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Journal : Sriwijaya Journal of Otorhinolaryngology

Effectiveness of Mesenchymal Stem Cells in Tissue Regeneration in Ear Injuries: A Meta-Analysis Hidayat, Rachmat
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 2 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v2i1.134

Abstract

Introduction: Ear injuries are a common health problem and can cause significant hearing loss. Tissue regeneration in injured ears is still a big challenge. Mesenchymal stem cells (MSCs) have shown potential for tissue regeneration in various organs, including the ear. This meta-analysis aims to evaluate the effectiveness of MSCs in tissue regeneration in ear injuries. Methods: We conducted a literature search in various electronic databases, including PubMed, Cochrane Library, and Scopus, for studies examining the use of MSCs in tissue regeneration in ear injuries. Inclusion criteria included randomized controlled studies, prospective observational studies, and cohort studies examining the effectiveness of MSCs on hearing improvement, regeneration of ear structures, and reduction of inflammation. Results: A total of 12 studies with a total of 342 participants met the inclusion criteria. The meta-analysis results showed that MSCs significantly improved hearing improvement (standardized mean difference [SMD] = 0.67, 95% confidence interval [CI] 0.42-0.92, p < 0.001) and ear structure regeneration (SMD = 0.53, 95% CI 0.28 -0.78, p < 0.001). MSCs also showed effectiveness in reducing inflammation (SMD = -0.48, 95% CI -0.73-0.23, p < 0.001). Conclusion: MSCs are an effective and safe therapy for tissue regeneration in ear injuries. Further research is needed to optimize treatment protocols and evaluate the long-term effectiveness of MSCs.
Risk Factors for Allergic Rhinitis in Students of SMA Negeri 1 Padang, Indonesia Hidayat, Rachmat; Sari, Puspa
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 1 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.224

