Ilahi, Rahmat Imam Pribadi Inggarsih, Rara Irawan Sastradinata Irawan Sastradinata Irham Irham Irsan Saleh Ismar Hamid Iwan Setiawan Jamalullail Jayawarsa, A.A. Ketut Joko Marwoto Joko Marwoto Junoretta Haviva Ernanto Kashardi, Kashardi Kemas Abdul Mutholib Luthfi Kemas Ya'kub Rahadiyanto Krishna, Hidan Bayu Krisna Murti Kumba Digdowiseiso, Kumba KURNIA KURNIA, KURNIA Lestari Barus, Irene Sukma Linda Purnama Listianingsih, Lona Lusia Hayati Lusia Hayati Lusia Hayati Lusia Hayati Lusia Hayati, Lusia Luthfi, Kemas Abdul Mutholib Mail, Abdul Maisya, Irin Makbruri Amin Malik, Aulia Januar Maria Margareth Wilson Marlinda, Dwi Martino Dwi Nugroho MARYANTI, LILIS Maslukin, Maslukin Mauladan, Ravy Maximillian Wilson Meilinda, Salsa Rizkia Mgs Irsan Saleh Mgs Irsan Saleh Mirna Dianita Muallin, Muallin Mubarok, E. Saefuddin Muhammad Anzarach Pratama Muhammad Bima Muhammad Irsan Saleh Muhammad Reagan Muhammad Reagen Muhammad Ridwan Muhammad Rizky Hidayatullah Muhlis Muhlis Mukti Zainuddin Murlena, Murlena Muslina Muslina Muthia, Putri Muthia, Putri Nadia Khoirina Najla Khairunnisa Nandang Iriadi Nani Solihati Nasriandi Nasriandi Ninuk Riesmiyantiningtias Nita Parisa Noorzaman, Sandi Noviyan, Rizky Dwi Nur Ainun Nur Riviati, Nur Nur, Suaib Nurdina, Mutia Nurhasanah Nurhayati, M Sinta nurliah, nurliah Nurpahni, Siti Salma Nurrahmah, Andi Oktaviyani, Hikmatul Olivia Azalia Putri Pamungkas, K J paosan, ahmad Patricia Wulandari Patry, Him Petty Purwanita Poku, Ham pongtiku, ita Prakarsa, Bambang Pramono, Yacob Agung Prayudhi, Risa Prihatina Anjela Purnamasari, Septi Puspa Sari, Puspa Puspa Zulaika Puspita, Sabrina Diah Puspitasari, Andini Putra, Suadi Sapta Putri Muthia Rachman, Andry Arifian Raden Ayu Adelia Safitri Raden Sunita Radiyati Umi Partan Radjikan Rahayu, Rosi Rahman, Ahadi Aulia Rahman, Ahadi Aulia Rahman, Alfi Rahmat Saleh Raihan Aqiilah N.L. , Andi Ahmad Ramadana, Radiyah Ramadhan, Hamzah Ramadhani, Anjas Ramli, Musdalifah Rara Inggarsih Rara Inggarsih Rashidah Unaib Al Zayid Rasyidah Jalil Reisha Notonegoro Resva Meinisasti Rety, Alghazali Riani Erna Rijaluddin, Khalid Rima Rachmawati Riri Juliantika Risnanosanti Risnanosanti Riswanto, A Heri Riswanto, A. Heri Riswanto, Andi Heri Riswanto, Heri Rosiyadi, Didi Safi'i, Imam Safruddin Sahidan Sahidan Sahidan Sahidan Sahni Putri, Andi Rani Saksitha, Deassy Arestya Salni Salni Saman, Saman Samsuri, Fhadil Hidayat Sapinah, Pipin Sarah Sari , Windy Dian Sari H. S., Maharani Puspita Sari, Anggi Psutpita Sari, Windy Dian Sarmila, Sarmila Sarnato, Ahmad Zain Satriansyah , Arief Sekarini, Ratih Ayu Sepang, Rosa Marten Septi Purnamasari Septi Purnamasari SEPTIAN, DIAN Shalita Dastamuar Shina Abdulkadir Sony Sanjaya Sonya Syarifah Sri Nita Sri Nita Sri Nita Sri Nita, Sri Sri Tuti Rahmawati Sri Vandayuli Riorini St. Aisjah Farhum, St. Aisjah Sudaramanto, Bagus Sujud, Atsari Surya Ade Saputera Surya Darma Surya Darma Syarif Burhan, Ahmad Tanjung, Enha Syahrul Taufiq Indera Jayadi Tiara Fatrin Triwani Triwani Triwani Tungki Pratama Umar Tungki Pratama Umar Tunru, Andi Alif Udi Rusadi Uswatun Hasanah Veithzal Rivai Zainal Wahyudin Wahyudin Wardani, M. Fikri Wardiansyah Wiganepdo, Suryatno Wijaya, Maya Septa Winda Ramadianti, Winda Wirna, Risalah Sabila Yeni Agustin Yuliansyah, Chandra Yundari, Yundari Yuni sahruni, Ade Yusnaini Yusnia Budiarti Zaidan, Naufal Muhamad Zakaria, Khairunnisa Zen, Agustian Ziske Maritska