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All Journal e-GIGI Prosiding Seminar Biologi Indonesian Journal of Cancer Chemoprevention Journal of Mathematical and Fundamental Sciences Indonesian Journal of Cancer Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kreativitas PKM SONDE (Sound of Dentistry) Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Poltekita: Jurnal Pengabdian Masyarakat ABDI MOESTOPO: Jurnal Pengabdian pada Masyarakat Narra J Proceeding Biology Education Conference Indonesian Journal of Cancer Jurnal Kedokteran Gigi Terpadu JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu
Ferry Sandra
Department Of Biochemistry And Molecular Biology, Division Of Oral Biology, Faculty Of Dentistry, Universitas Trisakti
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Role of Estrogen Receptor Alpha rs3798577 Polymorphism in Breast Carcinoma Risk Determination Pieri Kumaladewi; Wirsma Arif Harahap; Bastian Nova; Irianiwati Widodo; Ramadhan Karsono; Ferry Sandra; Bethy Suryawathy Hernowo
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2002

Abstract

BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the regulation and differentiation of breast tumorigenesis. Some ERα polymorphisms, including ERα rs3798577, are reported to be associated with the risk and aggressiveness of breast carcinoma since the site was reported to be targeted by microRNA, which can further modulate the ERα expression. Hence, this study was conducted to disclose the possible role of ERα SNP rs3798577 on breast carcinoma patients.METHODS: Samples were taken from the post-mastectomy breast carcinoma tissues of female patients and screened based on the completeness of medical and histopathological records. DNA isolation was proceeded using real time-polymerase chain reaction (RT-PCR) then analyzed for high resolution melting (HRM). The nucleotide base sequence was then analyzed based on rs3798577 ERα polymorphism. ER immunohistochemistry test was carried out and counted quantitatively based on the staining intensity and the percentage of the stained cells.RESULTS: Out of 65 samples, there were 33 samples as wild type and 32 samples as variant type. Most variant and wild type had >80% ERα percentage. Most variant type had middle ERα intensity, while wild type had strong ERα intensity. Higher percentage of variant type (52.2%) was found with weak ERα histoscore, meanwhile higher percentage of wild type (52.4%) was found with strong ERα histoscore, but not significant (p=0.725).CONCLUSION: ERα rs3798577 variant type had a lower ERα intensity and weaker ERα histoscore compared to the wild type, suggesting that ERα rs3798577 polymorphism might play a role in breast carcinoma risk determination.KEYWORDS: breast cancer, ERα, rs3798577, polymorphism, immunoexpression
Caffeic Acid Induces Apoptosis in MG-63 Osteosarcoma Cells via Protein Kinase C Delta (PKCδ) Translocation and Mitochondrial Membrane Potential Reduction Ferry Sandra; Muhammad Ihsan Rizal; Caecilia Caroline Aliwarga; Jenifer Christy Hadimartana; Maria Celinna
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2089

Abstract

BACKGROUND: Caffeic acid has been reported to activate caspases in MG-63 osteosarcoma cells, which can lead to apoptosis via both extrinsic and intrinsic apoptotic pathways. Translocation of protein kinase C delta (PKCδ), which reduces mitochondrial membrane potential (ΔΨm), is involved in apoptosis. The role of PKCδ translocation and ΔΨm alteration in caffeic acid-induced MG-63 cell apoptosis are largely unknown. Present study investigated the effect of caffeic acid on PKCδ translocation and ΔΨm in MG-63 cells.METHODS: MG-63 cells were cultured and starved, followed by pretreatment with or without Z-VAD-FMK and treatment with or without 10 μg/mL caffeic acid. MG-63 cells were collected, lysed, and processed to obtain cytosolic and mitochondrial fractions. Each fraction was subjected to immunoblotting analysis by using anti-PKCδ antibody. Mitochondrial membrane potential (ΔΨm) was measured using flow cytometry.RESULTS: Cytosolic PKCδ levels were higher than mitochondrial PKCδ levels in untreated and 1 h caffeic acid treatment groups. Inversely, cytosolic PKCδ levels were lower than the mitochondrial PKCδ levels after 6 and 12 h caffeic acid treatment. By Z-VAD-FMK pretreatment, cytosolic PKCδ levels were higher than mitochondrial PKCδ after 6 and 12 h caffeic acid treatment. After 6 h treatment with caffeic acid, ΔΨm was slightly shifted. More shifting occurred in MG-63 cells treated with caffeic acid for 12 h. The ΔΨm shifting was inhibited by Z-VAD-FMK pretreatment.CONCLUSION: Caffeic acid could trigger apoptosis of MG-63 osteosarcoma cells by inducing PKCδ translocation to mitochondria and reducing ΔΨm, which might cause MMP.KEYWORDS: caffeic acid, MG-63, osteosarcoma, PKCδ, mitochondrial membrane potential, mitochondrial membrane permeabilization, Z-VAD-FMK
Caffeic Acid Induces Intrinsic Apoptotic Pathway in MG-63 Osteosarcoma Cells Through Bid Truncation and Cytochrome c Release Ferry Sandra; Muhammad Ihsan Rizal; Ayasha Hajjar Audreyandra Wahid; Monica Andajana; Maria Celinna
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.2032