Abstract

Introduction: Allergic rhinitis (AR) is a disorder of the nasal mucosa caused by inflammation and initiated by a hypersensitivity reaction due to exposure to allergens. This study aimed to determine the risk factors associated with allergic rhinitis in SMA Negeri 1 Padang Indonesia students. Methods: This study was an observational study with a cross-sectional approach. A total of 500 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria were SMA Negeri 1 Padang, Indonesia students aged 15-17 years and willing to participate in the research as evidenced by the consent of their parents or guardians to participate in this study. Data analysis was carried out using SPSS software version 25. Univariate analysis was performed to present the frequency distribution of each variable test. Bivariate analysis was performed to determine the relationship between risk factors and incidence of rhinitis allergies, p < 0.05. Results: The results of the study show that gender is not related to the incidence of rhinitis allergies. Smoke exposure, owning pets, dust exposure, and a history of atopy are associated with events of rhinitis allergies, p<0.05. Conclusion: Smoke exposure, owning pets, dust exposure, and a history of atopy are risk factors for this incidence of allergic rhinitis in SMA Negeri 1 Padang, Indonesia students.
Co-Authors Abdul Mahatir Najar Abdulwahab Hakimi Abu Bakar Abu Bakar Abudarda, Andi Risda Fitrianti Achmar Mallawa Adnindya, Msy Rulan Agus Indra Jaya Agus Junaidi Agus Junaidi Agustian, Kresnawidiansyah Ahadi Aulia Rahman Ahmad Ahmad Ahmad Fatoni Ahmad Salim, Ahmad ahmad yani Ahmad Zain Sarnoto Ahmad, Arfandi Aji, Muhammad Pramono Alhan, Khusni Alif Tunru, Andi Alvian, M. Andri Anang Tribowo Andayani, Nurfitri Andiani, Lia Andres Andres Andriana, Nadila Andronias Siregar Annisa Wimaulia Azlin Anuar, Arman Bin Aprilyanti, Cindy Apriwandi . Arifin, Nurdin Arindi Maretzka Aryanto, Hermawan Noval Ayeshah A Rosdah Azakhia, Yolanda Citra Baharuddin Baharuddin Bainamus, Putri Milanda Bella Stevanny Bemba, Tonia Buchari Buchari Budi Pratiti Carla R Marchira Catherine Christine, Debbie Cinthya Callathea Dahlan, Dadang - Dariyanto, Erwin Debby Handayanti Harahap Dessa, Rima Djoko Widodo Edith Humries edy susanto Ella Amalia, Ella Ellya Verawati Elsa Iskandar Erizka Rivani Erma Agusliani Ester G Pansserga Fahcreza Faisal Syahputra, Faisal Fajarwati, Lia Fathonah, Andina Nur Fatmawati Fatmawati Fatmawati Fildzah Hashifah Taufiq Fiona Widyasari Firjatullah, Andhika Fauziana Griselda Griselda Hadi, Dudi Abdul hadi, marwan Handayani, Lisa Hani Subakti Haryanto Haryanto Herman Paninggiran Hermansyah Hermansyah Hermansyah Herry Hasnawi HUSNUL KHOTIMAH Ichsan, Amirul Ika Kartika Ikrima Ikrima Ilahi, Rahmat Imam Pribadi Inggarsih, Rara Irawan Sastradinata Irawan Sastradinata Irham Irham Irsan Saleh Ismar Hamid Iwan Setiawan Jamalullail Jayawarsa, A.A. Ketut Joko Marwoto Joko Marwoto Junoretta Haviva Ernanto Kashardi, Kashardi Kemas Abdul Mutholib Luthfi Kemas Ya'kub Rahadiyanto Krishna, Hidan Bayu Krisna Murti Kumba Digdowiseiso, Kumba KURNIA KURNIA, KURNIA Lestari Barus, Irene Sukma Linda Purnama Listianingsih, Lona Lusia Hayati Lusia Hayati Lusia Hayati Lusia Hayati Lusia Hayati, Lusia Luthfi, Kemas Abdul Mutholib Mail, Abdul Maisya, Irin Makbruri Amin Malik, Aulia Januar Maria Margareth Wilson Marlinda, Dwi Martino Dwi Nugroho MARYANTI, LILIS Maslukin, Maslukin Mauladan, Ravy Maximillian Wilson Meilinda, Salsa Rizkia Mgs Irsan Saleh Mgs Irsan Saleh Mirna Dianita Muallin, Muallin Mubarok, E. Saefuddin Muhammad Anzarach Pratama Muhammad Bima Muhammad Irsan Saleh Muhammad Reagan Muhammad Reagen Muhammad Ridwan Muhammad Rizky Hidayatullah Muhlis Muhlis Mukti Zainuddin Murlena, Murlena Muslina Muslina Muthia, Putri Muthia, Putri Nadia Khoirina Najla Khairunnisa Nandang Iriadi Nani Solihati Nasriandi Nasriandi Ninuk Riesmiyantiningtias Nita Parisa Noorzaman, Sandi Noviyan, Rizky Dwi Nur Ainun Nur Riviati, Nur Nur, Suaib Nurdina, Mutia Nurhasanah Nurhayati, M Sinta nurliah, nurliah Nurpahni, Siti Salma Nurrahmah, Andi Oktaviyani, Hikmatul Olivia Azalia Putri Pamungkas, K J paosan, ahmad Patricia Wulandari Patry, Him Petty Purwanita Poku, Ham pongtiku, ita Prakarsa, Bambang Pramono, Yacob Agung Prayudhi, Risa Prihatina Anjela Purnamasari, Septi Puspa Sari, Puspa Puspa Zulaika Puspita, Sabrina Diah Puspitasari, Andini Putra, Suadi Sapta Putri Muthia Rachman, Andry Arifian Raden Ayu Adelia Safitri Raden Sunita Radiyati Umi Partan Radjikan Rahayu, Rosi Rahman, Ahadi Aulia Rahman, Ahadi Aulia Rahman, Alfi Rahmat Saleh Raihan Aqiilah N.L. , Andi Ahmad Ramadana, Radiyah Ramadhan, Hamzah Ramadhani, Anjas Ramli, Musdalifah Rara Inggarsih Rara Inggarsih Rashidah Unaib Al Zayid Rasyidah Jalil Reisha Notonegoro Resva Meinisasti Rety, Alghazali Riani Erna Rijaluddin, Khalid Rima Rachmawati Riri Juliantika Risnanosanti Risnanosanti Riswanto, A Heri Riswanto, A. Heri Riswanto, Andi Heri Riswanto, Heri Rosiyadi, Didi Safi'i, Imam Safruddin Sahidan Sahidan Sahidan Sahidan Sahni Putri, Andi Rani Saksitha, Deassy Arestya Salni Salni Saman, Saman Samsuri, Fhadil Hidayat Sapinah, Pipin Sarah Sari , Windy Dian Sari H. S., Maharani Puspita Sari, Anggi Psutpita Sari, Windy Dian Sarmila, Sarmila Sarnato, Ahmad Zain Satriansyah , Arief Sekarini, Ratih Ayu Sepang, Rosa Marten Septi Purnamasari Septi Purnamasari SEPTIAN, DIAN Shalita Dastamuar Shina Abdulkadir Sony Sanjaya Sonya Syarifah Sri Nita Sri Nita Sri Nita Sri Nita, Sri Sri Tuti Rahmawati Sri Vandayuli Riorini St. Aisjah Farhum, St. Aisjah Sudaramanto, Bagus Sujud, Atsari Surya Ade Saputera Surya Darma Surya Darma Syarif Burhan, Ahmad Tanjung, Enha Syahrul Taufiq Indera Jayadi Tiara Fatrin Triwani Triwani Triwani Tungki Pratama Umar Tungki Pratama Umar Tunru, Andi Alif Udi Rusadi Uswatun Hasanah Veithzal Rivai Zainal Wahyudin Wahyudin Wardani, M. Fikri Wardiansyah Wiganepdo, Suryatno Wijaya, Maya Septa Winda Ramadianti, Winda Wirna, Risalah Sabila Yeni Agustin Yuliansyah, Chandra Yundari, Yundari Yuni sahruni, Ade Yusnaini Yusnia Budiarti Zaidan, Naufal Muhamad Zakaria, Khairunnisa Zen, Agustian Ziske Maritska