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All Journal Jurnal Kebijakan Kesehatan Indonesia Disease Prevention and Public Health Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Jurnal Manajemen Kesehatan Indonesia Sari Pediatri Jurnal Kesehatan Medical Laboratory Technology Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kesehatan Medika Saintika Journal of Maternal and Child Health Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Majalah Kedokteran Andalas Majalah Patologi Indonesia Menara Ilmu Bioscientia Medicina : Journal of Biomedicine and Translational Research Poltekita : Jurnal Ilmu Kesehatan Health and Medical Journal Human Care Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Andalas obstetrics and gynecology journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences AN-Nur: Jurnal Kajian dan Pengembangan Kesehatan Masyarakat JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Science and Society (IJSOC) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Andragogi Kesehatan Indonesian Journal of Advanced Research (IJAR) Jurnal Pengabdian Pada Masyarakat METHABDI JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Jurnal Kesehatan Masyarakat Indonesia (JKMI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Proceeding International Health Conference NERS Jurnal Keperawatan
Husna Yetti
Department Of Public Health And Community Medicine, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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PROGRAM “ASMARA - AYO SELAMATKAN MASA REMAJA” UNTUK MENCEGAH PERILAKU BERISIKO PADA SISWA SMPN 23 PADANG: Capacity Enhancement of Adolescent Health Cadres Through the Asmara - Let's Save Adolescence Program to Prevent Risky Behavior Among Students of 23 Junior High School, Padang Yetti, Husna; Burhan, Ida Rahmah; Rasyid, Rosfita; Lestari, Yuniar; Semiarty, Rima; Astiena, Adila Kasni; Fadila, Zurayya; Silvia, Nelmi; Abdiana; Machmud, Rizanda; Firdawati; Hardisman
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 8 No. 3 (2025)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v8i3.798

Abstract

Adolescence is a transitional period that is vulnerable to the emergence of risky behaviors, such as smoking, promiscuity, and lack of health concern. These behaviors can negatively impact adolescent growth and development physically, mentally, and socially. This community service activity aims to increase knowledge and awareness regarding preventing risky behaviors through a health education program for students of SMPN 23, Padang City. The activity methods include preparation and problem identification stages, coordination with partners, and implementation stages, including interactive counseling, group discussions, and distribution of leaflets and promotional banners. The first day of education targeted all students in grades VII and VIII of SMPN 23 Padang. On the second day, education focused on members of the Adolescent Health Cadre (KKR) and the Student Council (OSIS), totaling 27 people. Evaluation was carried out with pre-tests and post-tests to measure the increase in knowledge. The activity results showed a significant increase in the average knowledge score of the cadre students (77.78 to 94.07). In addition, the students showed enthusiasm and active involvement throughout the activity. This educational activity was successfully implemented smoothly and brought about an increase in knowledge among students, KKR cadres, and OSIS. Cadre students understand their role and are expected to be able to serve as peer educators when their peers encounter health issues or risky behavior. Similar activities, involving teachers and parents, need to be implemented continuously to optimize risky behavior prevention.
Loss of E-cadherin Expression Stratifies Aggressive versus Non-Aggressive Papillary Thyroid Carcinoma Dwi Yanti Fioni Putri; Yenita; Aswiyanti Asri; Tofrizal; Rony Rustam; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i2.1498

Abstract

Background: Papillary thyroid carcinoma (PTC) is generally indolent, yet specific histological subtypes defined by the World Health Organization (WHO) are linked to aggressive behavior and poor prognosis. The loss of the cell-adhesion protein E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT), a process implicated in tumor aggression. However, its role in stratifying PTC subtypes versus its correlation with tumor stage remains a significant controversy in the literature. This study aimed to disentangle these two parameters by clarifying the relationship between E-cadherin expression and both histological phenotype and tumor stage. Methods: This was an observational, cross-sectional pilot study on 40 randomly selected, formalin-fixed, paraffin-embedded (FFPE) PTC cases from a 2024 cohort (N=74) at a tertiary hospital in Indonesia. All cases were re-evaluated and classified according to the WHO 5th Edition (2022) criteria as non-aggressive (n=34) or aggressive (n=6). E-cadherin expression was assessed by immunohistochemistry (IHC) using a standardized semi-quantitative scoring system (product of intensity and proportion) adapted from previous studies, with inter-rater reliability assessed (Cohen’s Kappa = 0.88). Scores were dichotomized as 'High' (n=25) or 'Low' (n=15). The association between E-cadherin expression and both histological subtype and AJCC 8th Edition tumor stage (Early: I/II [n=32] vs. Advanced: III/IV [n=8]) was analyzed using Fisher's Exact Test, with Odds Ratios (OR) and 95% Confidence Intervals (CI) calculated. Results: High E-cadherin expression was observed in 62.5% of cases. A statistically significant and strong association was found between E-cadherin expression and histological subtype (p=0.021; OR 12.0; 95% CI 1.2–118.9). Low E-cadherin expression was present in 83.3% (5 of 6) of aggressive-subtype tumors, versus only 29.4% (10 of 34) of non-aggressive subtypes. In contrast, no significant correlation was found between E-cadherin expression and advanced tumor stage (p=0.126; OR 3.67; 95% CI 0.7–18.6). Conclusion: Loss of E-cadherin expression is a significant biomarker associated with high-risk, aggressive histological phenotypes in PTC. Its lack of correlation with tumor stage, confirmed by an uncertain OR, suggests E-cadherin's role is indicative of an inherent tumor biological phenotype (aggressiveness) rather than a linear marker of tumor progression (stage). This dichotomy, likely reflecting EMT/MET plasticity, positions E-cadherin IHC as a powerful ancillary tool for pathological risk stratification.
PENINGKATAN UPAYA KESEHATAN SEKOLAH DASAR NEGERI 05 SURAU GADANG MELALUI PELATIHAN DOKTER KECIL: Little Doctor Training As An Effort To Strengthen The School Health Program At SDN 05 Surau Gadang Post-Covid-19 Pandemic Burhan, Ida Rahmah; Yetti, Husna; Faathira, Ken Rabbani; Herinda, Dwi Putri; Genia, Dara Indah; Ansharina, Hafiznie; Sulthani, Muhammad Zhorif
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 8 No. 3 (2025)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v8i3.778