Abstract

BACKGROUND: Caffeic acid has been reported to induce apoptosis in MG-63 osteosarcoma cells via caspases activation. However, apoptotic pathway that is involved in the caffeic acid-induced apoptosis is still unclear. Present study aimed to investigate the role of cytochrome c (Cyt c) release and BH3-interacting death (Bid) activation in caffeic acid-induced apoptosis in MG-63 osteosarcoma cells.METHODS: MG-63 cells were cultured, pretreated with/without Z-VAD FMK and treated with/without 10 μg/mL caffeic acid. Treated MG-63 cells were then lysed, homogenized, and processed further to prepare cell lysate and mitochondrial fraction. Immunoblotting method was used to measure the amount of Bid and truncated Bid (t-Bid) as well as mitochondrial and cytosolic Cyt c.RESULTS: The amount of Bid and mitochondrial Cyt c in MG-63 cells decreased in a time-dependent manner, while the amount of t-Bid and cytosolic Cyt c increased in a time-dependent manner. By pretreatment of 100 μM Z-VAD-FMK for 2 h, the amount of Bid and mitochondrial Cyt c was significantly higher, while the amount of t-Bid and cytosolic Cyt c was significantly lower after caffeic acid treatment for 6 and 12 h compared to MG-63 cells that were not pretreated.CONCLUSION: Caffeic acid could induce Cyt c release through the activation of Bid in MG-63 osteosarcoma cells.KEYWORDS: caffeic acid, osteosarcoma, MG-63 cells, Bid, t-Bid, cytochrome c, Z-VAD-FMK
Caffeic Acid Inhibits Tumour Mass Formation in MG-63 Cells-induced Nude Mice Ferry Sandra; Dewi Ranggaini; Laifa Annisa Hendarmin; Nurrani Mustika Dewi; Melanie Sadono Djamil
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2078

Abstract

BACKGROUND: Formation of tumour mass is one symptom of osteosarcoma development. Caffeic acid has been known to provide effective treatment but has less side effect for some cancer therapy. Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo.METHODS: MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. After 90 days, mice were anaesthetised, and the nodule pictures were taken for observation and measurement. RESULTS: In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. Ten µg/mL caffeic acid pre-treatment was able to significantly lower the mass volume compared to the untreated (p<0.05). Meanwhile, the intra-tumour treatment of 10 µg/mL caffeic acid, even though not significant, was able to inhibit tumour mass formation.CONCLUSION: Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. This suggests that caffeic acid can be a potential anti-cancer agent.KEYWORDS: caffeic acid, osteosarcoma, MG-63 cells, tumour mass
Caffeic Acid Inhibits Swelling, Bone Loss, and Osteoclastogenesis in Adjuvant-induced Arthritis Rats Ferry Sandra; Muhammad Ihsan Rizal; Nurrani Mustika Dewi; Toshio Kukita
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.2033

