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All Journal Medula Juke Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya JITEK (Jurnal Ilmiah Teknosains) Jurnal Ilmu Kedokteran dan Kesehatan Acta Biochimica Indonesiana Jurnal Medika Malahayati SRIWIJAYA JOURNAL OF MEDICINE Jurnal Kesehatan Jurnal Ners Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Jurnal Kedokteran Raflesia Jurnal Pengabdian kepada Masyarakat Prosiding Konferensi Nasional PKM-CSR JCOMENT (Journal of Community Empowerment) Jurnal Informatika Polinema (JIP) Medic Nutricia : Jurnal Ilmu Kesehatan Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Syazili Mustofa
Fakultas Kedokteran Universitas Lampung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Minyak Jelantah 1,5 mL/Hari Selama 14 Hari Terhadap Histopatologi Hepar Rattus norvegicus Jantan Ersa, Rakhmigasti Citra; Susianti, Susianti; Kurniawaty, Evi; Mustofa, Syazili
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1088

Abstract

Using cooking oil multiple times can caused bad effect on health one of them is liver damage. Free radical content in reused cooking oil trigger oxidative stress then disturb the cellular respons in liver. This study aimed to determine the effect of giving reused cooking oil for 14 days on rats (Rattus norvegicus) liver histopathology. This study was a true experimental using 10 rats (Rattus norvegicus) and were devided by 2 groups, which are normal group (KN) and treatment group (KP) that was given 1,5 mL reused cooking oil per day. After 14 days of treatment, rats were terminated and the liver were taken. To observe rats liver histopathology, cloudy swelling scoring were used on 5 field of view. Score 0: there was no cloudy swelling and necrosis found, score 1: there was 1-20% cloudy swelling and necrosis found, score 2: there was 21-50% cloudy swelling and necrosis found, score 3: there was 51-75% cloudy swelling and necrosis found, and score 4: there was more than 75% cloudy swelling and necrosis found.It was found a minimal cloudy swelling on KN with average liver damage score was 0,04. In group KP it were found cloudy swelling degeneration on all over the liver with average liver damage score was 4. Mann-Whitney test showed a significant difference between groups. Giving reused cooking oil 1,5 ml/day for 14 days caused damage on male rats liver histopathology.
Hubungan Usia, Jenis Kelamin, dan Jarak Jahitan Luka dengan Kejadian Infeksi Luka Operasi pada Pasien Apendisitis Perforasi di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Tahun 2020-2021 Caesarridha, Dhaifany Karissa; Wintoko, Risal; Mustofa, Syazili; Soleha, Tri Umiana
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1094

Abstract

Surgical site infection is a type of nosocomial infection with the most common occurrence, which is 38% of all cases of nosocomial infection. The distance of sutures affects the local hemodynamics around the surgical wound and can cause the inhibition of thrombus formation which plays a role in the wound healing process so that it will inhibit wound healing which will lead to increase of bacterial growth and cause infection and tissue damage. This study is an unpaired comparative analytic method with a cross-sectional research design. The sampling technique is total sampling. The research subjects were patients with perforated appendicitis at RSUD Dr. H. Abdul Moeloek, Lampung in 2020-2021, totaling 37 people. The independent variable in this study were age, gender, and the distance between the sutures, while the dependent variable was the incidence of surgical site infection. The study showed that the distance of sutures had a correlation with the incidence of surgical site infection with a p value of 0.00 (<0.05), where the distance of sutures that <2 cm has a higher frequency of surgical site infections than the distance of sutures that ≥2 cm. Age also has a correlation with the incidence of surgical site infection with a p value of 0.041 (<0.05). Meanwhile, gender did not have a correlation with the incidence of surgical site infection with a p value of 0.728 (> 0.05). We can conclude that the distance of sutures and age have a correlation with the incidence of surgical site infection. Otherwise, gender is not associated with the incidence of surgical site infection.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter
Central Obesity as a Risk Factor for Low Back Pain Putri, Reny Arienta; Setiorini, Anggi; Mayasari, Diana; Mustofa, Syazili
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1380

