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All Journal HAYATI Journal of Biosciences Jurnal Akuakultur Indonesia ACTA VETERINARIA INDONESIANA Jurnal Ilmu dan Teknologi Kelautan Tropis Jurnal Ilmu-Ilmu Perairan dan Perikanan Indonesia Hemera Zoa Media Veteriner Forum Pasca Sarjana Jurnal Sain Veteriner Buletin Peternakan SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology JURNAL ANATOMI FISIOLOGI Jurnal Ilmu Ternak Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Majalah Kedokteran Bandung Jurnal Ilmu Ternak Veteriner JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) INDONESIAN JOURNAL OF PHARMACY BERITA BIOLOGI ZOO INDONESIA Jurnal Bioteknologi & Biosains Indonesia (JBBI) Omni-Akuatika Animal Production : Indonesian Journal of Animal Production Jurnal Matematika Sains dan Teknologi Buletin Ilmu Makanan Ternak Proceeding Simposium Nasional Kelautan dan Perikanan Indonesian Aquaculture Journal Jurnal Riset Akuakultur Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) ARSHI Veterinary Letters Jurnal Iktiologi Indonesia (Indonesian Journal of Ichthyology) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Journal of Aquaculture and Fish Health Majalah Farmasetika Zoo Indonesia Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine Journal of Fisheries & Marine Jurnal Kefarmasian Indonesia Jurnal Agripet Animal Production
Wasmen Manalu
Department Of Anatomy, Physiology And Pharmacology, Faculty Of Animal Medicine, IPB University, Jl. Lingkar Kampus IPB Darmaga, Bogor, West Java 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Public Health Veterinary Other

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The In Silico Toxicity of Serai Wangi (Cymbopogon nardus) and Mimba (Azadirachta indica anggraeni, Henny endah; Purwono, Rini Madyastuti; Sutardi, Lina Noviyanti; Mustika, Aulia Andi; Manalu, Wasmen; Andriyanto, Andriyanto
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.278-285

Abstract

Natural active-ingredient-based shampoos offer an effective and eco-friendly solution for maintaining the skin and hair health of companion animals. This study aimed to predict the toxicity of phytochemical compounds from citronella oil (Cymbopogon nardus) and neem oil (Azadirachta indica) using an in silico approach with the ProTox-II platform. The analyzed compounds included limonene, farnesene, eucalyptol, menthol, oleic acid, p-cymene, indole, (9Z)-9- octadecenamide, amylbenzene, p-cresol, camphor, and dieugenol, selected based on LC-MS/MS analysis. The evaluated toxicological parameters comprised oral acute toxicity (LD50), hepatotoxicity, immunotoxicity, genotoxicity (cytotoxicity, mutagenicity, carcinogenicity), as well as nuclear receptor signaling and stress response pathways. The results revealed that p-cymene exhibited the highest toxicity (LD50 = 3 mg/kg, class I), followed by oleic acid (LD50 = 48 mg/kg, class II), whereas amylbenzene was classified as non-toxic (LD50 = 6430 mg/kg, class VI). All compounds were predicted to be non-hepatotoxic and non-immunotoxic; however, p-cymene, indole, and amylbenzene showed potential carcinogenicity. Limonene was predicted to be active against AhR, ER, MMP, and ATAD5 receptors, while dieugenol was active against nrf2/ARE, HSE, and MMP. These predictions suggest that most compounds are safe for shampoo applications, except for p-cymene, which requires further evaluation. This study provides preliminary insights for the development of safe and effective natural-based shampoos.
A comparison of the Hematology Profiles from Preventive and Curative Tests on Lissachatina fulica Snail Mucin Cream for Atopic Dermatitis Supiyani, Atin; Manalu, Wasmen; Sutardi, Lina Noviyanti; Subangkit, Mawar; Andriyanto, Andriyanto
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.296-302

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Continuous use of topical NSAIDs in AD cases has been shown to cause adverse effects. Lissachatina fulica mucin (LFM) cream, a natural alternative, has been used for wound healing and can be used as a preventative or curative agent in AD. The objective of this study is to assess the efficacy of LFM cream, exploring its potential as a preventative and curative measure in AD. A total of 36 male BALB/c mice were divided into three cream dosage groups: 0%, 5%, and 10%. The two treatments were preventive and curative, and the two testing times were 0 and 5 days, with three replicates each. Mice were induced with atopic dermatitis by applying 1% DNCB to a 1x1 cm area on their dorsal area for seven days. The preventive group used LFM cream for seven days before DNCB, while the curative group used it after DNCB. Blood samples were collected on days 0 and 5 of the treatment period and analyzed using a hematology analyzer. The data were analyzed using a two-way ANOVA with GraphPad Prism 10, followed by Tukey's test at a 95% confidence level. The toxicity test confirmed that the LFM cream is non-toxic and safe for topical use. The DNCB compound 1% exhibited four main symptoms of atopic dermatitis: pruritus, erythema, excoriation, and lichenification. LFM cream was highly effective, significantly suppressing AD symptoms, with the ADSI score remaining below 2 (p<0.05). Specifically, the curative efficacy was demonstrated by a significant decrease in the ADSI score on day 5 (p<0.05). Hematological analysis revealed statistically significant differences (p<0.05) in the number of lymphocytes, neutrophils, and thrombocytes across groups. The LFM cream is effective and safe for preventative use and successfully treats acute AD at 5% concentration.