Abstract

BACKGROUND: Increase in inflammatory cytokine levels promotes pathological osteoclast differentiation. Caffeic acid has anti-inflammatory properties and can inhibit osteoclast bone resorption. In vitro studies have reported the ability of caffeic acid in inhibiting osteoclastogenesis pathways, however the in vivo study is rarely conducted. The aim of this study is to examine the role of caffeic acid in reducing inflammation and inhibiting osteoclastogenesis in Adjuvant-Induced Arthritis (AIA) rats.METHODS: Rats were injected with Freund’s Complete Adjuvant (CFA) and mineral oil. One day after injection, various concentration (0, 5, 25, 125 mg) of caffeic acid were given gastro-intestinally. Swelling degree in rats’ ankle joints was determined by measuring height and width of each ankle joint. Bone loss level was examined with soft X-ray, and then bone density was calculated. To examine osteoclastogenesis, ankle joints were stained with Tartrate-Resistant Acid Phosphatase (TRAP) and evaluated microscopically. RESULTS: Ankle joints of AIA rats had severe swelling before treated, yet the swelling was reduced based on concentration-dependent after receiving caffeic acid. Severe bone loss in AIA rats’ ankle joints were also observed, however the treatment of 125 mg caffeic acid showed remarkable inhibition effect toward rats’ bone loss. Osteoclastogenesis in AIA rats’ ankle joints were higher than the normal ones, as indicated with high TRAP-positive Multinucleated Cells (MNCs). But low number of TRAP-positive MNCs was observed in ankle joint of AIA rats that received 125 mg caffeic acid.CONCLUSION: Administration of caffeic acid can reduce the degree of swallowing, inhibit bone loss, and inhibit osteoclastogenesis in ankle joint of arthritis-induced rats.KEYWORDS: caffeic acid, osteoclastogenesis, bone loss, swelling, inflammation, RANKL, TNF-α
Peningkatan Pengetahuan Kesehatan Gigi dan Mulut pada Remaja: Siswa SMP St. Bellaminus Menteng Jakarta Ferry Sandra; Komariah Komariah; Wiena Widyastuti; Muhammad Novo Perwira Lubis; Bianda Claresta; Joceline Setiawan; Steward Steward; Maria Verena Emeralda; Louise Anastasya
Poltekita: Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2023): Januari-Maret
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (856.767 KB) | DOI: 10.33860/pjpm.v4i1.1434

Abstract

This community health service aims to educate and to train St. Bellarminus Junior High School Students on the importance of dental and oral health for adolescents. The community health service program was initialized with situational analysis. Students' prior knowledge (pre-test) was assessed with 16 questions using Google form on 61 students. For the intervention, education and training was performed virtually. After the intervention, post-test was conducted to evaluate the effectiveness. Pre- and post-test questions were divided in 3 categories, which were A: general health, B: dental and oral health, C: advanced dental and oral health. Based on the pre- and post-test results, the community service program had increased the numbers of students answering correctly for each question. The percentage of students answering correctly was elevated from 57.58% (pre-test results) to 72.23% (post-test results). Meanwhile, based on knowledge category, the A and B categories were both markedly elevated after the program, suggesting the program has given positive impact for the St. Bellarminus Junior High students. Since the community health service program has given positive impact for students, hence the program should be conducted continuously.
SITOTOKSISITAS EKSTRAK CAMPURAN BUAH SIRIH, PINANG, DAN KAPUR TERHADAP GALUR SEL 3T3 Rahmi Amtha; Najla Nadiah; Felix Wong; Ferry Sandra
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol. 6 No. 1 (2022): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v6i1.11979