Abstract

Central obesity, or abdominal obesity, is a condition marked by excessive fat accumulation around internal organs, leading to a variety of health complications such as cardiovascular disease, type 2 diabetes, and musculoskeletal disorders, including low back pain (LBP). Central obesity is defined by increased waist circumference, with values greater than 80 cm in women and 90 cm in men. The condition is primarily influenced by factors such as physical inactivity, poor eating habits, and aging. The relationship between central obesity and LBP is supported by studies indicating that abdominal fat increases mechanical load on the lumbar spine, contributing to disc degeneration and pain. Additionally, adipose tissue secretes pro-inflammatory cytokines that exacerbate inflammation and pain sensitization in the spine, leading to LBP. Obesity-related complications, such as muscle weakness and sleep disturbances, can further reduce quality of life. Preventive measures for LBP include physical exercise, weight reduction, and posture correction. Effective treatment options range from pharmacological therapies to physical rehabilitation and alternative medicine approaches. Understanding the link between central obesity and LBP is critical in developing preventive strategies and improving the management of this common condition.
Potensi Daun Jambu Air (Syzygium aquem) sebagai Fitofarmaka : Literature Review Febrianti, Arlin; Susianti, Susianti; Kusumaningtyas, Intan; Mustofa, Syazili
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1456

Abstract

Traditional medicine widely utilizes plant extracts from various parts of plants due to their secondary metabolite content, which possesses therapeutic effects. One plant with high pharmacological potential is the water apple leaf (*Syzygium aqueum*), belonging to the Myrtaceae family and commonly found in tropical regions such as Indonesia, Malaysia, and India. Water apple leaves have been used as phytopharmaceuticals because they contain various bioactive compounds that can be extracted and utilized for treating different diseases. The active compounds commonly found in water apple leaves include alkaloids, flavonoids, steroids, triterpenoids, and coumarins. Studies have shown that water apple leaf extracts exhibit various pharmacological activities, including antibacterial, antioxidant, anti-inflammatory, anticancer, antimicrobial, and antidiabetic properties. Additionally, the bioactive compounds in water apple leaves have the potential to be further developed as natural therapeutic agents for treating degenerative diseases and infections. This pharmacological potential positions water apple leaves as a promising phytopharmaceutical candidate for development in the pharmaceutical and healthcare industries. However, further research is required to explore the mechanisms of action, efficacy, and potential toxicity of the active compounds in water apple leaves. A comprehensive study in this area will enable the optimization of water apple leaves as a safe and effective natural therapy for various diseases.
Uji Toksisitas Subkronik Ekstrak Kulit Batang Bakau (Rhizophora Apiculata) Terhadap Kerusakan Ginjal Tikus Putih Jantan (Rattus Norvegicus) Galur Sparague Dawley Maulana, Rifadly Yusril; Mustofa, Syazili; Busman, Hendri; Kurniawaty, Evi
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1652

Abstract

Toxicity testing is a test to detect toxic effects of a substance in a biological system to obtain characteristic dose-response data from the test preparation. Rhizophora apiculata contains compounds such as alkaloids, flavonoids, triterpenoids, steroids, saponins, and tannins. Tannins are active compounds with potential antioxidant properties. This study is an experimental study using a Posttest Only Control Group Design and was conducted over 28 days on 30 rats divided into 5 groups: the control group (K), Treatment Group 1 at 114 mg/kg body weight (P1), Treatment Group 2 at 228 mg/kg body weight (P2), Treatment Group 3 at 456 mg/kg body weight (P3), and Treatment Group 4 at 912 mg/kg body weight (P4). Data were analyzed using the Kruskal-Wallis statistical test and the Mann-Whitney Post Hoc test. Based on the results of the Kruskal-Wallis statistical test, a p-value of 0.000 was obtained. Meanwhile, based on the results of the Mann-Whitney Post hoc statistical test, groups K, P1, P2, P3, and P4 showed significant differences (p<0.05), while groups P2 and P3, which received intervention or treatment, showed insignificant differences. Administration of mangrove bark extract (Rhizophora apiculata) for 28 days had a toxic effect on the kidneys at a dose of 114 mg/kgBW, with toxic effects in the form of tubular edema and glomerular edema. At doses of 228 mg/kgBW, 456 mg/kgBW, and 912 mg/kgBW, Higher doses resulted in more severe toxic effects on the histopathology of the kidneys of Sprague Dawley rats, as evidenced by tubular edema, glomerular edema, Bowman's space edema, and inflammatory cells.
Identification of Active Compound and Effectiveness Test of 96% Tithonia diversifolia Ethanol Extract on Mortality of Aedes aegypti Mosquito A.P, Gadila; Mustofa, Syazili; Graharti, Risti; Setyaningrum, Endah
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1758