Co-Authors - Hernawati . Safrida ., Chairul A Yani A.S. Satyaningtijas ABADI SUTISNA Abdul Zahid Adawiah . Ade Sunarma Ade Sunarma Adi Winanto Adi Winarto Adi Winarto Agik Suprayogi Agus Oman Sudrajat Agus Wahyana Anggara Agus Wahyana Anggara Agus Wahyana Anggara, Agus Wahyana Ahmad Subhan Ahmad Yani ahmad yani Aisjah Girindra Akhiruddin Maddu Alfred O. M. Dima Alifiana Fitrianingrum Almiahsari, Ashri Amrozi Andi Mu’nisa Andri Yanto Andriyanto Andriyanto Andriyanto Andriyanto . Andriyanto A Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto, Andriyanto Andriyanto Anggraeni, Henny Endah Anita Esfandiari Anuraga Jayanegara Arief Boediono Aryani Satyaningtijas Aswani, Tuti Aulia Andi Mustik Aulia Andi Mustika Aulia Andri Mustika Aurelia, Sharon Awaludin Azam B. Zaidy B P Purwanto B. P. Purwanto Bagus Priyo Purwanto Bambang Gunadi Bambang Gunadi Bambang Gunadi BAMBANG KIRANADI Bambang Kiranadi Bambang Kiranadi Bambang Pontjo Priosoeryanto Benny Heltonika Bondan Achmadi Cece Sumantri Chairul - Chairul Chairul Chairun Nisa Chatarina Umbul Wahyuni Christina Clarice Leksono Cut Dara Dewi Damiana Rita Ekastuti Daniel Happy Putra Debby Jacqualine Jochebed Rayer Dedy D. Solihin Deni Noviana Deni Radona, Deni Desrial DEWI APRI ASTUTI Dewi Ratih Agung Priyono Dewi Ratih Agungpriyono Dewi Ratih Agungpriyono Dewi Ratih Agungpriyono Diah Nugrahani Pristihadi Diky Yuliansah Diky Yuliansah Dwi Gunadi Dwi Setyaningsih Dwi Utari Rahmiati Dyah Iswantini Edwin Ligia Sastra Ekowati Handharyani Elpita Tarigan Elpita Tarigan Elpita Tarigan Elpita Tarigan Erli Chandra Etih Sudarnika Evy Ayu Arida EVY AYU ARIDA Fachriyan H. Pasaribu Firda Agustin Firda Agustin Firda Agustin, Firda Fitra Aji Pamungkas Fitra Aji Pamungkas Fitra Aji Pamungkas Fitria Senja Murtiningrum Friska Mery Montolalu Gandasari, Ira Agustina Dewi Ganjar Maulana Nugraha Ganjar Maulana Nugraha HADI SUNARYO Hamdika Yendri Hamdika Yendri Hamdika Yendri Hamdika Yendri Hamdika Yendri Putra Hamdika Yendri Putra Hamdika Yendri Putra Hamny Sofyan Hasya, Karin katina Henni Syawal HERA MAHESHWARI Hera Maheswari, Hera Hernawati Hernawati Hesti Wahyuningsih Huda Shalahudin Darusman Hurip Pratomo Hurip Pratomo Husna, Hanifati I Ketut Mudite I Komang Gede Wiryawan Iman Hernaman Iman Supriatna Irarang, Yusa Irfan Nurhidayat, Irfan Irma Herawati Suparto Irzaman, Irzaman Isdoni Bustaman Jakaria Jakaria Jihan Fadilah Rachman Nurullah Jola J.M.R. Londok Joni Haryadi, Joni Kapelle, Imanuel B. D. Kardiyo Praptokardiyo Kasiyati Kasiati Ketut Adnyane Mudite Kharisma Mardathilah Kharisma Mardathilah Kiranadi Bambang koekoeh santoso Koeswinarning Sigit Komang G. Wiryawan Komariah Komariah Komariah Krido Brahmo Putro Kusdiantoro Mohamad Kusumorini Nastiti Kusumorini Nastiti La Eddy La Jumadin Leliana Nugrahaning Widi Leliana Nugrahaning Widi