Abstract

The habit of betel quid chewing has been determined by the WHO as a risk factor for oral cancer due to the carcinogenic substances contained in the mixture. Betel quid chewing is a habit of chewing a mixture of betel, areca nut, and slaked lime with or without tobacco. Until now, betel quid chewing is still one of the habit of people in several countries in Southeast Asia, including Indonesia. The culture of betel quid chewing is still high, especially in eastern Indonesia. The composition of quid used may vary in each area. Eastern Indonesia uses more Piper betel inflorescence (betel fruit) than betel leaf. A study on the cytotoxicity of a mixture of betel fruit, areca nut, and lime originating from NTT Kupang, has never been carried out. This study aimed to determine the cytotoxicity of the mixture extracts mentioned above against 3T3 cell lines fibroblast and its Inhibitory Concentration of 50% (IC50). Cytotoxicity test using MTT assay was carried out on fibroblast 3T3 cell lines on betel mixtures with concentrations of 0, 30, 60, and 120 µg/mL at the 24 and 48 hour incubation period. The extract mixture shows the highest toxic concentration of 120 µg/mL with an incubation period of 48 hours. The IC50 of the extract at the 24 and 48 hour incubation period was 125,21 µg/mL, and 155.06 µg/mL respectively. The mixture of Piper betel inflorescence, areca nut, and lime extracts is cytotoxic against 3T3 cell lines. Keywords: cytotoxicity; piper betel inflorescence; areca nuts; slaked lime; 3T3 AbstrakKebiasaan menyirih telah ditetapkan oleh WHO sebagai salah satu faktor risiko terjadinya kanker mulut dikarenakan adanya bahan karsinogenik yang terkandung dalam campurannya. Menyirih merupakan suatu kebiasaan mengunyah campuran buah sirih, pinang, dan kapur dengan atau tanpa tembakau. Hingga kini menyirih masih menjadi salah satu kebiasaan masyarakat pada beberapa negara di Asia Tenggara termasuk Indonesia. Budaya mengunyah sirih masih cukup tinggi terutama di Indonesia bagian timur. Campuran sirih yang digunakannya dapat bervariasi. Indonesia timur lebih banyak menggunakan buah sirih dibandingkan daun sirih. Penelitian mengenai sitotoksisitas campuran buah sirih, pinang dan kapur yang berasal dari NTT Kupang, belum pernah dilakukan. Tujuan penelitian ini adalah untuk mengetahui sitotoksisitas campuran ekstrak buah sirih, pinang dan kapur terhadap galur sel fibroblast 3T3 serta Inhibitory Concentration of 50% (IC50). Uji sitotoksitas dengan MTT assay dilakukan pada galur sel fibroblast 3T3 terhadap campuran sirih dengan konsentrasi 0, 30, 60 dan 120 µg/mL pada masa inkubasi 24 dan 48 jam. Campuran ekstrak yang menunjukkan sitotoksik paling tinggi pada konsentrasi 120 µg/mL dalam masa inkubasi 48 jam. IC50 ekstrak pada masa inkubasi 24 dan 48 jam adalah 125,21 µg/mL dan 155,06 µg/mL. Campuran ekstrak buah sirih, pinang dan kapur bersifat sitotoksik terhadap galur sel 3T3.
Crucial Triad in Pulp-Dentin Complex Regeneration: Dental Stem Cells, Scaffolds, and Signaling Molecules Ferry Sandra; Andri Sutanto; Widya Wulandari; Reynaldo Lambertus; Maria Celinna; Nurrani Mustika Dewi; Solachuddin Jauhari Arief Ichwan
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2265

Abstract

BACKGROUND: Pulp damage can lead to dentinogenesis impairment, irreversible pulpitis, or pulp necrosis. Despite being the most used endodontic procedure to treat damaged pulp, root canal therapy only results in nonvital teeth which are prone to fractures and secondary infection. Pulp-dentin regeneration has a potential to regenerate structure similar to normal pulp-dentin complex, and can be achieved by combining dental stem cells, scaffold, and signaling molecules. This article reviews the role of various types of dental stem cells, scaffolds, signaling molecules, and their combinations in regenerating pulp-dentin complex.CONTENT: Dental pulp stem cell (DPSC), stem cell from human exfoliated deciduous teeth (SHED), and dental follicle stem cell (DFSC) were reported to regenerate pulp-dentin complex in situ. SHED might be more promising than DPSCs and DFSCs for regenerating pulp-dentin complex, since SHED have a higher proliferation potential and higher expression levels of signaling molecules. Scaffolds have characteristics resembling extracellular matrix, thus providing a suitable microenvironment for transplanted dental stem cells. To accelerate the regeneration process, exogenous signaling molecules are often delivered together with dental stem cells. Scaffolds and signaling molecules have different regenerative potential, including induction of cell proliferation and migration, formation of pulp- and/or dentin-like tissue, as well as angiogenesis and neurogenesis promotion.SUMMARY: Combinations of dental stem cells, scaffold, and signaling molecules are important to achieve the functional pulp-dentin complex formation. Current trends and future directions on regenerative endodontics should be explored. The right combination of dental stem cells, scaffold, and signaling molecules could be determined based on the patients’ characteristics. Incomplete pulp-dentin regeneration could be overcome by applying dental stem cells, scaffold, and/or signaling molecules in multiple visits.KEYWORDS: pulp-dentin regeneration, regenerative endodontics, dental stem cells, scaffold, signaling molecules
Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome Syanindita Puspa Wardhani; Khilmi Ainun Nadliroh; Al Mazida Fauzil Aishaqeena; Fahriza Abid Sonia; Achmad Guntur Hermawan Suryo Adji; Intan Masyfufah Hanim; Rizkia Milladina Hidayatulloh; Anna Fuji Rahimah; Ardian Rizal; Peter Sugita; Ferry Sandra; Djanggan Sargowo
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2137