Abstract

Elementary schools are strategic environments for developing healthy lifestyles from an early age through a promotive and preventive approach. The little doctor training program as school health cadres is one effective strategy for strengthening School Health Program (UKS). The training was initiated as a post-COVID-19 pandemic recovery program to revitalize UKS in response to the low implementation of UKS and the high percentage of students who have not implemented Clean and Healthy Living Behaviours (PHBS). To increase the capacity of students at SDN 05 Surau Gadang as school health cadres to achieve school health empowerment. The training was conducted in collaboration with the Nanggalo Community Health Centre with group-based interventions for 63 students in grades 3–5 at SDN 05 Surau Gadang, which included the delivery of material on UKS, PHBS, Primary Preventive Care (P3P), and First Aid for Accidents (P3K), as well as hands-on practice in six-step hand washing and first aid simulations. Evaluation was conducted using pre-tests and post-tests. There was an increase in the average knowledge score from 65.56 to 71.59 (p = 0.019), and the proportion of students in the “good” category increased from 36.5% to 46%. Little doctor training is effective in improving understanding of PHBS and UKS and forming independent elementary school health cadres. This program positively impacts the capacity of community health centres in optimizing ongoing little doctor training programs post-pandemic.
Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Karsinoma Urotelial Infiltratif Kandung Kemih Utami, Dini Andri; Agus, Salmiah; Yenita; Yetti, Husna
Majalah Patologi Indonesia Vol. 31 No. 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i2.499