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in tropical regions, with Asia accounting for 70% of global cases and Indonesia reporting a massive 90,269 cases in 2024. Vector control is the primary mitigation strategy due to limitations in available therapies and vaccines, yet reliance on chemical insecticides poses ecological toxicity and resistance risks, driving the need for safer bioinsecticide alternatives. Tithonia diversifolia is known to contain active phytochemical constituents with insecticidal potential. This true experimental study used a Post Test Only with Control Group design conducted from August to September 2025 involving 25 Aedes aegypti per group with four replications. Leaf simplicia were extracted using 96% ethanol, followed by alcohol-free verification, qualitative phytochemical screening, and formulation into spray preparations at concentrations of 5%, 10%, 15%, 20%, and 25%. Mortality was assessed over 24 hours, and statistical evaluation included univariate, bivariate, and probit analyses to determine LC50, LC90, LT50, and LT90. Extraction produced a 12.53% yield containing saponins, flavonoids, phenols, tannins, alkaloids, and steroids. Mosquito mortality increased with rising concentrations, with the highest effectiveness observed at 25%. The Kruskal–Wallis test confirmed significant differences between groups, while LC50 and LC90 values were 2.77% and 5.37%, respectively. Although the highest mortality was observed at 25%, the 20% concentration was considered optimal because it met WHO efficacy standards while using a lower extract concentration.
Co-Authors A.P, Gadila Achmad Gozali Ade Yonata Adityo Wibowo, Adityo Adli, Farhan Kamali Afriyana, Regi Agung Kurnia, Ahmad Fadila Agus Dwi Susanto Agus Wantoro Agustia Pratiwi Agustyas Tjiptaningrum agustyas tjiptaningrum Ahmad A Anindito Aisyah A Putri Amanda Febby Amanda Febby Febrina Amani Raya, Latansa Amertavia, Sindika Ananta, Yoga andestya nanda pratama Andika Ridwan Nugraha Harahap Anggi Adelia Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Anggraeni, Liza Annisa Adietya Pratama Antoni Antoni Apga Repindo Ari Wahyuni Asep Sukohar Asyifa, Takhfa Nur Aviv Fitria Yulia Ayu, Putu Ristyaning Benny Syahputra Gumay Betta Kurniawan Betta Kurniawan, Betta Budhi Antariksa Caesaria Sinta Zuya Caesarridha, Dhaifany Karissa Chicy WIdya Morfi Christi Natalia Sirait Dansen Frans Louise Draven Rudyanto David Tongon Silaen Debby Handayati Harahap Dewi Nur Fiana Dheti Efrilia Dheti Efrilia - Dimas Trend PB Dorisman, Hari Dwi Indria Anggraini Dwi Sarwindah Dyah Wulan Sumekar Rengganis Wardani Ekawati, Diyan Eksa, Dwi Robbiardy Elman Dani Firdaus Endah Setyaningrum Endah Setyaningrum, Endah Ersa, Rakhmigasti Citra Erumbia, Ilham Akbar Ety Apriliana Evi Kurniawaty Evy Kurniawaty Faisal Rohmadhiyaul Haq Faisal Yunus Faisol Rohmadhiyaul Haq Fauziah Hanif Fayza Syachrani Febrianti, Arlin Febrihartati, Isura Feby Aulia Hasanah Femmy Andrifianie Fikri Muhammad Rifai Patongai Firantika Dias Puteri Fitri, Ayu Tiara Fitria Saftarina Fitriyah . Fitriyah Fitriyah Fitriyah Fitriyah Fransisca Sinaga Fredison, Fredison Gerliandi, Egi Oktarian Gigih Setiawan Gilang Kukuh Megantoro Ginting, Bisart Giska Tri Putri Gusti Agung Putu Yogy Veda Ananta