Abstract

BACKGROUND: Cardiometabolic syndrome is a risk factor for the development of diseases related to cardiovascular disease and decreased renal function. Ganoderma lucidum polysaccharide peptide (GLPP) has been reported to have anti-inflammatory and antioxidant properties. The current study was conducted to investigate the role of GLPP in inflammatory, oxidative stress and renal function markers of cardiometabolic subjects.METHODS: A randomized double-blinded perspective control trial with pre-post design was conducted. Cardiometabolic syndrome subjects were treated with placebo or GLPP for 60 days. Blood serum was collected from each subject before the first capsule consumption and one day after the last capsule consumption. Serum tumor necrosis factor (TNF)-α, high-sensitivity-C-Reactive Protein (hs-CRP) and malondialdehyde (MDA) levels were measured using enzyme-linked immunosorbent assay, while superoxide dismutase (SOD) level was measured using colorimetric assay. Serum urea and creatinine levels were measured using a clinical analyzer. The Cockroft-Gault formula was used to calculate estimated glomerular filtration rate (eGFR).RESULTS: Compared with the control group, the MDA level was significantly reduced, while the SOD level was significantly increased in the GLPP treatment group. Furthermore, serum urea and creatinine were lowered, while eGFR was increased in the GLPP treatment group.CONCLUSION: Treatment of GLPP for 60 days could be beneficial for lowering oxidative stress and improving renal function of patients with cardiometabolic syndrome.KEYWORDS: Ganoderma lucidum, cardiometabolic syndrome, inflammation, oxidative stress, renal function
Total and Intratumoral CD8+ T Cell Expressions are Correlated with Miller Payne Grading and WHO Clinical Response of Neoadjuvant Chemotherapy Sonar Soni Panigoro; Sinta Chaira Maulanisa; Ahmad Kurnia; Denni Joko Purwanto; Primariadewi Rustamadji; Herqutanto Herqutanto; Ferry Sandra
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2110