Abstract

Background Urothelial carcinoma is the most common malignancy in the bladder with an incidence up to 95% and 70-85% of them are bladder infiltrating urothelial carcinoma. To improve the management of bladder urothelial carcinoma, prognostic factors are required. One such factor is angiogenesis, which affects growth, development and metastasis. Vascular endothelial growth factor (VEGF) is the main pro-angiogenic factor to control angiogenesis. Expression of VEGF is correlated with progression of bladder infiltrating urothelial carcinoma, such as grade and lymphovascular invasion. The aim of this study was to determine the correlation of VEGF expression with grade of differentiation and lymphovascular invasion in bladder infiltrating urothelial carcinoma. Methods This research was a retrospective observational cross sectional study with 48 cases of bladder infiltrating urothelial carcinoma in four Anatomical Pathology Laboratory in West Sumatera 2018 and 2019. Samples were reevaluated of HE slide for grade of differentiation and lymphovascular invasion. VEGF expressions in tumor cell s were analyzed using immunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant. Results Bladder infiltrating urothelial carcinoma high grade had more positive VEGF expression (91.7%), while low grade had more negative VEGF expression (58.3%). Lymphovascular invasion positive was mostly found with positive VEGF expression (75%). Statistical analysis showed significant correlation between VEGF expression with grade of differentiation (p=0.001) and lymphovascular invasion (p=0.004). Conclusion The conclusion was VEGF expression had significant correlation with grade of differentiation and lymphovascular invasion of bladder infiltrating urothelial carcinoma.
Co-Authors ', Ardian ', Herman Abdi Setia Putra Abdiana Abdiana Abdiana Abdiana Abdiana, Abdiana Adang Bachtiar Adelia Rachmita, Prima Adelin, Prima Adilla Kasni Astiena Adrial Adrial Afdal Afdal Afriani Afriani - Afriani Afriani, Nita Afriwardi Afriwardi Aini, Julpa Nurul Aisyah Elliyanti Aisyah Herviana Rifka Aisyah Putri Rezeki ALADIN ALADIN Aldino Desra Amel Yanis Amir, Arni Andani Eka Putra Anggelina Effendi Anggra Pramana Anggra Pramana Ansharina, Hafiznie Ariadi , Ariadi Arifni Arifin Arnis En Yulia Arnofyan, Budi Pratama Arya Vermasari Asterina, Asterina Astiena, Adila Kasni Aswad, Fitria Aswiyanti Asri Aswiyanti Asri Athiyyah, Salsa Naudzul Avit Suchitra Basyir, Vaulinne Berliandi, Lucky Bobby Indra Utama Brian Sri Prahastuti Daan Khambri Dasman, Hardisman Deddy Almasdy Defrin Defrin Defrin Defrin Desi Andriani Desia, Maya Dhyna Lidya Lestari Dia Rofinda, Zelly Dia Dini Andri Utami Diniy Miftahul Muthmainah Dolly Irfandy Dutia Gestin Dwi Yanti Fioni Putri Enda Gusnita Endrinaldi Ermayanti, Sabrina Erwani Erwani Eryati Darwin Essy Mandriani Etriyel Myh Etriyel, Etriyel Eva Decroli Faathira, Ken Rabbani Fadila, Zurayya Fajar Aria Phitra Fauzi Ahmad Hasibuan Fika Tri Anggraini Finny Fitry Yani Firdawati Firdawati Firdawati Firdawati Firdawati Firdawati, Firdawati Fitri Nur Handriyani Fitri Yanti Fitriani Karlita Genia, Dara Indah Hanum, Fathiya Juwita Hardian, Sonny Hardisman Hardisman Dasman Haris Pemuda Harun Harnavi Hasmiwati Haviz Yuad Henny Mulyani Henny Mulyani henny Mulyani Hera Novianti Herinda, Dwi Putri Herlina Herlina Herri Hidayanti, Rahmi Husnil Kadri Ida Rahma Burhan Ida Rahmah Burhan Idwar, Idwar Ifmaily Ifmaily Ifmaily, Ifmaily iftahillah - iftahillah Ikhsan Yusda Ilmiawati Ilmiawati, Ilmiawati Indrapriyatna, Ahmad Syafruddin Isniati Isniati Isra Analdo Arza Juniwati Juniwati Juniwati Juniwati Kamal Kasra Katelino Marpaung Kurnia, Nurul Syifa Kusumardani, Dini Laila Nur Azizah Lili Irawati Lili Irawati Loli Devianti Lucky Berliandi Malinda Meinapuri Masrul Masrul Masrul Maulana, Afdal Maya Amanda Mayetti Mayetti Media Fitri Mela Aryati Mellina Rahmi Miftah Irramah Morena, Sivia Heni Mudjiran Muhammad Helmi, Iqbal Mustika Sari Muttakia Hardy, Siti Khalisha Nada Utami Prahastiwi Nadhira Isza Qushoyyi Nana Liana Nelmi Silvia Nia Prima Shartika Nisura, Egi Nizwardi Azkha Nora Harminarti Novria Hesti Noza Hilbertina Noza Hilbertina Noza Hilbertina, Noza Nur Indrawaty Lipoeto Nur Indrawaty Lipoeto Nurhayati Nurhayati Nuzulia Irawati Octavia, Fatharani Nabila Putra Santoso Putri Widya Herman Rachmadijah Zuryati Nizar Rahmaddiansyah, Refa Rahman, Fikri Rahmani Welan Ramadani, Mery Rapida Saragih Ratu Fawwaz Efendi Rauza Sukma Rita Reno Afriza Neri Restu Susanti Reva Arianda Putra Rika Sarfika Rima Semiarty Rini Purnama Sari Rio Hendra Rismawati Yaswir Ritonga, Sukhri Herianto Rizanda Machmud Roery Yohanes Rony Rustam Rony Rustam Rosfita Rasyid Roza Sri Yanti Rozi Sastra Purna Rusli Yulianter RZ Nizar Safnita, Dewi Salmiah Agus Salmiah Agus Salsabila Oktaverina Salsabilla Dhiyaa Syifa Salshabilla, Miftah Saptino Miro Selfi Renita Rusjdi Sharfina Shinta Pertiwi Shreshta Dewi Silvi Korprina Silvia Harpeni Simarmata, Sondang Sirazudeen, Nurhaslinda sondang - nora Suchitra, Avit Sulthani, Muhammad Zhorif Surika Martalina Susanti, Yenila Syamel Muhammad Talsi Transino Tofrizal tofrizal - tofrizal Transino, Talsi Utama, Bobby Indra Utami, Dini Andri Vaulinne Basyir Wizia, Lady Yantri Miaputra Yenila Susanti Yenita . Yenita Afriyeni Yessi Ardiani Yolanda Dwi Santi Violentina Yollanda Dwi Santi Violentina Yuniar Lestari Yuniar Lestari Yusrawati Yusrawati Zukri Afriadi Zulen, Ilham Andhika