Leliana Nugrahaning Widi Leliana Nugrahaning Widi Leliana Nugrahaning Widi Leliana Widi Leliana Widi Lendrawati Lendrawati Leo Sapelani Soinbala Lies Parede Lina Noviyanti Sutardi Lis Rosmanah Livana Dethris Rawung Lucia Johana Lambey M. Zairin Junior M.Y Sumaryadi Madyastuti, Rini Maneewong, Sattabongkoch Mardathilah, Kharisma Mas Yedi Sumaryadi Masriani . Meillisa C. Mainassy Mia Fitriana, And Mien Th. R. Lapian Mohamad Hasil Tamzil Mohamad Yamin Mohamad Yogie Hendrawan Mohammad Miftahurrohman Mokhamad Fakhrul Ulum, Mokhamad Muhaimin Hamzah MUHAMMAD AGUS SUPRAYUDI Muhammad Darjat Darulfalah Muhammad Darjat Darulfalah Muhammad Junior Zairin Muhammad Rizki Muhammad Zairin Jr Muhammad Zairin Jr. Murniaty Simorangkir Mustika, Aulia A. Nabila Martha Ludi Miftahurahma Nahrowi Nahrowi Nastiti Kusomorini Nastiti Kusomorini NASTITI KUSUMORINI Nastiti Kusumorini Nastiti Kusumorini NASTITI KUSUMORINI Ni Made Ria Isriyanthi Nur Bambang Priyo Utomo Nur Bambang Priyo Utomo Nurhidayat - Nurhidayat, Nurhidayat Odang Carman Ong Huey, Lynette Pollung Hasiholan Siagian PONIMAN PONIMAN Pudji Achmadi Purwantiningsih Sugita Putra, Hamdika Yendri Putut I. Pudjiono R G Sianturi Raden Roro Sri Pudji Sinarni Dewi Rahminiwati, Min Rarah Ratih Adjie Maheswari Resi Milna Revolson Mege Riasari Gail Sianturi Riasari Gail Sianturi Riasari Gail Sianturi Ridi Arif RIDWAN AFFANDI Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Risna Anggraeni Ronny Rachman Noor Rosdianto, Aziiz Mardanarian Rosdianto, Aziiz Mardanarian Rosmanah, Lis Rudi Priyanto Rudi Priyanto Rudy Priyanto Rukmiasih Rukmiasih Ruqiah Ganda Putri Panjaitan Sabri Mustafa Safrida Safrida SATA YOSHIDA SRIE RAHAYU Sela Septima Mariya Sharon Aurellia Silmy Kamila Widyanti Silmy Kamila Widyanti Sitti Wajizah Sitti Wajizah Sri Catur Setyawatiningsih Sri Catur Setyawatiningsih Sri Nuryati Sri Subekti Subangkit, Mawar Suhendro, Ikhsan Sumiati Sumiati Sumiati Sumiati Sumiaty Aiba Sunarno . Sunarno s Sunarno s Supiyani, Atin Sutiastuti Wahyuwardani Sutiastuti Wahyuwardani SYAHRUN HAMDANI NASUTION Tarigan, Ronald TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN TATI NURHAYATI Tiltje Andretha Ransaleleh TOHA SUTARDI Toto Toharmat Tri Budhi Murdiati Tri Budhi Murdiati Tuti Aswani Tutik Wresdiyati Umi Cahyaningsih UUS SAEPULOH Uus Saepuloh Wahyuni, Sri Wida Lesmanawati WIDANARNI WIDANARNI Widi, Leliana Nugrahaning wirahadikesuma, ikhwan Wirahadikesuma, Ikhwan Wirahadikesuma Wiranda G Piliang Wiranda G Piliang Wiranda G. Piliang Wiwin Winarsih Y. Hadiroseyani Yayuk Sri Rahayu Yendri, Hamdika Yetmaneli, Yetmaneli Yudha Trinoegraha Adiputra Yudha Trinoegraha Adiputra Yulia Yellita Yuliansah, Diky Yulvian Sani yuri, Nurasmi yuri Yusa Irarang Yusa Irarang Yusa Irarang Yusfiati Yusfiati Yuvensius Yuvensius Zora, Nelda Fliza Zulfa Zakiah