Abstract

BACKGROUND: Chemotherapy has reported to stimulate immune system through direct activation of cluster of differentiation (CD)8+ T cells. Neoadjuvant chemotherapy (NAC) is known to improve the clinical response of locally advanced breast cancer (LABC) patients. However, the immune response-related factor evaluation of NAC in LABC patients has not been routinely performed. Therefore, current study was conducted to evaluate the correlation of NAC-induced CD8+ T cell with chemotherapy response based on Miller Payne grading and World Health Organization (WHO) criteria.METHODS: LABC patients were recruited and data regarding age, gender, tumor, nodal stages, histopathological grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67 were obtained. Biopsy and mastectomy tissues were collected and processed for hematoxylin-eosin and CD8 immunohistochemical staining. CD8+ T cell expression in peritumoral and intratumoral areas were documented and measured. Clinical responses based on Miller Payne grading and WHO were analyzed and correlated with CD8+ T cell expression.RESULTS: There were more subjects with high expression of total (80%), intratumoral (82.5%) and peritumoral (65%) CD8+ T cell expressions. The total (p=0.013) and intratumoral (p=0.015) CD8+ T cell expression, but not peritumoral CD8+ T cell expression, were significantly correlated with Miller Payne Grading. The total (p=0.009) and intratumoral (p=0.001) CD8+ T cell expressions were also significantly correlated with WHO clinical response.CONCLUSION: Total and intratumoral CD8+ T cell expressions are correlated with Miller Payne grading and WHO clinical response of NAC. Therefore, total and intratumoral CD8+ T cell expressions could be suggested as a predictive marker for clinical response of NAC.KEYWORDS: breast cancer, neoadjuvant chemotherapy, CD8, clinical response, Miller Payne, intratumoral, peritumoral 
Co-Authors Abdul Gani Soulisa Abdul Gani Soulisa Achmad Guntur Hermawan Suryo Adji Achmad Kemal Harzif Addin Trirahmanto Ade Prijanti Dwisaptarini Adriana Todingrante Afiana Rohmani Ahmad Dian Wahyudiono Ahmad Kurnia Ahmad R. Utomo Ahmad R. Utomo Aida Fitri Nazillah Al Mazida Fauzil Aishaqeena Alfred Pakpahan, Alfred Ali Sulaiman Alida Roswita Harahap Alpha Fardah Athiyyah Amalia Isnaeni, Nur Amelia Astriani Putri Aminuddin Aminuddin Amirudin Eso Anang Endaryanto Andayani, Lia H. Andi Asadul Islam Andi Wijaya Andi Wijaya Andon Hestiantoro Andri Sutanto Andrian Nova Fitri Andrijono Andrijono Andy Darma Andy Wirahadikusumah Anggraeni, Rezky Angliana Chouw Angliana Chouw Angliana Chouw Angliana Chouw Ani Retno Prijanti Anie Apriani Anna Fuji Rahimah Annisa Amalia Annisa Putri Ariyani Annistri, Savrinda Anwar Santoso Aprisia, Kartika Dwi Ardian Rizal Aria Kekalih Arief Boediono Ariesanti, Yessy Arif Kurniawan Arif Santoso Arif Satria Arimaswti Arimaswati Ariyani, Annisa Putri Armelia Sari Arum Kartikadewi Arya Nur Ihsan Aryani Hayuningtyas, Ria Aryu Candra Asmarinah Asmarinah Ayasha Hajjar Audreyandra Wahid Ayu Rahadiyanti Ayunita Tri Wirattami Aznan Lelo Bambang Sutrisna Bambang Sutrisna Bastian Nova Benyamin Lukito Bethy Suryawathy Hernowo Bianda Claresta Bianda Claresta Blanca Sarizta Boedi Oetomo Roeslan, Boedi Oetomo Boenjamin Setiawan Britanto Dani Wicaksono Budi Utomo Budiono, Bernardus Parish Bukhari, Agussalim Caecilia Caroline Aliwarga Caesary Cloudya P Caesary Cloudya Panjaitan Cahyono Kaelan Camy F. Surjadi Caroline T. Sardjono Caroline Tan Sardjono