Gusti Wahyu, Pratiwi Hakim Alhaady Juhana Hakim Alhaady Juhana, Hakim Alhaady Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Busman Herdato, M. Junus Didiek I Made Afryan SL I Made Galih Fradiva Giantara Idzni Mardhiyah Ifan Aulia Candra Ilma Puteri Hutami Indri Windarti Infianto, Andreas Intan Kusumaningtyas Intanri Kurniati Isnamurti Ciptaningrum Isura Febrihartati Izzati, Marwah Aulia Jamsari Jamsari Jati, Pandu Kumaya Jhons Fatriyadi Suwandi Karima, Nisa Karina, Salwa Al Kevin Jeremia Purba Khairun Nisa Khairun Nisa Khoiri, Ratu Kirana Siva Kholis Abdurachim Audah Kurniawaty, Evi Kusumajati, Pusparini Linda Septiani Listiandoko, Raden Dicky Wirawan Lucky Togihon M. Rakha Gerizha M., Tria Mallarangeng, Andi Nafisah Tendri Adjeng Maulana, Rifadly Yusril Mayasari, Diana Meiwa Rizky Ardhi Blla Putri Mentariasih Maulida Mia Esta Poetri Afdal Faisal Mirza Purwitasari Morfi, Chicy Widya Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Maulana Muhammad Ricky Ramadhian Muhartono Muhartono Muhartono NA, Ahmad Mufid Nadhifa, Farin Nadya Febriani Namdes, Fitri Cyntya Naufal Rivo Aditya Ni Sayu Putu Desya Laksmi Putri Nicholas Alfa Nickyta Yolandita Rosti Novita Carolia Novita Carolia Novita Carolia Nuriah Nuriah Nuriah, Nuriah Nursidiq, Iqbal Muhammad Rafi Oktadoni Saputra, Oktadoni Pinaka Baladika, Dimas Trend Poty, Pitha Maykania Pralia Winda Sari Pratama, Arianda Puan Raissa Lenka Puteri, Vadiyani Fricillya Putra, Andika Chandra Putranata, Naufal R. Putri Adilla Putri, Reny Arienta Rahmasari, Fania Asfi rahmawati, selvi Ramadhan, Muhammad Alif Ramadhana Komala Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi PS Ratna Dewi Puspita Sari Retno A S Soemarwoto Retno Ariza S Soemarwoto Retno Ariza S. Soemarwoto Retno Ariza Soeprihatini Soemarwoto Rheza Paleva Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Putra Sanjaya Rizki Putra Sanjaya Rizki Putra Sanjaya Rizqun Nisa Afriyanti Rosari HS, Felicya Rr Astri Nur Azizah Utama Rusmini, Hetti S Rahmanisa Sani, Nanda Apri Saputra, Tetra Arya Saputra, Tito Tri Sarasmita Nirmala Dewi Septiani, Linda Setiorini, Anggi Shina Megaputri Shinta Nareswari, Shinta Sidik, Faizah Zahrah Silaen, David Silvia Andriani Sinaga, Fransisca T.Y. Sinaga, Fransisca TY Siti Hazrina Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza S Soemarwoto, Retno Ariza Soeprihatini Soeprihatini Soemarwoto, Retno Ariza Soeprihatini, Retno Ariza Soraya Rahmanisa Soraya Rahmanisa Soraya Rahmanisa Sri Janahtul Hayati Sri Janahtul Hayati Sri Puji Hartini Suharyani Suharyani Suharyani Suharyani Sukarti Sukarti Suryadi Islami Suryani Agustina Daulay Susianti Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutyarso Sutyarso Sutyarso Suwarno, Sukarti San Syahrani, Fitri Aulia Syaka, Muthiiah Khodista Syakir, Muhammad Addin Syiefa Renanda Surya Tarigan, Clara Yulianti Terza Aflika Happy Tito Tri Saputra Tito Tri Saputra Tito Tri Saputra Tiwuk Susantiningsih Tri Putri, Giska Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Veny Anisya Victoria Hawarima Virginia, Nur Ayu W Bahagia Wawan Abdullah Setiawan Wayan Ferly Aryana Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Wulan, Anggraini Janar Yana Ayu, Dwi Yandri Yanwirasti Yuningrum, Hesti Zen Hafy Zulia Yasminanindita Fahmi Zulkifli