Caroline Tan Sardjono Chandra Risdian Chandra Risdian Chantika Amardhia Paramita Putri Ciptadhi Tri Oka Binartha Ciptadhi Tri Oka, Ciptadhi Tri Cloudya P, Caesary Cloudya Panjaitan, Caesary Dea Jane Sungkono Denni Joko Purwanto Devi Nisa Hidayati Deviyanti Pratiwi Dewi Liliany Margaretta, Dewi Liliany Dewi Lilyani Margaretha Dewi Ranggaini Dewi, Dian Andriani Ratna Dhaniar, Afifah Yumna dharma Lindarto, dharma Diah Savitri Ernawati Dian R Laksmitawati Dian Ratih Laksmitawati Diana Nur Afifah, Diana Nur Dina Keumala Sari Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djoko Wahono Soeatmadji Dominica Dian Saraswati Sumantri Dwi Davidson Rihibiha Dwifulqi, Hernindya Edi Handoko Eka Seftiana Indahsari Elina Ardiani Sidharta Elisabeth Pricilia Sunata Elline, Elline Ellyza Nasrul Elvita Rahmi Daulay Em Yunir, Em Enny Probosari Enos Tangke Arung, Enos Tangke Ergia Latifolia Eriawan Agung Nugroho, Eriawan Agung Erizal Sugiono Erlina Sih Mahanani, Erlina Sih Ervi Afifah Fahriza Abid Sonia Farhat, Farhat Farid Sastra Nagara Farid Sastra Nagara, Farid Sastra Fatmawati Fatmawati Fauzia Purnamasari Febriyeni, Febriyeni Felix Wong Fibryanto, Eko Fillah Fithra Dieny Fitriasih Fitriasih Fitriyadi Kusuma Franciscus D. Suyatna Frans D. Suyatna Frisca Frisca FX Budhianto Suhadi George Mathew Gita Pratama Gwendy Aniko Hadrian, Gary Halim, Johni HANA RATNAWATI Hariyono Winarto Harry Akza Putrawan Harry Murti Harryanto Wijaya Harryanto Wijaya Hartono, Tiffany Harun Iskandar Hayatun Nufus Hayuningtyas, Ria A. Hayuningtyas, Ria Aryani Hendradi Surjotomo Hendy Setyo Yudhanto Heri Wibowo Herqutanto Herqutanto Hidajat, Boerhan Hilary Limen Huda Shalahudin Darusman I Gusti Made Reza Gunadi Ranuh I Putu Sudayasa Ibnu Suryatmojo Ichwan, Solachuddin Jauhari Arief Ida Parwati Idrus Alwi Ihsan Rizal, Muhammad Ikhsan Nur Arifin Ilham Jaya Patellongi Ilhamjaya Patellongi Indra Bachtiar Indradewa, Rhian Indrayadi Gunardi Indriyanti Rafi Sukmawati Indriyanti Rafi Sukmawati Ingrid Suryanti Surono Intan Masyfufah Hanim Irawan Yusuf Irawan Yusuf Irianiwati Widodo Irvan Septrian S P R Irvanyuni Japutri Ivet Suriapranata Jackson Jackson, Jackson James Handojo Jamhari Jamhari Janti Sudiono Janti Sudiono Janti Sudiono Janti Sudiono Janti Sudiono Jasmine Shafira Jasmine Shafira, Jasmine Jeanne A. Pawitan Jeanne A. Pawitan Jenifer Christy Hadimartana Jennifer Putri Jessica Nathalia Chandra Jessica Nathalia Chandra, Jessica Nathalia Joceline Setiawan Johan Arief Budiman Juliani Hardja Buntara, Magdalena Juminten Saimin Junita Briskila Jusak Nugraha Jusuf Rachmat Karina Febriani Hudono Karyono Mintaroem Kent Wijaya Setiawan Ketherin Ketherin Ketherin Ketherin Ketherin Ketherin Ketherin, Ketherin Khairun Nisa Kharima Abdullah Kharima Abdullah, Kharima Khilmi Ainun Nadliroh Kirana, Farenza Okta Komariah Komariah Komariah Komariah Komariah Komariah Kusuma, Yohanna Laifa Annisa Hendarmin Laila Nuranna Lee, Kyung H. Lee, Kyung Hoon Lelyana, Shelly Leo Alberto Porjo Lia Hapsari Andayani Lidya Imelda Laksmi Linda Lison Linda Sari Sembiring Livia Alvita Liza Meutia Sari Louise Anastasya Luki Astuti Luthfiatul Khusna M Novo P Lubis Maesaroh Maesaroh Makmun, Armanto Mansyur Arif Mansyur Arif Marcellus Simadibrata Maria Celinna Maria Celinna Maria Evi Novianti Maria Verena Emeralda Marshel Tendean Marshel Tendean MARTHA ARDIARIA Maulanisa, Sinta C. Maurin Merlina Meita Hendrianingtyas Melanie S Djamil Melanie Sadono Djamil Melanie Sadono Djamil Melanie Sadono Djamil Melanie Sadono Djamil, Melanie Sadono Melina Setiawan Melinia Melinia Meta Ariyani Sidharta Meta Ariyani Sidharta, Meta Ariyani Mirta Hediyati Reksodiputro Mohammad Aris Widodo Mohammad Aris Widodo Mohammad Sadikin Mohammad Sadikin Monica Andajana Muhamad Rizki Fadlan Muhammad Diah Muhammad Hamdan Muhammad Ihsan Rizal, Muhammad Ihsan Muhammad Novo Perwira Lubis Muharam, Muharam Muharam, Raden Mulyawati, Sufiah Asri MUTMAINNAH, FITRI Nadhia Sari Afiana Nadhia Sari Afiana, Nadhia Sari Nadiah, Najla Nadya Saputri Halim Najla Nadiah Naliani, Silvia Nani Maharani Nanik Setjowati Nasrul Zubir Neni Susilaningsih Nenni Pratiwi Nova Adrian Noviasti Rahma Utami Novriansyah, Robin Nur Ahmad Tabri Nur Indah Purnamasari Nur Zam Zam Nuralifah Nuralifah, Nuralifah Nurani Hayati Nuri Dyah Indrasari Nurjannah Lihawa Nurrani Mustika Dewi Nurrani Mustika Dewi Nurrani Mustika Dewi, Nurrani Mustika Nurul Fauziah Nyoman Suci Widiastiti Oetomo Roeslan, Boedi Olivia Nauli Komala P Lubis, M Novo Pande Putu Erawijantari Pang, Tiffany Parawansah Parawansah Pendrianto Pendrianto Peter Kabo Peter Sugita Pieri Kumaladewi Prasetya, David Eka Pratitis, Visi Endah Primariadewi Rustamadji Primariadewi Rustamadji Pudji Rahajoe Pudji Rahaju Pukovisa Prawiroharjo, Pukovisa Putri Y Suyanto Putri Y Suyanto, Putri Y Putri, Indah Aprianti Quan Yong Tang Rachma Purwanti Rafika Indah Paramita Rahmawati Rahmawati Rahmawati, Dicha Yuliadewi Rahmi Amtha Rahmi Amtha Rahmi Annisa Ramadhan Karsono Ramadhan Ramadhan Rambu Beppy Hamuaty Rambu Beppy Hamuaty, Rambu Beppy Ranggaini, Dewi Ratna Akbari Ganie Respati, Danendra Rakha Putra Retno Asih Setyoningrum Reynaldo Lambertus Rifqi Fauzan Hakim Riko Nofrizal Rio Auricknaga Kintono Riris L. Puspitasari Riris L. Puspitasari Rita Lahirin Rita Lahirin, Rita Ritawaty Ritawaty Rizal Rizal Rizkia Milladina Hidayatulloh Roihatul Mutiah Ronald Winardi Kartika Rosalina Tjandrawinata Roya Khosravi-Far Roya Khosravi-Far Ryco Giftyan Ardika Saleha Sungkar Saptawati Bardosono Saraswati, Jaya Sari, Armelia Sarwono Waspadji Scania, Alifah Evi Seila Arumwardana Septrian S P R, Irvan Setiawan, Kent Wijaya Siti Mega Komariyah SITI NURUL HIDAYATI Soehartono Soehartono Solachuddin Jauhari Arief Ichwan Sonar Soni Panigoro Soulisa, Abdul Gani Soulissa, Abdul G. Sri Mutya Sekarutami Stefani, Rosita Steffi Kurniawan Steward Hadi Steward Steward Sudarmo, Subijanto Marto Suhendro Suhendro Sukartini, Ninik Susi Tjahyani Susy Tjahyani Suzzana Immanuel Syafiqa Amelia, Dinda Syafira Noor Pratiwi Syakib Bakri Syanindita Puspa Wardhani Syarifin, Andi Noor Kholidha Tadahiko Iijima Tadahiko Iijima Taramalinda, Elizabeth Yuliani Taslim, Nurpudji Astuti Tatsushi Muta Teguh Santoso Teguh, Sharren Timotius Andi Kadrianto Tjandra, Kevin Christian Tjandrawati Mozef Tjandrawati Mozef Tjandrawati Mozef Todung Silalahi Toshio Kukita Toshio Kukita Trijani Suwandi Trisfilha, Pretty Tugas Ratmono Tulandi, Togas Uleng Bahrun Victor Reiner Sutanto, Aldrich Virgi Saputra Wa Ode Siti Rahayu Fathanah Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wibi Riawan Widiastiti, Nyoman Suci Widya Wulandari Widyastuti, Wiena Wiena Widyastuti Wijaya, Haryanto William Yusuf, Timotius Winarko Luminturahardjo Wirsma Arif Harahap Yanni Dirgantara Yanni Dirgantara Yanni Dirgantara Yanuarita Tursinawati Yefta Moenadjat Yenti Purnamasari Yohanna Feter Yohanna Feter, Yohanna Yora Nindita Yudi Her Oktaviono, Yudi Her Yuliani Taramalinda, Elizabeth Yusra Yusra Yusrina Lukitasari Yuyus Kusnadi Zulfikar Lubis Zulfikri Muhktar